메뉴 건너뛰기




Volumn 11, Issue 2, 2014, Pages 167-174

The therapeutic potential of milk thistle in diabetes

Author keywords

Anti diabetic; Bioavailability; HbA1c; Milk thistle; PPAR gamma; Silibin; Type 2 diabetes

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CATALASE; CYTOCHROME P450 2E1; DIPEPTIDYL CARBOXYPEPTIDASE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE PEROXIDASE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; N (G), N (G) DIMETHYLARGININE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PYRUVATE KINASE; SILIBININ; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; ANTIOBESITY AGENT; FLAVONOLIGNAN; PLANT EXTRACT; SILYMARIN;

EID: 84908061964     PISSN: 16136071     EISSN: 16140575     Source Type: Journal    
DOI: 10.1900/RDS.2014.11.167     Document Type: Review
Times cited : (53)

References (45)
  • 2
    • 11144332015 scopus 로고    scopus 로고
    • Potential utility of natural polyphenols for reversing fat-induced insulin resistance
    • McCarty MF. Potential utility of natural polyphenols for reversing fat-induced insulin resistance. Med Hypotheses 2005. 64(3):628-635.
    • (2005) Med Hypotheses , vol.64 , Issue.3 , pp. 628-635
    • McCarty, M.F.1
  • 6
    • 84908070734 scopus 로고    scopus 로고
    • Inhibition of high glucose-induced protein mono-ADPribosylation restores neuritogenesis and sodium-pump activity in SY5Y neuroblastoma cells
    • Di Giulio AM, Lesma E, Germani E, Gorio A. Inhibition of high glucose-induced protein mono-ADPribosylation restores neuritogenesis and sodium-pump activity in SY5Y neuroblastoma cells. J Neurosci Res 1999. 46(5):565-571.
    • (1999) J Neurosci Res , vol.46 , Issue.5 , pp. 565-571
    • Di Giulio, A.M.1    Lesma, E.2    Germani, E.3    Gorio, A.4
  • 7
    • 35848964400 scopus 로고    scopus 로고
    • The flavonoid silibinin decreases glucose-6-phosphate hydrolysis in perifused rat hepatocytes by an inhibitory effect on glucose-6-phosphatase
    • Guigas B, Naboulsi R, Villanueva GR, Taleux N, Lopez-Novoa JM, Leverve XM, El-Mir LY. The flavonoid silibinin decreases glucose-6-phosphate hydrolysis in perifused rat hepatocytes by an inhibitory effect on glucose-6-phosphatase. Cell Physiol Biochem 2007. 20(6):925-934.
    • (2007) Cell Physiol Biochem , vol.20 , Issue.6 , pp. 925-934
    • Guigas, B.1    Naboulsi, R.2    Villanueva, G.R.3    Taleux, N.4    Lopez-Novoa, J.M.5    Leverve, X.M.6    El-Mir, L.Y.7
  • 8
    • 67649438677 scopus 로고    scopus 로고
    • Silibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a potential upregulation of the insig pathway
    • Park
    • Park. Silibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a potential upregulation of the insig pathway. Int J Mol Med 2009. 23:633-637.
    • (2009) Int J Mol Med , vol.23 , pp. 633-637
  • 11
    • 43049100691 scopus 로고    scopus 로고
    • Interrelation between the inhibition of glycolytic flux by silibinin and the lowering of mitochondrial ROS production in perifused rat hepatocytes
    • Detaille D, Sanchez C, Sanz N, Lopez-Novoa JM, Leverve X, El-Mir MY. Interrelation between the inhibition of glycolytic flux by silibinin and the lowering of mitochondrial ROS production in perifused rat hepatocytes. Life Sci 2008. 82(21-22):1070-1076.
    • (2008) Life Sci , vol.82 , Issue.21-22 , pp. 1070-1076
    • Detaille, D.1    Sanchez, C.2    Sanz, N.3    Lopez-Novoa, J.M.4    Leverve, X.5    El-Mir, M.Y.6
  • 12
    • 0030571010 scopus 로고    scopus 로고
    • Alterations of protein mono-ADPribosylation and diabetic neuropathy: A novel pharmacological approach
    • Di Giulio AM. Alterations of protein mono-ADPribosylation and diabetic neuropathy: a novel pharmacological approach. Eur J Pharmacol 1996. 311(1):21-28.
