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Volumn 111, Issue 41, 2014, Pages 14794-14799

IKK phosphorylates RelB to modulate its promoter specificity and promote fibroblast migration downstream of TNF receptors

Author keywords

Metalloproteinase; NF kappab; Posttranslational modification; TNFalpha

Indexed keywords

I KAPPA B; I KAPPA B KINASE; NF-KAPPAB INHIBITOR ALPHA; PHOSPHOSERINE; STROMELYSIN; TRANSCRIPTION FACTOR RELB; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

EID: 84907937912     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1410124111     Document Type: Article
Times cited : (20)

References (40)
  • 1
    • 77953496625 scopus 로고    scopus 로고
    • The nf-kappab family of transcription factors and its regulation
    • Oeckinghaus A, Ghosh S (2009) The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol 1(4):a000034.
    • (2009) Cold Spring Harb Perspect Biol , vol.1 , Issue.4 , pp. a000034
    • Oeckinghaus, A.1    Ghosh, S.2
  • 2
    • 0036781052 scopus 로고    scopus 로고
    • Nf-kappab regulation in the immune system
    • Li Q, Verma IM (2002) NF-kappaB regulation in the immune system. Nat Rev Immunol 2(10):725-734.
    • (2002) Nat Rev Immunol , vol.2 , Issue.10 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 3
    • 84858726313 scopus 로고    scopus 로고
    • Regulation of cell death and autophagy by ikk and nf-κb: Critical mechanisms in immune function and cancer
    • Baldwin AS (2012) Regulation of cell death and autophagy by IKK and NF-κB: Critical mechanisms in immune function and cancer. Immunol Rev 246(1):327-345.
    • (2012) Immunol Rev , vol.246 , Issue.1 , pp. 327-345
    • Baldwin, A.S.1
  • 4
    • 43749098070 scopus 로고    scopus 로고
    • Nf-kappab and cancer-identifying targets and mechanisms
    • Naugler WE, Karin M (2008) NF-kappaB and cancer-identifying targets and mechanisms. Curr Opin Genet Dev 18(1):19-26.
    • (2008) Curr Opin Genet Dev , vol.18 , Issue.1 , pp. 19-26
    • Naugler, W.E.1    Karin, M.2
  • 5
    • 84858744393 scopus 로고    scopus 로고
    • It takes two to tango: Iκbs, the multifunctional partners of nf-κb
    • Hinz M, Arslan SC, Scheidereit C (2012) It takes two to tango: IκBs, the multifunctional partners of NF-κB. Immunol Rev 246(1):59-76.
    • (2012) Immunol Rev , vol.246 , Issue.1 , pp. 59-76
    • Hinz, M.1    Arslan, S.C.2    Scheidereit, C.3
  • 6
    • 84858734708 scopus 로고    scopus 로고
    • Nf-κb and chromatin: Ten years on the path from basic mechanisms to candidate drugs
    • Natoli G (2012) NF-κB and chromatin: Ten years on the path from basic mechanisms to candidate drugs. Immunol Rev 246(1):183-192.
    • (2012) Immunol Rev , vol.246 , Issue.1 , pp. 183-192
    • Natoli, G.1
  • 7
    • 83855162723 scopus 로고    scopus 로고
    • Principles of dimer-specific gene regulation revealed by a comprehensive characterization of nf-κb family dna binding
    • Siggers T, et al. (2012) Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-κB family DNA binding. Nat Immunol 13(1):95-102.
    • (2012) Nat Immunol , vol.13 , Issue.1 , pp. 95-102
    • Siggers, T.1
  • 8
    • 67349162130 scopus 로고    scopus 로고
    • Tumour necrosis factor and cancer
    • Balkwill F (2009) Tumour necrosis factor and cancer. Nat Rev Cancer 9(5):361-371.
    • (2009) Nat Rev Cancer , vol.9 , Issue.5 , pp. 361-371
    • Balkwill, F.1
  • 9
    • 0028931441 scopus 로고
    • Specific inhibition of relb/p52 transcriptional activity by the c-terminal domain of p100
    • Dobrzanski P, Ryseck RP, Bravo R (1995) Specific inhibition of RelB/p52 transcriptional activity by the C-terminal domain of p100. Oncogene 10(5):1003-1007.
