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Volumn 38, Issue 10, 2014, Pages 1145-1153

Subcutaneous omacetaxine mepesuccinate in patients with chronic myeloid leukemia in tyrosine kinase inhibitor-resistant patients: Review and perspectives

Author keywords

BCR ABL mutation; Chronic phase CML; Imatinib; Imatinib resistance; T315I

Indexed keywords

ABELSON KINASE; ALPHA INTERFERON; CYTARABINE; HOMOHARRINGTONINE; IMATINIB; NILOTINIB; PONATINIB; PROTEIN TYROSINE KINASE INHIBITOR; TOZASERTIB; ANTINEOPLASTIC AGENT; HARRINGTONINE DERIVATIVE;

EID: 84908021723     PISSN: 01452126     EISSN: 18735835     Source Type: Journal    
DOI: 10.1016/j.leukres.2014.05.007     Document Type: Review
Times cited : (26)

References (82)
  • 1
    • 0015694748 scopus 로고
    • Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
    • Rowley J.D. Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 1973, 243:290-293.
    • (1973) Nature , vol.243 , pp. 290-293
    • Rowley, J.D.1
  • 2
    • 77958595179 scopus 로고    scopus 로고
    • Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International Randomized Study of Interferon and STI571 (IRIS)
    • Hughes T.P., Hochhaus A., Branford S., Muller M.C., Kaeda J.S., Foroni L., et al. Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International Randomized Study of Interferon and STI571 (IRIS). Blood 2010, 116:3758-3765.
    • (2010) Blood , vol.116 , pp. 3758-3765
    • Hughes, T.P.1    Hochhaus, A.2    Branford, S.3    Muller, M.C.4    Kaeda, J.S.5    Foroni, L.6
  • 3
    • 0036090222 scopus 로고    scopus 로고
    • Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
    • Graham S.M., Jorgensen H.G., Allan E., Pearson C., Alcorn M.J., Richmond L., et al. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood 2002, 99:319-325.
    • (2002) Blood , vol.99 , pp. 319-325
    • Graham, S.M.1    Jorgensen, H.G.2    Allan, E.3    Pearson, C.4    Alcorn, M.J.5    Richmond, L.6
  • 4
    • 45749093747 scopus 로고    scopus 로고
    • Resistance and relapse with imatinib in CML: causes and consequences
    • Deininger M. Resistance and relapse with imatinib in CML: causes and consequences. J Natl Comprehen Cancer Network: JNCCN 2008, 6(Suppl 2):S11-S21.
    • (2008) J Natl Comprehen Cancer Network: JNCCN , vol.6 , pp. S11-S21
    • Deininger, M.1
  • 5
    • 84884911671 scopus 로고    scopus 로고
    • The BCR-ABLT315I mutation compromises survival in chronic phase chronic myelogenous leukemia patients resistant to tyrosine kinase inhibitors, in a matched pair analysis
    • Nicolini F.E., Ibrahim A.R., Soverini S., Martinelli G., Muller M.C., Hochhaus A., et al. The BCR-ABLT315I mutation compromises survival in chronic phase chronic myelogenous leukemia patients resistant to tyrosine kinase inhibitors, in a matched pair analysis. Haematologica 2013, 98:1510-1516.
    • (2013) Haematologica , vol.98 , pp. 1510-1516
    • Nicolini, F.E.1    Ibrahim, A.R.2    Soverini, S.3    Martinelli, G.4    Muller, M.C.5    Hochhaus, A.6
  • 6
    • 84863124648 scopus 로고    scopus 로고
    • Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival
    • Hamilton A., Helgason G.V., Schemionek M., Zhang B., Myssina S., Allan E.K., et al. Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival. Blood 2012, 119:1501-1510.
    • (2012) Blood , vol.119 , pp. 1501-1510
    • Hamilton, A.1    Helgason, G.V.2    Schemionek, M.3    Zhang, B.4    Myssina, S.5    Allan, E.K.6
  • 7
    • 34948830170 scopus 로고    scopus 로고
    • Interferon-alpha or homoharringtonine as salvage treatment for chronic myeloid leukemia patients who acquire the T315I BCR-ABL mutation
    • de Lavallade H., Khorashad J.S., Davis H.P., Milojkovic D., Kaeda J.S., Goldman J.M., et al. Interferon-alpha or homoharringtonine as salvage treatment for chronic myeloid leukemia patients who acquire the T315I BCR-ABL mutation. Blood 2007, 110:2779-2780.
    • (2007) Blood , vol.110 , pp. 2779-2780
    • de Lavallade, H.1    Khorashad, J.S.2    Davis, H.P.3    Milojkovic, D.4    Kaeda, J.S.5    Goldman, J.M.6
  • 8
    • 84871193504 scopus 로고    scopus 로고
    • Subcutaneous omacetaxine mepesuccinate in patients with chronic phase (CP) or accelerated phase (AP) chronic myeloid leukemia (CML) resistant/intolerant to two or three approved tyrosine-kinase inhibitors (TKIs)
    • (suppl; abstr 6513)
    • Nicolini F.E., Lipton J.H., Kantarjian H., Wetzler M., Akard L.P., Baccarani M., et al. Subcutaneous omacetaxine mepesuccinate in patients with chronic phase (CP) or accelerated phase (AP) chronic myeloid leukemia (CML) resistant/intolerant to two or three approved tyrosine-kinase inhibitors (TKIs). J. Clin. Oncol. 2012, 30. (suppl; abstr 6513).
    • (2012) J. Clin. Oncol. , vol.30
    • Nicolini, F.E.1    Lipton, J.H.2    Kantarjian, H.3    Wetzler, M.4    Akard, L.P.5    Baccarani, M.6
  • 10
    • 0021027516 scopus 로고
    • Cytotoxicity and sister chromatid exchanges induced in vitro by six anticancer drugs developed in the People's Republic of China
    • Huang C.C., Han C.S., Yue X.F., Shen C.M., Wang S.W., Wu F.G., et al. Cytotoxicity and sister chromatid exchanges induced in vitro by six anticancer drugs developed in the People's Republic of China. J Natl Cancer Inst 1983, 71:841-847.
