Identification of children and adolescents at risk for renal scarring after a first urinary tract infection: A meta-analysis with individual patient data

JAMA Pediatrics

Volumn 168, Issue 10, 2014, Pages 893-900

  Shaikh, Nader ^a,b   Craig, Jonathan C ^c   Rovers, Maroeska M ^d   Da Dalt, Liviana ^e   Gardikis, Stefanos ^f   Hoberman, Alejandro ^a   Montini, Giovanni ^g   Rodrigo, Carlos ^h   Taskinen, Seppo ⁱ   Tuerlinckx, David ^j   Shope, Timothy ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^c UNIVERSITY OF SYDNEY   (Australia)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^e UNIVERSITY OF PADOVA   (Italy)

^f DEMOCRITUS UNIVERSITY OF THRACE MEDICAL SCHOOL   (Greece)

^g UNIVERSITY OF BOLOGNA   (Italy)

^h HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

ⁱ UNIVERSITY OF HELSINKI   (Finland)

^j UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

more..

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; SUCCIMER TC 99M;

ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL PRACTICE; COHORT ANALYSIS; DIAGNOSTIC TEST ACCURACY STUDY; ESCHERICHIA COLI; FEMALE; FEVER; FOLLOW UP; HIGH RISK POPULATION; HUMAN; KIDNEY SCAR; KIDNEY SCINTISCANNING; MAJOR CLINICAL STUDY; MALE; MICTURITION CYSTOURETHROGRAPHY; PATIENT CODING; PATIENT IDENTIFICATION; POLYMORPHONUCLEAR CELL; PREDICTION; PREDICTOR VARIABLE; PROGNOSIS; TEMPERATURE; URINARY TRACT INFECTION; VESICOURETERAL REFLUX; COMPLICATION; INFANT; KIDNEY DISEASE; META ANALYSIS; MICROBIOLOGY; NEWBORN; PRESCHOOL CHILD; RISK FACTOR; SCAR;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CICATRIX; COHORT STUDIES; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; KIDNEY DISEASES; MALE; RISK FACTORS; URINARY TRACT INFECTIONS;

EID: 84908010484     PISSN: 21686203     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamapediatrics.2014.637     Document Type: Article

References (65)