    • (1996) Eur J Pharmacol , vol.311 , Issue.1 , pp. 21-28
    • Di Giulio, A.M.1
  • 13
    • 84884758908 scopus 로고    scopus 로고
    • Effect of silymarin on streptozotocinnicotinamide-induced type 2 diabetic nephropathy in rats
    • Nasri H. Effect of silymarin on streptozotocinnicotinamide-induced type 2 diabetic nephropathy in rats. Iran J Kidn Dis 2013. 7(5):414-415.
    • (2013) Iran J Kidn Dis , vol.7 , Issue.5 , pp. 414-415
    • Nasri, H.1
  • 16
    • 84899555078 scopus 로고    scopus 로고
    • Silymarin induces expression of pancreatic Nkx6.1 transcription factor and beta-cell neogenesis in a pancreatectomy model
    • Soto C, Raya L, Perez J, Gonzalez I, Perez S. Silymarin induces expression of pancreatic Nkx6.1 transcription factor and beta-cell neogenesis in a pancreatectomy model. Molecules 2014. 19(4):4654-4668.
    • (2014) Molecules , vol.19 , Issue.4 , pp. 4654-4668
    • Soto, C.1    Raya, L.2    Perez, J.3    Gonzalez, I.4    Perez, S.5
  • 18
    • 84905495859 scopus 로고    scopus 로고
    • Silybin reduces obliterated retinal capillaries in experimental diabetic retinopathy in rats
    • Zhang HT, Shi K, Baskota A, Zhou FL, Chen YX, Tian HM. Silybin reduces obliterated retinal capillaries in experimental diabetic retinopathy in rats. Eur J Pharmacol 2014. 740:233-239.
    • (2014) Eur J Pharmacol , vol.740 , pp. 233-239
    • Zhang, H.T.1    Shi, K.2    Baskota, A.3    Zhou, F.L.4    Chen, Y.X.5    Tian, H.M.6
  • 20
    • 84903777316 scopus 로고    scopus 로고
    • Engineered silybin nanoparticles educe efficient control in experimental diabetes
    • Das S, Roy P, Pal R, Auddy RG, Chakraborti AS, Mukherjee A. Engineered silybin nanoparticles educe efficient control in experimental diabetes. Plos One 2014. 9(7):e101818.
    • (2014) Plos One , vol.9 , Issue.7
    • Das, S.1    Roy, P.2    Pal, R.3    Auddy, R.G.4    Chakraborti, A.S.5    Mukherjee, A.6
  • 21
    • 79952159257 scopus 로고    scopus 로고
    • Antioxidant and hepatoprotective effects of silibinin in a rat model of nonalcoholic steatohepatitis
    • Haddad Y, Vallerand D, Brault A, Haddad PS. Antioxidant and hepatoprotective effects of silibinin in a rat model of nonalcoholic steatohepatitis. Evid Based Complement Alternat Med 2011. 2011:1-10.
    • (2011) Evid Based Complement Alternat Med , vol.2011 , pp. 1-10
    • Haddad, Y.1    Vallerand, D.2    Brault, A.3    Haddad, P.S.4
  • 22
    • 84876471326 scopus 로고    scopus 로고
    • Effect and the probable mechanisms of silibinin in regulating insulin resistance in the liver of rats with non-alcoholic fatty liver
    • Yao J, Zhi M, Gao X, Hu P, Li C, Yang X. Effect and the probable mechanisms of silibinin in regulating insulin resistance in the liver of rats with non-alcoholic fatty liver. Braz J Med Biol Res 2013. 46(3):270-277.
    • (2013) Braz J Med Biol Res , vol.46 , Issue.3 , pp. 270-277
    • Yao, J.1    Zhi, M.2    Gao, X.3    Hu, P.4    Li, C.5    Yang, X.6
  • 23
    • 0031464157 scopus 로고    scopus 로고
    • Silibinin, a plant extract with anti-oxidant and membrane stabilizing properties, protects exocrine pancreas form cyclosporine A toxicity
    • Von Shonfled, Weisbrod B, Muller MK. Silibinin, a plant extract with anti-oxidant and membrane stabilizing properties, protects exocrine pancreas form cyclosporine A toxicity. Cell Mol Life Sci 1997. 53(11-12):917-920.
