메뉴 건너뛰기




Volumn 46, Issue 3, 2013, Pages 270-277

Effect and the probable mechanisms of silibinin in regulating insulin resistance in the liver of rats with non-alcoholic fatty liver

Author keywords

Insulin resistance; Non alcoholic fatty liver disease; Silibinin; Visceral obesity

Indexed keywords

GLUCOSE 6 PHOSPHATASE; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); SILIBININ; TRIACYLGLYCEROL LIPASE;

EID: 84876471326     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/1414-431X20122551     Document Type: Article
Times cited : (69)

References (40)
  • 1
    • 70349770695 scopus 로고    scopus 로고
    • Epidemiology and natural history of non-alcoholic steatohepatitis
    • doi: 10.1016/j.cld.2009.07.005
    • Argo CK, Caldwell SH. Epidemiology and natural history of non-alcoholic steatohepatitis. Clin Liver Dis 2009; 13: 511-531, doi: 10.1016/j.cld.2009.07.005.
    • (2009) Clin Liver Dis , vol.13 , pp. 511-531
    • Argo, C.K.1    Caldwell, S.H.2
  • 2
    • 84984562986 scopus 로고    scopus 로고
    • How common is non-alcoholic fatty liver disease in the Asia-Pacific region and are there local differences?
    • doi: 10.1111/j.1440-1746.2007.05042.x
    • Amarapurkar DN, Hashimoto E, Lesmana LA, Sollano JD, Chen PJ, Goh KL. How common is non-alcoholic fatty liver disease in the Asia-Pacific region and are there local differences? J Gastroenterol Hepatol 2007; 22: 788-793, doi: 10.1111/j.1440-1746.2007.05042.x.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 788-793
    • Amarapurkar, D.N.1    Hashimoto, E.2    Lesmana, L.A.3    Sollano, J.D.4    Chen, P.J.5    Goh, K.L.6
  • 3
    • 70449427988 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: Confronting the global epidemic requires better awareness
    • doi: 10.1111/j.1440-1746.2009.06026.x
    • de Silva HJ, Dassanayake AS. Non-alcoholic fatty liver disease: confronting the global epidemic requires better awareness. J Gastroenterol Hepatol 2009; 24: 1705-1707, doi: 10.1111/j.1440-1746.2009.06026.x.
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 1705-1707
    • de Silva, H.J.1    Dassanayake, A.S.2
  • 4
    • 79957833378 scopus 로고    scopus 로고
    • Silybin and the liver: From basic research to clinical practice
    • doi: 10.3748/wjg.v17.i18.2288
    • Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. World J Gastroenterol 2011; 17: 2288-2301, doi: 10.3748/wjg.v17.i18.2288.
    • (2011) World J Gastroenterol , vol.17 , pp. 2288-2301
    • Loguercio, C.1    Festi, D.2
  • 5
    • 26944447173 scopus 로고    scopus 로고
    • Effects of a new pharmacological complex (silybin + vitamin-E + phospholipids) on some markers of the metabolic syndrome and of liver fibrosis in patients with hepatic steatosis. Preliminary study
    • Trappoliere M, Federico A, Tuccillo C, de Sio I, Di Leva A, Niosi M, et al. [Effects of a new pharmacological complex (silybin + vitamin-E + phospholipids) on some markers of the metabolic syndrome and of liver fibrosis in patients with hepatic steatosis. Preliminary study]. Minerva Gastroenterol Dietol 2005; 51: 193-199.
    • (2005) Minerva Gastroenterol Dietol , vol.51 , pp. 193-199
    • Trappoliere, M.1    Federico, A.2    Tuccillo, C.3    de Sio, I.4    Di Leva, A.5    Niosi, M.6
  • 6
    • 33646770979 scopus 로고    scopus 로고
    • A new silybin-vitamin Ephospholipid complex improves insulin resistance and liver damage in patients with non-alcoholic fatty liver disease: Preliminary observations
    • doi: 10.1136/gut.2006.091967
    • Federico A, Trappoliere M, Tuccillo C, de Sio I, Di Leva A, Del Vecchio Blanco C, et al. A new silybin-vitamin Ephospholipid complex improves insulin resistance and liver damage in patients with non-alcoholic fatty liver disease: preliminary observations. Gut 2006; 55: 901-902, doi: 10.1136/gut.2006.091967.