    • (1983) J Natl Cancer Inst , vol.71 , pp. 841-847
    • Huang, C.C.1    Han, C.S.2    Yue, X.F.3    Shen, C.M.4    Wang, S.W.5    Wu, F.G.6
  • 11
    • 0017153556 scopus 로고
    • Cephalotaxine esters in the treatment of acute leukemia. A preliminary clinical assessment
    • Group CRC Cephalotaxine esters in the treatment of acute leukemia. A preliminary clinical assessment. Chin Med J 1976, 2:263-272.
    • (1976) Chin Med J , vol.2 , pp. 263-272
  • 13
    • 0015381726 scopus 로고
    • Antitumor alkaloids from Cephalotaxus harringtonia: structure and activity
    • Powell R., Weislerder D., Smith C.R. Antitumor alkaloids from Cephalotaxus harringtonia: structure and activity. J Pharm Sci 1972, 61:1227-1230.
    • (1972) J Pharm Sci , vol.61 , pp. 1227-1230
    • Powell, R.1    Weislerder, D.2    Smith, C.R.3
  • 14
    • 0017409621 scopus 로고
    • Cytotoxicity and cell cycle specificity of homoharringtonine
    • Baaske D.M., Heinstein P. Cytotoxicity and cell cycle specificity of homoharringtonine. Antimicrob Agents Chemother 1977, 12:298-300.
    • (1977) Antimicrob Agents Chemother , vol.12 , pp. 298-300
    • Baaske, D.M.1    Heinstein, P.2
  • 15
  • 16
    • 0017577805 scopus 로고
    • Inhibition of translation in eukaryotic systems by harringtonine
    • Fresno M., Jimenez A., Vazquez D. Inhibition of translation in eukaryotic systems by harringtonine. Euro J Biochem/FEBS 1977, 72:323-330.
    • (1977) Euro J Biochem/FEBS , vol.72 , pp. 323-330
    • Fresno, M.1    Jimenez, A.2    Vazquez, D.3
  • 17
    • 0017764624 scopus 로고
    • The antitumor effects and pharmacologic actions of harringtonine
    • Department of Pharmacology IoMM The antitumor effects and pharmacologic actions of harringtonine. Chin Med J 1977, 3:131-136.
    • (1977) Chin Med J , vol.3 , pp. 131-136
  • 18
    • 0025230334 scopus 로고
    • Effect of homoharringtonine on proliferation and differentiation of human leukemic cells in vitro
    • Zhou J.Y., Chen D.L., Shen Z.S., Koeffler H.P. Effect of homoharringtonine on proliferation and differentiation of human leukemic cells in vitro. Cancer Res 1990, 50:2031-2035.
    • (1990) Cancer Res , vol.50 , pp. 2031-2035
    • Zhou, J.Y.1    Chen, D.L.2    Shen, Z.S.3    Koeffler, H.P.4
  • 19
    • 33645471372 scopus 로고    scopus 로고
    • Semisynthetic homoharringtonine induces apoptosis via inhibition of protein synthesis and triggers rapid myeloid cell leukemia-1 down-regulation in myeloid leukemia cells
    • Tang R., Faussat A.M., Majdak P., Marzac C., Dubrulle S., Marjanovic Z., et al. Semisynthetic homoharringtonine induces apoptosis via inhibition of protein synthesis and triggers rapid myeloid cell leukemia-1 down-regulation in myeloid leukemia cells. Mol Cancer Thera 2006, 5:723-731.
    • (2006) Mol Cancer Thera , vol.5 , pp. 723-731
    • Tang, R.1    Faussat, A.M.2    Majdak, P.3    Marzac, C.4    Dubrulle, S.5    Marjanovic, Z.6
  • 20
    • 79958139921 scopus 로고    scopus 로고
    • Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells
    • Allan E.K., Holyoake T.L., Craig A.R., Jorgensen H.G. Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells. Leukemia 2011, 25:985-994.
    • (2011) Leukemia , vol.25 , pp. 985-994
    • Allan, E.K.1    Holyoake, T.L.2    Craig, A.R.3    Jorgensen, H.G.4
  • 21
    • 38349043669 scopus 로고    scopus 로고
    • High-content single-cell drug screening with phosphospecific flow cytometry
    • Krutzik P.O., Crane J.M., Clutter M.R., Nolan G.P. High-content single-cell drug screening with phosphospecific flow cytometry. Nat Chem Biol 2008, 4:132-142.
    • (2008) Nat Chem Biol , vol.4 , pp. 132-142
    • Krutzik, P.O.1    Crane, J.M.2    Clutter, M.R.3    Nolan, G.P.4
  • 22
    • 68749110580 scopus 로고    scopus 로고
    • Inhibitory effects of omacetaxine on leukemic stem cells and BCR-ABL-induced chronic myeloid leukemia and acute lymphoblastic leukemia in mice
    • Chen Y., Hu Y., Michaels S., Segal D., Brown D., Li S. Inhibitory effects of omacetaxine on leukemic stem cells and BCR-ABL-induced chronic myeloid leukemia and acute lymphoblastic leukemia in mice. Leukemia 2009, 23:1446-1454.
    • (2009) Leukemia , vol.23 , pp. 1446-1454
    • Chen, Y.1    Hu, Y.2    Michaels, S.3    Segal, D.4    Brown, D.5    Li, S.6
  • 23
    • 78650983120 scopus 로고    scopus 로고
    • Homoharringtonine reduced Mcl-1 expression and induced apoptosis in chronic lymphocytic leukemia
    • Chen R., Guo L., Chen Y., Jiang Y., Wierda W.G., Plunkett W. Homoharringtonine reduced Mcl-1 expression and induced apoptosis in chronic lymphocytic leukemia. Blood 2011, 117:156-164.