    • (1995) Oncogene , vol.10 , Issue.5 , pp. 1003-1007
    • Dobrzanski, P.1    Ryseck, R.P.2    Bravo, R.3
  • 10
    • 84859998939 scopus 로고    scopus 로고
    • Control of nf-κb activity by proteolysis
    • Baud V, Derudder E (2011) Control of NF-κB activity by proteolysis. Curr Top Microbiol Immunol 349:97-114.
    • (2011) Curr Top Microbiol Immunol , vol.349 , pp. 97-114
    • Baud, V.1    Derudder, E.2
  • 11
    • 0037413709 scopus 로고    scopus 로고
    • Relb is required for peyer's patch development: Differential regulation of p52-relb by lymphotoxin and tnf
    • Yilmaz ZB, Weih DS, Sivakumar V, Weih F (2003) RelB is required for Peyer's patch development: Differential regulation of p52-RelB by lymphotoxin and TNF. EMBO J 22(1):121-130.
    • (2003) EMBO J , vol.22 , Issue.1 , pp. 121-130
    • Yilmaz, Z.B.1    Weih, D.S.2    Sivakumar, V.3    Weih, F.4
  • 12
    • 0037931474 scopus 로고    scopus 로고
    • Relb/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: Critical roles for p100
    • Derudder E, et al. (2003) RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: Critical roles for p100. J Biol Chem 278(26):23278-23284.
    • (2003) J Biol Chem , vol.278 , Issue.26 , pp. 23278-23284
    • Derudder, E.1
  • 13
    • 33846323310 scopus 로고    scopus 로고
    • A fourth ikappab protein within the nf-kappab signaling module
    • Basak S, et al. (2007) A fourth IkappaB protein within the NF-kappaB signaling module. Cell 128(2):369-381.
    • (2007) Cell , vol.128 , Issue.2 , pp. 369-381
    • Basak, S.1
  • 14
    • 26844572062 scopus 로고    scopus 로고
    • Rela repression of relb activity induces selective gene activation downstream of tnf receptors
    • Jacque E, Tchenio T, Piton G, Romeo PH, Baud V (2005) RelA repression of RelB activity induces selective gene activation downstream of TNF receptors. Proc Natl Acad Sci USA 102(41):14635-14640.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.41 , pp. 14635-14640
    • Jacque, E.1    Tchenio, T.2    Piton, G.3    Romeo, P.H.4    Baud, V.5
  • 15
    • 78649670803 scopus 로고    scopus 로고
    • Classical nf-kappab activation negatively regulates noncanonical nf-kappab-dependent cxcl12 expression
    • Madge LA, May MJ (2010) Classical NF-kappaB activation negatively regulates noncanonical NF-kappaB-dependent CXCL12 expression. J Biol Chem 285(49):38069-38077.
    • (2010) J Biol Chem , vol.285 , Issue.49 , pp. 38069-38077
    • Madge, L.A.1    May, M.J.2
  • 16
    • 45549105396 scopus 로고    scopus 로고
    • Stabilization of relb requires multidomain interactions with p100/p52
    • Fusco AJ, et al. (2008) Stabilization of RelB requires multidomain interactions with p100/p52. J Biol Chem 283(18):12324-12332.
    • (2008) J Biol Chem , vol.283 , Issue.18 , pp. 12324-12332
    • Fusco, A.J.1
  • 17
    • 0028817585 scopus 로고
    • Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of relb, a member of the nf-kappa b/rel family
    • Weih F, et al. (1995) Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family. Cell 80(2):331-340.
    • (1995) Cell , vol.80 , Issue.2 , pp. 331-340
    • Weih, F.1
  • 18
    • 0029851721 scopus 로고    scopus 로고
    • Inducible activation of relb in fibroblasts
    • Olashaw NE (1996) Inducible activation of RelB in fibroblasts. J Biol Chem 271(48): 30307-30310.
    • (1996) J Biol Chem , vol.271 , Issue.48 , pp. 30307-30310
    • Olashaw, N.E.1
  • 19
    • 79251536527 scopus 로고    scopus 로고
    • Iκb kinase β regulates epithelium migration during corneal wound healing
    • Chen L, Meng Q, Kao W, Xia Y (2011) IκB kinase β regulates epithelium migration during corneal wound healing. PLoS ONE 6(1):e16132.