    • (2006) Gut , vol.55 , pp. 901-902
    • Federico, A.1    Trappoliere, M.2    Tuccillo, C.3    de Sio, I.4    Di Leva, A.5    Del Vecchio Blanco, C.6
  • 7
    • 79961059179 scopus 로고    scopus 로고
    • Effect of silybin on high-fat-induced fatty liver in rats
    • Yao J, Zhi M, Minhu C. Effect of silybin on high-fat-induced fatty liver in rats. Braz J Med Biol Res 2011; 44: 652-659.
    • (2011) Braz J Med Biol Res , vol.44 , pp. 652-659
    • Yao, J.1    Zhi, M.2    Minhu, C.3
  • 8
    • 80051545931 scopus 로고    scopus 로고
    • Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss
    • doi: 10.1136/gut.2011.242073
    • Hallsworth K, Fattakhova G, Hollingsworth KG, Thoma C, Moore S, Taylor R, et al. Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss. Gut 2011; 60: 1278-1283, doi: 10.1136/gut.2011.242073.
    • (2011) Gut , vol.60 , pp. 1278-1283
    • Hallsworth, K.1    Fattakhova, G.2    Hollingsworth, K.G.3    Thoma, C.4    Moore, S.5    Taylor, R.6
  • 9
    • 79959365503 scopus 로고    scopus 로고
    • The association between the metabolic syndrome and alanine amino transferase is mediated by insulin resistance via related metabolic intermediates (the Cohort on Diabetes and Atherosclerosis Maastricht [CODAM] study)
    • doi: 10.1016/j.metabol.2010.09.006
    • Jacobs M, van Greevenbroek MM, van der Kallen CJ, Ferreira I, Feskens EJ, Jansen EH, et al. The association between the metabolic syndrome and alanine amino transferase is mediated by insulin resistance via related metabolic intermediates (the Cohort on Diabetes and Atherosclerosis Maastricht [CODAM] study). Metabolism 2011; 60: 969-975, doi: 10.1016/j.metabol.2010.09.006.
    • (2011) Metabolism , vol.60 , pp. 969-975
    • Jacobs, M.1    van Greevenbroek, M.M.2    van der Kallen, C.J.3    Ferreira, I.4    Feskens, E.J.5    Jansen, E.H.6
  • 10
    • 76149131004 scopus 로고    scopus 로고
    • The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance
    • doi: 10.1210/er.2009-0003
    • Pagel-Langenickel I, Bao J, Pang L, Sack MN. The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance. Endocr Rev 2010; 31: 25-51, doi: 10.1210/er.2009-0003.
    • (2010) Endocr Rev , vol.31 , pp. 25-51
    • Pagel-Langenickel, I.1    Bao, J.2    Pang, L.3    Sack, M.N.4
  • 11
    • 84873683616 scopus 로고    scopus 로고
    • Insulin resistance/hyperinsulinemia and cancer mortality: The Cremona study at the 15th year of follow-up
    • doi: 10.1007/ s00592-011-0361-2
    • Perseghin G, Calori G, Lattuada G, Ragogna F, Dugnani E, Garancini MP, et al. Insulin resistance/hyperinsulinemia and cancer mortality: the Cremona study at the 15th year of follow-up. Acta Diabetol 2012; 49: 421-428, doi: 10.1007/ s00592-011-0361-2.
    • (2012) Acta Diabetol , vol.49 , pp. 421-428
    • Perseghin, G.1    Calori, G.2    Lattuada, G.3    Ragogna, F.4    Dugnani, E.5    Garancini, M.P.6
  • 12
    • 84859705556 scopus 로고    scopus 로고
    • Predictors for incidence and remission of NAFLD in the general population during a seven-year prospective follow-up
    • doi: 10.1016/j.jhep.2011.12.011
    • Zelber-Sagi S, Lotan R, Shlomai A, Webb M, Harrari G, Buch A, et al. Predictors for incidence and remission of NAFLD in the general population during a seven-year prospective follow-up. J Hepatol 2012; 56: 1145-1151, doi: 10.1016/j.jhep.2011.12.011.