    • (2011) Blood , vol.117 , pp. 156-164
    • Chen, R.1    Guo, L.2    Chen, Y.3    Jiang, Y.4    Wierda, W.G.5    Plunkett, W.6
  • 24
    • 84862020469 scopus 로고    scopus 로고
    • Omacetaxine mepesuccinate prevents cytokine-dependent resistance to nilotinib in vitro: potential role of the common beta-subunit c of cytokine receptors
    • Klag T., Hartel N., Erben P., Schwaab J., Schnetzke U., Schenk T., et al. Omacetaxine mepesuccinate prevents cytokine-dependent resistance to nilotinib in vitro: potential role of the common beta-subunit c of cytokine receptors. Leukemia 2012, 26:1321-1328.
    • (2012) Leukemia , vol.26 , pp. 1321-1328
    • Klag, T.1    Hartel, N.2    Erben, P.3    Schwaab, J.4    Schnetzke, U.5    Schenk, T.6
  • 25
    • 0033179760 scopus 로고    scopus 로고
    • BCL-2 family members and the mitochondria in apoptosis
    • Gross A., McDonnell J.M., Korsmeyer S.J. BCL-2 family members and the mitochondria in apoptosis. Genes Dev 1999, 13:1899-1911.
    • (1999) Genes Dev , vol.13 , pp. 1899-1911
    • Gross, A.1    McDonnell, J.M.2    Korsmeyer, S.J.3
  • 26
    • 46149088684 scopus 로고    scopus 로고
    • Anti-myeloma effect of homoharringtonine with concomitant targeting of the myeloma-promoting molecules, Mcl-1, XIAP, and beta-catenin
    • Kuroda J., Kamitsuji Y., Kimura S., Ashihara E., Kawata E., Nakagawa Y., et al. Anti-myeloma effect of homoharringtonine with concomitant targeting of the myeloma-promoting molecules, Mcl-1, XIAP, and beta-catenin. Int J Hematol 2008, 87:507-515.
    • (2008) Int J Hematol , vol.87 , pp. 507-515
    • Kuroda, J.1    Kamitsuji, Y.2    Kimura, S.3    Ashihara, E.4    Kawata, E.5    Nakagawa, Y.6
  • 27
    • 79953743709 scopus 로고    scopus 로고
    • Omacetaxine as an anticancer therapeutic: what is old is new again
    • Wetzler M., Segal D. Omacetaxine as an anticancer therapeutic: what is old is new again. Curr Pharma Des 2011, 17:59-64.
    • (2011) Curr Pharma Des , vol.17 , pp. 59-64
    • Wetzler, M.1    Segal, D.2
  • 28
    • 84865256975 scopus 로고    scopus 로고
    • Association of differential gene expression with imatinib mesylate and omacetaxine mepesuccinate toxicity in lymphoblastoid cell lines
    • Kulkarni H., Goring H.H., Diego V., Cole S., Walder K.R., Collier G.R., et al. Association of differential gene expression with imatinib mesylate and omacetaxine mepesuccinate toxicity in lymphoblastoid cell lines. BMC Med Genomics 2012, 5:37.
    • (2012) BMC Med Genomics , vol.5 , pp. 37
    • Kulkarni, H.1    Goring, H.H.2    Diego, V.3    Cole, S.4    Walder, K.R.5    Collier, G.R.6
  • 30
    • 33846261532 scopus 로고    scopus 로고
    • Phase I/II study of subcutaneous homoharringtonine in patients with chronic myeloid leukemia who have failed prior therapy
    • Quintas-Cardama A., Kantarjian H., Garcia-Manero G., O'Brien S., Faderl S., Estrov Z., et al. Phase I/II study of subcutaneous homoharringtonine in patients with chronic myeloid leukemia who have failed prior therapy. Cancer 2007, 109:248-255.
    • (2007) Cancer , vol.109 , pp. 248-255
    • Quintas-Cardama, A.1    Kantarjian, H.2    Garcia-Manero, G.3    O'Brien, S.4    Faderl, S.5    Estrov, Z.6
  • 31
    • 17644366012 scopus 로고    scopus 로고
    • Semi-synthetic homoharringtonine (MyelostatVR) for chronic myeloid leukemia in accelerated phase after imatinib failure
    • [abstract]
    • Burton C., Ranger A., Nadal E. Semi-synthetic homoharringtonine (MyelostatVR) for chronic myeloid leukemia in accelerated phase after imatinib failure. Blood 2003, 102. [abstract].
    • (2003) Blood , vol.102
    • Burton, C.1    Ranger, A.2    Nadal, E.3
  • 32
    • 72249105250 scopus 로고    scopus 로고
    • Subcutaneous hemi-synthetic homoharringtonine (HHT) in combination with imatinib mesylate (Gleevec) in patients (PTS) with STI-resistant chronic myelogenous leukemia (CML): preliminary results of a pilot study
    • [abstract]
    • Maloisel F., Rousselot P., Morariu R. Subcutaneous hemi-synthetic homoharringtonine (HHT) in combination with imatinib mesylate (Gleevec) in patients (PTS) with STI-resistant chronic myelogenous leukemia (CML): preliminary results of a pilot study. Blood (Annu Meet Abs) 2003, 102. [abstract].
    • (2003) Blood (Annu Meet Abs) , vol.102
    • Maloisel, F.1    Rousselot, P.2    Morariu, R.3
  • 33
    • 0028787176 scopus 로고
    • Homoharringtonine therapy induces responses in patients with chronic myelogenous leukemia in late chronic phase
    • O'Brien S., Kantarjian H., Keating M., Beran M., Koller C., Robertson L.E., et al. Homoharringtonine therapy induces responses in patients with chronic myelogenous leukemia in late chronic phase. Blood 1995, 86:3322-3326.