    • (2011) PLoS ONE , vol.6 , Issue.1 , pp. e16132
    • Chen, L.1    Meng, Q.2    Kao, W.3    Xia, Y.4
  • 20
    • 39049183044 scopus 로고    scopus 로고
    • Regulation and function of ikk and ikk-related kinases
    • Häcker H, Karin M (2006) Regulation and function of IKK and IKK-related kinases. Sci STKE 2006(357):re13.
    • (2006) Sci STKE 2006 , Issue.357 , pp. re13
    • Häcker, H.1    Karin, M.2
  • 21
    • 34548076607 scopus 로고    scopus 로고
    • Interferon-gamma regulation of tnfalpha-induced matrix metalloproteinase 3 expression and migration of human glioma t98g cells
    • Cheng SM, Xing B, Li JC, Cheung BK, Lau AS (2007) Interferon-gamma regulation of TNFalpha-induced matrix metalloproteinase 3 expression and migration of human glioma T98G cells. Int J Cancer 121(6):1190-1196.
    • (2007) Int J Cancer , vol.121 , Issue.6 , pp. 1190-1196
    • Cheng, S.M.1    Xing, B.2    Li, J.C.3    Cheung, B.K.4    Lau, A.S.5
  • 22
    • 84869411578 scopus 로고    scopus 로고
    • Control of relb during dendritic cell activation integrates canonical and noncanonical nf-κb pathways
    • Shih VF, et al. (2012) Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways. Nat Immunol 13(12):1162-1170.
    • (2012) Nat Immunol , vol.13 , Issue.12 , pp. 1162-1170
    • Shih, V.F.1
  • 23
    • 84858735072 scopus 로고    scopus 로고
    • The noncanonical nf-κb pathway
    • Sun SC (2012) The noncanonical NF-κB pathway. Immunol Rev 246(1):125-140.
    • (2012) Immunol Rev , vol.246 , Issue.1 , pp. 125-140
    • Sun, S.C.1
  • 24
    • 58449136060 scopus 로고    scopus 로고
    • The alternative nf-kb activation pathway and cancer: Friend or foe?
    • Baud V, Jacque E (2008) [The alternative NF-kB activation pathway and cancer: Friend or foe?] Med Sci (Paris) 24(12):1083-1088.
    • (2008) Med Sci (Paris) , vol.24 , Issue.12 , pp. 1083-1088
    • Baud, V.1    Jacque, E.2
  • 25
    • 24944489952 scopus 로고    scopus 로고
    • Stimulus specificity of gene expression programs determined by temporal control of ikk activity
    • Werner SL, Barken D, Hoffmann A (2005) Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science 309(5742):1857-1861.
    • (2005) Science , vol.309 , Issue.5742 , pp. 1857-1861
    • Werner, S.L.1    Barken, D.2    Hoffmann, A.3
  • 26
    • 80052734912 scopus 로고    scopus 로고
    • A20-binding inhibitor of nuclear factor-kappab (nf-kappab)- 2 (abin-2) is an activator of inhibitor of nf-kappab (ikappab) kinase alpha (ikkalpha)- mediated nf-kappab transcriptional activity
    • Leotoing L, et al. (2011) A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)- 2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)- mediated NF-kappaB transcriptional activity. J Biol Chem 286(37):32277-32288.
    • (2011) J Biol Chem , vol.286 , Issue.37 , pp. 32277-32288
    • Leotoing, L.1
  • 27
    • 33750457370 scopus 로고    scopus 로고
    • Post-translational modifications regulating the activity and function of the nuclear factor kappa b pathway
    • Perkins ND (2006) Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway. Oncogene 25(51):6717-6730.
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6717-6730
    • Perkins, N.D.1
  • 28
    • 17844386319 scopus 로고    scopus 로고
    • Ikkalpha limits macrophage nf-kappab activation and contributes to the resolution of inflammation
    • Lawrence T, Bebien M, Liu GY, Nizet V, Karin M (2005) IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature 434(7037):1138-1143.
    • (2005) Nature , vol.434 , Issue.7037 , pp. 1138-1143
    • Lawrence, T.1    Bebien, M.2    Liu, G.Y.3    Nizet, V.4    Karin, M.5
  • 29
    • 0032589462 scopus 로고    scopus 로고