    • (2012) J Hepatol , vol.56 , pp. 1145-1151
    • Zelber-Sagi, S.1    Lotan, R.2    Shlomai, A.3    Webb, M.4    Harrari, G.5    Buch, A.6
  • 13
    • 34548127047 scopus 로고    scopus 로고
    • Post-load insulin resistance is an independent predictor of hepatic fibrosis in virus C chronic hepatitis and in non-alcoholic fatty liver disease
    • doi: 10.1136/gut.2006.107946
    • Svegliati-Baroni G, Bugianesi E, Bouserhal T, Marini F, Ridolfi F, Tarsetti F, et al. Post-load insulin resistance is an independent predictor of hepatic fibrosis in virus C chronic hepatitis and in non-alcoholic fatty liver disease. Gut 2007; 56: 1296-1301, doi: 10.1136/gut.2006.107946.
    • (2007) Gut , vol.56 , pp. 1296-1301
    • Svegliati-Baroni, G.1    Bugianesi, E.2    Bouserhal, T.3    Marini, F.4    Ridolfi, F.5    Tarsetti, F.6
  • 14
    • 34249650125 scopus 로고    scopus 로고
    • Insulin resistance in hepatocytes and sinusoidal liver cells: Mechanisms and consequences
    • doi: 10.1016/j.jhep.2007.04.002
    • Leclercq IA, Da Silva Morais A, Schroyen B, Van Hul N, Geerts A. Insulin resistance in hepatocytes and sinusoidal liver cells: mechanisms and consequences. J Hepatol 2007; 47: 142-156, doi: 10.1016/j.jhep.2007.04.002.
    • (2007) J Hepatol , vol.47 , pp. 142-156
    • Leclercq, I.A.1    Da Silva Morais, A.2    Schroyen, B.3    van Hul, N.4    Geerts, A.5
  • 16
    • 80052213096 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease
    • doi: 10.3109/ 10408363.2011.596521
    • Smith BW, Adams LA. Non-alcoholic fatty liver disease. Crit Rev Clin Lab Sci 2011; 48: 97-113, doi: 10.3109/ 10408363.2011.596521.
    • (2011) Crit Rev Clin Lab Sci , vol.48 , pp. 97-113
    • Smith, B.W.1    Adams, L.A.2
  • 17
    • 67649236153 scopus 로고    scopus 로고
    • 3,5-Diiodo-L-thyronine, by modulating mitochondrial functions, reverses hepatic fat accumulation in rats fed a high-fat diet
    • doi: 10.1016/j.jhep.2009.03.023
    • Mollica MP, Lionetti L, Moreno M, Lombardi A, De Lange P, Antonelli A, et al. 3,5-Diiodo-L-thyronine, by modulating mitochondrial functions, reverses hepatic fat accumulation in rats fed a high-fat diet. J Hepatol 2009; 51: 363-370, doi: 10.1016/j.jhep.2009.03.023.
    • (2009) J Hepatol , vol.51 , pp. 363-370
    • Mollica, M.P.1    Lionetti, L.2    Moreno, M.3    Lombardi, A.4    de Lange, P.5    Antonelli, A.6
  • 19
    • 79959421554 scopus 로고    scopus 로고
    • Multimodality imaging of beta-cells in mouse models of type 1 and 2 diabetes
    • doi: 10.2337/db10-0907
    • Yong J, Rasooly J, Dang H, Lu Y, Middleton B, Zhang Z, et al. Multimodality imaging of beta-cells in mouse models of type 1 and 2 diabetes. Diabetes 2011; 60: 1383-1392, doi: 10.2337/db10-0907.
    • (2011) Diabetes , vol.60 , pp. 1383-1392
    • Yong, J.1    Rasooly, J.2    Dang, H.3    Lu, Y.4    Middleton, B.5    Zhang, Z.6
  • 20
    • 79957832006 scopus 로고    scopus 로고
    • Exendin-4 improves blood glucose control in both young and aging normal nondiabetic mice, possible contribution of beta cell independent effects
    • doi: 10.1371/journal.-pone.0020443
    • Fan R, Kang Z, He L, Chan J, Xu G. Exendin-4 improves blood glucose control in both young and aging normal nondiabetic mice, possible contribution of beta cell independent effects. PLoS One 2011; 6: e20443, doi: 10.1371/journal.-pone.0020443.
