The synergistic effects of the RGD density and the microenvironment on the behavior of encapsulated cells: In vitro and in vivo direct comparative study

Journal of Biomedical Materials Research - Part A

Volumn 102, Issue 11, 2014, Pages 3965-3972

  Santos, Edorta ^a,b   Garate, Ane ^a,b   Pedraz, José Luis ^a,b   Orive, Gorka ^a,b   Hernández, Rosa María ^a,b  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

Author keywords

Ligand density; Microcapsule; Microenvironment; RGD; Scaffold

Indexed keywords

AMINO ACIDS; BIOMATERIALS; CELL CULTURE; CELLS; ENCAPSULATION; SCAFFOLDS;

ALGINATE MICROCAPSULES; CELL ENCAPSULATIONS; COMPARATIVE STUDIES; DIFFERENT DENSITIES; LIGAND DENSITY; MICROCAPSULES; MICROENVIRONMENTS; RGD;

SCAFFOLDS (BIOLOGY);

ALGINIC ACID; ARGINYLGLYCYLASPARTIC ACID; F ACTIN; ALGINATE POLYLYSINE ALGINATE; ARGINYL-GLYCYL-ASPARTIC ACID; MICROCAPSULE; OLIGOPEPTIDE; POLYLYSINE;

ANIMAL CELL; ARTICLE; CELL ENCAPSULATION; CELL FUNCTION; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; IMMOBILIZED CELL; IN VITRO STUDY; IN VIVO STUDY; MICROENCAPSULATION; MICROENVIRONMENT; MOUSE; MYOBLAST; NONHUMAN; ANALOGS AND DERIVATIVES; ANIMAL; CELL LINE; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; MICROCAPSULE; PHARMACOLOGY; STEM CELL NICHE;

ALGINATES; ANIMALS; CAPSULES; CELL LINE; CELLS, IMMOBILIZED; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; MYOBLASTS; OLIGOPEPTIDES; POLYLYSINE; STEM CELL NICHE;

EID: 84908056181     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.35073     Document Type: Article

References (49)

