-
1
-
-
33646712747
-
Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer
-
Nahta R, Yu D, Hung MC, Hortobagyi GN, Esteva FJ (2006) Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol 3(5):269-280.
-
(2006)
Nat Clin Pract Oncol
, vol.3
, Issue.5
, pp. 269-280
-
-
Nahta, R.1
Yu, D.2
Hung, M.C.3
Hortobagyi, G.N.4
Esteva, F.J.5
-
2
-
-
0034638917
-
Overexpression of ErbB2 in cancer and ErbB2-targeting strategies
-
Yu D, Hung MC (2000) Overexpression of ErbB2 in cancer and ErbB2-targeting strategies. Oncogene 19(53):6115-6121.
-
(2000)
Oncogene
, vol.19
, Issue.53
, pp. 6115-6121
-
-
Yu, D.1
Hung, M.C.2
-
3
-
-
0024337144
-
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
-
Slamon DJ, et al. (1989) Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244(4905):707-712.
-
(1989)
Science
, vol.244
, Issue.4905
, pp. 707-712
-
-
Slamon, D.J.1
-
4
-
-
84864367360
-
The ERBB network: At last, cancer therapy meets systems biology
-
Yarden Y, Pines G (2012) The ERBB network: At last, cancer therapy meets systems biology. Nat Rev Cancer 12(8):553-563.
-
(2012)
Nat Rev Cancer
, vol.12
, Issue.8
, pp. 553-563
-
-
Yarden, Y.1
Pines, G.2
-
5
-
-
0026472124
-
Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease
-
Guy CT, et al. (1992) Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc Natl Acad Sci USA 89(22):10578-10582.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, Issue.22
, pp. 10578-10582
-
-
Guy, C.T.1
-
6
-
-
0023713558
-
Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene
-
Muller WJ, Sinn E, Pattengale PK, Wallace R, Leder P (1988) Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell 54(1):105-115.
-
(1988)
Cell
, vol.54
, Issue.1
, pp. 105-115
-
-
Muller, W.J.1
Sinn, E.2
Pattengale, P.K.3
Wallace, R.4
Leder, P.5
-
7
-
-
0029912203
-
All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired
-
Baulida J, Kraus MH, Alimandi M, Di Fiore PP, Carpenter G (1996) All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired. J Biol Chem 271(9):5251-5257.
-
(1996)
J Biol Chem
, vol.271
, Issue.9
, pp. 5251-5257
-
-
Baulida, J.1
Kraus, M.H.2
Alimandi, M.3
Di Fiore, P.P.4
Carpenter, G.5
-
8
-
-
0032526729
-
Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers
-
Lenferink AE, et al. (1998) Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers. EMBO J 17(12):3385-3397.
-
(1998)
EMBO J
, vol.17
, Issue.12
, pp. 3385-3397
-
-
Lenferink, A.E.1
-
9
-
-
0034628471
-
Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
-
Bilder D, Perrimon N (2000) Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature 403(6770):676-680.
-
(2000)
Nature
, vol.403
, Issue.6770
, pp. 676-680
-
-
Bilder, D.1
Perrimon, N.2
-
10
-
-
0036806134
-
The LAP family: A phylogenetic point of view
-
Santoni MJ, Pontarotti P, Birnbaum D, Borg JP (2002) The LAP family: A phylogenetic point of view. Trends Genet 18(10):494-497.
-
(2002)
Trends Genet
, vol.18
, Issue.10
, pp. 494-497
-
-
Santoni, M.J.1
Pontarotti, P.2
Birnbaum, D.3
Borg, J.P.4
-
11
-
-
0033776145
-
ERBIN: A basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor
-
Borg JP, et al. (2000) ERBIN: A basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor. Nat Cell Biol 2(7):407-414.
-
(2000)
Nat Cell Biol
, vol.2
, Issue.7
, pp. 407-414
-
-
Borg, J.P.1
-
12
-
-
0035374514
-
Erbin is a protein concentrated at post-synaptic membranes that interacts with PSD-95
-
Huang YZ, Wang Q, Xiong WC, Mei L (2001) Erbin is a protein concentrated at post-synaptic membranes that interacts with PSD-95. J Biol Chem 276(22):19318-19326.