    • (1997) Cell Mol Life Sci , vol.53 , Issue.11-12 , pp. 917-920
    • Shonfled, V.1    Weisbrod, B.2    Muller, M.K.3
  • 25
    • 2342419096 scopus 로고    scopus 로고
    • Study of the hypoglycaemic activity of Fraxinus excelsior and Silybum marianum in an animal model of type 1 diabetes mellitus
    • Maghrani M, Zeggwagh NA, Lemhadri A, El Amraoui M, Michel JB, Eddouks M. Study of the hypoglycaemic activity of Fraxinus excelsior and Silybum marianum in an animal model of type 1 diabetes mellitus. J Ethnopharmacol 2004. 91(2-3):309-316.
    • (2004) J Ethnopharmacol , vol.91 , Issue.2-3 , pp. 309-316
    • Maghrani, M.1    Zeggwagh, N.A.2    Lemhadri, A.3    El Amraoui, M.4    Michel, J.B.5    Eddouks, M.6
  • 26
    • 84895067588 scopus 로고    scopus 로고
    • Beneficial effects of silibinin against the progression of metabolic syndrome, increased oxidative stress, and liver steatosis in Psammomys obesus, a relevant animal model of human obesity and diabetes
    • Bouderba S, Sanchez-Martin C, Villanueva GR, Detaille D, Koceir EA. Beneficial effects of silibinin against the progression of metabolic syndrome, increased oxidative stress, and liver steatosis in Psammomys obesus, a relevant animal model of human obesity and diabetes. J Diabetes 2014. 6(2):184-192.
    • (2014) J Diabetes , vol.6 , Issue.2 , pp. 184-192
    • Bouderba, S.1    Sanchez-Martin, C.2    Villanueva, G.R.3    Detaille, D.4    Koceir, E.A.5
  • 27
    • 77955638295 scopus 로고    scopus 로고
    • Chronic treatment of silymarin improves hyperalgesia and motor nerve conduction velocity in diabetic neuropathic rat
    • Baluchnejadmojarad T, Roghani M, Khastehkhodaie Z. Chronic treatment of silymarin improves hyperalgesia and motor nerve conduction velocity in diabetic neuropathic rat. Phytother Res 2010. 24(8):1120-1125.
    • (2010) Phytother Res , vol.24 , Issue.8 , pp. 1120-1125
    • Baluchnejadmojarad, T.1    Roghani, M.2    Khastehkhodaie, Z.3
  • 28
    • 0027240649 scopus 로고
    • Silymarin reduces hyperinsulinemia, malondialdehyde levels, and daily insulin need in cirrhotic diabetic patients
    • Velussi M, Cernigoi AM, Viezzoli L, Dapas F, Caffau C, Zilli M. Silymarin reduces hyperinsulinemia, malondialdehyde levels, and daily insulin need in cirrhotic diabetic patients. Curr Therap Res 1993. 53(5):533-545.
    • (1993) Curr Therap Res , vol.53 , Issue.5 , pp. 533-545
    • Velussi, M.1    Cernigoi, A.M.2    Viezzoli, L.3    Dapas, F.4    Caffau, C.5    Zilli, M.6
  • 29
    • 0037111357 scopus 로고    scopus 로고
    • Thiol-inducing and immunoregulatory effects of flavonoids in peripheral blood mononuclear cells from patients with end-stage diabetic nephropathy
    • Dietzmann J, Thiel U, Ansorge S, Neumann KH, Tüger M. Thiol-inducing and immunoregulatory effects of flavonoids in peripheral blood mononuclear cells from patients with end-stage diabetic nephropathy. Free Radic Biol Med 2002. 33(10):1347-1354.
    • (2002) Free Radic Biol Med , vol.33 , Issue.10 , pp. 1347-1354
    • Dietzmann, J.1    Thiel, U.2    Ansorge, S.3    Neumann, K.H.4    Tüger, M.5
  • 30
    • 84868704907 scopus 로고    scopus 로고
    • Effect of addition of silymarin to renin-angiotensin system inhibitors on proteinuria in type 2 diabetic patients with overt nephropathy: A randomized, double-blind, placebo-controlled trial
    • Fallahzadeh MK, Dormanesh B, Sagheb MM, Roozbeh J, Vessal G, Pakfetrat M, Daneshbod Y, Kamali-Sarvestani E, Lankarani KB. Effect of addition of silymarin to renin-angiotensin system inhibitors on proteinuria in type 2 diabetic patients with overt nephropathy: a randomized, double-blind, placebo-controlled trial. Am J Kidney Dis 2012. 60(6):896-903.
