-
1
-
-
0015694748
-
A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
-
Rowley JD. A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature. 1973;243(5405):290-3.
-
(1973)
Nature
, vol.243
, Issue.5405
, pp. 290-293
-
-
Rowley, J.D.1
-
2
-
-
77958595179
-
Longterm prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: An analysis from the International Randomized Study of Interferon and STI571 (IRIS)
-
Hughes TP, Hochhaus A, Branford S, Muller MC, Kaeda JS, Foroni L, et al. Longterm prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International Randomized Study of Interferon and STI571 (IRIS). Blood. 2010;116(19):3758-65.
-
(2010)
Blood
, vol.116
, Issue.19
, pp. 3758-3765
-
-
Hughes, T.P.1
Hochhaus, A.2
Branford, S.3
Muller, M.C.4
Kaeda, J.S.5
Foroni, L.6
-
3
-
-
0036090222
-
Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
-
Graham SM, Jorgensen HG, Allan E, Pearson C, Alcorn MJ, Richmond L, et al. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood. 2002;99(1):319-25.
-
(2002)
Blood
, vol.99
, Issue.1
, pp. 319-325
-
-
Graham, S.M.1
Jorgensen, H.G.2
Allan, E.3
Pearson, C.4
Alcorn, M.J.5
Richmond, L.6
-
4
-
-
33744486584
-
Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction
-
Copland M, Hamilton A, Elrick LJ, Baird JW, Allan EK, Jordanides N, et al. Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood. 2006;107(11):4532-9.
-
(2006)
Blood
, vol.107
, Issue.11
, pp. 4532-4539
-
-
Copland, M.1
Hamilton, A.2
Elrick, L.J.3
Baird, J.W.4
Allan, E.K.5
Jordanides, N.6
-
5
-
-
34247329753
-
Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells
-
Jorgensen HG, Allan EK, Jordanides NE, Mountford JC, Holyoake TL. Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells. Blood.2007;109(9): 4016-9.
-
(2007)
Blood
, vol.109
, Issue.9
, pp. 4016-4019
-
-
Jorgensen, H.G.1
Allan, E.K.2
Jordanides, N.E.3
Mountford, J.C.4
Holyoake, T.L.5
-
6
-
-
0001686739
-
Multiple BCRABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
-
Shah NP, Nicoll JM, Nagar B, Gorre ME, Paquette RL, Kuriyan J, et al. Multiple BCRABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell. 2002;2(2):117-25.
-
(2002)
Cancer Cell
, vol.2
, Issue.2
, pp. 117-125
-
-
Shah, N.P.1
Nicoll, J.M.2
Nagar, B.3
Gorre, M.E.4
Paquette, R.L.5
Kuriyan, J.6
-
7
-
-
73949105873
-
Dasatinib treatment of chronic-phase chronic myeloid leukemia: Analysis of responses according to preexisting BCR-ABL mutations
-
Muller MC, Cortes JE, Kim DW, Druker BJ, Erben P, Pasquini R, et al. Dasatinib treatment of chronic-phase chronic myeloid leukemia: analysis of responses according to preexisting BCR-ABL mutations. Blood. 2009;114(24):4944-53.
-
(2009)
Blood
, vol.114
, Issue.24
, pp. 4944-4953
-
-
Muller, M.C.1
Cortes, J.E.2
Kim, D.W.3
Druker, B.J.4
Erben, P.5
Pasquini, R.6
-
8
-
-
70249105789
-
Impact of baseline BCR-ABL mutations on response to nilotinib in patients with chronic myeloid leukemia in chronic phase
-
Hughes T, Saglio G, Branford S, Soverini S, Kim DW, Muller MC, et al. Impact of baseline BCR-ABL mutations on response to nilotinib in patients with chronic myeloid leukemia in chronic phase. J Clin Oncol. 2009;27(25):4204-10.
-
(2009)
J Clin Oncol
, vol.27
, Issue.25
, pp. 4204-4210
-
-
Hughes, T.1
Saglio, G.2
Branford, S.3
Soverini, S.4
Kim, D.W.5
Muller, M.C.6
-
9
-
-
21144451094
-
In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinibresistant Abl kinase domain mutants
-
O'Hare T, Walters DK, Stoffregen EP, Jia T, Manley PW, Mestan J, et al. In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinibresistant Abl kinase domain mutants. Cancer Res. 2005;65(11):4500-5.
