Multiple alternative splicing and differential expression pattern of the glycogen synthase kinase-3β (GSK3β) gene in goat (Capra hircus)

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Hou, Yuguo ^a   Wang, Yilin ^a   Wang, Yan ^a   Zhong, Tao ^a   Li, Li ^a   Zhang, Hongping ^a   Wang, Linjie ^a  

^a SICHUAN AGRICULTURAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; GLYCOGEN SYNTHASE KINASE 3BETA1; GLYCOGEN SYNTHASE KINASE 3BETA2; GLYCOGEN SYNTHASE KINASE 3BETA3; GLYCOGEN SYNTHASE KINASE 3BETA4; GLYCOGEN SYNTHASE KINASE 3BETA5; GLYCOGEN SYNTHASE KINASE 3BETA6; ISOENZYME; MITOGEN ACTIVATED PROTEIN KINASE P38; UNCLASSIFIED DRUG; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA;

ALTERNATIVE RNA SPLICING; ANIMAL TISSUE; ARTICLE; BIOINFORMATICS; BRAIN; CONTROLLED STUDY; DNA SEQUENCE; DOMESTIC GOAT; ENZYME ACTIVE SITE; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC VARIABILITY; GLYCOGEN SYNTHASE KINASE 3BETA GENE; HEART; KIDNEY; LIVER; LONGISSIMUS DORSI MUSCLE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; SPLEEN; UTERUS; WESTERN BLOTTING; ANIMAL; FEMALE; GENETICS; GOAT;

CAPRA HIRCUS;

ALTERNATIVE SPLICING; ANIMALS; FEMALE; GENE EXPRESSION; GLYCOGEN SYNTHASE KINASE 3; GOATS;

EID: 84908102179     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0109555     Document Type: Article

References (37)

