K-ras point mutation occurs in the early stage of carcinogenesis in lung cancer

British Journal of Cancer

Volumn 77, Issue 5, 1998, Pages 720-723

  Sagawa, M ^a,b   Saito, Y ^b   Fujimura, S ^b   Linnoila, R I ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Genetic heterogeneity; K ras; Lung cancer; Preneoplastic lesion; Selective ultraviolet radiation fractionation

Indexed keywords

ALANINE; CYSTEINE; PHENYLALANINE; VALINE;

ARTICLE; CANCER STAGING; CARCINOGENESIS; CHROMOSOME MICRODISSECTION; HUMAN; HUMAN TISSUE; LUNG CANCER; MAJOR CLINICAL STUDY; ONCOGENE K RAS; POINT MUTATION; POLYMERASE CHAIN REACTION; PRECANCER; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SQUAMOUS CELL CARCINOMA; ULTRAVIOLET RADIATION;

EID: 0031886443     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.118     Document Type: Article

References (15)

1. Hung J, Kishimoto Y, Sugio K, Virmani A, McIntire DD, Minna JD and Gazdar AF (1995) Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma. JAMA 273: 558-563
2. Koeffler HP, McCorrmick F and Denny C (1991) Molecular mechanisms of cancer. West J Med 155: 505-514
3. Li Z-H, Zheng J, Weiss LM and Shihata D (1994) c-K-ras and p53 mutations occur very early in adenocarcinoma of the lung. Am J Pathol 144: 303-309
4. Mills NE, Fishman CL, Slebos J, Anderson SE, Rom WN and Jacobson DR (1995) Detection of K-ras oncogene mutations in bronchoalveolar lavage fluid for lung cancer diagnosis. J Natl Cancer Inst 87: 1056-1060
5. Mirchandani D, Zheng J, Miller GJ, Ghosh AK, Shibata DK, Cote RJ and Roy-Burman P (1995) Heterogeneity in intratumor distribution of p53 mutations in human prostate cancer. Am J Pathol 147: 92-101
6. Mitsudomi T, Viallet J, Mulshine JL, Linnoila RI, Minna JD and Gazdar AF (1991) Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines. Oncogene 6: 1353-1362
7. Ohshima S, Shimizu Y and Takahama M (1994) Detection of c-Ki-ras gene mutation in paraffin sections of adenocarcinoma and atypical bronchioloalveolar cell hyperplasia of human lung. Virchows Archiv 424: 129-134
8. Shibata D, Hawes D, Li Z-H, Hernandez AM, Spruck CH and Nichols PW (1992) Specific genetic analysis of microscopic tissue after selective ultraviolet radiation fractionation and the polymerase chain reaction. Am J Pathol 141: 539-543
9. Shibata D, Schaeffer J, Li Z-H, Capella G and Perucho M (1993) Genetic heterogeneity of the c-K-ras locus in colorectal adenomas but not in adenocarcinomas. J Natl Cancer Inst 85: 1058-1063
10. Sugio K, Kishimoto Y, Virmani AK, Hung JY and Gazdar AF (1994) K-ras mutations are a relatively late event in the pathogenesis of lung carcinomas. Cancer Res 54: 5811-5815
11. Sundaresan V, Ganly P, Hasleton P, Rudd R, Sinha G, Bleehen NM and Rabbitts P (1992) p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus. Oncogene 7: 1989-1997
12. Thiberville L, Payne P, Vierkinds J, LeRiche J, Horsman D, Nouvet G, Palcic B and Lam S (1995) Evidence of cumulative gene losses with progression of premalignant epithelial lesions to carcinoma of the bronchus. Cancer Res 55: 5133-5139
13. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, Nakamura Y, White R, Smits AMM and Bos JL (1988) Genetic alterations during colorectal-tumor development. N Engl J Med 319: 525-532
14. Westra WH, Slebos RJC, Offerhaus GJA, Goodman SN, Evers SG, Kensler TW, Askin FB, Rodenhuis S and Hruban RH (1993) K-ras oncogene activation in lung adenocarcinomas from former smokers. Cancer 72: 432-438
15. Westra WH, Baas IO, Hruban RH, Askin FB, Wilson K, Offerhaus GJA and Slebos RJC (1996) K-ras oncogene activation in atypical alveolar hyperplasias of the human lung. Cancer Res 56: 2224-2228