1. Shaikh N, Ewing AL, Bhatnagar S, Hoberman A. Risk of renal scarring in children with a first urinary tract infection: a systematic review. Pediatrics. 2010;126(6):1084-1091.
2. WennerstromM, Hansson S, Hedner T, Himmelmann A, Jodal U. Ambulatory blood pressure 16-26 years after the first urinary tract infection in childhood. J Hypertens. 2000;18(4):485-491.
3. Martinell J, Lidin-Janson G, Jagenburg R, Sivertsson R, Claesson I, Jodal U. Girls prone to urinary infections followed into adulthood: indices of renal disease. Pediatr Nephrol. 1996;10(2):139-142.
4. Jacobson SH, Eklof O, Eriksson CG, Lins LE, Tidgren B, Winberg J. Development of hypertension and uraemia after pyelonephritis in childhood: 27 year followup. BMJ. 1989;299(6701):703-706.
5. el-Khatib M, Packham DK, Becker GJ, Kincaid-Smith P. Pregnancy-related complications in women with reflux nephropathy. Clin Nephrol. 1994;41(1):50-55.
6. Patzer L, Seeman T, Luck C,Wuhl E, Janda J, Misselwitz J. Day- and night-time blood pressure elevation in children with higher grades of renal scarring. J Pediatr. 2003;142(2):117-122.
7. Round J, Fitzgerald AC, Hulme C, Lakhanpaul M, Tullus K. Urinary tract infections in children and the risk of ESRF. Acta Paediatr. 2012;101(3):278-282.
8. Gleeson FV, Gordon I. Imaging in urinary tract infection. Arch Dis Child. 1991;66(11):1282-1283.
9. Martinell J, Claesson I, Lidin-Janson G, Jodal U. Urinary infection, reflux and renal scarring in females continuously followed for 13-38 years. Pediatr Nephrol. 1995;9(2):131-136.
10. Olbing H, Claesson I, Ebel KD, et al. Renal scars and parenchymal thinning in children with vesicoureteral reflux: a 5-year report of the International Reflux Study in Children (European branch). J Urol. 1992;148(5, pt 2):1653-1656.
11. Ataei N, Madani A, Habibi R, Khorasani M. Evaluation of acute pyelonephritis with DMSA scans in children presenting after the age of 5 years. Pediatr Nephrol. 2005;20(10):1439-1444.
12. Benador D, Benador N, Slosman D, Mermillod B, Girardin E. Are younger children at highest risk of renal sequelae after pyelonephritis? Lancet. 1997; 349(9044):17-19.
13. Ditchfield MR, Summerville D, Grimwood K, et al. Time course of transient cortical scintigraphic defects associated with acute pyelonephritis. Pediatr Radiol. 2002;32(12):849-852.
14. Goldraich NP, Goldraich IH. Followup of conservatively treated children with high and low grade vesicoureteral reflux: a prospective study. J Urol. 1992;148(5, pt 2):1688-1692.
15. Lin K-Y, Chiu N-T, Chen M-J, et al. Acute pyelonephritis and sequelae of renal scar in pediatric first febrile urinary tract infection. Pediatr Nephrol. 2003;18(4):362-365.
16. Pecile P, Miorin E, Romanello C, et al. Procalcitonin: a marker of severity of acute pyelonephritis among children. Pediatrics. 2004;114 (2):e249-e254. http://pediatrics.aappublications.org/content/114/2/e249.long. Accessed April 30, 2013.
17. Brandstrom P, Neveus T, Sixt R, Stokland E, Jodal U, Hansson S. The Swedish Reflux Trial in Children, IV: renal damage. J Urol. 2010;184(1):292-297.
18. Coulthard MG, Lambert HJ, Keir MJ. Do systemic symptoms predict the risk of kidney scarring after urinary tract infection? Arch Dis Child. 2009;94(4):278-281.
19. Preda I, Jodal U, Sixt R, Stokland E, Hansson S. Value of ultrasound in evaluation of infantswith first urinary tract infection.JUrol. 2010;183(5):1984-1988.
20. Hoberman A,Wald ER, Hickey RW, et al. Oral versus initial intravenous therapy for urinary tract infections in young febrile children. Pediatrics. 1999;104(1, pt 1):79-86.
21. Jakobsson B, Svensson L. Transient pyelonephritic changes on 99mtechnetium- dimercaptosuccinic acid scan for at least five months after infection. Acta Paediatr. 1997;86(8):803-807.
22. Craig JC, Wheeler DM, Irwig L, Howman-Giles RB. How accurate is dimercaptosuccinic acid scintigraphy for the diagnosis of acute pyelonephritis? ameta-analysis of experimental studies. J Nucl Med. 2000;41(6):986-993.
