The highly polymorphic CYP6M7 cytochrome P450 gene partners with the directionally selected CYP6P9a and CYP6P9b genes to expand the pyrethroid resistance front in the malaria vector Anopheles funestus in Africa

BMC Genomics

Volumn 15, Issue 1, 2014, Pages

  Riveron, Jacob M ^a   Ibrahim, Sulaiman S ^a   Chanda, Emmanuel ^b   Mzilahowa, Themba ^c   Cuamba, Nelson ^d   Irving, Helen ^a   Barnes, Kayla G ^a   Ndula, Miranda ^a   Wondji, Charles S ^a  

^a LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^b MINISTRY OF HEALTH   (Zambia)

^c UNIVERSITY OF MALAWI   (Malawi)

^d INSTITUTO NACIONAL DE SAÚDE   (Mozambique)

Author keywords

Anopheles funestus; CYP6M7; Cytochrome P450; Directional selection; Insecticide resistance; Malaria; Pyrethroids

Indexed keywords

CARBAMIC ACID; CHLORPHENOTANE; DELTAMETHRIN; PERMETHRIN; PYRETHROID; CYTOCHROME P450; INSECTICIDE; RECOMBINANT PROTEIN;

ADULT; ANIMAL TISSUE; ANOPHELES FUNESTUS; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; CYP6M7 GENE; CYP6P9A GENE; CYP6P9B GENE; DIRECTIONAL SELECTION; DNA SEQUENCE; DOWN REGULATION; DROSOPHILA MELANOGASTER; FEMALE; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOME ANALYSIS; IN VITRO STUDY; MALAWI; MICROARRAY ANALYSIS; MOZAMBIQUE; NONHUMAN; NUCLEOTIDE SEQUENCE; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN AFRICAN; TISSUE SPECIFICITY; ZAMBIA; AFRICA; ANIMAL; ANOPHELES; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; GENETIC POLYMORPHISM; GENETICS; GENOME; HAPLOTYPE; KINETICS; MALARIA; METABOLISM; PARASITOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TRANSGENIC ANIMAL;

ANOPHELES FUNESTUS;

AFRICA; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANOPHELES; CYTOCHROME P-450 ENZYME SYSTEM; DROSOPHILA MELANOGASTER; DRUG RESISTANCE; FEMALE; GENE EXPRESSION PROFILING; GENETIC VARIATION; GENOME; HAPLOTYPES; INSECTICIDES; KINETICS; MALARIA; POLYMORPHISM, GENETIC; PYRETHRINS; REAL-TIME POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS;

EID: 84908095120     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-15-817     Document Type: Article

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