-
(2001)
J Biol Chem
, vol.276
, Issue.22
, pp. 19318-19326
-
-
Huang, Y.Z.1
Wang, Q.2
Xiong, W.C.3
Mei, L.4
-
13
-
-
34548233208
-
Erbin inhibits transforming growth factor beta signaling through a novel Smad-interacting domain
-
Dai F, et al. (2007) Erbin inhibits transforming growth factor beta signaling through a novel Smad-interacting domain. Mol Cell Biol 27(17):6183-6194.
-
(2007)
Mol Cell Biol
, vol.27
, Issue.17
, pp. 6183-6194
-
-
Dai, F.1
-
14
-
-
33644854068
-
Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex
-
Dai P, Xiong WC, Mei L (2006) Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex. J Biol Chem 281(2):927-933.
-
(2006)
J Biol Chem
, vol.281
, Issue.2
, pp. 927-933
-
-
Dai, P.1
Xiong, W.C.2
Mei, L.3
-
15
-
-
0037428508
-
Erbin suppresses the MAP kinase pathway
-
Huang YZ, Zang M, Xiong WC, Luo Z, Mei L (2003) Erbin suppresses the MAP kinase pathway. J Biol Chem 278(2):1108-1114.
-
(2003)
J Biol Chem
, vol.278
, Issue.2
, pp. 1108-1114
-
-
Huang, Y.Z.1
Zang, M.2
Xiong, W.C.3
Luo, Z.4
Mei, L.5
-
16
-
-
33845965383
-
Identification of differentially expressed genes involved in the formation of multicellular tumor spheroids by HT-29 colon carcinoma cells
-
Dardousis K, et al. (2007) Identification of differentially expressed genes involved in the formation of multicellular tumor spheroids by HT-29 colon carcinoma cells. Mol Ther 15(1):94-102.
-
(2007)
Mol Ther
, vol.15
, Issue.1
, pp. 94-102
-
-
Dardousis, K.1
-
17
-
-
0034010129
-
The p120 catenin family: Complex roles in adhesion, signaling and cancer
-
Anastasiadis PZ, Reynolds AB (2000) The p120 catenin family: Complex roles in adhesion, signaling and cancer. J Cell Sci 113(Pt 8):1319-1334.
-
(2000)
J Cell Sci
, vol.113
, pp. 1319-1334
-
-
Anastasiadis, P.Z.1
Reynolds, A.B.2
-
18
-
-
67249129534
-
Erbin regulates NRG1 signaling and myelination
-
Tao Y, et al. (2009) Erbin regulates NRG1 signaling and myelination. Proc Natl Acad Sci USA 106(23):9477-9482.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.23
, pp. 9477-9482
-
-
Tao, Y.1
-
19
-
-
34548863946
-
Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
-
Herschkowitz JI, et al. (2007) Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol 8(5):R76.
-
(2007)
Genome Biol
, vol.8
, Issue.5
, pp. R76
-
-
Herschkowitz, J.I.1
-
20
-
-
0037076342
-
Initiating oncogenic event determines gene-expression patterns of human breast cancer models
-
Desai KV, et al. (2002) Initiating oncogenic event determines gene-expression patterns of human breast cancer models. Proc Natl Acad Sci USA 99(10):6967-6972.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.10
, pp. 6967-6972
-
-
Desai, K.V.1
-
21
-
-
0026587657
-
Induction of mammary tumors by expression of polyomavirus middle T oncogene: A transgenic mouse model for metastatic disease
-
Guy CT, Cardiff RD, Muller WJ (1992) Induction of mammary tumors by expression of polyomavirus middle T oncogene: A transgenic mouse model for metastatic disease. Mol Cell Biol 12(3):954-961.
-
(1992)
Mol Cell Biol
, vol.12
, Issue.3
, pp. 954-961
-
-
Guy, C.T.1
Cardiff, R.D.2
Muller, W.J.3
-
22
-
-
33745686009
-
RNA interference-based functional dissection of the 17q12 amplicon in breast cancer reveals contribution of coamplified genes
-
Kao J, Pollack JR (2006) RNA interference-based functional dissection of the 17q12 amplicon in breast cancer reveals contribution of coamplified genes. Genes Chromosomes Cancer 45(8):761-769.