    • (1995) Blood , vol.86 , pp. 3322-3326
    • O'Brien, S.1    Kantarjian, H.2    Keating, M.3    Beran, M.4    Koller, C.5    Robertson, L.E.6
  • 34
    • 80052907820 scopus 로고    scopus 로고
    • Treatment of chronic phase (CP) chronic myeloid leukemia (CML) patients who harbor the BCR-ABL T315I mutation with subcutaneous omacetaxine results in improved survival compared to historical data
    • Nanda N., Cortes C., Lipton J., Rea D., Digumarti R., Chuah C., et al. Treatment of chronic phase (CP) chronic myeloid leukemia (CML) patients who harbor the BCR-ABL T315I mutation with subcutaneous omacetaxine results in improved survival compared to historical data. Haematologica 2011, 96:422-423.
    • (2011) Haematologica , vol.96 , pp. 422-423
    • Nanda, N.1    Cortes, C.2    Lipton, J.3    Rea, D.4    Digumarti, R.5    Chuah, C.6
  • 35
    • 77957089790 scopus 로고    scopus 로고
    • Safety and efficacy of subcutaneous-administered omacetaxine mepesuccinate in chronic myeloid leukemia (CML) patients who are resistant or intolerant to two or more tyrosine kinase inhibitors-results of a multicenter phase 2/3 study
    • [abstract]
    • Cortes-Franco J., Raghunadharao D., Parikh P., Wetzler M., Lipton J., Jones D., et al. Safety and efficacy of subcutaneous-administered omacetaxine mepesuccinate in chronic myeloid leukemia (CML) patients who are resistant or intolerant to two or more tyrosine kinase inhibitors-results of a multicenter phase 2/3 study. Blood (Annu Meet Abs) 2009, 114. [abstract].
    • (2009) Blood (Annu Meet Abs) , vol.114
    • Cortes-Franco, J.1    Raghunadharao, D.2    Parikh, P.3    Wetzler, M.4    Lipton, J.5    Jones, D.6
  • 36
    • 84872358218 scopus 로고    scopus 로고
    • Pharmacokinetic study of omacetaxine mepesuccinate administered subcutaneously to patients with advanced solid and hematologic tumors
    • Nemunaitis J., Mita A., Stephenson J., Mita M.M., Sarantopoulos J., Padmanabhan-Iyer S., et al. Pharmacokinetic study of omacetaxine mepesuccinate administered subcutaneously to patients with advanced solid and hematologic tumors. Cancer Chemother Pharmacol 2013, 71:35-41.
    • (2013) Cancer Chemother Pharmacol , vol.71 , pp. 35-41
    • Nemunaitis, J.1    Mita, A.2    Stephenson, J.3    Mita, M.M.4    Sarantopoulos, J.5    Padmanabhan-Iyer, S.6
  • 38
    • 0026045437 scopus 로고
    • The metabolism of homoharringtonine by liver microsomes of rats and rabbits
    • Cui Y.Y., Wang M.Z. The metabolism of homoharringtonine by liver microsomes of rats and rabbits. Yao xue xue bao=Acta Pharma Sinica 1991, 26:274-279.
    • (1991) Yao xue xue bao=Acta Pharma Sinica , vol.26 , pp. 274-279
    • Cui, Y.Y.1    Wang, M.Z.2
  • 40
    • 84878369242 scopus 로고    scopus 로고
    • Homoharringtonine-based induction regimens for patients with de-novo acute myeloid leukaemia: a multicentre, open-label, randomised, controlled phase 3 trial
    • Jin J., Wang J.X., Chen F.F., Wu D.P., Hu J., Zhou J.F., et al. Homoharringtonine-based induction regimens for patients with de-novo acute myeloid leukaemia: a multicentre, open-label, randomised, controlled phase 3 trial. Lancet Oncol 2013, 14:599-608.
    • (2013) Lancet Oncol , vol.14 , pp. 599-608
    • Jin, J.1    Wang, J.X.2    Chen, F.F.3    Wu, D.P.4    Hu, J.5    Zhou, J.F.6
  • 41
    • 84887131224 scopus 로고    scopus 로고
    • Clinical investigation of homoharringtonine in combination with all-transretinoic acid and arsenic trioxide for acute promyelocytic leukemia
    • Pei R.Z., Li S.Y., Zhang P.S., Ma J.X., Liu X.H., Du X.H., et al. Clinical investigation of homoharringtonine in combination with all-transretinoic acid and arsenic trioxide for acute promyelocytic leukemia. Zhonghua xue ye xue za zhi=Zhonghua xueyexue zazhi 2013, 34:144-148.
    • (2013) Zhonghua xue ye xue za zhi=Zhonghua xueyexue zazhi , vol.34 , pp. 144-148
    • Pei, R.Z.1    Li, S.Y.2    Zhang, P.S.3    Ma, J.X.4    Liu, X.H.5    Du, X.H.6
  • 42
    • 77749288978 scopus 로고    scopus 로고
    • Mechanisms of resistance to tyrosine kinase inhibitors in chronic myeloid leukemia and recent therapeutic strategies to overcome resistance
    • Bixby D., Talpaz M. Mechanisms of resistance to tyrosine kinase inhibitors in chronic myeloid leukemia and recent therapeutic strategies to overcome resistance. Hematol/Educ Programe Am Soc Hematol Am Soc Hematol Educ Program 2009, 461-476.
    • (2009) Hematol/Educ Programe Am Soc Hematol Am Soc Hematol Educ Program , pp. 461-476
    • Bixby, D.1    Talpaz, M.2
  • 43
    • 24744443720 scopus 로고    scopus 로고
    • High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: correlation with clonal cytogenetic evolution but not response to therapy
    • Willis S.G., Lange T., Demehri S., Otto S., Crossman L., Niederwieser D., et al. High-sensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: correlation with clonal cytogenetic evolution but not response to therapy. Blood 2005, 106:2128-2137.
    • (2005) Blood , vol.106 , pp. 2128-2137
    • Willis, S.G.1    Lange, T.2    Demehri, S.3    Otto, S.4    Crossman, L.5    Niederwieser, D.6
  • 44
    • 0037108448 scopus 로고    scopus 로고
    • BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90
    • Gorre M.E., Ellwood-Yen K., Chiosis G., Rosen N., Sawyers C.L. BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90. Blood 2002, 100:3041-3044.
