Frequency and clinical outcomes of ESKAPE bacteremia in solid organ transplantation and the risk factors for mortality

Transplant Infectious Disease

Volumn 16, Issue 5, 2014, Pages 767-774

  Ye, Q F ^a,b   Zhao, J ^a   Wan, Q Q ^a   Qiao, B B ^b   Zhou, J D ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

Author keywords

Bacteremia; ESKAPE; Mortality; Risk factors; Solid organ transplantation

Indexed keywords

ACINETOBACTER BAUMANNII; ADULT; ARTICLE; BACTEREMIA; ENTEROBACTER; ENTEROBACTER CLOACAE; ENTEROCOCCUS FAECIUM; FEMALE; GRAFT RECIPIENT; HUMAN; INFECTION RISK; KLEBSIELLA PNEUMONIAE; MAJOR CLINICAL STUDY; MALE; MORTALITY; NONHUMAN; ORGAN TRANSPLANTATION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RETROSPECTIVE STUDY; SEPTIC SHOCK; STAPHYLOCOCCUS AUREUS; ACINETOBACTER INFECTIONS; ADVERSE EFFECTS; AGE; ANTIBIOTIC RESISTANCE; CHINA; ENTEROBACTERIACEAE INFECTION; GRAM POSITIVE INFECTION; KLEBSIELLA INFECTIONS; MICROBIOLOGY; MIDDLE AGED; PSEUDOMONAS INFECTIONS; RISK; STAPHYLOCOCCAL INFECTIONS;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; ADULT; AGE FACTORS; BACTEREMIA; CHINA; DRUG RESISTANCE, BACTERIAL; ENTEROBACTER; ENTEROBACTERIACEAE INFECTIONS; ENTEROCOCCUS FAECIUM; FEMALE; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; MIDDLE AGED; ORGAN TRANSPLANTATION; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RETROSPECTIVE STUDIES; RISK; SHOCK, SEPTIC; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 84907954503     PISSN: 13982273     EISSN: 13993062     Source Type: Journal    
DOI: 10.1111/tid.12278     Document Type: Article

References (61)

