Zebrafish bioassay-guided microfractionation identifies anticonvulsant steroid glycosides from the Philippine medicinal plant Solanum torvum

ACS Chemical Neuroscience

Volumn 5, Issue 10, 2014, Pages 993-1004

  Challal, Soura ^a   Buenafe, Olivia E M ^b   Queiroz, Emerson F ^a   Maljevic, Snezana ^c   Marcourt, Laurence ^a   Bock, Merle ^c   Kloeti, Werner ^a   Dayrit, Fabian M ^d   Harvey, Alan L ^e   Lerche, Holger ^c   Esguerra, Camila V ^b   De Witte, Peter A M ^b   Wolfender, Jean Luc ^a   Crawford, Alexander D ^b  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d ATENEO DE MANILA UNIVERSITY   (Philippines)

^e UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

antiepileptic activity; HPLC microfractionation; saponins; Solanaceae; Solanum torvum; Zebrafish

Indexed keywords

3BETA,6ALPHA,23 TRIHYDROXY 5ALPHA SPIROSTANE 6 O BETA DEXTRO XYLOPYRANOSYL(1-3) O BETA DEXTRO QUINOVOPYRANOSIDE; AGLYCONE; ANTICONVULSIVE AGENT; GLYCOSIDE; PANICULONIN A; PANICULONIN B; PENTETRAZOLE; SOLANOLIDE; SOLANOLIDE 20 EPIMER; STEROID; TORVOSIDE J; TORVOSIDE K; TORVOSIDE L; TRITERPENE; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID A RECEPTOR; PLANT EXTRACT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; BIOASSAY; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG ISOLATION; DRUG METABOLISM; DRUG SCREENING; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; NONHUMAN; PLANT LEAF; SEIZURE; SOLANUM TORVUM; TRADITIONAL MEDICINE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ZEBRA FISH; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DISEASE MODEL; DRUG DEVELOPMENT; DRUG EFFECTS; FRACTIONATION; GENETICS; LARVA; MEDICINAL PLANT; METABOLISM; MICROTECHNOLOGY; OOCYTE; PATCH CLAMP TECHNIQUE; PROCEDURES; SEIZURES; SOLANUM; XENOPUS LAEVIS;

DANIO RERIO; SOLANACEAE; SOLANUM TORVUM;

ANIMALS; ANTICONVULSANTS; BIOLOGICAL ASSAY; CHEMICAL FRACTIONATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; DRUG DISCOVERY; GLYCOSIDES; HYDROLYSIS; LARVA; MICROTECHNOLOGY; MOLECULAR STRUCTURE; OOCYTES; PATCH-CLAMP TECHNIQUES; PENTYLENETETRAZOLE; PLANT EXTRACTS; PLANTS, MEDICINAL; RECEPTORS, GABA-A; SEIZURES; SOLANUM; XENOPUS LAEVIS; ZEBRAFISH;

EID: 84908048871     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn5001342     Document Type: Article

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