    • (2002) Blood , vol.100 , pp. 3041-3044
    • Gorre, M.E.1    Ellwood-Yen, K.2    Chiosis, G.3    Rosen, N.4    Sawyers, C.L.5
  • 45
    • 40849105148 scopus 로고    scopus 로고
    • Dynamics of BCR-ABL mutated clones prior to hematologic or cytogenetic resistance to imatinib
    • Ernst T., Erben P., Muller M.C., Paschka P., Schenk T., Hoffmann J., et al. Dynamics of BCR-ABL mutated clones prior to hematologic or cytogenetic resistance to imatinib. Haematologica 2008, 93:186-192.
    • (2008) Haematologica , vol.93 , pp. 186-192
    • Ernst, T.1    Erben, P.2    Muller, M.C.3    Paschka, P.4    Schenk, T.5    Hoffmann, J.6
  • 46
    • 84872462658 scopus 로고    scopus 로고
    • BCR-ABL1 compound mutations in tyrosine kinase inhibitor-resistant CML: frequency and clonal relationships
    • Khorashad J.S., Kelley T.W., Szankasi P., Mason C.C., Soverini S., Adrian L.T., et al. BCR-ABL1 compound mutations in tyrosine kinase inhibitor-resistant CML: frequency and clonal relationships. Blood 2013, 121:489-498.
    • (2013) Blood , vol.121 , pp. 489-498
    • Khorashad, J.S.1    Kelley, T.W.2    Szankasi, P.3    Mason, C.C.4    Soverini, S.5    Adrian, L.T.6
  • 47
    • 33750077276 scopus 로고    scopus 로고
    • Frequency and clinical significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib mesylate
    • Jabbour E., Kantarjian H., Jones D., Talpaz M., Bekele N., O'Brien S., et al. Frequency and clinical significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib mesylate. Leukemia 2006, 20:1767-1773.
    • (2006) Leukemia , vol.20 , pp. 1767-1773
    • Jabbour, E.1    Kantarjian, H.2    Jones, D.3    Talpaz, M.4    Bekele, N.5    O'Brien, S.6
  • 48
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
    • Talpaz M., Shah N.P., Kantarjian H., Donato N., Nicoll J., Paquette R., et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 2006, 354:2531-2541.
    • (2006) N Engl J Med , vol.354 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3    Donato, N.4    Nicoll, J.5    Paquette, R.6
  • 49
    • 33745086350 scopus 로고    scopus 로고
    • Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
    • Kantarjian H., Giles F., Wunderle L., Bhalla K., O'Brien S., Wassmann B., et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 2006, 354:2542-2551.
    • (2006) N Engl J Med , vol.354 , pp. 2542-2551
    • Kantarjian, H.1    Giles, F.2    Wunderle, L.3    Bhalla, K.4    O'Brien, S.5    Wassmann, B.6
  • 50
    • 33744461022 scopus 로고    scopus 로고
    • Mutation status and clinical outcome of 89 imatinib mesylate-resistant chronic myelogenous leukemia patients: a retrospective analysis from the French intergroup of CML (Fi(phi)-LMC GROUP)
    • Nicolini F.E., Corm S., Le Q.H., Sorel N., Hayette S., Bories D., et al. Mutation status and clinical outcome of 89 imatinib mesylate-resistant chronic myelogenous leukemia patients: a retrospective analysis from the French intergroup of CML (Fi(phi)-LMC GROUP). Leukemia 2006, 20:1061-1066.
    • (2006) Leukemia , vol.20 , pp. 1061-1066
    • Nicolini, F.E.1    Corm, S.2    Le, Q.H.3    Sorel, N.4    Hayette, S.5    Bories, D.6
  • 51
    • 34548721201 scopus 로고    scopus 로고
    • Clinical outcome of 27 imatinib mesylate-resistant chronic myelogenous leukemia patients harboring a T315I BCR-ABL mutation
    • Nicolini F.E., Hayette S., Corm S., Bachy E., Bories D., Tulliez M., et al. Clinical outcome of 27 imatinib mesylate-resistant chronic myelogenous leukemia patients harboring a T315I BCR-ABL mutation. Haematologica 2007, 92:1238-1241.
    • (2007) Haematologica , vol.92 , pp. 1238-1241
    • Nicolini, F.E.1    Hayette, S.2    Corm, S.3    Bachy, E.4    Bories, D.5    Tulliez, M.6
  • 52
    • 73949111062 scopus 로고    scopus 로고
    • Epidemiologic study on survival of chronic myeloid leukemia and Ph(+) acute lymphoblastic leukemia patients with BCR-ABL T315I mutation
    • Nicolini F.E., Mauro M.J., Martinelli G., Kim D.W., Soverini S., Muller M.C., et al. Epidemiologic study on survival of chronic myeloid leukemia and Ph(+) acute lymphoblastic leukemia patients with BCR-ABL T315I mutation. Blood 2009, 114:5271-5278.
    • (2009) Blood , vol.114 , pp. 5271-5278
    • Nicolini, F.E.1    Mauro, M.J.2    Martinelli, G.3    Kim, D.W.4    Soverini, S.5    Muller, M.C.6
  • 53
    • 84877082097 scopus 로고    scopus 로고
    • The quantitative level of T315I mutated BCR-ABL predicts for major molecular response to second-line nilotinib or dasatinib treatment in patients with chronic myeloid leukemia
    • Lange T., Ernst T., Gruber F.X., Maier J., Cross M., Muller M.C., et al. The quantitative level of T315I mutated BCR-ABL predicts for major molecular response to second-line nilotinib or dasatinib treatment in patients with chronic myeloid leukemia. Haematologica 2013, 98:714-717.
    • (2013) Haematologica , vol.98 , pp. 714-717
    • Lange, T.1    Ernst, T.2    Gruber, F.X.3    Maier, J.4    Cross, M.5    Muller, M.C.6
  • 54
    • 67349233062 scopus 로고    scopus 로고
    • Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia
    • Hochhaus A., O'Brien S.G., Guilhot F., Druker B.J., Branford S., Foroni L., et al. Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia. Leukemia 2009, 23:1054-1061.
