Single-cell analyses of regulatory network perturbations using enhancer-targeting TALEs suggest novel roles for PU.1 during haematopoietic specification

Development (Cambridge)

Volumn 141, Issue 20, 2014, Pages 4018-4030

  Wilkinson, Adam C ^a   Kawata, Viviane K S ^a,b   Schütte, Judith ^a   Gao, Xuefei ^c   Antoniou, Stella ^d   Baumann, Claudia ^d   Woodhouse, Steven ^a   Hannah, Rebecca ^a   Tanaka, Yosuke ^a   Swiers, Gemma ^d   Moignard, Victoria ^a   Fisher, Jasmin ^e,f   Hidetoshi, Shimauchi ^b   Tijssen, Marloes R ^g   De Bruijn, Marella F T R ^d   Liu, Pentao ^c   Göttgens, Berthold ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b TOHOKU UNIVERSITY   (Japan)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e MICROSOFT RESEARCH   (United Kingdom)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^g UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Haematopoiesis; PU.1; Regulatory networks; Transcription activator like effectors

Indexed keywords

DNA BINDING PROTEIN; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PU 1; UNCLASSIFIED DRUG; ONCOPROTEIN; PROTO-ONCOGENE PROTEIN SPI-1; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ARTICLE; CELL SPECIFICITY; DNA SEQUENCE; EMBRYO; ENDOTHELIUM; ENHANCER REGION; FEMALE; GENE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE REPRESSION; HEMATOPOIESIS; HEMATOPOIETIC CELL; MALE; MOUSE; NONHUMAN; PROTEIN DOMAIN; PU.1 GENE; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCL GENE; SINGLE CELL ANALYSIS; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE; XANTHOMONAS; ANIMAL; CELL DIFFERENTIATION; COCULTURE; CYTOLOGY; ENDOTHELIUM CELL; GENE EXPRESSION PROFILING; HEMATOPOIETIC STEM CELL; HUMAN; K562 CELL LINE; METABOLISM; PHENOTYPE; PHYSIOLOGY; TRANSGENE;

ANIMALS; CELL DIFFERENTIATION; COCULTURE TECHNIQUES; ENDOTHELIAL CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; K562 CELLS; MICE; MICE, TRANSGENIC; PHENOTYPE; PROTO-ONCOGENE PROTEINS; SINGLE-CELL ANALYSIS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSGENES; XANTHOMONAS;

EID: 84908090150     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.115709     Document Type: Article

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