-
1
-
-
0029888870
-
Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat
-
Stein DT, Esser V, Stevenson BE, Lane KE, Whiteside JH, Daniels MB, et al. Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat. J Clin Invest (1996) 97:2728-35. doi: 10.1172/JCI118727
-
(1996)
J Clin Invest
, vol.97
, pp. 2728-2735
-
-
Stein, D.T.1
Esser, V.2
Stevenson, B.E.3
Lane, K.E.4
Whiteside, J.H.5
Daniels, M.B.6
-
2
-
-
0032102146
-
A fatty acid-dependent step is critically important for both glucose- and non-glucose-stimulated insulin secretion
-
Dobbins RL, Chester MW, Stevenson BE, Daniels MB, Stein DT, McGarry JD. A fatty acid-dependent step is critically important for both glucose- and non-glucose-stimulated insulin secretion. J Clin Invest (1998) 101:2370-6. doi:10.1172/JCI1813
-
(1998)
J Clin Invest
, vol.101
, pp. 2370-2376
-
-
Dobbins, R.L.1
Chester, M.W.2
Stevenson, B.E.3
Daniels, M.B.4
Stein, D.T.5
McGarry, J.D.6
-
3
-
-
0031683543
-
Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans
-
Dobbins RL, Chester MW, Daniels MB, McGarry JD, Stein DT. Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans. Diabetes (1998) 47:1613-8. doi:10.2337/diabetes.47.10.1613
-
(1998)
Diabetes
, vol.47
, pp. 1613-1618
-
-
Dobbins, R.L.1
Chester, M.W.2
Daniels, M.B.3
McGarry, J.D.4
Stein, D.T.5
-
4
-
-
0037024360
-
Identification of G protein-coupled receptor genes from the human genome sequence
-
Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S. Identification of G protein-coupled receptor genes from the human genome sequence. FEBS Lett (2002) 520:97-101. doi:10.1016/S0014-5793(02)02775-8
-
(2002)
FEBS Lett
, vol.520
, pp. 97-101
-
-
Takeda, S.1
Kadowaki, S.2
Haga, T.3
Takaesu, H.4
Mitaku, S.5
-
5
-
-
0037434991
-
Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40
-
Itoh Y, Kawamata Y, Harada M, Kobayashi M, Fujii R, Fukusumi S, et al. Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature (2003) 422:173-6. doi:10.1038/nature01478
-
(2003)
Nature
, vol.422
, pp. 173-176
-
-
Itoh, Y.1
Kawamata, Y.2
Harada, M.3
Kobayashi, M.4
Fujii, R.5
Fukusumi, S.6
-
6
-
-
0037838892
-
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids
-
Briscoe CP, Tadayyon M, Andrews JL, Benson WG, Chambers JK, Eilert MM, et al. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J Biol Chem (2003) 278:11303-11. doi:10.1074/jbc.M211495200
-
(2003)
J Biol Chem
, vol.278
, pp. 11303-11311
-
-
Briscoe, C.P.1
Tadayyon, M.2
Andrews, J.L.3
Benson, W.G.4
Chambers, J.K.5
Eilert, M.M.6
-
7
-
-
36049012236
-
Production and characterization of a monoclonal antibody against GPR40 FFAR1; free fatty acid receptor 1)
-
Hirasawa A, Itsubo C, Sadakane K, Hara T, Shinagawa S, Koga H, et al. Production and characterization of a monoclonal antibody against GPR40 (FFAR1; free fatty acid receptor 1). Biochem Biophys Res Commun (2008) 365:22-8. doi:10.1016/j.bbrc.2007.10.142
-
(2008)
Biochem Biophys Res Commun
, vol.365
, pp. 22-28
-
-
Hirasawa, A.1
Itsubo, C.2
Sadakane, K.3
Hara, T.4
Shinagawa, S.5
Koga, H.6
-
8
-
-
84882761792
-
GPR40 protein levels are crucial to the regulation of stimulated hormone secretion in pancreatic islets. Lessons from spontaneous obesity-prone and non-obese type 2 diabetes in rats.