1. Fishman JA. Infection in solid-organ transplant recipients. N Engl J Med 2007; 357: 2601-2614.
2. Moreno A, Cervera C, Gavalda J, et al. Bloodstream infections among transplant recipients: results of a nationwide surveillance in Spain. Am J Transplant 2007; 7: 2579-2586.
3. Kusne S, Dummer JS, Singh N, et al. Infections after liver transplantation: an analysis of 101 consecutive cases. Medicine 1988; 67: 132-143.
4. George DL, Arnow PM, Fox AS, et al. Bacterial infection as a complication of liver transplantation: epidemiology and risk factors. Rev Infect Dis 1991; 13: 387-396.
5. Wagener MM, Yu VL. Bacteremia in transplant recipients: a prospective study of demographics, etiologic agents; risk factors, and outcomes. Am J Infect Control 1992; 20: 239-247.
6. Singh N, Gayowski T, Wagener MM, et al. Bloodstream infections in liver transplant recipients receiving tacrolimus. Clin Transplant 1997; 11: 275-281.
7. Candel FJ, Grima E, Matesanz M, et al. Bacteremia and septic shock after solid-organ transplantation. Transplant Proc 2005; 37: 4097-4099.
8. Singh N, Wagener MM, Obman A, et al. Bacteremias in liver transplant recipients: shift toward gram-negative bacteria as predominant pathogens. Liver Transpl 2004; 10: 844-849.
9. Singh N, Gayowski T, Rihs JD, et al. Evolving trends in multiple-antibiotic- resistant bacteria in liver transplant recipients: a longitudinal study of antimicrobial susceptibility patterns. Liver Transpl 2001; 7: 22-26.
10. Sigurdsson L, Reyes J, Kocoshis SA, et al. Bacteremia after intestinal transplantation in children correlates temporally with rejection or gastrointestinal lymphoproliferative disease. Transplantation 2000; 70: 302-305.
11. McClean K, Kneteman N, Taylor G. Comparative risk of bloodstream infection in organ transplant recipients. Infect Control Hosp Epidemiol 1994; 15: 582-584.
12. Moreno A, Mensa J, Almela M, et al. 138 Episodes of bacteremia or fungemia in patients with solid organ (renal or hepatic) transplantation. Med Clin (Barc) 1994; 103: 161-164.
13. Lee SO, Kang SH, Abdel-Massih RC, et al. Spectrum of early-onset and late-onset bacteremias after liver transplantation: implications for management. Liver Transpl 2011; 17: 733-741.
14. Linares L, García-Goez JF, Cervera C, et al. Early bacteremia after solid organ transplantation. Transplant Proc 2009; 41: 2262-2264.
15. Palmer SM, Alexander BD, Sanders LL, et al. Significance of blood stream infection after lung transplantation: analysis in 176 consecutive patients. Transplant 2000; 69: 2360-2366.
16. Kim S, Kim Y, Jun Y, et al. Epidemiology and risk factors for bacteremia in 144 consecutive living-donor liver transplant recipients. Yonsei Med J 2009; 50: 112-121.
17. Iida T, Kaido T, Yagi S, et al. Posttransplant bacteremia in adult living donor liver transplant recipients. Liver Transpl 2010; 16: 1379-1385.
18. Hashimoto M, Sugawara Y, Tamura S, et al. Bloodstream infection after living donor liver transplantation. Scand J Infect Dis 2008; 40: 509-516.
19. Hsu RB, Chang CI, Fang CT, et al. Bloodstream infection in heart transplant recipients: 12-year experience at a university hospital in Taiwan. Eur J Cardiothorac Surg 2011; 40: 1362-1367.
20. Florescu DF, Qiu F, Langnas AN, et al. Bloodstream infections during the first year after pediatric intestinal transplantation. Pediatr Infect Dis J 2012; 31: 700-704.
21. Akhter K, Timpone J, Matsumoto C, et al. Six-month incidence of bloodstream infections in intestinal transplant patients. Transpl Infect Dis 2012; 14: 242-247.
22. Al-Hasan MN, Razonable RR, Eckel-Passow JE, et al. Incidence rate and outcome of gram-negative bloodstream infection in solid organ transplant recipients. Am J Transplant 2009; 9: 835-843.
23. Hsu J, Andes DR, Knasinski V, et al. Statins are associated with improved outcomes of bloodstream infection in solid-organ transplant recipients. Eur J Clin Microbiol Infect Dis 2009; 28: 1343-1351.
24. Danziger-Isakov LA, Sweet S, Delamorena M, et al. Epidemiology of bloodstream infections in the first year after pediatric lung transplantation. Pediatric Infect Dis J 2005; 24: 324-330.
25. Kawecki D, Kwiatkowski A, Michalak G, et al. Etiologic agents of bacteremia in the early period after simultaneous pancreas-kidney transplantation. Transplant Proc 2009; 41: 3151-3153.
26. Singh RP, Farney AC, Rogers J. Analysis of bacteremia after pancreatic transplantation with enteric drainage. Transplant Proc 2008; 40: 506-509.
27. Rabkin DG, Stifelman MD, Birkhoff J, et al. Early catheter removal decreases incidence of urinary tract infections in renal transplant recipients. Transplant Proc 1998; 30: 4314-4316.
28. Osman Y, Ali-El-Dein B, Shokeir AA, et al. Routine insertion of ureteral stent in live-donor renal transplantation: is it worthwhile. Urology 2005; 65: 867-871.
29. Wade JJ, Rolando N, Hallar K, et al. Bacterial and fungal infections after liver transplantation: an analysis of 284 patients. Hepatology 1995; 21: 1328-1366.
30. Rice LB. Progress and challenges in implementing the research on ESKAPE pathogens. Infect Control Hosp Epidemiol 2010; 31: S7-S10.
31. Rice LB. Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. J Infect Dis 2008; 197: 1079-1081.
32. Boucher HW, Talbot GH, Bradley JS, et al. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis 2009; 48: 1-12.
33. Bales PM, Renke EM, May SL, et al. Purification and characterization of biofilm-associated EPS exopolysaccharides from ESKAPE organisms and other pathogens. PLoS One 2013; 8: e67950.