1. Sayyar B, Dodd M, Wen J, Ma S, Marquez-Curtis L, Janowska-Wieczorek A, Hortelano G. Encapsulation of factor IX-engineered mesenchymal stem cells in fibrinogen-alginate microcapsules enhances their viability and transgene secretion. J Tissue Eng 2012;3:2041731412462018.
2. Karoubi G, Ormiston ML, Stewart DJ, Courtman DW. Single-cell hydrogel encapsulation for enhanced survival of human marrow stromal cells. Biomaterials 2009;30:5445-5455.
3. Kong HJ, Smith MK, Mooney DJ. Designing alginate hydrogels to maintain viability of immobilized cells. Biomaterials 2003;24:4023-4029.
4. Hersel U, Dahmen C, Kessler H. RGD modified polymers: Biomaterials for stimulated cell adhesion and beyond. Biomaterials 2003;24:4385-4415.
5. Hsiong SX, Huebsch N, Fischbach C, Kong HJ, Mooney DJ. Integrin-adhesion ligand bond formation of preosteoblasts and stem cells in three-dimensional RGD presenting matrices. Biomacromolecules 2008;9:1843-1851.
6. Orive G, De Castro M, Kong HJ, Hernandez RM, Ponce S, Mooney DJ, Pedraz JL. Bioactive cell-hydrogel microcapsules for cellbased drug delivery. J Control Release 2009;135:203-210.
7. Salinas CN, Anseth KS. The influence of the RGD peptide motif and its contextual presentation in PEG gels on human mesenchymal stem cell viability. J Tissue Eng Regen Med 2008;2:296-304.
8. Rowley JA, Madlambayan G, Mooney DJ. Alginate hydrogels as synthetic extracellular matrix materials. Biomaterials 1999;20:45-53.
9. Santos E, Hernandez RM, Pedraz JL, Orive G. Novel advances in the design of three-dimensional bio-scaffolds to control cell fate: Translation from 2D to 3D. Trends Biotechnol 2012;30:331-341.
10. Comisar WA, Hsiong SX, Kong HJ, Mooney DJ, Linderman JJ. Multi-scale modeling to predict ligand presentation within RGD nanopatterned hydrogels. Biomaterials 2006;27:2322-2329.
11. Bellis SL. Advantages of RGD peptides for directing cell association with biomaterials. Biomaterials 2011;32:4205-4210.
12. Barker TH. The role of ECM proteins and protein fragments in guiding cell behavior in regenerative medicine. Biomaterials 2011; 32:4211-4214.
13. Collier JH, Segura T. Evolving the use of peptides as components of biomaterials. Biomaterials 2011;32:4198-4204.
14. Williams DF. The role of short synthetic adhesion peptides in regenerative medicine: The debate. Biomaterials 2011;32:4195-4197.
15. Ferris DM, Moodie GD, Dimond PM, Gioranni CW, Ehrlich MG, Valentini RF. RGD-coated titanium implants stimulate increased bone formation in vivo. Biomaterials 1999;20:2323-2331.
16. Eid K, Chen E, Griffith L, Glowacki J. Effect of RGD coating on osteocompatibility of PLGA-polymer disks in a rat tibial wound. J Biomed Mater Res 2001;57:224-231.
17. Alsberg E, Anderson KW, Albeiruti A, Rowley JA, Mooney DJ. Engineering growing tissues. Proc Natl Acad Sci USA 2002;99: 12025-12030.
18. Allen LT, Tosetto M, Miller IS, O'Connor DP, Penney SC, Lynch I, Keenan AK, Pennington SR, Dawson KA, Gallagher WM. Surfaceinduced changes in protein adsorption and implications for cellular phenotypic responses to surface interaction. Biomaterials 2006;27:3096-3108.
19. Roach P, Farrar D, Perry CC. Surface tailoring for controlled protein adsorption: Effect of topography at the nanometer scale and chemistry. J Am Chem Soc 2006;128:3939-3945.
20. Heino J, Ignotz RA, Hemler ME, Crouse C, Massague J. Regulation of cell adhesion receptors by transforming growth factorbeta. Concomitant regulation of integrins that share a common beta 1 subunit. J Biol Chem 1989;264:380-388.
21. Sinha RK, Tuan RS. Regulation of human osteoblast integrin expression by orthopedic implant materials. Bone 1996;18:451-457.
22. Pierschbacher MD, Ruoslahti E. Influence of stereochemistry of the sequence Arg-Gly-Asp-Xaa on binding specificity in cell adhesion. J Biol Chem 1987;262:17294-17298.
23. Shin H, Jo S, Mikos AG. Biomimetic materials for tissue engineering. Biomaterials 2003;24:4353-4364.
24. Lagunas A, Comelles J, Martinez E, Prats-Alfonso E, Acosta GA, Albericio F, Samitier J. Cell adhesion and focal contact formation on linear RGD molecular gradients: Study of non-linear concentration dependence effects. Nanomedicine 2012;8:432-439.
