Stereoselective lithiation and carboxylation of Boc-protected bicyclopyrrolidine: Synthesis of a key building block for HCV protease inhibitor telaprevir

Organic Process Research and Development

Volumn 18, Issue 10, 2014, Pages 1234-1244

  Tanoury, Gerald J ^a   Chen, Minzhang ^a,b   Dong, Yong ^a,c   Forslund, Raymond ^a,d   Jurkauskas, Valdas ^a,e   Jones, Andrew D ^a,c   Belmont, Daniel ^a  

^a VERTEX PHARMACEUTICALS   (United States)

^b WUXI APPTEC   (China)

^c Drug Metabolism and Pharmacokinetics   (United States)

^d IRONWOOD PHARMACEUTICALS INC   (United States)

^e CUBIST PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUILDING BLOCKES; LITHIATION; PROTEASE INHIBITOR; STEREO-SELECTIVE;

EID: 84908073322     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op500040j     Document Type: Article

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