-
(2005)
Cancer Res
, vol.65
, Issue.11
, pp. 4500-4505
-
-
O'Hare, T.1
Walters, D.K.2
Stoffregen, E.P.3
Jia, T.4
Manley, P.W.5
Mestan, J.6
-
10
-
-
33846228789
-
Contribution of ABL kinase domain mutations to imatinib resistance in different subsets of Philadelphia-positive patients: By the GIMEMA Working Party on Chronic Myeloid Leukemia
-
Soverini S, Colarossi S, Gnani A, Rosti G, Castagnetti F, Poerio A, et al. Contribution of ABL kinase domain mutations to imatinib resistance in different subsets of Philadelphia-positive patients: by the GIMEMA Working Party on Chronic Myeloid Leukemia. Clin Cancer Res. 2006; 12(24):7374-9.
-
(2006)
Clin Cancer Res
, vol.12
, Issue.24
, pp. 7374-7379
-
-
Soverini, S.1
Colarossi, S.2
Gnani, A.3
Rosti, G.4
Castagnetti, F.5
Poerio, A.6
-
11
-
-
34547660333
-
Targeted therapy and the T315I mutation in Philadelphia-positive leukemias
-
Soverini S, Iacobucci I, Baccarani M, Martinelli G. Targeted therapy and the T315I mutation in Philadelphia-positive leukemias. Haematologica. 2007;92(4): 437-9.
-
(2007)
Haematologica
, vol.92
, Issue.4
, pp. 437-439
-
-
Soverini, S.1
Iacobucci, I.2
Baccarani, M.3
Martinelli, G.4
-
12
-
-
33744461022
-
Mutation status and clinical outcome of 89 imatinib mesylate-resistant chronic myelogenous leukemia patients: A retrospective analysis from the French intergroup of CML (Fi(φ{symbol})-LMC group)
-
Nicolini FE, Corm S, Le QH, Sorel N, Hayette S, Bories D, et al. Mutation status and clinical outcome of 89 imatinib mesylate-resistant chronic myelogenous leukemia patients: a retrospective analysis from the French intergroup of CML (Fi(φ{symbol})-LMC group). Leukemia. 2006; 20(6):1061-6.
-
(2006)
Leukemia
, vol.20
, Issue.6
, pp. 1061-1066
-
-
Nicolini, F.E.1
Corm, S.2
Le, Q.H.3
Sorel, N.4
Hayette, S.5
Bories, D.6
-
13
-
-
34548721201
-
Clinical outcome of 27 imatinib mesylate-resistant chronic myelogenous leukemia patients harboring a T315I BCR-ABL mutation
-
Nicolini FE, Hayette S, Corm S, Bachy E, Bories D, Tulliez M, et al. Clinical outcome of 27 imatinib mesylate-resistant chronic myelogenous leukemia patients harboring a T315I BCR-ABL mutation. Haematologica. 2007; 92(9):1238-41.
-
(2007)
Haematologica
, vol.92
, Issue.9
, pp. 1238-1241
-
-
Nicolini, F.E.1
Hayette, S.2
Corm, S.3
Bachy, E.4
Bories, D.5
Tulliez, M.6
-
14
-
-
73949111062
-
Epidemiologic study on survival of chronic myeloid leukemia and Ph(+) acute lymphoblastic leukemia patients with BCRABL T315I mutation
-
Nicolini FE, Mauro MJ, Martinelli G, Kim DW, Soverini S, Muller MC, et al. Epidemiologic study on survival of chronic myeloid leukemia and Ph(+) acute lymphoblastic leukemia patients with BCRABL T315I mutation. Blood. 2009;114(26): 5271-8.
-
(2009)
Blood
, vol.114
, Issue.26
, pp. 5271-5278
-
-
Nicolini, F.E.1
Mauro, M.J.2
Martinelli, G.3
Kim, D.W.4
Soverini, S.5
Muller, M.C.6
-
15
-
-
80755185510
-
Allogeneic stem cell transplantation for patients harboring T315I BCR-ABL mutated leukemias
-
Nicolini FE, Basak GW, Soverini S, Martinelli G, Mauro MJ, Muller MC, et al. Allogeneic stem cell transplantation for patients harboring T315I BCR-ABL mutated leukemias. Blood. 2011;118(20):5697-700.
-
(2011)
Blood
, vol.118
, Issue.20
, pp. 5697-5700
-
-
Nicolini, F.E.1
Basak, G.W.2
Soverini, S.3
Martinelli, G.4
Mauro, M.J.5
Muller, M.C.6
-
16
-
-
33747154547
-
Evolving concepts in the management of chronic myeloid leukemia: Recommendations from an expert panel on behalf of the European LeukemiaNet
-
Baccarani M, Saglio G, Goldman J, Hochhaus A, Simonsson B, Appelbaum F, et al. Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood. 2006; 108(6):1809-20.
