Preparation of the metabotropic glutamate receptor 5 (mGluR5) PET tracer [18F]FPEB for human use: An automated radiosynthesis and a novel one-pot synthesis of its radiolabeling precursor

Applied Radiation and Isotopes

Volumn 94, Issue , 2014, Pages 349-354

  Lim, Keunpoong ^a   Labaree, David ^a   Li, Songye ^a   Huang, Yiyun ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

MGluR5; PET; Radiotracer synthesis; Suzuki coupling; 18F FPEB

Indexed keywords

AROMATIC COMPOUNDS; CLINICAL RESEARCH; POLYETHYLENE TEREPHTHALATES; RADIOACTIVE TRACERS; TRACERS;

METABOTROPIC GLUTAMATE RECEPTORS; MGLUR5; PRODUCTION METHODS; RADIOTRACER SYNTHESIS; REFERENCE STANDARD; SUZUKI COUPLINGS; SYNTHETIC APPROACH; [^18F]FPEB;

SYNTHESIS (CHEMICAL);

3 FLUORO 5 (2 PYRIDINYLETHYNYL)BENZONITRILE F 18; BENZENE DERIVATIVE; METABOTROPIC RECEPTOR 5; NITROBENZONITRILE; TRACER; UNCLASSIFIED DRUG; 3-FLUORO-5-((PYRIDIN-3-YL)ETHYNYL)BENZONITRILE; FLUORINE; NITRILE; PYRIDINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT;

ARTICLE; AUTOMATION; CLINICAL RESEARCH; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ISOTOPE LABELING; ONE POT SYNTHESIS; PHYSICAL CHEMISTRY; POSITRON EMISSION TOMOGRAPHY; REACTION ANALYSIS; SUZUKI REACTION; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR IMAGING; PROCEDURES; ROBOTICS; SYNTHESIS;

FLUORINE RADIOISOTOPES; HUMANS; ISOTOPE LABELING; MOLECULAR IMAGING; NITRILES; POSITRON-EMISSION TOMOGRAPHY; PYRIDINES; RADIOPHARMACEUTICALS; RECEPTOR, METABOTROPIC GLUTAMATE 5; ROBOTICS;

EID: 84908001884     PISSN: 09698043     EISSN: 18729800     Source Type: Journal    
DOI: 10.1016/j.apradiso.2014.09.006     Document Type: Article

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