-
(2006)
Genes Chromosomes Cancer
, vol.45
, Issue.8
, pp. 761-769
-
-
Kao, J.1
Pollack, J.R.2
-
23
-
-
33845209913
-
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
-
Neve RM, et al. (2006) A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 10(6):515-527.
-
(2006)
Cancer Cell
, vol.10
, Issue.6
, pp. 515-527
-
-
Neve, R.M.1
-
24
-
-
84875882766
-
Erbin interacts with TARP γ-2 for surface expression of AMPA receptors in cortical interneurons
-
Tao Y, et al. (2013) Erbin interacts with TARP γ-2 for surface expression of AMPA receptors in cortical interneurons. Nat Neurosci 16(3):290-299.
-
(2013)
Nat Neurosci
, vol.16
, Issue.3
, pp. 290-299
-
-
Tao, Y.1
-
25
-
-
0034854417
-
ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini
-
Muthuswamy SK, Li D, Lelievre S, Bissell MJ, Brugge JS (2001) ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nat Cell Biol 3(9):785-792.
-
(2001)
Nat Cell Biol
, vol.3
, Issue.9
, pp. 785-792
-
-
Muthuswamy, S.K.1
Li, D.2
Lelievre, S.3
Bissell, M.J.4
Brugge, J.S.5
-
26
-
-
48949120867
-
Palmitoylation of ERBIN is required for its plasma membrane localization
-
Izawa I, Nishizawa M, Hayashi Y, Inagaki M (2008) Palmitoylation of ERBIN is required for its plasma membrane localization. Genes Cells 13(7):691-701.
-
(2008)
Genes Cells
, vol.13
, Issue.7
, pp. 691-701
-
-
Izawa, I.1
Nishizawa, M.2
Hayashi, Y.3
Inagaki, M.4
-
27
-
-
0347503571
-
Basolateral targeting by leucine-rich repeat domains in epithelial cells
-
Legouis R, et al. (2003) Basolateral targeting by leucine-rich repeat domains in epithelial cells. EMBO Rep 4(11):1096-1102.
-
(2003)
EMBO Rep
, vol.4
, Issue.11
, pp. 1096-1102
-
-
Legouis, R.1
-
28
-
-
39749084606
-
Analysis of integrin beta4 expression in human breast cancer: Association with basal-like tumors and prognostic significance
-
Lu S, Simin K, Khan A, Mercurio AM (2008) Analysis of integrin beta4 expression in human breast cancer: Association with basal-like tumors and prognostic significance. Clin Cancer Res 14(4):1050-1058.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.4
, pp. 1050-1058
-
-
Lu, S.1
Simin, K.2
Khan, A.3
Mercurio, A.M.4
-
29
-
-
0037081179
-
Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: A tissue microarray study
-
Xie W, et al. (2002) Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: A tissue microarray study. Cancer Res 62(2):497-505.
-
(2002)
Cancer Res
, vol.62
, Issue.2
, pp. 497-505
-
-
Xie, W.1
-
30
-
-
2942618768
-
A renaissance for SRC
-
Yeatman TJ (2004) A renaissance for SRC. Nat Rev Cancer 4(6):470-480.
-
(2004)
Nat Rev Cancer
, vol.4
, Issue.6
, pp. 470-480
-
-
Yeatman, T.J.1
-
31
-
-
0035793546
-
Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90
-
Xu W, et al. (2001) Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. J Biol Chem 276(5):3702-3708.
-
(2001)
J Biol Chem
, vol.276
, Issue.5
, pp. 3702-3708
-
-
Xu, W.1
-
32
-
-
0036461584
-
Hsp90, not Grp94, regulates the intracellular trafficking and stability of nascent ErbB2
-
Xu W, Mimnaugh EG, Kim JS, Trepel JB, Neckers LM (2002) Hsp90, not Grp94, regulates the intracellular trafficking and stability of nascent ErbB2. Cell Stress Chaperones 7(1):91-96.