23. Stewart GB, Altman DG, Askie LM, Duley L, Simmonds MC, Stewart LA. Statistical analysis of individual participant datameta-analyses: a comparison of methods and recommendations for practice. PLoS One. 2012;7(10):e46042. doi:10 .1371/journal.pone.0046042.
24. Hosmer D, Lemeshow S. Applied Logistic Regression. New York, NY: John Wiley & Sons; 2000.
25. Maldonado G, Greenland S. Simulation study of confounder-selection strategies. Am J Epidemiol. 1993;138(11):923-936.
26. Bursac Z, Gauss CH, Williams DK, Hosmer DW. Purposeful selection of variables in logistic regression. Source Code Biol Med. 2008;3:17. doi:10.1186/1751-0473-3-17.
27. Gorelick MH, Shaw KN. Clinical decision rule to identify febrile young girls at risk for urinary tract infection. Arch Pediatr Adolesc Med. 2000;154(4): 386-390.
28. Shaikh N, Morone NE, Lopez J, et al. Does this child have a urinary tract infection? JAMA. 2007; 298(24):2895-2904.
29. Shaikh N, Hoberman A, Rockette HE, Kurs-Lasky M. Identifying children with vesicoureteral reflux: a comparison of 2 approaches. J Urol. 2012;188(5):1895-1899.
30. Royston P, Moons KG, Altman DG, Vergouwe Y. Prognosis and prognostic research: developing a prognostic model. BMJ. 2009;338:b604. doi:10 .1136/bmj.b604.
31. Agras K, Ortapamuk H, Naldoken S, Tuncel A, Atan A. Resolution of cortical lesions on serial renal scans in children with acute pyelonephritis. Pediatr Radiol. 2007;37(2):153-158.
32. Biggi A, Dardanelli L, Cussino P, et al. Prognostic value of the acute DMSA scan in children with first urinary tract infection. Pediatr Nephrol. 2001;16 (10):800-804.
33. Bressan S, Andreola B, Zucchetta P, et al. Procalcitonin as a predictor of renal scarring in infants and young children. Pediatr Nephrol. 2009; 24(6):1199-1204.
34. Camacho V, Estorch M, Fraga G, et al. DMSA study performed during febrile urinary tract infection: a predictor of patient outcome? Eur J Nucl Med Mol Imaging. 2004;31(6):862-866.
35. Craig JC, Irwig LM, Knight JF, Sureshkumar P, Roy LP. Symptomatic urinary tract infection in preschool Australian children. J Paediatr Child Health. 1998;34(2):154-159.
36. Imperiale A, Olianti C, Sestini S, et al. 123I-hippuran renal scintigraphy with evaluation of single-kidney clearance for predicting renal scarring after acute urinary tract infection: comparison with 99mTc-DMSA scanning. J Nucl Med. 2003;44(11): 1755-1760.
37. Karavanaki K, Angelos Haliotis F, Sourani M, et al. DMSA scintigraphy in febrile urinary tract infections could be omitted in children with low procalcitonin levels. Infect Dis Clin Pract. 2007;15 (6):377-381.
38. Kotoula A, Gardikis S, Tsalkidis A, et al. Comparative efficacies of procalcitonin and conventional inflammatory markers for prediction of renal parenchymal inflammation in pediatric first urinary tract infection. Urology. 2009;73(4):782-786.
39. Levtchenko E, Lahy C, Levy J, Ham H, Piepsz A. Treatment of children with acute pyelonephritis: a prospective randomized study. Pediatr Nephrol. 2001;16(11):878-884.
40. Montini G, Toffolo A, Zucchetta P, et al. Antibiotic treatment for pyelonephritis in children: multicentre randomised controlled non-inferiority trial. BMJ. 2007;335(7616):386-388.
41. Oh MM, Jin MH, Bae JH, Park HS, Lee JG, Moon G. The role of vesicoureteral reflux in acute renal cortical scintigraphic lesion and ultimate scar formation. J Urol. 2008;180(5):2167-2170.
42. Prat C, Dominguez J, Rodrigo C, et al. Elevated serum procalcitonin values correlate with renal scarring in children with urinary tract infection. Pediatr Infect Dis J. 2003;22(5):438-442.
43. Preda I, Jodal U, Sixt R, Stokland E, Hansson S. Imaging strategy for infants with urinary tract infection: a new algorithm. J Urol. 2011;185(3): 1046-1052.
44. Rosenberg AR, Rossleigh MA, Brydon MP, Bass SJ, Leighton DM, Farnsworth RH. Evaluation of acute urinary tract infection in children by dimercaptosuccinic acid scintigraphy: a prospective study. J Urol. 1992;148(5, pt 2):1746-1749.
45. Sheu JN, Chang HM, Chen SM, Hung TW, Lue KH. The role of procalcitonin for acute pyelonephritis and subsequent renal scarring in infants and young children.JUrol. 2011;186(5):2002-2008.
