Application of a modified gaseous exposure system to the in vitro toxicological assessment of tobacco smoke toxicants

Environmental and Molecular Mutagenesis

Volumn 55, Issue 8, 2014, Pages 662-672

  Breheny, Damien ^a   Cunningham, Fiona ^a   Kilford, Joanne ^b   Payne, Rebecca ^b   Dillon, Deborah ^a   Meredith, Clive ^a  

^a BRITISH AMERICAN TOBACCO   (United Kingdom)

^b Department of Genetic and Molecular Toxicology   (United Kingdom)

Author keywords

Ames; Ethylene oxide; Gaseous exposure; in vitro; Vitrocell VC 10

Indexed keywords

ETHYLENE OXIDE; TOBACCO SMOKE; MUTAGENIC AGENT; PASSIVE SMOKING; SMOKE;

AMES TEST; ARTICLE; ENVIRONMENTAL EXPOSURE; GENOTOXICITY; IN VITRO STUDY; NONHUMAN; TOXICOLOGY; ADVERSE EFFECTS; ANALYSIS; CHEMISTRY; DEVICES; DRUG EFFECTS; MUTAGEN TESTING; PASSIVE SMOKING; PROCEDURES; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM; SMOKE; TOBACCO;

ETHYLENE OXIDE; IN VITRO TECHNIQUES; MUTAGENICITY TESTS; MUTAGENS; SALMONELLA TYPHIMURIUM; SMOKE; TOBACCO; TOBACCO SMOKE POLLUTION;

EID: 84907969236     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.21876     Document Type: Article

References (39)