25. Connelly JT, Garcia AJ, Levenston ME. Inhibition of in vitro chondrogenesis in RGD-modified three-dimensional alginate gels. Biomaterials 2007;28:1071-1083.
26. Re'em T, Tsur-Gang O, Cohen S. The effect of immobilized RGD peptide in macroporous alginate scaffolds on TGFbeta1-induced chondrogenesis of human mesenchymal stem cells. Biomaterials 2010;31:6746-6755.
27. Bidarra SJ, Barrias CC, Fonseca KB, Barbosa MA, Soares RA, Granja PL. Injectable in situ crosslinkable RGD-modified alginate matrix for endothelial cells delivery. Biomaterials 2011;32:7897-7904.
28. Kim SY, Oh HK, Ha JM, Ahn HY, Shin JC, Baek SH, Lim SC, Joe YA. RGD-peptide presents anti-adhesive effect, but not direct proapoptotic effect on endothelial progenitor cells. Arch Biochem Biophys 2007;459:40-49.
29. Lee KY, Mooney DJ. Alginate: Properties and biomedical applications. Prog Polym Sci 2012;37:106-126.
30. Machida-Sano I, Ogawa S, Ueda H, Kimura Y, Satoh N, Namiki H. Effects of composition of iron-cross-linked alginate hydrogels for cultivation of human dermal fibroblasts. Int J Biomater 2012;2012: 820513.
31. Leung A, Nielsen L, Trau M, Timmins N. Tissue transplantation by stealth-coherent alginate microcapsules for immunoisolation. Biochem Eng J 2010;48:337-347.
32. Orive G, Tam SK, Pedraz JL, Halle JP. Biocompatibility of alginate- poly-L-lysine microcapsules for cell therapy. Biomaterials 2006;27:3691-3700.
33. Pawar SN, Edgar KJ. Alginate derivatization: A review of chemistry, properties and applications. Biomaterials 2012;33:3279-3305.
34. Ponce S, Orive G, Hernández R, Gascun AR, Pedraz JL, de Haan BJ, Faas MM, Mathieu HJ, de Vos P. Chemistry and the biological response against immunoisolating alginate-polycation capsules of different composition. Biomaterials 2006;27:4831-4839.
35. Lim F, Sun AM. Microencapsulated islets as bioartificial endocrine pancreas. Science 1980;210:908-910.
36. Aota S, Nagai T, Yamada KM. Characterization of regions of fibronectin besides the arginine-glycine-aspartic acid sequence required for adhesive function of the cell-binding domain using site-directed mutagenesis. J Biol Chem 1991;266:15938-15943.
37. Woods A, Couchman JR, Johansson S, Hook M. Adhesion and cytoskeletal organisation of fibroblasts in response to fibronectin fragments. EMBO J 1986;5:665-670.
38. Sawyer AA, Hennessy KM, Bellis SL. Regulation of mesenchymal stem cell attachment and spreading on hydroxyapatite by RGD peptides and adsorbed serum proteins. Biomaterials 2005;26: 1467-1475.
39. Sawyer AA, Hennessy KM, Bellis SL. The effect of adsorbed serum proteins, RGD and proteoglycan-binding peptides on the adhesion of mesenchymal stem cells to hydroxyapatite. Biomaterials 2007;28:383-392.
40. Houseman BT, Mrksich M. The microenvironment of immobilized Arg-Gly-Asp peptides is an important determinant of cell adhesion. Biomaterials 2001;22:943-955.
41. Stupack DG, Cheresh DA. Get a ligand, get a life: Integrins, signaling and cell survival. J Cell Sci 2002;115:3729-3738.
42. Stupack DG, Cheresh DA. Apoptotic cues from the extracellular matrix: Regulators of angiogenesis. Oncogene 2003;22: 9022-9029.
43. Arnaout MA, Mahalingam B, Xiong JP. Integrin structure, allostery, and bidirectional signaling. Annu Rev Cell Dev Biol 2005;21: 381-410.
44. Barczyk M, Carracedo S, Gullberg D. Integrins. Cell Tissue Res 2010;339:269-280.
45. Evangelista MB, Hsiong SX, Fernandes R, Sampaio P, Kong HJ, Barrias CC, Salema R, Barbosa MA, Mooney DJ, Granja PL. Upregulation of bone cell differentiation through immobilization within a synthetic extracellular matrix. Biomaterials 2007;28:3644-3655.
46. Rowley JA, Mooney DJ. Alginate type and RGD density control myoblast phenotype. J Biomed Mater Res 2002;60:217-223.
47. Neff JA, Tresco PA, Caldwell KD. Surface modification for controlled studies of cell-ligand interactions. Biomaterials 1999;20: 2377-2393.
48. Comisar WA, Kazmers NH, Mooney DJ, Linderman JJ. Engineering RGD nanopatterned hydrogels to control preosteoblast behavior: A combined computational and experimental approach. Biomaterials 2007;28:4409-4417.
49. Plopper GE, McNamee HP, Dike LE, Bojanowski K, Ingber DE. Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex. Mol Biol Cell 1995; 6:1349-1365.