1. Rylatt DB, Aitken A, Bilham T, Condon GD, Embi N, et al. (1980) Glycogen synthase from rabbit skeletal muscle. Amino acid sequence at the sites phosphorylated by glycogen synthase kinase-3, and extension of the N-terminal sequence containing the site phosphorylated by phosphorylase kinase. Eur J Biochem 107: 529-537.
2. Frame S, Cohen P (2001) GSK3 takes centre stage more than 20 years after its discovery. Biochem J 359: 1-16.
3. Jope RS, Johnson GV (2004) The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci 29: 95-102.
4. Liang MH, Chuang DM (2006) Differential roles of glycogen synthase kinase-3 isoforms in the regulation of transcriptional activation. J Biol Chem 281: 30479-30484.
5. Doble BW, Woodgett JR (2003) GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci 116: 1175-1186.
6. Cohen P, Frame S (2001) The renaissance of GSK3. Nat Rev Mol Cell Biol 2: 769-776.
7. Kubic JD, Mascarenhas JB, Iizuka T, Wolfgeher D, Lang D (2012) GSK-3 promotes cell survival, growth, and PAX3 levels in human melanoma cells. Mol Cancer Res 10: 1065-1076.
8. Hye A, Kerr F, Archer N, Foy C, Poppe M, et al. (2005) Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease. Neurosci Lett 373: 1-4.
9. Takashima A (2006) GSK-3 is essential in the pathogenesis of Alzheimer's disease. Journal of Alzheimer's Disease 9: 309-317.
10. Henriksen EJ, Kinnick TR, Teachey MK, O'Keefe MP, Ring D, et al. (2003) Modulation of muscle insulin resistance by selective inhibition of GSK-3 in Zucker diabetic fatty rats. Am J Physiol Endocrinol Metab 284: E892-900.
11. Alon LT, Pietrokovski S, Barkan S, Avrahami L, Kaidanovich-Beilin O, et al. (2011) Selective loss of glycogen synthase kinase-3alpha in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation. FEBS Lett 585: 1158-1162.
12. Dajani R, Fraser E, Roe SM, Young N, Good V, et al. (2001) Crystal Structure of Glycogen Synthase Kinase 3β. Cell 105: 721-732.
13. Woodgett JR (1990) Molecular cloning and expression of glycogen synthase kinase-3/factor A. EMBO J 9: 2431-2438.
14. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378: 785-789.
15. Xianjun Fang, Shuang Xing Yu, Yiling Lu, Robert C. Bast J, Woodgett JR (2000) Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. PNAS 97: 11960-11965.
16. Hughes K, Nikolakaki E, Plyte SE, Totty NF, Woodgett JR (1993) Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation. EMBO J 12: 803-808.
17. Gillespie JR, Ulici V, Dupuis H, Higgs A, Dimattia A, et al. (2011) Deletion of glycogen synthase kinase-3beta in cartilage results in up-regulation of glycogen synthase kinase-3alpha protein expression. Endocrinology 152: 1755-1766.
18. Matsuda T, Zhai P, Maejima Y, Hong C, Gao S, et al. (2008) Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload. Proc Natl Acad Sci U S A 105: 20900-20905.
19. Cho J, Rameshwar P, Sadoshima J (2009) Distinct roles of glycogen synthase kinase (GSK)-3alpha and GSK-3beta in mediating cardiomyocyte differentiation in murine bone marrow-derived mesenchymal stem cells. J Biol Chem 284: 36647-36658.
20. Schaffer B, Wiedau-Pazos M, Geschwind DH (2003) Gene structure and alternative splicing of glycogen synthase kinase 3 beta (GSK-3beta) in neural and non-neural tissues. Gene 302: 73-81.
21. Mukai F, Ishiguro K, Sano Y, Fujita SC (2002) Alternative splicing isoform of tau protein kinase I/glycogen synthase kinase 3beta. J Neurochem 81: 1073-1083.
22. Caceres JF, Kornblihtt AR (2002) Alternative splicing: multiple control mechanisms and involvement in human disease. Trends Genet 18: 186-193.
23. Annelie E Abrahamssona, Ifat Gerona (2009) GSK-3b missplicing contributes to leukemia stem cell generation. PNAS 106: 3925-3929.
24. Soutar MP, KimWY, Williamson R, Peggie M, Hastie CJ, et al. (2010) Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain. J Neurochem 115: 974-983.
25. Saeki K, Machida M, Kinoshita Y, Takasawa R, Tanuma SI (2011) Glycogen synthase kinase-3β2 has lower phosphorylation activity to tau than glycogen synthase kinase-3β1. Biol Pharm Bull 34: 146-149.
26. Castano Z, Gordon-Weeks PR, Kypta RM (2010) The neuron-specific isoform of glycogen synthase kinase-3beta is required for axon growth. J Neurochem 113: 117-130.
27. Wang L, Zuo B, Xu D, Ren Z, Zhang H, et al. (2012) Alternative splicing of the porcine glycogen synthase kinase 3beta (GSK-3beta) gene with differential expression patterns and regulatory functions. PLoS One 7: e40250.
28. Dong Y, Xie M, Jiang Y, Xiao N, Du X, et al. (2013) Sequencing and automated whole-genome optical mapping of the genome of a domestic goat (Capra hircus). Nat Biotechnol 31: 135-141.
29. Knighton DR, Zheng JH, Ten Eyck LF, Ashford VA, Xuong NH, et al. (1991) Crystal structure of the catalytic subunit of cyclic adenosine monophosphatedependent protein kinase. Science 253: 407-414.
30. Welsh GI, Miller CM, Loughlin AJ, Price NT, Proud CG (1998) Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin. FEBS Letters 421: 125-130.
31. G I Welsh, Proud CG (1993) Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B. Biochem J 294: 625-629.
32. Philip Cohen PCSF (2001) The renaissance of GSK3. Nature Reviews Molecular Cell Biology 2: 769-776.
33. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143: 1174-1189.
34. Alison Wood-Kaczmara MK, Koichi Ishigurob, Karen L Philpottc, Phillip R Gordon-Weeksa (2009) An alternatively spliced form of glycogen synthase kinase-3b is targeted to growing neurites and growth cones. Molecular and Cellular Neuroscience 42: 184-194.
35. Thornton TM, Pedraza-Alva G, Deng B, Wood CD, Aronshtam A, et al. (2008) Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation. Science 320: 667-670.
36. Rommel C, Bodine SC, Clarke BA, Rossman R, Nunez L, et al. (2001) Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/ mTOR and PI(3)K/Akt/GSK3 pathways. Nat Cell Biol 3: 1009-1013.
37. Martin M, Rehani K, Jope RS, Michalek SM (2005) Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol 6: 777-784.