-
(2006)
Blood
, vol.108
, Issue.6
, pp. 1809-1820
-
-
Baccarani, M.1
Saglio, G.2
Goldman, J.3
Hochhaus, A.4
Simonsson, B.5
Appelbaum, F.6
-
17
-
-
73349122639
-
Chronic myeloid leukemia: An update of concepts and management recommendations of European LeukemiaNet
-
Baccarani M, Cortes J, Pane F, Niederwieser D, Saglio G, Apperley J, et al. Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet. J Clin Oncol. 2009; 27(35):6041-51.
-
(2009)
J Clin Oncol
, vol.27
, Issue.35
, pp. 6041-6051
-
-
Baccarani, M.1
Cortes, J.2
Pane, F.3
Niederwieser, D.4
Saglio, G.5
Apperley, J.6
-
18
-
-
79952327332
-
Dynamics of mutant BCR-ABL-positive clones after cessation of tyrosine kinase inhibitor therapy
-
Hanfstein B, Muller MC, Kreil S, Ernst T, Schenk T, Lorentz C, et al. Dynamics of mutant BCR-ABL-positive clones after cessation of tyrosine kinase inhibitor therapy. Haematologica. 2011;96(3):360-6.
-
(2011)
Haematologica
, vol.96
, Issue.3
, pp. 360-366
-
-
Hanfstein, B.1
Muller, M.C.2
Kreil, S.3
Ernst, T.4
Schenk, T.5
Lorentz, C.6
-
19
-
-
35448967331
-
Part I: Mechanisms of resistance to imatinib in chronic myeloid leukaemia
-
Apperley JF. Part I: mechanisms of resistance to imatinib in chronic myeloid leukaemia. Lancet Oncol. 2007;8(11):1018-29.
-
(2007)
Lancet Oncol
, vol.8
, Issue.11
, pp. 1018-1029
-
-
Apperley, J.F.1
-
20
-
-
33845893074
-
Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants
-
Skaggs BJ, Gorre ME, Ryvkin A, Burgess MR, Xie Y, Han Y, et al. Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants. Proc Natl Acad Sci USA. 2006;103(51):19466-71.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, Issue.51
, pp. 19466-19471
-
-
Skaggs, B.J.1
Gorre, M.E.2
Ryvkin, A.3
Burgess, M.R.4
Xie, Y.5
Han, Y.6
-
21
-
-
53549104402
-
Activation of tyrosine kinases by mutation of the gatekeeper threonine
-
Azam M, Seeliger MA, Gray NS, Kuriyan J, Daley GQ. Activation of tyrosine kinases by mutation of the gatekeeper threonine. Nat Struct Mol Biol. 2008;15(10):1109-18.
-
(2008)
Nat Struct Mol Biol
, vol.15
, Issue.10
, pp. 1109-1118
-
-
Azam, M.1
Seeliger, M.A.2
Gray, N.S.3
Kuriyan, J.4
Daley, G.Q.5
-
22
-
-
0038137081
-
A mutation conferring resistance to imatinib at the time of diagnosis of chronic myelogenous leukemia
-
Roche-Lestienne C, Lai JL, Darre S, Facon T, Preudhomme C. A mutation conferring resistance to imatinib at the time of diagnosis of chronic myelogenous leukemia. N Engl J Med. 2003;348(22):2265-6.
-
(2003)
N Engl J Med
, vol.348
, Issue.22
, pp. 2265-2266
-
-
Roche-Lestienne, C.1
Lai, J.L.2
Darre, S.3
Facon, T.4
Preudhomme, C.5
-
23
-
-
40849105148
-
Dynamics of BCR-ABL mutated clones prior to hematologic or cytogenetic resistance to imatinib
-
Ernst T, Erben P, Muller MC, Paschka P, Schenk T, Hoffmann J, et al. Dynamics of BCR-ABL mutated clones prior to hematologic or cytogenetic resistance to imatinib. Haematologica. 2008;93(2):186-92.
-
(2008)
Haematologica
, vol.93
, Issue.2
, pp. 186-192
-
-
Ernst, T.1
Erben, P.2
Muller, M.C.3
Paschka, P.4
Schenk, T.5
Hoffmann, J.6
-
24
-
-
24744443720
-
Highsensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: Correlation with clonal cytogenetic evolution but not response to therapy
-
Willis SG, Lange T, Demehri S, Otto S, Crossman L, Niederwieser D, et al. Highsensitivity detection of BCR-ABL kinase domain mutations in imatinib-naive patients: correlation with clonal cytogenetic evolution but not response to therapy. Blood. 2005;106(6):2128-37.