    • (2012) Am J Kidney Dis , vol.60 , Issue.6 , pp. 896-903
    • Fallahzadeh, M.K.1    Dormanesh, B.2    Sagheb, M.M.3    Roozbeh, J.4    Vessal, G.5    Pakfetrat, M.6    Daneshbod, Y.7    Kamali-Sarvestani, E.8    Lankarani, K.B.9
  • 31
    • 33845618025 scopus 로고    scopus 로고
    • The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: A randomized, double-blind, placebocontrolled, clinical trial
    • Huseini HF, Larijani B, Heshmat R, Fakhrzadeh H, Radjabipour B, Toliat T, Raza M. The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebocontrolled, clinical trial. Phytother Res 2006. 20(12):1036-1039.
    • (2006) Phytother Res , vol.20 , Issue.12 , pp. 1036-1039
    • Huseini, H.F.1    Larijani, B.2    Heshmat, R.3    Fakhrzadeh, H.4    Radjabipour, B.5    Toliat, T.6    Raza, M.7
  • 32
    • 84887887852 scopus 로고    scopus 로고
    • Preliminary study about the possible glycemic clinical advantage in using a fixed combination of Berberis aristata and Silybum marianum standardized extracts versus only Berberis aristata in patients with type 2 diabetes
    • Di Pierro F, Putignano P, Montesi L, Moscatiello S, Marchesini Reggiani G, Villanova N. Preliminary study about the possible glycemic clinical advantage in using a fixed combination of Berberis aristata and Silybum marianum standardized extracts versus only Berberis aristata in patients with type 2 diabetes. Clin Pharmacol 2013. 5:167-174.
    • (2013) Clin Pharmacol , vol.5 , pp. 167-174
    • Di Pierro, F.1    Putignano, P.2    Montesi, L.3    Moscatiello, S.4    Marchesini Reggiani, G.5    Villanova, N.6
  • 34
    • 33645307385 scopus 로고    scopus 로고
    • Effects of Silybum marianum on serum hepatitis C virus RNA, alanine aminotransferase levels and well-being in patients with chronic hepatitis C
    • Gordon A, Hobbs DA, Bowden DS, Bailey MJ, Mitchell J, Francis AJ, Roberts SK. Effects of Silybum marianum on serum hepatitis C virus RNA, alanine aminotransferase levels and well-being in patients with chronic hepatitis C. J Gastroenterol Hepatol 2006. 21(1):275-280.
    • (2006) J Gastroenterol Hepatol , vol.21 , Issue.1 , pp. 275-280
    • Gordon, A.1    Hobbs, D.A.2    Bowden, D.S.3    Bailey, M.J.4    Mitchell, J.5    Francis, A.J.6    Roberts, S.K.7
  • 35
    • 43049118972 scopus 로고    scopus 로고
    • Silymarin in the treatment of patients with primary sclerosing cholangitis: An open-label pilot study
    • Angulo P, Jorgensen RA, Kowdley KV, Lindor KD. Silymarin in the treatment of patients with primary sclerosing cholangitis: an open-label pilot study. Dig Dis Sci 2008. 53(6):1716-1720.
    • (2008) Dig Dis Sci , vol.53 , Issue.6 , pp. 1716-1720
    • Angulo, P.1    Jorgensen, R.A.2    Kowdley, K.V.3    Lindor, K.D.4
  • 36
    • 38749102800 scopus 로고    scopus 로고
    • Maca (Lepidium meyenii) and yacon (Smallanthus sonchifolius) in combination with silymarin as food supplements: In vivo safety assessment
    • Valentova K, Stejskal D, Bartek J, Dvorackova S, Kren V, Ulrichova J, Simanek V. Maca (Lepidium meyenii) and yacon (Smallanthus sonchifolius) in combination with silymarin as food supplements: in vivo safety assessment. Food Chem Toxicol 2008. 46(3):1006-1013.