-
(2002)
Cell Stress Chaperones
, vol.7
, Issue.1
, pp. 91-96
-
-
Xu, W.1
Mimnaugh, E.G.2
Kim, J.S.3
Trepel, J.B.4
Neckers, L.M.5
-
33
-
-
0037853218
-
ErbB2 degradation mediated by the co-chaperone protein CHIP
-
Zhou P, et al. (2003) ErbB2 degradation mediated by the co-chaperone protein CHIP. J Biol Chem 278(16):13829-13837.
-
(2003)
J Biol Chem
, vol.278
, Issue.16
, pp. 13829-13837
-
-
Zhou, P.1
-
34
-
-
33845804718
-
Loss of Hsp90 association upregulates Src-dependent ErbB2 activity
-
Xu W, Yuan X, Beebe K, Xiang Z, Neckers L (2007) Loss of Hsp90 association upregulates Src-dependent ErbB2 activity. Mol Cell Biol 27(1):220-228.
-
(2007)
Mol Cell Biol
, vol.27
, Issue.1
, pp. 220-228
-
-
Xu, W.1
Yuan, X.2
Beebe, K.3
Xiang, Z.4
Neckers, L.5
-
35
-
-
0033520487
-
In vivo protein transduction: Delivery of a biologically active protein into the mouse
-
Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF (1999) In vivo protein transduction: Delivery of a biologically active protein into the mouse. Science 285(5433):1569-1572.
-
(1999)
Science
, vol.285
, Issue.5433
, pp. 1569-1572
-
-
Schwarze, S.R.1
Ho, A.2
Vocero-Akbani, A.3
Dowdy, S.F.4
-
36
-
-
0029991439
-
Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer
-
Baselga J, et al. (1996) Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. J Clin Oncol 14(3):737-744.
-
(1996)
J Clin Oncol
, vol.14
, Issue.3
, pp. 737-744
-
-
Baselga, J.1
-
37
-
-
0032850677
-
Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
-
Cobleigh MA, et al. (1999) Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol 17(9):2639-2648.
-
(1999)
J Clin Oncol
, vol.17
, Issue.9
, pp. 2639-2648
-
-
Cobleigh, M.A.1
-
38
-
-
19044380618
-
Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth
-
Agus DB, et al. (2002) Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth. Cancer Cell 2(2):127-137.
-
(2002)
Cancer Cell
, vol.2
, Issue.2
, pp. 127-137
-
-
Agus, D.B.1
-
39
-
-
33845886440
-
Lapatinib plus capecitabine for HER2-positive advanced breast cancer
-
Geyer CE, et al. (2006) Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 355(26):2733-2743.
-
(2006)
N Engl J Med
, vol.355
, Issue.26
, pp. 2733-2743
-
-
Geyer, C.E.1
-
40
-
-
79952264098
-
New strategies in HER2-overexpressing breast cancer: Many combinations of targeted drugs available
-
Abramson V, Arteaga CL (2011) New strategies in HER2-overexpressing breast cancer: Many combinations of targeted drugs available. Clin Cancer Res 17(5):952-958.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.5
, pp. 952-958
-
-
Abramson, V.1
Arteaga, C.L.2
-
41
-
-
34247588567
-
Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer
-
Scaltriti M, et al. (2007) Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer. J Natl Cancer Inst 99(8):628-638.
-
(2007)
J Natl Cancer Inst
, vol.99
, Issue.8
, pp. 628-638
-
-
Scaltriti, M.1
-
42
-
-
34548507214
-
Endocytic down-regulation of ErbB2 is stimulated by cleavage of its C-terminus
-
Lerdrup M, et al. (2007) Endocytic down-regulation of ErbB2 is stimulated by cleavage of its C-terminus. Mol Biol Cell 18(9):3656-3666.
-
(2007)
Mol Biol Cell
, vol.18
, Issue.9
, pp. 3656-3666
-
-
Lerdrup, M.1
-
43
-
-
34347226346
-
Protein kinase Calpha determines HER2 fate in breast carcinoma cells with HER2 protein overexpression without gene amplification
-
Magnifico A, et al. (2007) Protein kinase Calpha determines HER2 fate in breast carcinoma cells with HER2 protein overexpression without gene amplification. Cancer Res 67(11):5308-5317.