1. Adamson J, Thorne D, Dalrymple A, Dillon D, Meredith C. 2013. Assessment of cigarette smoke particle deposition within the Vitrocell(R) exposure module using quartz crystal microbalances. Chem Cent J 7:50.
2. Agurell E, Cederberg H, Ehrenberg L, Lindahl-Kiessling K, Rannug U, Tornqvist M. 1991. Genotoxic effects of ethylene oxide and propylene oxide: A comparative study. Mutat Res 250:229-237.
3. Ames BN, McCann J, Yamasaki E. 1975. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat Res 31:347-364.
4. Anderson SE, Khurshid SS, Meade BJ, Lukomska E, Wells JR. 2013. Toxicological analysis of limonene reaction products using an in vitro exposure system. Toxicol In Vitro 27:721-730.
5. Araki A, Noguchi T, Kato F, Matsushima T. 1994. Improved method for mutagenicity testing of gaseous compounds by using a gas sampling bag. Mutat Res 307:335-344.
6. Aufderheide M, Knebel JW, Ritter D. 2002. A method for the in vitro exposure of human cells to environmental and complex gaseous mixtures: application to various types of atmosphere. Altern Lab Anim 30:433-441.
7. Aufderheide M. 2005. Direct exposure methods for testing native atmospheres. Exp Toxicol Pathol 57:213-226.
8. Aufderheide M, Gressmann H. 2007. A modified Ames assay reveals the mutagenicity of native cigarette mainstream smoke and its gas vapour phase. Exp Toxicol Pathol 58:383-392.
9. Aufderheide M, Gressmann H. 2008. Mutagenicity of native cigarette mainstream smoke and its gas/vapour phase by use of different tester strains and cigarettes in a modified Ames assay. Mutat Res 656:82-87.
10. Bakand S, Winder C, Khalil C, Hayes A. 2005. Toxicity assessment of industrial chemicals and airborne contaminants: Transition from in vivo to in vitro test methods: a review. Inhal Toxicol 17:775-787.
11. BeruBe K, Aufderheide M, Breheny D, Clothier R, Combes R, Duffin R, Forbes B, Gaca M, Gray A, Hall I, et al. 2009. In vitro models of inhalation toxicity and disease. The report of a FRAME workshop. Altern Lab Anim 37:89-141.
12. Brody JS, Steiling K. 2011. Interaction of cigarette exposure and airway epithelial cell gene expression. Annu Rev Physiol 73:437-456.
13. Burns DM, Dybing E, Gray N, Hecht S, Anderson C, Sanner T, O'Connor R, Djordjevic M, Dresler C, Hainaut P, et al. 2008. Mandated lowering of toxicants in cigarette smoke: A description of the World Health Organization TobReg proposal. Tob Control 17:132-141.
14. Coggins CR 2010. A further review of inhalation studies with cigarette smoke and lung cancer in experimental animals, including transgenic mice. Inhal Toxicol 22:974-983.
15. de Serres F, Shelby M. 1979. Recommendations on data production and analysis using the Salmonella/microsome mutagenicity assay. Mutat Res 64:159-165.
16. Doll R, Peto R, Boreham J, Sutherland I. 2004. Mortality in relation to smoking: 50 years' observations on male British doctors. BMJ 328:1519.
17. Food and Drug Administration. Harmful and Potentially Harmful Constituents in Tobacco Products and Tobacco Smoke; Established List. Federal Register 77:200034-200037.
18. Hagiwara Y, Watanabe M, Oda Y, Sofuni T, Nohmi T. 1993. Specificity and sensitivity of Salmonella typhimurium YG1041 and YG1042 strains possessing elevated levels of both nitroreductase and acetyltransferase activity. Mutat Res 291:171-180.
19. Hong HH, Houle CD, Ton TV, Sills RC 2007. K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse. Toxicol Pathol 35:81-85.
20. Huertas A, Palange P. 2011. COPD: A multifactorial systemic disease. Ther Adv Respir Dis 5:217-224.
21. IARC. 2008. IARC monographs on the evaluation of carcinogenic risks to humans. Volume 97. 1, 3-butadiene, ethylene oxide and vinyl halides (vinyl fluoride, vinyl chloride and vinyl bromide). IARC Monogr Eval Carcinog Risks Hum 97:3-471.
22. Kilford J, Thorne D, Payne R, Dalrymple A, Clements J, Meredith C, Dillon, D. 2014. A methodology for the assessment of mainstream cigarette smoke genotoxicity using the bacterial reverse mutation assay and an aerosol-based exposure system. Mutat Res (in press).
23. Maron DM, Ames BN. 1983. Revised methods for the Salmonella mutagenicity test. Mutat Res 113:173-215.
24. Morin JP, Hasson V, Fall M, Papaioanou E, Preterre D, Gouriou F, Keravec V, Konstandopoulos A, Dionnet F. 2008. Prevalidation of in vitro continuous flow exposure systems as alternatives to in vivo inhalation safety evaluation experimentations: Outcome from MAAPHRI-PCRD5 research program. Exp Toxicol Pathol 60:195-205.
25. Owen K. 2013. Regulatory toxicology considerations for the development of inhaled pharmaceuticals. Drug Chem Toxicol 36:109-118.
26. Pariselli F, Sacco MG, Rembges D. 2009. An optimized method for in vitro exposure of human derived lung cells to volatile chemicals. Exp Toxicol Pathol 61:33-39.
27. Parsons BL, Manjanatha MG, Myers MB, McKim KL, Shelton SD, Wang Y, Gollapudi BB, Moore NP, Haber LT, Moore MM. 2013. Temporal changes in K-ras mutant fraction in lung tissue of big blue B6C3F1 mice exposed to ethylene oxide. Toxicol Sci 136:26-38.
28. Persoz C, Leleu C, Achard S, Fasseu M, Menotti J, Meneceur P, Momas I, Derouin F, Seta N. 2011. Sequential air-liquid exposure of human respiratory cells to chemical and biological pollutants. Toxicol Lett 207:53-59.
29. Rach J, Budde J, Mohle N, Aufderheide M. 2013. Direct exposure at the air-liquid interface: Evaluation of an in vitro approach for simulating inhalation of airborne substances. J Appl Toxicol 5:506-515.
30. Rodgman A, Perfetti TA. 2013. The Chemical Components of Tobacco and Tobacco Smoke, 2nd ed. Boca Raton: CRC Press. p 2332.
31. Roemer E, Schramke H, Weiler H, Buettner A, Kausche S, Weber S, Berges A, Stueber M, Muench M, Trelles-Sticken E, et al. 2012. Mainstream smoke chemistry and in vitro and in vivo toxicity of the reference cigarettes 3R4F and 2R4F. Beiträge zur Tabakforschung International/Contributions to Tobacco Research 25:316-335.
32. Sagawa M, Saito Y, Fujimura S, Linnoila, RI. 1998. K-ras point mutation occurs in the early stage of carcinogenesis in lung cancer. Br J Cancer 77:720-723.
33. Schmalz C, Wunderlich HG, Heinze R, Frimmel FH, Zweiner C, Grummt T. 2011. Application of an optimized system for the well-defined exposure of human lung cells to trichloramine and indoor pool air. J Water Health 9:586-596.
34. Thier R, Bolt HM. 2000. Carcinogenicity and genotoxicity of ethylene oxide: New aspects and recent advances. Crit Rev Toxicol 30:595-608.
35. Thorne D, Adamson J. 2013. A review of in vitro cigarette smoke exposure systems. Exp Toxicol Pathol 65:1183-1193.
36. Thorne D, Kilford J, Payne R, Adamson J, Scott K, Dalrymple A, Meredith C, Dillon D. 2013. Characterisation of a Vitrocell(R) VC 10 in vitro smoke exposure system using dose tools and biological analysis. Chem Cent J 7:146.
37. Victorin K, Stahlberg M. 1988. A method for studying the mutagenicity of some gaseous compounds in Salmonella typhimurium. Environ Mol Mutagen 11:65-77.
38. ® system. Toxicol In Vitro 25:2080-2087.
39. Zhong BZ, Gu ZW, Whong WZ, Wallace WE, Ong TM. 1991. Comparative-study of micronucleus assay and chromosomal aberration analysis in V79 cells exposed to ethylene-oxide. Teratog Carcinog Mutagen 11:227-233.