34. Sandiumenge A, Lisboa T, Gomez F, et al. Effect of antibiotic diversity on ventilator-associated pneumonia caused by ESKAPE organisms. Chest 2011; 140: 643-651.
35. Sandiumenge A, Rello J. Ventilator-associated pneumonia caused by ESKAPE organisms: cause, clinical features, and management. Curr Opin Pulm Med 2012; 18: 187-193.
36. Llaca-Díaz JM, Mendoza-Olazarán S, Camacho-Ortiz A, et al. One-year surveillance of ESKAPE pathogens in an intensive care unit of Monterrey, Mexico. Chemotherapy 2012; 58: 475-481.
37. Bodro M, Sabé N, Tubau F, et al. Risk factors and outcomes of bacteremia caused by drug-resistant ESKAPE pathogens in solid-organ transplant recipients. Transplantation 2013; 96: 843-849.
38. Bow EJ. There should be no ESKAPE for febrile neutropenic cancer patients: the dearth of effective antibacterial drugs threatens anticancer efficacy. J Antimicrob Chemother 2013; 68: 492-495.
39. Garner JS, Jarvis WR, Emori TG, et al. CDC definitions of nosocomial infections. Am J Infect Control 1988; 16: 128-140.
40. Kollef MH, Micek ST. Strategies to prevent antimicrobial resistance in the intensive care unit. Crit Care Med 2005; 33: 1845-1853.
41. Levry MM, Fink MP, Marshall JC, et al., for the international sepsis definitions conference. 2001 SCCM/ESICM/ACCP/ATS/SIS International sepsis definition conference. Intensive Care Med 2003; 29: 530-538.
42. Zhou JD, Guo JJ, Zhang Q, et al. Drug resistance of infectious pathogens after liver transplantation. Hepatobiliary Pancreat Dis Int 2006; 5: 190-194.
43. National Committee for Clinical Laboratory Standards (NCCLS). Performance Standards for Antimicrobial Susceptibility Testing: 12th Informational Supplement. M100-S12. Wayne, PA: NCCLS; 2002.
44. Jarlier V, Nicolas M-H, Fournier G, et al. Extended broad-spectrum beta-lactamases conferring transferable resistance to newer beta-lactam agents in Enterobacteriaceae: hospital prevalence and susceptibility patterns. Rev Infect Dis 1988; 10: 867-878.
45. Rhomberg P, Jones R, Sader H, Fritsche T. Antimicrobial resistance rates and clonality results from the Meropenem Yearly Susceptibility Test Information Collection (MYSTIC) programme: report of year five (2003). Diagn Microbiol Infect Dis 2004; 49: 273-281.
46. Garza-Gonzalez E, Llaca-Diaz JM, Bosques-Padilla FJ, Gonzalez GM. Prevalence of multidrug-resistant bacteria at a tertiary-care teaching hospital in Mexico: special focus on Acinetobacter baumannii. Chemotherapy 2010; 56: 275-279.
47. Seifert H, Dowzicky M. A longitudinal analysis of antimicrobial susceptibility in clinical institutions in Germany as part of the tigecycline evaluation and surveillance trial (2004-2007). Chemotherapy 2009; 55: 241-252.
48. Zhong L, Men TY, Li H, et al. Multidrug-resistant gram-negative bacterial infections after liver transplantation - spectrum and risk factors. J Infect 2012; 64: 299-310.
49. Shi SH, Kong HS, Xu J, et al. Multidrug resistant gram-negative bacilli as predominant bacteremic pathogens in liver transplant recipients. Transpl Infect Dis 2009; 11: 405-412.
50. Kim YJ, Yoon JH, Kim SI, et al. High mortality associated with Acinetobacter species infection in liver transplant patients. Transplant Proc 2011; 43: 2397-2399.
51. Ariza-Heredia EJ, Patel R, Blumberg EA, et al. Outcomes of transplantation using organs from a donor infected with Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae. Transpl Infect Dis 2012; 14: 229-236.
52. Serefhanoglu K, Timurkaynak F, Arslan H, et al. Bacteremia among liver and kidney transplant recipients: etiologic agents and antimicrobial susceptibilities. Braz J Infect Dis 2011; 15: 408-409.
53. Brown DF, Hope R, Livermore DM, et al.; BSAC Working Parties on Resistance Surveillance. Non-susceptibility trends among enterococci and non-pneumococcal streptococci from bacteremias in the UK and Ireland, 2001-06. J Antimicrob Chemother 2008; 62 (Suppl 2): ii75-ii85.
54. European Centre for Disease Prevention and Control. Annual Epidemiological Report 2011 - reporting on 2009 surveillance data and 2010 epidemic intelligence data; 2011.
55. Alp E, Klaassen CH, Doganay M, et al. MRSA genotypes in Turkey: persistence over 10 years of a single clone of ST239. J Infect 2009; 58: 433-438.
56. Klevens RM, Morrison MA, Nadle J, et al.; Active Bacterial Core (ABCs) MRSA Investigators. Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA 2007; 298: 1763-1771.
57. Shi SH, Kong HS, Jia CK, et al. Coagulase-negative Staphylococcus and Enterococcus as predominant pathogens in liver transplant recipients with Gram-positive coccal bacteremia. Chin Med J (Engl) 2010; 123: 1983-1988.
58. de Kraker ME, Wolkewitz M, Davey PG, et al.; BURDEN Study Group. Clinical impact of antimicrobial resistance in European hospitals: excess mortality and length of hospital stay related to methicillin-resistant Staphylococcus aureus bloodstream infections. Antimicrob Agents Chemother 2011; 55: 1598-1605.
59. Bert F, Larroque B, Paugam-Burtz C, et al. Microbial epidemiology and outcome of bloodstream infections in liver transplant recipients: an analysis of 259 episodes. Liver Transpl 2010; 16: 393-401.
60. Hidron AI, Edwards JR, Patel J, et al. NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007. Infect Control Hosp Epidemiol 2008; 29: 996-1011.
61. Weinstein MP, Towns ML, Quartey SM, et al. The clinical of positive blood cultures in the 1990s: a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults. Clin Infect Dis 1997; 24: 584-602.