    • (2011) PLoS One , vol.6
    • Fan, R.1    Kang, Z.2    He, L.3    Chan, J.4    Xu, G.5
  • 21
    • 0033961701 scopus 로고    scopus 로고
    • Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: Studies in subjects with various degrees of glucose tolerance and insulin sensitivity
    • doi: 10.2337/diacare. 23.1.57
    • Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 2000; 23: 57-63, doi: 10.2337/diacare. 23.1.57.
    • (2000) Diabetes Care , vol.23 , pp. 57-63
    • Bonora, E.1    Targher, G.2    Alberiche, M.3    Bonadonna, R.C.4    Saggiani, F.5    Zenere, M.B.6
  • 22
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • doi: 10.1002/hep.20701
    • Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41: 1313-1321, doi: 10.1002/hep.20701.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    van Natta, M.3    Behling, C.4    Contos, M.J.5    Cummings, O.W.6
  • 23
    • 79953829629 scopus 로고    scopus 로고
    • Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation
    • doi: 10.1007/s00441-011-1132-7
    • Kuwashiro S, Terai S, Oishi T, Fujisawa K, Matsumoto T, Nishina H, et al. Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation. Cell Tissue Res 2011; 344: 125-134, doi: 10.1007/s00441-011-1132-7.
    • (2011) Cell Tissue Res , vol.344 , pp. 125-134
    • Kuwashiro, S.1    Terai, S.2    Oishi, T.3    Fujisawa, K.4    Matsumoto, T.5    Nishina, H.6
  • 24
    • 79959379215 scopus 로고    scopus 로고
    • Validation of the non-alcoholic fatty liver disease activity score
    • doi: 10.1111/j.1365-2036.2011.04695.x
    • Hjelkrem M, Stauch C, Shaw J, Harrison SA. Validation of the non-alcoholic fatty liver disease activity score. Aliment Pharmacol Ther 2011; 34: 214-218, doi: 10.1111/j.1365-2036.2011.04695.x.
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 214-218
    • Hjelkrem, M.1    Stauch, C.2    Shaw, J.3    Harrison, S.A.4
  • 26
    • 84856257461 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease markers are associated with insulin resistance in type 1 diabetes
    • doi: 10.1007/s10620-011-1807-7
    • Bolum T, Kolaric B, Duvnjak L, Duvnjak M. Nonalcoholic fatty liver disease markers are associated with insulin resistance in type 1 diabetes. Dig Dis Sci 2011; 56: 3655-3663, doi: 10.1007/s10620-011-1807-7.
    • (2011) Dig Dis Sci , vol.56 , pp. 3655-3663
    • Bolum, T.1    Kolaric, B.2    Duvnjak, L.3    Duvnjak, M.4
  • 27
    • 80052635573 scopus 로고    scopus 로고
    • Clodronate liposomes improve metabolic profile and reduce visceral adipose macrophage content in diet-induced obese mice
    • doi: 10.1371/journal.-pone.0024358
    • Feng B, Jiao P, Nie Y, Kim T, Jun D, van Rooijen N, et al. Clodronate liposomes improve metabolic profile and reduce visceral adipose macrophage content in diet-induced obese mice. PLoS One 2011; 6: e24358, doi: 10.1371/journal.-pone.0024358.
    • (2011) PLoS One , vol.6
    • Feng, B.1    Jiao, P.2    Nie, Y.3    Kim, T.4    Jun, D.5    van Rooijen, N.6
  • 28
    • 79551481321 scopus 로고    scopus 로고
    • Insulin sensitivity and regional fat gain in response to overfeeding
    • doi: 10.1038/oby.2010.274
    • Votruba SB, Jensen MD. Insulin sensitivity and regional fat gain in response to overfeeding. Obesity 2011; 19: 269-275, doi: 10.1038/oby.2010.274.
