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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 21, 2014, Pages 5102-5106

Discovery of potent and selective GIRK1/2 modulators via 'molecular switches' within a series of 1-(3-cyclopropyl-1-phenyl-1H-pyrazol-5-yl)ureas

(4) Wen, Wandong a,b Wu, Wenjun a Weaver, C David b Lindsley, Craig W b,c,d

a NORTHWEST A F UNIVERSITY (China)

b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE (United States)

c VANDERBILT UNIVERSITY MEDICAL CENTER (United States)

d VANDERBILT UNIVERSITY (United States)

Author keywords

Activators; GIRK; Inhibitors; Kir< inf>3.x; Thallium flux

Indexed keywords

POTASSIUM CHANNEL AFFECTING AGENT; PYRAZOLE DERIVATIVE; UREA DERIVATIVE; CARBANILAMIDE DERIVATIVE; CID 56642816; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; PROTEIN BINDING; PYRAZOLE; UREA;

ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG POTENCY; EC50; IC50; MOLECULAR SWITCH; STRUCTURE ACTIVITY RELATION; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG SCREENING; METABOLISM; MICROSOME; RAT;

ANIMALS; DRUG EVALUATION, PRECLINICAL; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; MICROSOMES; PHENYLUREA COMPOUNDS; PROTEIN BINDING; PYRAZOLES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 84907968005 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.08.061 Document Type: Article

Times cited : (13)

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