-
Meidute Abaraviciene S, Muhammed SJ, Amisten S, Lundquist I, Salehi A. GPR40 protein levels are crucial to the regulation of stimulated hormone secretion in pancreatic islets. Lessons from spontaneous obesity-prone and non-obese type 2 diabetes in rats. Mol Cell Endocrinol (2013) 381:150-9. doi:10.1016/j.mce.2013.07.025
-
(2013)
Mol Cell Endocrinol
, vol.381
, pp. 150-159
-
-
Meidute Abaraviciene, S.1
Muhammed, S.J.2
Amisten, S.3
Lundquist, I.4
Salehi, A.5
-
9
-
-
27844449497
-
GPR40 gene expression in human pancreas and insulinoma
-
Tomita T, Masuzaki H, Noguchi M, Iwakura H, Fujikura J, Tanaka T, et al. GPR40 gene expression in human pancreas and insulinoma. Biochem Biophys Res Commun (2005) 338:1788-90. doi:10.1016/j.bbrc.2005.10.161
-
(2005)
Biochem Biophys Res Commun
, vol.338
, pp. 1788-1790
-
-
Tomita, T.1
Masuzaki, H.2
Noguchi, M.3
Iwakura, H.4
Fujikura, J.5
Tanaka, T.6
-
10
-
-
33646395425
-
Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion
-
Tomita T, Masuzaki H, Iwakura H, Fujikura J, Noguchi M, Tanaka T, et al. Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion. Diabetologia (2006) 49:962-8. doi:10.1007/s00125-006-0193-8
-
(2006)
Diabetologia
, vol.49
, pp. 962-968
-
-
Tomita, T.1
Masuzaki, H.2
Iwakura, H.3
Fujikura, J.4
Noguchi, M.5
Tanaka, T.6
-
11
-
-
84870910500
-
GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function
-
Odori S, Hosoda K, Tomita T, Fujikura J, Kusakabe T, Kawaguchi Y, et al. GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function. Metabolism (2013) 62:70-8. doi:10.1016/j.metabol.2012.06.010
-
(2013)
Metabolism
, vol.62
, pp. 70-78
-
-
Odori, S.1
Hosoda, K.2
Tomita, T.3
Fujikura, J.4
Kusakabe, T.5
Kawaguchi, Y.6
-
12
-
-
84857126831
-
Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1
-
Kebede M, Ferdaoussi M, Mancini A, Alquier T, Kulkarni RN, Walker MD, et al. Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1. Proc Natl Acad Sci U S A (2012) 109:2376-81. doi:10.1073/pnas.1114350109
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 2376-2381
-
-
Kebede, M.1
Ferdaoussi, M.2
Mancini, A.3
Alquier, T.4
Kulkarni, R.N.5
Walker, M.D.6
-
13
-
-
34548170247
-
Regulation of the gene encoding GPR40, a fatty acid receptor expressed selectively in pancreatic beta cells
-
Bartoov-Shifman R, Ridner G, Bahar K, Rubins N, Walker MD. Regulation of the gene encoding GPR40, a fatty acid receptor expressed selectively in pancreatic beta cells. J Biol Chem (2007) 282:23561-71. doi:10.1074/jbc.M702115200
-
(2007)
J Biol Chem
, vol.282
, pp. 23561-23571
-
-
Bartoov-Shifman, R.1
Ridner, G.2
Bahar, K.3
Rubins, N.4
Walker, M.D.5
-
14
-
-
20944433543
-
The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse
-
Steneberg P, Rubins N, Bartoov-Shifman R, Walker MD, Edlund H. The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metab (2005) 1:245-58. doi:10.1016/j.cmet.2005.03.007
-
(2005)
Cell Metab
, vol.1
, pp. 245-258
-
-
Steneberg, P.1
Rubins, N.2
Bartoov-Shifman, R.3
Walker, M.D.4
Edlund, H.5
-
15
-
-
52249093427
-
The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding
-
Kebede M, Alquier T, Latour MG, Semache M, Tremblay C, Poitout V. The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding. Diabetes (2008) 57:2432-7. doi:10.2337/db08-0553
-
(2008)
Diabetes
, vol.57
, pp. 2432-2437
-
-
Kebede, M.1
Alquier, T.2
Latour, M.G.3
Semache, M.4
Tremblay, C.5
Poitout, V.6
-
16
-
-
58149100292
-
Lack of FFAR1/GPR40 does not protect mice from high-fat diet-induced metabolic disease
-
Lan H, Hoos LM, Liu L, Tetzloff G, Hu W, Abbondanzo SJ, et al. Lack of FFAR1/GPR40 does not protect mice from high-fat diet-induced metabolic disease. Diabetes (2008) 57:2999-3006. doi:10.2337/db08-0596
-
(2008)
Diabetes
, vol.57
, pp. 2999-3006
-
-
Lan, H.1
Hoos, L.M.2
Liu, L.3
Tetzloff, G.4
Hu, W.5
Abbondanzo, S.J.6
-
17
-
-
34047177401
-
GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo
-
Latour MG, Alquier T, Oseid E, Tremblay C, Jetton TL, Luo J, et al. GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo. Diabetes (2007) 56:1087-94. doi:10.2337/db06-1532
-
(2007)
Diabetes
, vol.56
, pp. 1087-1094
-
-
Latour, M.G.1
Alquier, T.2
Oseid, E.3
Tremblay, C.4
Jetton, T.L.5
Luo, J.6
-
18
-
-
70350561694
-
Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets
-
Alquier T, Peyot ML, Latour MG, Kebede M, Sorensen CM, Gesta S, et al. Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets. Diabetes (2009) 58:2607-15. doi:10.2337/db09-0362
-
(2009)
Diabetes
, vol.58
, pp. 2607-2615
-
-
Alquier, T.1
Peyot, M.L.2
Latour, M.G.3
Kebede, M.4
Sorensen, C.M.5
Gesta, S.6
-
19
-
-
65549114432
-
Overexpression of gpr40 in pancreatic ß-cells augments glucose stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice
-
Nagasumi K, Esaki R, Iwachidow K, Yasuhara Y, Ogi K, Tanaka H, et al. Overexpression of gpr40 in pancreatic ß-cells augments glucose stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice. Diabetes (2009) 58:1067-76. doi:10.2337/db08-1233
-
(2009)
Diabetes
, vol.58
, pp. 1067-1076
-
-
Nagasumi, K.1
Esaki, R.2
Iwachidow, K.3
Yasuhara, Y.4
Ogi, K.5
Tanaka, H.6
-
20
-
-
52749098923
-
Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion
-
Edfalk S, Steneberg P, Edlund H. Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion. Diabetes (2008) 57:2280-7. doi:10.2337/db08-0307
-
(2008)
Diabetes
, vol.57
, pp. 2280-2287
-
-
Edfalk, S.1
Steneberg, P.2
Edlund, H.3
-
21
-
-
58149464981
-
Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells
-
Parker HE, Habib AM, Rogers GJ, Gribble FM, Reimann F. Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells. Diabetologia (2009) 52:289-98. doi:10.1007/s00125-008-1202-x
-
(2009)
Diabetologia
, vol.52
, pp. 289-298
-
-
Parker, H.E.1
Habib, A.M.2
Rogers, G.J.3
Gribble, F.M.4
Reimann, F.5
-
22
-
-
79952315396
-
The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin
-
Liou AP, Lu X, Sei Y, Zhao X, Pechhold S, Carrero RJ, et al. The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin. Gastroenterology (2011) 140:903-12. doi:10.1053/j.gastro.2010.10.012
-
(2011)
Gastroenterology
, vol.140
, pp. 903-912
-
-
Liou, A.P.1
Lu, X.2
Sei, Y.3
Zhao, X.4
Pechhold, S.5
Carrero, R.J.6
-
23
-
-
77956500937
-
Discovery of TAK-875: a potent, selective, and orally bioavailable GPR40 agonist
-
Negoro N, Sasaki S, Mikami S, Ito M, Suzuki M, Tsujihata Y, et al. Discovery of TAK-875: a potent, selective, and orally bioavailable GPR40 agonist. ACS Med Chem Lett (2010) 1:290-4. doi:10.1021/ml1000855
-
(2010)
ACS Med Chem Lett
, vol.1
, pp. 290-294
-
-
Negoro, N.1
Sasaki, S.2
Mikami, S.3
Ito, M.4
Suzuki, M.5
Tsujihata, Y.6
-
24
-
-
80053138180
-
TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats
-
Tsujihata Y, Ito R, Suzuki M, Harada A, Negoro N, Yasuma T, et al. TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats. J Pharmacol Exp Ther (2011) 339:228-37. doi:10.1124/jpet.111.183772
-
(2011)
J Pharmacol Exp Ther
, vol.339
, pp. 228-237
-
-
Tsujihata, Y.1
Ito, R.2
Suzuki, M.3
Harada, A.4
Negoro, N.5
Yasuma, T.6
-
25
-
-
84856019616
-
The effects of TAK-875, a selective G protein-coupled receptor 40/free fatty acid 1 agonist, on insulin and glucagon secretion in isolated rat and human islets
-
Yashiro H, Tsujihata Y, Takeuchi K, Hazama M, Johnson PR, Rorsman P. The effects of TAK-875, a selective G protein-coupled receptor 40/free fatty acid 1 agonist, on insulin and glucagon secretion in isolated rat and human islets. J Pharmacol Exp Ther (2012) 340:483-9. doi:10.1124/jpet.111.187708
-
(2012)
J Pharmacol Exp Ther
, vol.340
, pp. 483-489
-
-
Yashiro, H.1
Tsujihata, Y.2
Takeuchi, K.3
Hazama, M.4
Johnson, P.R.5
Rorsman, P.6
-
26
-
-
84859625938
-
TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial
-
Burant CF, Viswanathan P, Marcinak J, Cao C, Vakilynejad M, Xie B, et al. TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet (2012) 379:1403-11. doi:10.1016/S0140-6736(11)61879-5
-
(2012)
Lancet
, vol.379
, pp. 1403-1411
-
-
Burant, C.F.1
Viswanathan, P.2
Marcinak, J.3
Cao, C.4
Vakilynejad, M.5
Xie, B.6
-
27
-
-
84873835561
-
Randomized, double-blind, dose-ranging study of TAK-875, a novel GPR40 agonist, in Japanese patients with inadequately controlled type 2 diabetes
-
Kaku K, Araki T, Yoshinaka R. Randomized, double-blind, dose-ranging study of TAK-875, a novel GPR40 agonist, in Japanese patients with inadequately controlled type 2 diabetes. Diabetes Care (2013) 36:245-50. doi:10.2337/dc12-0872
-
(2013)
Diabetes Care
, vol.36
, pp. 245-250
-
-
Kaku, K.1
Araki, T.2
Yoshinaka, R.3
|