Thymopentin nanoparticles engineered with high loading efficiency, improved pharmacokinetic properties, and enhanced immunostimulating effect using soybean phospholipid and PHBHHx polymer

Molecular Pharmaceutics

Volumn 11, Issue 10, 2014, Pages 3371-3377

  Wu, Chengyu ^a   Zhang, Mengtian ^a   Zhang, Zhirong ^a   Wan, Ka Wai ^b   Ahmed, Waqar ^b   Phoenix, David A ^b   Elhissi, Abdelbary M A ^b   Sun, Xun ^a  

^a SICHUAN UNIVERSITY   (China)

^b UNIVERSITY OF CENTRAL LANCASHIRE   (United Kingdom)

Author keywords

controlled release; immunoregulation; NPs; PHBHHx; phospholipid complex; TP5

Indexed keywords

COPOLYMER; NANOCARRIER; PHOSPHOLIPID DERIVATIVE; POLY(3 HYDROXYBUTYRATE CO 3 HYDROXYHEXANOATE); SOYBEAN PHOSPHOLIPID; SUPEROXIDE DISMUTASE; THYMOPENTIN; UNCLASSIFIED DRUG; WATER; IMMUNOLOGICAL ADJUVANT; NANOPARTICLE; PHOSPHOLIPID; POLYMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD3+ T LYMPHOCYTE; CD4 CD8 RATIO; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHRONOPHARMACOLOGY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUBILITY; IMMUNE DEFICIENCY; IMMUNOMODULATION; IMMUNOREGULATION; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; LOAD CARRYING CAPACITY; MALE; NANOENCAPSULATION; NANOENGINEERING; NANOPHARMACEUTICS; NONHUMAN; NORMAL VALUE; POLYMERIZATION; RAT; ZETA POTENTIAL; ANIMAL; CHEMISTRY; IMMUNOLOGY; SOYBEAN; WISTAR RAT;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; MALE; NANOPARTICLES; PHOSPHOLIPIDS; POLYMERS; RATS; RATS, WISTAR; SOYBEANS; THYMOPENTIN;

EID: 84908013288     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400722r     Document Type: Article

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