    • (2009) Leukemia , vol.23 , pp. 1054-1061
    • Hochhaus, A.1    O'Brien, S.G.2    Guilhot, F.3    Druker, B.J.4    Branford, S.5    Foroni, L.6
  • 55
    • 84876100195 scopus 로고    scopus 로고
    • Re-emergence of interferon-alpha in the treatment of chronic myeloid leukemia
    • Talpaz M., Hehlmann R., Quintas-Cardama A., Mercer J., Cortes J. Re-emergence of interferon-alpha in the treatment of chronic myeloid leukemia. Leukemia 2013, 27:803-812.
    • (2013) Leukemia , vol.27 , pp. 803-812
    • Talpaz, M.1    Hehlmann, R.2    Quintas-Cardama, A.3    Mercer, J.4    Cortes, J.5
  • 56
    • 84862656602 scopus 로고    scopus 로고
    • Successful treatment of a chronic-phase T-315I-mutated chronic myelogenous leukemia patient with a combination of imatinib and interferon-alfa
    • Itonaga H., Tsushima H., Hata T., Matsuo E., Imanishi D., Imaizumi Y., et al. Successful treatment of a chronic-phase T-315I-mutated chronic myelogenous leukemia patient with a combination of imatinib and interferon-alfa. Int J Hematol 2012, 95:209-213.
    • (2012) Int J Hematol , vol.95 , pp. 209-213
    • Itonaga, H.1    Tsushima, H.2    Hata, T.3    Matsuo, E.4    Imanishi, D.5    Imaizumi, Y.6
  • 57
    • 84904304127 scopus 로고    scopus 로고
    • Induction of sustained deep molecular response in a patient with chronic-phase T315I-mutated chronic myeloid leukemia with interferon-alpha monotherapy
    • Ilander M., Koskenvesa P., Hernesniemi S., Lion T., Porkka K., Mustjoki S. Induction of sustained deep molecular response in a patient with chronic-phase T315I-mutated chronic myeloid leukemia with interferon-alpha monotherapy. Leuk. Lymphoma 2014, 55:934-937.
    • (2014) Leuk. Lymphoma , vol.55 , pp. 934-937
    • Ilander, M.1    Koskenvesa, P.2    Hernesniemi, S.3    Lion, T.4    Porkka, K.5    Mustjoki, S.6
  • 58
    • 31644438945 scopus 로고    scopus 로고
    • Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680
    • Young M.A., Shah N.P., Chao L.H., Seeliger M., Milanov Z.V., Biggs W.H., et al. Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680. Cancer Res 2006, 66:1007-1014.
    • (2006) Cancer Res , vol.66 , pp. 1007-1014
    • Young, M.A.1    Shah, N.P.2    Chao, L.H.3    Seeliger, M.4    Milanov, Z.V.5    Biggs, W.H.6
  • 59
    • 84873570889 scopus 로고    scopus 로고
    • MK-0457, an Aurora kinase and BCR-ABL inhibitor, is active in patients with BCR-ABL T315I leukemia
    • Giles F.J., Swords R.T., Nagler A., Hochhaus A., Ottmann O.G., Rizzieri D.A., et al. MK-0457, an Aurora kinase and BCR-ABL inhibitor, is active in patients with BCR-ABL T315I leukemia. Leukemia 2013, 27:113-117.
    • (2013) Leukemia , vol.27 , pp. 113-117
    • Giles, F.J.1    Swords, R.T.2    Nagler, A.3    Hochhaus, A.4    Ottmann, O.G.5    Rizzieri, D.A.6
  • 60
    • 70350507997 scopus 로고    scopus 로고
    • AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance
    • O'Hare T., Shakespeare W.C., Zhu X., Eide C.A., Rivera V.M., Wang F., et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell 2009, 16:401-412.
    • (2009) Cancer Cell , vol.16 , pp. 401-412
    • O'Hare, T.1    Shakespeare, W.C.2    Zhu, X.3    Eide, C.A.4    Rivera, V.M.5    Wang, F.6
  • 61
    • 84887127701 scopus 로고    scopus 로고
    • A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias
    • Cortes J., Kim D., Pinella-Ibarz J. A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias. N Engl J Med 2013, 369:1783-1796.
    • (2013) N Engl J Med , vol.369 , pp. 1783-1796
    • Cortes, J.1    Kim, D.2    Pinella-Ibarz, J.3
  • 64
    • 33747156914 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation for patients with chronic myeloid leukemia and acute lymphocytic leukemia after Bcr-Abl kinase mutation-related imatinib failure
    • Jabbour E., Cortes J., Kantarjian H.M., Giralt S., Jones D., Jones R., et al. Allogeneic stem cell transplantation for patients with chronic myeloid leukemia and acute lymphocytic leukemia after Bcr-Abl kinase mutation-related imatinib failure. Blood 2006, 108:1421-1423.
    • (2006) Blood , vol.108 , pp. 1421-1423
    • Jabbour, E.1    Cortes, J.2    Kantarjian, H.M.3    Giralt, S.4    Jones, D.5    Jones, R.6
  • 65
    • 84908053948 scopus 로고    scopus 로고
    • Impact of allogeneic stem cell transplantation as salvage therapy after T315I mutation detection in chronic myeloid leukemia (CML) and Ph+ acute lymphoblastic leukemia (ALL) patients
    • Nicolini F.E., Zhou W., Martinelli G. Impact of allogeneic stem cell transplantation as salvage therapy after T315I mutation detection in chronic myeloid leukemia (CML) and Ph+ acute lymphoblastic leukemia (ALL) patients. Blood (Ann Meet Abs) 2009, 114.
    • (2009) Blood (Ann Meet Abs) , pp. 114
    • Nicolini, F.E.1    Zhou, W.2    Martinelli, G.3
  • 66
    • 80755185510 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation for patients harboring T315I BCR-ABL mutated leukemias
    • Nicolini F.E., Basak G.W., Soverini S., Martinelli G., Mauro M.J., Muller M.C., et al. Allogeneic stem cell transplantation for patients harboring T315I BCR-ABL mutated leukemias. Blood 2011, 118:5697-5700.
