Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed

Insect Biochemistry and Molecular Biology

Volumn 41, Issue 7, 2011, Pages 492-502

  Stevenson, Bradley J ^a   Bibby, Jaclyn ^b   Pignatelli, Patricia ^a   Muangnoicharoen, Sant ^a   O'Neill, Paul M ^c   Lian, Lu Yun ^c   Müller, Pie ^a,d,e   Nikou, Dimitra ^a   Steven, Andrew ^a   Hemingway, Janet ^a   Sutcliffe, Michael J ^b   Paine, Mark J I ^a  

^a LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

^d SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^e UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Detoxification; Insecticide resistance; Malaria; Mixed function oxidase; Mosquito

Indexed keywords

CYTOCHROME P450; DELTAMETHRIN; INSECTICIDE; NITRILE; PERMETHRIN; PYRETHROID; RECOMBINANT PROTEIN;

ANIMAL; ANOPHELES GAMBIAE; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; DISEASE CARRIER; DRUG DETOXIFICATION; DRUG EFFECT; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; INSECTICIDE RESISTANCE; KINETICS; MALARIA FALCIPARUM; MALPIGHIAN TUBULE; MASS SPECTROMETRY; METABOLISM; MOLECULAR CLONING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARASITOLOGY; PHYSIOLOGY; PLASMID; PLASMODIUM FALCIPARUM; PROTEIN BINDING;

ANIMALS; ANOPHELES GAMBIAE; BINDING SITES; CLONING, MOLECULAR; CYTOCHROME P-450 ENZYME SYSTEM; ESCHERICHIA COLI; INSECT VECTORS; INSECTICIDE RESISTANCE; INSECTICIDES; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MALARIA, FALCIPARUM; MALPIGHIAN TUBULES; MASS SPECTROMETRY; METABOLIC DETOXICATION, DRUG; MODELS, MOLECULAR; NITRILES; PERMETHRIN; PLASMIDS; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PYRETHRINS; RECOMBINANT PROTEINS;

ANOPHELES GAMBIAE; ESCHERICHIA COLI;

EID: 79959191971     PISSN: 09651748     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ibmb.2011.02.003     Document Type: Article

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