Broad-spectrum analgesic efficacy of IBNtxA is mediated by exon 11-associated splice variants of the mu-opioid receptor gene

Pain

Volumn 155, Issue 10, 2014, Pages 2063-2070

  Wieskopf, Jeffrey S ^a   Pan, Ying Xian ^b   Marcovitz, Jaclyn ^a   Tuttle, Alexander H ^a   Majumdar, Susruta ^b   Pidakala, John ^a   Pasternak, Gavril W ^b   Mogil, Jeffrey S ^a  

^a MCGILL UNIVERSITY   (Canada)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Chronic pain; mRNA expression; mu Opioid; Splice variants; Synergy; Transgenic

Indexed keywords

ANALGESIC AGENT; IODOBENZOYLNALTREXAMIDE; MESSENGER RNA; MORPHINE; MU OPIATE RECEPTOR; UNCLASSIFIED DRUG; ISOPROTEIN; NALTREXONE; NARCOTIC ANALGESIC AGENT;

ADULT; ALTERNATIVE RNA SPLICING; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG INHIBITION; DRUG POTENCY; EXON; FEMALE; GENE EXPRESSION; GENETIC VARIABILITY; MALE; MOUSE; NERVE INJURY; NEUROPATHIC HYPERSENSITIVITY; NONHUMAN; PAIN; RECEPTOR DOWN REGULATION; SPINAL GANGLION; SPONTANEOUS PAIN; THERMAL PAIN; YOUNG ADULT; ANALOGS AND DERIVATIVES; ANIMAL; DRUG EFFECTS; GENETICS; HEAT; KNOCKOUT MOUSE; PAIN THRESHOLD;

ANALGESICS, OPIOID; ANIMALS; EXONS; FEMALE; HOT TEMPERATURE; MALE; MICE; MICE, KNOCKOUT; NALTREXONE; PAIN; PAIN THRESHOLD; PROTEIN ISOFORMS; RECEPTORS, OPIOID, MU;

EID: 84908087487     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2014.07.014     Document Type: Article

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