    • (2011) Blood , vol.118 , pp. 5697-5700
    • Nicolini, F.E.1    Basak, G.W.2    Soverini, S.3    Martinelli, G.4    Mauro, M.J.5    Muller, M.C.6
  • 67
    • 0030465768 scopus 로고    scopus 로고
    • A phase II trial of amonafide, caracemide, and homoharringtonine in the treatment of patients with advanced renal cell cancer
    • Witte R.S., Hsieh P., Elson P., Oken M.M., Trump D.L. A phase II trial of amonafide, caracemide, and homoharringtonine in the treatment of patients with advanced renal cell cancer. Invest N Drugs 1996, 14:409-413.
    • (1996) Invest N Drugs , vol.14 , pp. 409-413
    • Witte, R.S.1    Hsieh, P.2    Elson, P.3    Oken, M.M.4    Trump, D.L.5
  • 68
    • 0032762487 scopus 로고    scopus 로고
    • A phase II trial of homoharringtonine and caracemide in the treatment of patients with advanced large bowel cancer
    • Witte R.S., Lipsitz S., Goodman T.L., Asbury R.F., Wilding G., Strnad C.M., et al. A phase II trial of homoharringtonine and caracemide in the treatment of patients with advanced large bowel cancer. Invest N Drugs 1999, 17:173-177.
    • (1999) Invest N Drugs , vol.17 , pp. 173-177
    • Witte, R.S.1    Lipsitz, S.2    Goodman, T.L.3    Asbury, R.F.4    Wilding, G.5    Strnad, C.M.6
  • 69
    • 0026499681 scopus 로고
    • Homoharringtonine in combination with cytarabine for patients with acute myelogenous leukemia
    • Feldman E., Arlin Z., Ahmed T., Mittelman A., Puccio C., Chun H., et al. Homoharringtonine in combination with cytarabine for patients with acute myelogenous leukemia. Leukemia 1992, 6:1189-1191.
    • (1992) Leukemia , vol.6 , pp. 1189-1191
    • Feldman, E.1    Arlin, Z.2    Ahmed, T.3    Mittelman, A.4    Puccio, C.5    Chun, H.6
  • 70
    • 0034667856 scopus 로고    scopus 로고
    • Homoharringtonine and low-dose cytarabine in the management of late chronic-phase chronic myelogenous leukemia
    • Kantarjian H., Talpaz M., Smith T.L., Cortes J., Giles F.J., Rios M.B., et al. Homoharringtonine and low-dose cytarabine in the management of late chronic-phase chronic myelogenous leukemia. J. Clin. Oncol. 2000, 18:3513-3521.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 3513-3521
    • Kantarjian, H.1    Talpaz, M.2    Smith, T.L.3    Cortes, J.4    Giles, F.J.5    Rios, M.B.6
  • 71
    • 0033564350 scopus 로고    scopus 로고
    • Sequential homoharringtonine and interferon-alpha in the treatment of early chronic phase chronic myelogenous leukemia
    • O'Brien S., Kantarjian H., Koller C., Feldman E., Beran M., Andreeff M., et al. Sequential homoharringtonine and interferon-alpha in the treatment of early chronic phase chronic myelogenous leukemia. Blood 1999, 93:4149-4153.
    • (1999) Blood , vol.93 , pp. 4149-4153
    • O'Brien, S.1    Kantarjian, H.2    Koller, C.3    Feldman, E.4    Beran, M.5    Andreeff, M.6
  • 72
    • 0036534203 scopus 로고    scopus 로고
    • Simultaneous homoharringtonine and interferon-alpha in the treatment of patients with chronic-phase chronic myelogenous leukemia
    • O'Brien S., Talpaz M., Cortes J., Shan J., Giles F.J., Faderl S., et al. Simultaneous homoharringtonine and interferon-alpha in the treatment of patients with chronic-phase chronic myelogenous leukemia. Cancer 2002, 94:2024-2032.
    • (2002) Cancer , vol.94 , pp. 2024-2032
    • O'Brien, S.1    Talpaz, M.2    Cortes, J.3    Shan, J.4    Giles, F.J.5    Faderl, S.6
  • 73
    • 84879361543 scopus 로고    scopus 로고
    • Long-term effect of interferon-alpha combined with homoharringtonine on chronic myelogenous leukemia in chronic phase
    • Zhu J., Ding B., Li Y. Long-term effect of interferon-alpha combined with homoharringtonine on chronic myelogenous leukemia in chronic phase. Leuke Lymph 2013, 54:1426-1429.
    • (2013) Leuke Lymph , vol.54 , pp. 1426-1429
    • Zhu, J.1    Ding, B.2    Li, Y.3
  • 74
    • 17644395643 scopus 로고    scopus 로고
    • Phase I/II trial of adding semisynthetic homoharringtonine in chronic myeloid leukemia patients who have achieved partial or complete cytogenetic response on imatinib
    • Marin D., Kaeda J.S., Andreasson C., Saunders S.M., Bua M., Olavarria E., et al. Phase I/II trial of adding semisynthetic homoharringtonine in chronic myeloid leukemia patients who have achieved partial or complete cytogenetic response on imatinib. Cancer 2005, 103:1850-1855.
    • (2005) Cancer , vol.103 , pp. 1850-1855
    • Marin, D.1    Kaeda, J.S.2    Andreasson, C.3    Saunders, S.M.4    Bua, M.5    Olavarria, E.6
  • 75
    • 0041887168 scopus 로고    scopus 로고
    • Results of triple therapy with interferon-alpha, cytarabine, and homoharringtonine, and the impact of adding imatinib to the treatment sequence in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in early chronic phase
    • O'Brien S., Giles F., Talpaz M., Cortes J., Rios M.B., Shan J., et al. Results of triple therapy with interferon-alpha, cytarabine, and homoharringtonine, and the impact of adding imatinib to the treatment sequence in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in early chronic phase. Cancer 2003, 98:888-893.