-
(2005)
Blood
, vol.106
, Issue.6
, pp. 2128-2137
-
-
Willis, S.G.1
Lange, T.2
Demehri, S.3
Otto, S.4
Crossman, L.5
Niederwieser, D.6
-
25
-
-
34948830170
-
Interferon-alpha or homoharringtonine as salvage treatment for chronic myeloid leukemia patients who acquire the T315I BCR-ABL mutation
-
de Lavallade H, Khorashad JS, Davis HP, Milojkovic D, Kaeda JS, Goldman JM, et al. Interferon-alpha or homoharringtonine as salvage treatment for chronic myeloid leukemia patients who acquire the T315I BCR-ABL mutation. Blood. 2007;110(7): 2779-80.
-
(2007)
Blood
, vol.110
, Issue.7
, pp. 2779-2780
-
-
de Lavallade, H.1
Khorashad, J.S.2
Davis, H.P.3
Milojkovic, D.4
Kaeda, J.S.5
Goldman, J.M.6
-
26
-
-
79952276567
-
The durable clearance of the T315I BCR-ABL mutated clone in chronic phase chronic myelogenous leukemia patients on omacetaxine allows tyrosine kinase inhibitor rechallenge
-
Nicolini FE, Chomel JC, Roy L, Legros L, Chabane K, Ducastelle S, et al. The durable clearance of the T315I BCR-ABL mutated clone in chronic phase chronic myelogenous leukemia patients on omacetaxine allows tyrosine kinase inhibitor rechallenge. Clin Lymphoma Myeloma Leuk. 2010;10(5):394-9.
-
(2010)
Clin Lymphoma Myeloma Leuk
, vol.10
, Issue.5
, pp. 394-399
-
-
Nicolini, F.E.1
Chomel, J.C.2
Roy, L.3
Legros, L.4
Chabane, K.5
Ducastelle, S.6
-
27
-
-
54349089682
-
Finding of kinase domain mutations in patients with chronic phase chronic myeloid leukemia responding to imatinib may identify those at high risk of disease progression
-
Khorashad JS, de Lavallade H, Apperley JF, Milojkovic D, Reid AG, Bua M, et al. Finding of kinase domain mutations in patients with chronic phase chronic myeloid leukemia responding to imatinib may identify those at high risk of disease progression. J Clin Oncol. 2008;26(29): 4806-13.
-
(2008)
J Clin Oncol
, vol.26
, Issue.29
, pp. 4806-4813
-
-
Khorashad, J.S.1
de Lavallade, H.2
Apperley, J.F.3
Milojkovic, D.4
Reid, A.G.5
Bua, M.6
-
28
-
-
33947280081
-
Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy
-
Hochhaus A, Kantarjian HM, Baccarani M, Lipton JH, Apperley JF, Druker BJ, et al. Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood. 2007;109(6):2303-9.
-
(2007)
Blood
, vol.109
, Issue.6
, pp. 2303-2309
-
-
Hochhaus, A.1
Kantarjian, H.M.2
Baccarani, M.3
Lipton, J.H.4
Apperley, J.F.5
Druker, B.J.6
-
29
-
-
80051573352
-
BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: Recommendations from an expert panel on behalf of European LeukemiaNet
-
Soverini S, Hochhaus A, Nicolini FE, Gruber F, Lange T, Saglio G, et al. BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet. Blood. 2011; 118(5):1208-15.
-
(2011)
Blood
, vol.118
, Issue.5
, pp. 1208-1215
-
-
Soverini, S.1
Hochhaus, A.2
Nicolini, F.E.3
Gruber, F.4
Lange, T.5
Saglio, G.6
-
30
-
-
84860841611
-
Initial findings from the PACE trial: A pivotal phase 2 study of Ponatinib in patients with CML and Ph+ ALL resistant or intolerant to dasatinib or nilotinib, or with the T315I mutation
-
Abstract 109
-
Cortes J, Kim D, Pinilla-Ibarz J. Initial findings from the PACE trial: a pivotal phase 2 study of Ponatinib in patients with CML and Ph+ ALL resistant or intolerant to dasatinib or nilotinib, or with the T315I mutation. Blood. 2011;118(21):52. Abstract 109.
-
(2011)
Blood
, vol.118
, Issue.21
, pp. 52
-
-
Cortes, J.1
Kim, D.2
Pinilla-Ibarz, J.3
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