Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in the major malaria vector Anopheles funestus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 1, 2013, Pages 252-257

  Riveron, Jacob M ^a   Irving, Helen ^a   Ndula, Miranda ^a   Barnes, Kayla G ^a   Ibrahim, Sulaiman S ^a   Paine, Mark J I ^a   Wondji, Charles S ^a  

^a LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

GAL4 UAS expression; Heterologous expression; Metabolic resistance; P450 allelic variation

Indexed keywords

BIFENTHRIN; CARBON MONOXIDE; CYHALOTHRIN; CYTOCHROME P450; CYTOCHROME P450 6P9A; CYTOCHROME P450 6P9B; DELTAMETHRIN; PERMETHRIN; PYRETHROID; UNCLASSIFIED DRUG;

AFRICA; ANIMAL EXPERIMENT; ANOPHELES FUNESTUS; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; DROSOPHILA MELANOGASTER; ESCHERICHIA COLI; FEMALE; GENE DOSAGE; GENE DUPLICATION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; MALARIA CONTROL; MALE; MICROARRAY ANALYSIS; MORTALITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN MOTIF; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ALLELES; ANIMALS; ANOPHELES; BASE SEQUENCE; CYTOCHROME P-450 ENZYME SYSTEM; DROSOPHILA MELANOGASTER; DRUG RESISTANCE; INSECT VECTORS; MALARIA; MALAWI; MICROARRAY ANALYSIS; MOLECULAR SEQUENCE DATA; MOZAMBIQUE; PYRETHRINS; REAL-TIME POLYMERASE CHAIN REACTION; SELECTION, GENETIC; SEQUENCE ANALYSIS, DNA;

ANOPHELES FUNESTUS; DROSOPHILA MELANOGASTER;

EID: 84871983035     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1216705110     Document Type: Article

References (27)

