Akt involved in diazoxide preconditioning against rat hippocampal neuronal apoptosis induced by anoxia-reoxygenation injury

National Medical Journal of China

Volumn 90, Issue 7, 2010, Pages 492-495

  Liu, Rong Guo ^a   Song, Na ^a   Li, Jie Meng ^a   Cui, Xiang ^a   Chen, Yan Qing ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cell hypoxia; Diazoxide; Proto Oncogene Protein c akt; Proto oncogene protein c bcl 2

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; DIAZOXIDE; OXYGEN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL HYPOXIA; CONTROLLED STUDY; HIPPOCAMPUS; IN VITRO STUDY; NERVE CELL; NEUROPROTECTION; NONHUMAN; OPTICAL DENSITY; PROTEIN EXPRESSION; RAT; REOXYGENATION; TREATMENT DURATION; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANOXIA; CELL CULTURE; CYTOLOGY; DRUG EFFECT; METABOLISM; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; ANOXIA; APOPTOSIS; CELLS, CULTURED; DIAZOXIDE; HIPPOCAMPUS; NEURONS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84871460638     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0376-2491.2010.07.017     Document Type: Article

References (13)

1. Shake J G, Peck E A, Marban E, et al. Pharmacologically induced preconditioning with diazoxide: a novel approach to brain protection. Ann Thorac Surg, 2001, 72: 1849-1854.
2. Dimagl U, Simon R P, Hallenbeck J M. Ischemic tolerance and endogenous neuroprotection trends. Neurosci, 2003, 26: 248-254.
3. 2006, 58: 345-350.
4. Bossenmeyer P C, Lievre V, Grojean S, et al. Sequential expression patterns of apoptosis and cell cycle-related proteins in neuronal response to severe or mild transient anoxia. Neuroscience, 2002, 114: 869-882.
5. Obrenovitch T P. Molecular physiology of preconditioning-induced brain tolerance to ischemia. Physiol Rev, 2008, 88: 211-247.
6. Song G, Ouyang G, Bao S. The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med, 2005, 9: 59-71.
7. 3K-Akt-NFkappaB pathway in osteosarcoma cells. Br J Pharmacol, 2005, 146: 633-641.
8. Hersey P, Zhuang L, Zhang X D. Current strategies in overcoming resistance of cancer cells to apoptosis melanoma as a model. Int Rev Cytol, 2006, 251: 131-158.
9. Mullonkal C J, Toledo-Pereyra L H. Akt in ischemia and reperfusion. J Invest Surg, 2007, 20: 195-203.
10. Yip W K, Leong V C, Abdullah M A, et al. Overexpression of phospho-Akt correlates with phosphorylation of EGF receptor, FKHR and BAD in nasopharyngeal carcinoma. Oncol Rep, 2008, 19: 319-328.
11. 3K/Akt pathway. Acta Pharmacol Sin, 2008, 29: 815-822.
12. Allard D, Figg N, Bennett M R, et al. Akt regulates the survival of vascular smooth muscle cells via inhibition of FoxO3a and GSK3. J Biol Chem, 2008, 283: 19739-19747.
13. 3-K signaling and by promoting Bax/Bcl-XL binding. J Neurochem, 2008, 106: 1248-1258.