    • (2003) Cancer , vol.98 , pp. 888-893
    • O'Brien, S.1    Giles, F.2    Talpaz, M.3    Cortes, J.4    Rios, M.B.5    Shan, J.6
  • 76
    • 84884146561 scopus 로고    scopus 로고
    • Subcutaneous omacetaxine mepesuccinate in patients with chronic-phase chronic myeloid leukemia previously treated with 2 or more tyrosine kinase inhibitors including imatinib
    • Cortes J.E., Nicolini F.E., Wetzler M., Lipton J.H., Akard L., Craig A., et al. Subcutaneous omacetaxine mepesuccinate in patients with chronic-phase chronic myeloid leukemia previously treated with 2 or more tyrosine kinase inhibitors including imatinib. Clin Lymph, Myeloma Leuke 2013, 13:584-591.
    • (2013) Clin Lymph, Myeloma Leuke , vol.13 , pp. 584-591
    • Cortes, J.E.1    Nicolini, F.E.2    Wetzler, M.3    Lipton, J.H.4    Akard, L.5    Craig, A.6
  • 77
    • 84879589256 scopus 로고    scopus 로고
    • Omacetaxine mepesuccinate for patients with accelerated phase chronic myeloid leukemia with resistance or intolerance to two or more tyrosine kinase inhibitors
    • Nicolini F.E., Khoury H.J., Akard L., Rea D., Kantarjian H., Baccarani M., et al. Omacetaxine mepesuccinate for patients with accelerated phase chronic myeloid leukemia with resistance or intolerance to two or more tyrosine kinase inhibitors. Haematologica 2013, 98:e78-e79.
    • (2013) Haematologica , vol.98 , pp. e78-e79
    • Nicolini, F.E.1    Khoury, H.J.2    Akard, L.3    Rea, D.4    Kantarjian, H.5    Baccarani, M.6
  • 78
    • 84866860218 scopus 로고    scopus 로고
    • Phase 2 study of subcutaneous omacetaxine mepesuccinate after TKI failure in patients with chronic-phase CML with T315I mutation
    • Cortes J., Lipton J.H., Rea D., Digumarti R., Chuah C., Nanda N., et al. Phase 2 study of subcutaneous omacetaxine mepesuccinate after TKI failure in patients with chronic-phase CML with T315I mutation. Blood 2012, 120:2573-2580.
    • (2012) Blood , vol.120 , pp. 2573-2580
    • Cortes, J.1    Lipton, J.H.2    Rea, D.3    Digumarti, R.4    Chuah, C.5    Nanda, N.6
  • 79
    • 34548745204 scopus 로고    scopus 로고
    • BCR-ABL(T315I) transcript disappearance in an imatinib-resistant CML patient treated with homoharringtonine: a new therapeutic challenge
    • Legros L., Hayette S., Nicolini F.E., Raynaud S., Chabane K., Magaud J.P., et al. BCR-ABL(T315I) transcript disappearance in an imatinib-resistant CML patient treated with homoharringtonine: a new therapeutic challenge. Leukemia 2007, 21:2204-2206.
    • (2007) Leukemia , vol.21 , pp. 2204-2206
    • Legros, L.1    Hayette, S.2    Nicolini, F.E.3    Raynaud, S.4    Chabane, K.5    Magaud, J.P.6
  • 80
    • 79952276567 scopus 로고    scopus 로고
    • The durable clearance of the T315I BCR-ABL mutated clone in chronic phase chronic myelogenous leukemia patients on omacetaxine allows tyrosine kinase inhibitor rechallenge
    • Nicolini F.E., Chomel J.C., Roy L., Legros L., Chabane K., Ducastelle S., et al. The durable clearance of the T315I BCR-ABL mutated clone in chronic phase chronic myelogenous leukemia patients on omacetaxine allows tyrosine kinase inhibitor rechallenge. Clin Lymph, Myeloma Leuke 2010, 10:394-399.
    • (2010) Clin Lymph, Myeloma Leuke , vol.10 , pp. 394-399
    • Nicolini, F.E.1    Chomel, J.C.2    Roy, L.3    Legros, L.4    Chabane, K.5    Ducastelle, S.6
  • 81
    • 84859483944 scopus 로고    scopus 로고
    • Undetectable molecular residual disease after omacetaxine and nilotinib combination therapy in an imatinib-resistant chronic myeloid leukaemia patient harbouring the BCR-ABL1 T315I gatekeeper mutation
    • Coude M.M., Luycx O., Cariou M.E., Maarek O., Dombret H., Cayuela J.M., et al. Undetectable molecular residual disease after omacetaxine and nilotinib combination therapy in an imatinib-resistant chronic myeloid leukaemia patient harbouring the BCR-ABL1 T315I gatekeeper mutation. Br. J. Haematol. 2012, 157:407-410.
    • (2012) Br. J. Haematol. , vol.157 , pp. 407-410
    • Coude, M.M.1    Luycx, O.2    Cariou, M.E.3    Maarek, O.4    Dombret, H.5    Cayuela, J.M.6
  • 82
    • 84884146561 scopus 로고    scopus 로고
    • Subcutaneous omacetaxine mepesuccinate in patients with chronic-phase chronic myeloid leukemia previously treated with 2 or more tyrosine kinase inhibitors including imatinib
    • Cortes J., Nicolini F.E., Wetzler M., Lipton J.H., Akard L., Craig A., et al. Subcutaneous omacetaxine mepesuccinate in patients with chronic-phase chronic myeloid leukemia previously treated with 2 or more tyrosine kinase inhibitors including imatinib. Clin. Lymphoma Myeloma Leuk. 2013, 13:584-591.
    • (2013) Clin. Lymphoma Myeloma Leuk. , vol.13 , pp. 584-591
    • Cortes, J.1    Nicolini, F.E.2    Wetzler, M.3    Lipton, J.H.4    Akard, L.5    Craig, A.6


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