Early treatment of acute pyelonephritis in children fails to reduce renal scarring: Data from the italian renal infection study trials

Pediatrics

Volumn 122, Issue 3, 2008, Pages 486-490

  Hewitt, Ian K ^a   Zucchetta, Pietro ^b   Rigon, Luca ^c   Maschio, Francesca ^d   Molinari, Pier Paolo ^e   Tomasi, Lisanna ^b   Toffolo, Antonella ^f   Pavanello, Luigi ^g   Crivellaro, Carlo ^b   Bellato, Stefano ⁱ   Montini, Giovanni ^b,h  

^a PRINCESS MARGARET HOSPITAL FOR CHILDREN   (Australia)

^b UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^c Camposampiero Hospital   (Italy)

^d Mestre Hospital   (Italy)

^e Bologna General Hospital   (Italy)

^f Motta di Livenza Hospital   (Italy)

^g Castelfranco Hospital   (Italy)

^h Hospital of Chioggia   (Italy)

ⁱ Ospedale Civile di Arzignano   (Italy)

Author keywords

Antibiotic treatment; Renal scar; Technetium 99m dimercaptosuccinic acid scan; Urinary tract infection

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; CEFTRIAXONE; SUCCIMER TC 99M; ANTIINFECTIVE AGENT;

ACUTE PYELONEPHRITIS; ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC THERAPY; ARTICLE; CHILD; FEMALE; FEVER; HUMAN; INCIDENCE; INFANT; ITALY; KIDNEY INJURY; KIDNEY SCAR; KIDNEY SCINTISCANNING; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE DRUG DOSE; THERAPY DELAY; VESICOURETERAL REFLUX; ACUTE DISEASE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; FOLLOW UP; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY; MULTICENTER STUDY; NEWBORN; ORAL DRUG ADMINISTRATION; PATHOLOGY; PRESCHOOL CHILD; PREVALENCE; PROGNOSIS; PYELONEPHRITIS; RANDOMIZED CONTROLLED TRIAL; RETROSPECTIVE STUDY; SCAR; SCINTISCANNING; TIME; TREATMENT FAILURE;

ACUTE DISEASE; ADMINISTRATION, ORAL; AMOXICILLIN-POTASSIUM CLAVULANATE COMBINATION; ANTI-BACTERIAL AGENTS; CEFTRIAXONE; CHILD; CHILD, PRESCHOOL; CICATRIX; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFANT; INFANT, NEWBORN; INJECTIONS, INTRAVENOUS; ITALY; KIDNEY; MALE; PREVALENCE; PROGNOSIS; PYELOCYSTITIS; RETROSPECTIVE STUDIES; TIME FACTORS; TREATMENT FAILURE;

EID: 51649098817     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2007-2894     Document Type: Article

References (27)

1. Jakobsson B, Berg U, Svensson L. Renal scarring after acute pyelonephritis. Arch Dis Child. 1994;70(2):111-115
2. Stokland E, Hellstrom M, Jacobsson B, et al. Renal damage one year after first urinary tract infection: role of dimercaptosuc-cinic acid scintigraphy. J Pediatr. 1996;129(6):815-820
3. Benador D, Benador N, Slosman D, Mermillod B, Girardin E.Are younger children at highest risk of renal sequelae after pyelonephritis? Lancet. 1997;349(9044):17-19
4. 4.Wald E. Urinary tract infections in infants and children: a comprehensive overview. Curr Opin Pediatr. 2004;16(1):85-88
5. Schlager TA. Urinary tract infections in children younger than 5 years of age: epidemiology, diagnosis, treatment, outcomes and prevention. Paediatr Drugs. 2001;3(3):219-227
6. American Academy of Pediatrics: Practice parameter: the diagnosis, treatment, and evaluation of the initial urinary tract infection in febrile infants and young children. Pediatrics. 1999; 103(4):843-852
7. Winter AL, Hardy BE, Alton DJ, Arbus GS, Churchill BM. Acquired renal scars in children. J Urol. 1983;129(6): 1190-1194
8. Smellie JM, Poulton A, Prescod NP. Retrospective study of children with renal scarring associated with reflux and urinary infection. BMJ. 1994;308(6938):1193-1196
9. Montini G, Toffolo A, Zucchetta P, et al. The IRIS 1 study of antibiotic treatment of pyelonephritis in children: a multi-center randomized controlled non-inferiority trial. BMJ. 2007; 335(7616):386-388
10. Montini G, Rigon L, Zucchetta P, et al. Prophylaxis after first febrile urinary tract infection in children? A multicenter, randomized, controlled, noninferiority trial. Pediatrics. In press
11. th ed. Philadelphia, PA: Saunders; 2003
12. Rushton HG. The evaluation of acute pyelonephritis and renal scarring with technetium-99m-dimercaptosuccinic acid renal scintigraphy: evolving concepts and future directions. Pediatr Nephrol. 1997;11(1):108-120
13. Schwartz GJ, Haycock GB, Edelmann CM Jr, Spitzer A. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics. 1976;58(2): 259-263
14. Piepsz A, Colarinha P, Gordon I, et al. Guidelines for 99mTc-DMSA scintigraphy in children. Eur J Nucl Med. 2001;28(3): BP37-BP41
15. Linshaw AM. Controversies in childhood urinary tract infections. World J Urol. 1999;17(6):383-395
16. Jahnukainen T, Chen M, Celsi G. Mechanisms of renal damage owing to infection. Pediatr Nephrol. 2005;20(8):1043-1053
17. Jodal U. The natural history of bactiuria in childhood. Infect Dis Clin North Am. 1987;1(4):713-729
18. Bartkowski DP. Recognizing UTIs in infants and children: early treatment prevents permanent damage. Postgrad Med. 2001; 109(1):171-172, 177-181
19. Hiraoka M, Hashimoto G, Tsuchida S, Tsukahara H, Ohshima Y, Mayumi M. Early treatment of urinary infection prevents renal damage on cortical scintigraphy. Pediatr Nephrol. 2003; 18(2):115-118
20. Cincinnati Children's Hospital Medical Center, UTI Guideline Team: Evidence-based clinical practice guideline for the management of first time urinary tract infection in children 12 years of age or less. Available at: www.cincinnatichildrens.org/svc/alpha/h/health-policy/ev-based/uti.htm. Accessed July 3, 2008
21. Hoberman A, Wald ER, Hickey RW, et al. Oral versus initial intravenous therapy for urinary tract infections in young febrile children. Pediatrics. 1999;104(1):79-86
22. Jantausch BA, O'Donnell R, Wiedermann BL. Urinary inter-leukin-6 and interleukin-8 in children with urinary tract infection. Pediatr Nephrol. 2000;15(3-4):236-240
23. Kassir K, Vargas-Shiraishi O, Zaldivar F, Berman M, Singh J, Arrietta A. Cytokine profiles of pediatric patients treated with antibiotics for pyelonephritis: potential therapeutic impact. ClinDiagn Lab Immunol. 2001;8(6):1060-1063
24. Slotki IN, Asscher AW. Prevention of scarring in experimental pyelonephritis in the rat by early antibiotic therapy. Nephron. 1982;30(3):262-268
25. Glauser MP, Meylan P, Bille J. The inflammatory response and tissue damage. Pediatr Nephrol. 1987;1(4):615-622
26. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med. 1999;340(6):448-454
27. Vermeire S, Van Assche G, Rutgeerts P. Laboratory markers in IBD: useful, magic, or unnecessary toys? Gut. 2006;55(3): 426-431