46. Spasojevic-Dimitrijeva B, Zivkovic M, Stankovic A, Stojkovic L, Kostic M. The IL-6 -174G/C polymorphism and renal scarring in children with first acute pyelonephritis. Pediatr Nephrol. 2010;25 (10):2099-2106.
47. Stokland E, HellstromM, Jacobsson B, Jodal U, Sixt R. Renal damage one year after first urinary tract infection: role of dimercaptosuccinic acid scintigraphy. J Pediatr. 1996;129(6):815-820.
48. Taskinen S, Ronnholm K. Post-pyelonephritic renal scars are not associated with vesicoureteral reflux in children. J Urol. 2005;173(4):1345-1348.
49. Tuerlinckx D, Vander Borght T, Glupczynski Y, et al. Is procalcitonin a good marker of renal lesion in febrile urinary tract infection? Eur J Pediatr. 2005;164(10):651-652.
50. Tullus K, Fituri O, Linne T, et al. Urine interleukin-6 and interleukin-8 in children with acute pyelonephritis, in relation to DMSA scintigraphy in the acute phase and at 1-year follow-up. Pediatr Radiol. 1994;24(7):513-515.
51. Zaffanello M, Cataldi L, BrugnaraM, Franchini M, Bruno C, Fanos V. Hidden high-grade vesicoureteral reflux is the main risk factor for chronic renal damage in children under the age of two years with first urinary tract infection. Scand J Urol Nephrol. 2009;43(6):494-500.
52. Zaki M, Badawi M, Al Mutari G, Ramadan D, Adul Rahman M. Acute pyelonephritis and renal scarring in Kuwaiti children: a follow-up study using 99mTc DMSA renal scintigraphy. Pediatr Nephrol. 2005;20(8):1116-1119.
53. Ammenti A, Cataldi L, Chimenz R, et al; Italian Society of Pediatric Nephrology. Febrile urinary tract infections in young children: recommendations for the diagnosis, treatment and follow-up. Acta Paediatr. 2012;101(5):451-457.
54. Roberts KB; Subcommittee on Urinary Tract Infection, Steering Committee on Quality Improvement and Management. Urinary tract infection: clinical practice guideline for the diagnosis and management of the initial UTI in febrile infants and children 2 to 24 months. Pediatrics. 2011;128(3):595-610.
55. National Collaborating Centre forWomen's and Children's Health. Urinary tract infection in children: diagnosis, treatment and long term management. http://www.nice.org.uk/nicemedia/live/11819/36028/36028.pdf. Accessed April 30, 2013.
56. Royal Children's Hospital Melbourne. Urinary tract infection guideline. http://www.rch.org.au/clinicalguide/guideline-index/Urinary-Tract-Infection-Guideline/. Accessed April 30, 2013.
57. Honkinen O, Jahnukainen T, Mertsola J, Eskola J, Ruuskanen O. Bacteremic urinary tract infection in children. Pediatr Infect Dis J. 2000;19(7):630-634.
58. Jantunen ME, Siitonen A, Ala-HouhalaM, et al. Predictive factors associatedwith significant urinary tract abnormalities in infantswith pyelonephritis. Pediatr Infect Dis J. 2001;20(6):597-601.
59. Berg UB, Johansson SB. Age as a main determinant of renal functional damage in urinary tract infection. Arch Dis Child. 1983;58(12):963-969.
60. Pylkkanen J, Vilska J, Koskimies O. The value of level diagnosis of childhood urinary tract infection in predicting renal injury. Acta Paediatr Scand. 1981; 70(6):879-883.
61. Doganis D, Siafas K,Mavrikou M, et al. Does early treatment of urinary tract infection prevent renal damage? Pediatrics. 2007;120(4):e922-e928. doi:10.1542/peds.2006-2417.
62. Hewitt IK, Zucchetta P, Rigon L, et al. Early treatment of acute pyelonephritis in children fails to reduce renal scarring: data from the Italian Renal Infection Study Trials. Pediatrics. 2008;122(3): 486-490.
63. Huang YY, Chen MJ, Chiu NT, Chou HH, Lin KY, Chiou YY. Adjunctive oralmethylprednisolone in pediatric acute pyelonephritis alleviates renal scarring. Pediatrics. 2011;128(3):e496-e504. doi:10 .1542/peds.2010-0297.
64. Shaikh N. Corticosteroids for Children With Febrile Urinary Tract Infections (STARRS). http://clinicaltrials.gov/ct2/show/NCT01391793. Accessed March 19, 2014.
65. Keren R, Carpenter MA, Hoberman A, et al. Rationale and design issues of the Randomized Intervention for ChildrenWith Vesicoureteral Reflux (RIVUR) study. Pediatrics. 2008;122(suppl 5): S240-S250.