1. WHO (2012) Global Plan for Insecticide Resistance Management (GPIRM) (World Health Organization, Geneva).
2. Bassat Q, et al. (2008) Malaria in rural Mozambique. Part II: Children admitted to hospital. Malar J 7:37.
3. PMI (2011) President's Malaria Initiative (PMI): Malaria Operational Plan (MOP) Malawi, Year Six-FY 2012. PMI Report. Available at www.pmi.gov/countries/ mops/fy12/malawi-mop-fy12.pdf.
4. Hargreaves K, et al. (2000) Anopheles funestus resistant to pyrethroid insecticides in South Africa. Med Vet Entomol 14(2):181-189. (Pubitemid 30400186)
5. Sharp BL, et al. (2007) Seven years of regional malaria control collaboration: Mozambique, South Africa, and Swaziland. Am J Trop Med Hyg 76(1):42-47. (Pubitemid 351627800)
6. Casimiro S, Coleman M, Mohloai P, Hemingway J, Sharp B (2006) Insecticide resistance in Anopheles funestus (Diptera: Culicidae) from Mozambique. J Med Entomol 43(2): 267-275. (Pubitemid 44743536)
7. Cuamba N, Morgan JC, Irving H, Steven A, Wondji CS (2010) High level of pyrethroid resistance in an Anopheles funestus population of the Chokwe District in Mozambique. PLoS ONE 5(6):e11010.
8. Hunt R, Edwardes M, Coetzee M (2010) Pyrethroid resistance in southern African Anopheles funestus extends to Likoma Island in Lake Malawi. Parasit Vectors 3:122.
9. Casimiro S, Coleman M, Hemingway J, Sharp B (2006) Insecticide resistance in Anopheles arabiensis and Anopheles gambiae from Mozambique. J Med Entomol 43(2):276-282. (Pubitemid 44743537)
10. Brooke BD, et al. (2001) Bioassay and biochemical analyses of insecticide resistance in southern African Anopheles funestus (Diptera: Culicidae). Bull Entomol Res 91(4):265-272. (Pubitemid 32817821)
11. Wondji CS, et al. (2009) Two duplicated P450 genes are associated with pyrethroid resistance in Anopheles funestus, a major malaria vector. Genome Res 19(3):452-459.
12. Wondji CS, et al. (2007) Mapping a quantitative trait locus (QTL) conferring pyrethroid resistance in the African malaria vector Anopheles funestus. BMC Genomics 8:34.
13. Irving H, Riveron JM, Ibrahim SS, Lobo NF, Wondji CS (2012) Positional cloning of rp2 QTL associates the P450 genes CYP6Z1, CYP6Z3 and CYP6M7 with pyrethroid resistance in the malaria vector Anopheles funestus. Heredity (Edinb) 109(6):383-392.
14. Puinean AM, et al. (2010) Amplification of a cytochrome P450 gene is associated with resistance to neonicotinoid insecticides in the aphid Myzus persicae. PLoS Genet 6(6): e1000999.
15. Bariami V, Jones CM, Poupardin R, Vontas J, Ranson H (2012) Gene amplification, ABC transporters and cytochrome P450s: Unraveling the molecular basis of pyrethroid resistance in the dengue vector, Aedes aegypti. PLoS Negl Trop Dis 6(6):e1692.
16. Itokawa K, Komagata O, Kasai S, Masada M, Tomita T (2011) Cis-acting mutation and duplication: History of molecular evolution in a P450 haplotype responsible for insecticide resistance in Culex quinquefasciatus. Insect Biochem Mol Biol 41(7):503-512.
17. Mitchell SN, et al. (2012) Identification and validation of a gene causing cross-resistance between insecticide classes in Anopheles gambiae from Ghana. Proc Natl Acad Sci USA 109(16):6147-6152.
18. Müller P, et al. (2008) Field-caught permethrin-resistant Anopheles gambiae overexpress CYP6P3, a P450 that metabolises pyrethroids. PLoS Genet 4(11): e1000286.
19. Feyereisen R (2011) Insect CYP genes and P450 enzymes. Insect Molecular Biology and Biochemistry, ed Gilbert LI (Elsevier, Oxford), pp. 236-316.
20. Zhu F, et al. (2010) A brain-specific cytochrome P450 responsible for the majority of deltamethrin resistance in the QTC279 strain of Tribolium castaneum. Proc Natl Acad Sci USA 107(19):8557-8562.
21. Bogwitz MR, et al. (2005) Cyp12a4 confers lufenuron resistance in a natural population of Drosophila melanogaster. Proc Natl Acad Sci USA 102(36):12807-12812. (Pubitemid 41279447)
22. Daborn PJ, et al. (2007) Evaluating the insecticide resistance potential of eight Drosophila melanogaster cytochrome P450 genes by transgenic over-expression. Insect Biochem Mol Biol 37(5):512-519. (Pubitemid 46602982)
23. Graveley BR, et al. (2011) The developmental transcriptome of Drosophila melanogaster. Nature 471(7339):473-479.
24. McCart C, Ffrench-Constant RH (2008) Dissecting the insecticide- resistance-associated cytochrome P450 gene Cyp6g1. Pest Manag Sci 64(6):639-645. (Pubitemid 351810102)
25. Mao W, Rupasinghe SG, Zangerl AR, Berenbaum MR, Schuler MA (2007) Allelic variation in the Depressaria pastinacella CYP6AB3 protein enhances metabolism of plant allelochemicals by altering a proximal surface residue and potential interactions with cytochrome P450 reductase. J Biol Chem 282(14):10544-10552. (Pubitemid 47093417)
26. Ingelman-Sundberg M, Sim SC, Gomez A, Rodriguez-Antona C (2007) Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects. Pharmacol Ther 116(3):496-526. (Pubitemid 350116943)
27. Gregory R, et al. (2011) A de novo expression profiling of Anopheles funestus, malaria vector in Africa, using 454 pyrosequencing. PLoS ONE 6(2):e17418.