    • (2011) Obesity , vol.19 , pp. 269-275
    • Votruba, S.B.1    Jensen, M.D.2
  • 29
    • 3342957096 scopus 로고    scopus 로고
    • Sagittal abdominal diameter is a strong anthropometric marker of insulin resistance and hyperproinsulinemia in obese men
    • doi: 10.2337/diacare.27.8.2041
    • Riserus U, Arnlov J, Brismar K, Zethelius B, Berglund L, Vessby B. Sagittal abdominal diameter is a strong anthropometric marker of insulin resistance and hyperproinsulinemia in obese men. Diabetes Care 2004; 27: 2041-2046, doi: 10.2337/diacare.27.8.2041.
    • (2004) Diabetes Care , vol.27 , pp. 2041-2046
    • Riserus, U.1    Arnlov, J.2    Brismar, K.3    Zethelius, B.4    Berglund, L.5    Vessby, B.6
  • 30
    • 41549125912 scopus 로고    scopus 로고
    • Global transcript profiles of fat in monozygotic twins discordant for BMI: Pathways behind acquired obesity
    • doi: 10.1371/ journal.pmed.0050051
    • Pietilainen KH, Naukkarinen J, Rissanen A, Saharinen J, Ellonen P, Keranen H, et al. Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity. PLoS Med 2008; 5: e51, doi: 10.1371/ journal.pmed.0050051.
    • (2008) PLoS Med , vol.5
    • Pietilainen, K.H.1    Naukkarinen, J.2    Rissanen, A.3    Saharinen, J.4    Ellonen, P.5    Keranen, H.6
  • 31
    • 3543029821 scopus 로고    scopus 로고
    • Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
    • doi: 10.1074/jbc.M313478200
    • Samuel VT, Liu ZX, Qu X, Elder BD, Bilz S, Befroy D, et al. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 2004; 279: 32345-32353, doi: 10.1074/jbc.M313478200.
    • (2004) J Biol Chem , vol.279 , pp. 32345-32353
    • Samuel, V.T.1    Liu, Z.X.2    Qu, X.3    Elder, B.D.4    Bilz, S.5    Befroy, D.6
  • 32
    • 81255157669 scopus 로고    scopus 로고
    • Adipose triglyceride lipase affects triacylglycerol metabolism at brain barriers
    • doi: 10.1111/j.1471-4159.2011.07498.x
    • Etschmaier K, Becker T, Eichmann TO, Schweinzer C, Scholler M, Tam-Amersdorfer C, et al. Adipose triglyceride lipase affects triacylglycerol metabolism at brain barriers. J Neurochem 2011; 119: 1016-1028, doi: 10.1111/j.1471-4159.2011.07498.x.
    • (2011) J Neurochem , vol.119 , pp. 1016-1028
    • Etschmaier, K.1    Becker, T.2    Eichmann, T.O.3    Schweinzer, C.4    Scholler, M.5    Tam-Amersdorfer, C.6
  • 33
    • 68049085521 scopus 로고    scopus 로고
    • Adipose triacylglycerol lipase deletion alters whole body energy metabolism and impairs exercise performance in mice
    • doi: 10.1152/ ajpendo.00190.2009
    • Huijsman E, van de Par C, Economou C, van der Poel C, Lynch GS, Schoiswohl G, et al. Adipose triacylglycerol lipase deletion alters whole body energy metabolism and impairs exercise performance in mice. Am J Physiol Endocrinol Metab 2009; 297: E505-E513, doi: 10.1152/ ajpendo.00190.2009.
    • (2009) Am J Physiol Endocrinol Metab , vol.297
    • Huijsman, E.1    van de Par, C.2    Economou, C.3    van der Poel, C.4    Lynch, G.S.5    Schoiswohl, G.6
  • 34
    • 63449127032 scopus 로고    scopus 로고
    • Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores
    • doi: 10.1194/jlr.R800031-JLR200
    • Zechner R, Kienesberger PC, Haemmerle G, Zimmermann R, Lass A. Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores. J Lipid Res 2009; 50: 3-21, doi: 10.1194/jlr.R800031-JLR200.
