Increased polyubiquitination and proteasomal degradation of a Munc18-1 disease-linked mutant causes temperature-sensitive defect in exocytosis

Cell Reports

Volumn 9, Issue 1, 2014, Pages 206-218

  Martin, Sally ^a   Papadopulos, Andreas ^a   Tomatis, Vanesa M ^a   Sierecki, Emma ^a   Malintan, Nancy T ^a   Gormal, Rachel S ^a   Giles, Nichole ^a   Johnston, Wayne A ^a   Alexandrov, Kirill ^a   Gambin, Yann ^a   Collins, Brett M ^a   Meunier, Frederic A ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; MUNC18 PROTEIN; SNARE PROTEIN; SYNTAXIN 1A; PROTEASOME; PROTEIN BINDING;

ARTICLE; BRAIN DISEASE; CELL MEMBRANE; EXOCYTOSIS; GENE MUTATION; IN VITRO STUDY; LYSOSOME; NEUROSECRETORY CELL; NEUROTRANSMISSION; PHENOTYPE; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STABILITY; SYNAPSE VESICLE; TEMPERATURE SENSITIVITY; UBIQUITINATION; WILD TYPE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; POINT MUTATION; PROTEIN SECONDARY STRUCTURE; RAT;

ANIMALS; EXOCYTOSIS; HUMANS; MODELS, MOLECULAR; MUNC18 PROTEINS; POINT MUTATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RATS; SNARE PROTEINS; UBIQUITINATION;

EID: 84907966407     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.08.059     Document Type: Article

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