    • (2008) Food Chem Toxicol , vol.46 , Issue.3 , pp. 1006-1013
    • Valentova, K.1    Stejskal, D.2    Bartek, J.3    Dvorackova, S.4    Kren, V.5    Ulrichova, J.6    Simanek, V.7
  • 37
    • 63049112752 scopus 로고    scopus 로고
    • Clinical efficacy, safety and tolerability of BIO-C (micronized Silymarin) as a galactagogue
    • Di Pierro F, Callegari A, Carotenuto D, Tapia MM. Clinical efficacy, safety and tolerability of BIO-C (micronized Silymarin) as a galactagogue. Acta Biomed 2008. 79(3):205-210.
    • (2008) Acta Biomed , vol.79 , pp. 205-210
    • Di Pierro, F.1    Callegari, A.2    Carotenuto, D.3    Tapia, M.M.4
  • 38
    • 84866792868 scopus 로고    scopus 로고
    • The treatment of melasma by silymarin cream
    • Altaei T. The treatment of melasma by silymarin cream. BMC Dermatol 2012. 12(1):18.
    • (2012) BMC Dermatol , vol.12 , Issue.1 , pp. 18
    • Altaei, T.1
  • 39
    • 84874114645 scopus 로고    scopus 로고
    • Silibinin: An old drug in the high tech era of liver transplantation
    • Ferenci P, Beinhardt S. Silibinin: an old drug in the high tech era of liver transplantation. J Hepatol 2013. 58(3):409-411.
    • (2013) J Hepatol , vol.58 , Issue.3 , pp. 409-411
    • Ferenci, P.1    Beinhardt, S.2
  • 40
    • 0016441620 scopus 로고
    • Les proprietes pharmacologiques de la silybine et de la silymarine
    • Lecomte J. Les proprietes pharmacologiques de la silybine et de la silymarine. Rev Med Liege 1975. 30:110-114.
    • (1975) Rev Med Liege , vol.30 , pp. 110-114
    • Lecomte, J.1
  • 41
    • 34249907027 scopus 로고    scopus 로고
    • Review of clinical trials evaluating safety and efficacy of milk thistle (Silybum marianum (L.) Gaertn)
    • Tamayo C, Diamond S. Review of clinical trials evaluating safety and efficacy of milk thistle (Silybum marianum (L.) Gaertn). Integr Cancer Ther 2007. 6(2):146-157.
    • (2007) Integr Cancer Ther , vol.6 , Issue.2 , pp. 146-157
    • Tamayo, C.1    Diamond, S.2
  • 42
    • 57949097025 scopus 로고    scopus 로고
    • Drug-drug interactions of silymarin on the perspective of pharmacokinetics
    • Wu JW, Lin LC, Tsai TH. Drug-drug interactions of silymarin on the perspective of pharmacokinetics. J Ethnopharmacol 2009. 121(2):185-193.
    • (2009) J Ethnopharmacol , vol.121 , Issue.2 , pp. 185-193
    • Wu, J.W.1    Lin, L.C.2    Tsai, T.H.3
  • 43
    • 70350068120 scopus 로고    scopus 로고
    • Bioavailability and activity of phytosome complexes from botanical polyphenols: The silymarin, curcumin, green tea, and grape seed extracts
    • Kidd PM. Bioavailability and activity of phytosome complexes from botanical polyphenols: the silymarin, curcumin, green tea, and grape seed extracts. Altern Med Rev 2009. 14(3):226-246.
    • (2009) Altern Med Rev , vol.14 , Issue.3 , pp. 226-246
    • Kidd, P.M.1
  • 44
    • 78651077286 scopus 로고    scopus 로고
    • Mixed micelles loaded with silybin-polyene phosphatidylcholine complex improve drug solubility
    • Duan R, Sun X, Liu J, Gong T, Zhang Z. Mixed micelles loaded with silybin-polyene phosphatidylcholine complex improve drug solubility. Acta Pharmacol Sin 2010. 32(1):108-115.
    • (2010) Acta Pharmacol Sin , vol.32 , Issue.1 , pp. 108-115
    • Duan, R.1    Sun, X.2    Liu, J.3    Gong, T.4    Zhang, Z.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.