-
(2007)
Cancer Res
, vol.67
, Issue.11
, pp. 5308-5317
-
-
Magnifico, A.1
-
44
-
-
0141841783
-
Different mechanisms are implicated in ERBB2 gene overexpression in breast and in other cancers
-
Vernimmen D, Gueders M, Pisvin S, Delvenne P, Winkler R (2003) Different mechanisms are implicated in ERBB2 gene overexpression in breast and in other cancers. Br J Cancer 89(5):899-906.
-
(2003)
Br J Cancer
, vol.89
, Issue.5
, pp. 899-906
-
-
Vernimmen, D.1
Gueders, M.2
Pisvin, S.3
Delvenne, P.4
Winkler, R.5
-
45
-
-
9444252957
-
Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycin
-
Austin CD, et al. (2004) Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycin. Mol Biol Cell 15(12):5268-5282.
-
(2004)
Mol Biol Cell
, vol.15
, Issue.12
, pp. 5268-5282
-
-
Austin, C.D.1
-
46
-
-
0036789884
-
Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu
-
Xu W, et al. (2002) Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu. Proc Natl Acad Sci USA 99(20):12847-12852.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.20
, pp. 12847-12852
-
-
Xu, W.1
-
47
-
-
0042697321
-
Polar expression of ErbB-2/HER2 in epithelia
-
Shelly M, et al. (2003) Polar expression of ErbB-2/HER2 in epithelia. Bimodal regulation by Lin-7. Dev Cell 5(3):475-486.
-
(2003)
Bimodal Regulation by Lin-7. Dev Cell
, vol.5
, Issue.3
, pp. 475-486
-
-
Shelly, M.1
-
48
-
-
77954945333
-
Targeting the dynamic HSP90 complex in cancer
-
Trepel J, Mollapour M, Giaccone G, Neckers L (2010) Targeting the dynamic HSP90 complex in cancer. Nat Rev Cancer 10(8):537-549.
-
(2010)
Nat Rev Cancer
, vol.10
, Issue.8
, pp. 537-549
-
-
Trepel, J.1
Mollapour, M.2
Giaccone, G.3
Neckers, L.4
-
49
-
-
84880918492
-
Flotillins as regulators of ErbB2 levels in breast cancer
-
Pust S, et al. (2013) Flotillins as regulators of ErbB2 levels in breast cancer. Oncogene 32(29):3443-3451.
-
(2013)
Oncogene
, vol.32
, Issue.29
, pp. 3443-3451
-
-
Pust, S.1
-
50
-
-
84856821109
-
Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression
-
Schulz R, et al. (2012) Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression. J Exp Med 209(2):275-289.
-
(2012)
J Exp Med
, vol.209
, Issue.2
, pp. 275-289
-
-
Schulz, R.1
-
51
-
-
6344243850
-
Pathology and genetics of tumours of the breast and female genital organs
-
eds Tavassoli F, Devilee P, (WHO, Geneva)
-
Ellis IO, et al. (2003) Pathology and genetics of tumours of the breast and female genital organs. World Health Organization Classification of Tumours, eds Tavassoli F, Devilee P, (WHO, Geneva), pp 14-41.
-
(2003)
World Health Organization Classification of Tumours
, pp. 14-41
-
-
Ellis, I.O.1
-
52
-
-
0026072872
-
Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: Experience from a large study with long-term follow-up
-
Elston CW, Ellis IO (1991) Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: Experience from a large study with long-term follow-up. Histopathology 19(5):403-410.
-
(1991)
Histopathology
, vol.19
, Issue.5
, pp. 403-410
-
-
Elston, C.W.1
Ellis, I.O.2
-
53
-
-
0029145870
-
Histological grading of breast carcinomas: A study of interobserver agreement
-
Robbins P, et al. (1995) Histological grading of breast carcinomas: A study of interobserver agreement. Hum Pathol 26(8):873-879.
-
(1995)
Hum Pathol
, vol.26
, Issue.8
, pp. 873-879
-
-
Robbins, P.1
|