    • (2009) J Lipid Res , vol.50 , pp. 3-21
    • Zechner, R.1    Kienesberger, P.C.2    Haemmerle, G.3    Zimmermann, R.4    Lass, A.5
  • 35
    • 80055057797 scopus 로고    scopus 로고
    • Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance
    • doi: 10.1002/hep.24571
    • Lee HY, Birkenfeld AL, Jornayvaz FR, Jurczak MJ, Kanda S, Popov V, et al. Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance. Hepatology 2011; 54: 1650-1660, doi: 10.1002/hep.24571.
    • (2011) Hepatology , vol.54 , pp. 1650-1660
    • Lee, H.Y.1    Birkenfeld, A.L.2    Jornayvaz, F.R.3    Jurczak, M.J.4    Kanda, S.5    Popov, V.6
  • 36
    • 0141532189 scopus 로고    scopus 로고
    • Primacy of hepatic insulin resistance in the development of the metabolic syndrome induced by an isocaloric moderate-fat diet in the dog
    • doi: 10.2337/diabetes.52.10.2453
    • Kim SP, Ellmerer M, Van Citters GW, Bergman RN. Primacy of hepatic insulin resistance in the development of the metabolic syndrome induced by an isocaloric moderate-fat diet in the dog. Diabetes 2003; 52: 2453-2460, doi: 10.2337/diabetes.52.10.2453.
    • (2003) Diabetes , vol.52 , pp. 2453-2460
    • Kim, S.P.1    Ellmerer, M.2    van Citters, G.W.3    Bergman, R.N.4
  • 37
    • 77956838050 scopus 로고    scopus 로고
    • Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via G(alpha)i-protein-coupled receptors and the AKT pathway
    • doi: 10.1194/jlr.M004929
    • Cao R, Cronk ZX, Zha W, Sun L, Wang X, Fang Y, et al. Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via G(alpha)i-protein-coupled receptors and the AKT pathway. J Lipid Res 2010; 51: 2234-2244, doi: 10.1194/jlr.M004929.
    • (2010) J Lipid Res , vol.51 , pp. 2234-2244
    • Cao, R.1    Cronk, Z.X.2    Zha, W.3    Sun, L.4    Wang, X.5    Fang, Y.6
  • 38
    • 12144279575 scopus 로고    scopus 로고
    • Molecular evidence supporting the portal theory: A causative link between visceral adiposity and hepatic insulin resistance
    • doi: 10.1152/ ajpendo.00203.2004
    • Kabir M, Catalano KJ, Ananthnarayan S, Kim SP, Van Citters GW, Dea MK, et al. Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance. Am J Physiol Endocrinol Metab 2005; 288: E454-E461, doi: 10.1152/ ajpendo.00203.2004.
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Kabir, M.1    Catalano, K.J.2    Ananthnarayan, S.3    Kim, S.P.4    van Citters, G.W.5    Dea, M.K.6
  • 39
    • 77958127193 scopus 로고    scopus 로고
    • Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: Improvement of fasting glycemia in diabetic db/db mice
    • doi: 10.1124/mol.110.065714
    • Nagashima T, Shigematsu N, Maruki R, Urano Y, Tanaka H, Shimaya A, et al. Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice. Mol Pharmacol 2010; 78: 961-970, doi: 10.1124/mol.110.065714.
    • (2010) Mol Pharmacol , vol.78 , pp. 961-970
    • Nagashima, T.1    Shigematsu, N.2    Maruki, R.3    Urano, Y.4    Tanaka, H.5    Shimaya, A.6
  • 40
    • 33751507689 scopus 로고    scopus 로고
    • Aberrant Forkhead box O1 function is associated with impaired hepatic metabolism
    • doi: 10.1210/en.2006-0541
    • Qu S, Altomonte J, Perdomo G, He J, Fan Y, Kamagate A, et al. Aberrant Forkhead box O1 function is associated with impaired hepatic metabolism. Endocrinology 2006; 147: 5641-5652, doi: 10.1210/en.2006-0541.
    • (2006) Endocrinology , vol.147 , pp. 5641-5652
    • Qu, S.1    Altomonte, J.2    Perdomo, G.3    He, J.4    Fan, Y.5    Kamagate, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.