    • Ikappab kinases phosphorylate nf-kappab p65 subunit on serine 536 in the transactivation domain
    • Sakurai H, Chiba H, Miyoshi H, Sugita T, Toriumi W (1999) IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain. J Biol Chem 274(43):30353-30356.
    • (1999) J Biol Chem , vol.274 , Issue.43 , pp. 30353-30356
    • Sakurai, H.1    Chiba, H.2    Miyoshi, H.3    Sugita, T.4    Toriumi, W.5
  • 30
    • 80052208984 scopus 로고    scopus 로고
    • The role of rela (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration
    • Msaki A, et al. (2011) The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration. Mol Biol Cell 22(17):3032-3040.
    • (2011) Mol Biol Cell , vol.22 , Issue.17 , pp. 3032-3040
    • Msaki, A.1
  • 31
    • 17144422434 scopus 로고    scopus 로고
    • Regulation of nf-kappab and p53 through activation of atr and chk1 by the arf tumour suppressor
    • Rocha S, Garrett MD, Campbell KJ, Schumm K, Perkins ND (2005) Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. EMBO J 24(6):1157-1169.
    • (2005) EMBO J , vol.24 , Issue.6 , pp. 1157-1169
    • Rocha, S.1    Garrett, M.D.2    Campbell, K.J.3    Schumm, K.4    Perkins, N.D.5
  • 32
    • 84859430011 scopus 로고    scopus 로고
    • Fbxw7α- And gsk3-mediated degradation of p100 is a prosurvival mechanism in multiple myeloma
    • Busino L, et al. (2012) Fbxw7α- And GSK3-mediated degradation of p100 is a prosurvival mechanism in multiple myeloma. Nat Cell Biol 14(4):375-385.
    • (2012) Nat Cell Biol , vol.14 , Issue.4 , pp. 375-385
    • Busino, L.1
  • 33
    • 9144275033 scopus 로고    scopus 로고
    • Activation of ikkalpha target genes depends on recognition of specific kappab binding sites by relb:p52 dimers
    • Bonizzi G, et al. (2004) Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. EMBO J 23(21):4202-4210.
    • (2004) EMBO J , vol.23 , Issue.21 , pp. 4202-4210
    • Bonizzi, G.1
  • 34
    • 80052282195 scopus 로고    scopus 로고
    • Malt1-dependent relb cleavage promotes canonical nf-kappab activation in lymphocytes and lymphoma cell lines
    • Hailfinger S, et al. (2011) Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines. Proc Natl Acad Sci USA 108(35):14596-14601.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.35 , pp. 14596-14601
    • Hailfinger, S.1
  • 35
    • 0035819033 scopus 로고    scopus 로고
    • Signal-specific and phosphorylation-dependent relb degradation: A potential mechanism of nf-kappab control
    • Marienfeld R, et al. (2001) Signal-specific and phosphorylation-dependent RelB degradation: A potential mechanism of NF-kappaB control. Oncogene 20(56):8142-8147.
    • (2001) Oncogene , vol.20 , Issue.56 , pp. 8142-8147
    • Marienfeld, R.1
  • 36
    • 42149185026 scopus 로고    scopus 로고
    • Daxx represses relb target promoters via dna methyltransferase recruitment and dna hypermethylation
    • Puto LA, Reed JC (2008) Daxx represses RelB target promoters via DNA methyltransferase recruitment and DNA hypermethylation. Genes Dev 22(8):998-1010.
    • (2008) Genes Dev , vol.22 , Issue.8 , pp. 998-1010
    • Puto, L.A.1    Reed, J.C.2
  • 37
    • 34047095373 scopus 로고    scopus 로고
    • Oestrogen signalling inhibits invasive phenotype by repressing relb and its target bcl2
    • Wang X, et al. (2007) Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2. Nat Cell Biol 9(4):470-478.
    • (2007) Nat Cell Biol , vol.9 , Issue.4 , pp. 470-478
    • Wang, X.1
  • 38
    • 65949109942 scopus 로고    scopus 로고
    • Relb enhances prostate cancer growth: Implications for the role of the nuclear factor-kappab alternative pathway in tumorigenicity
    • Xu Y, et al. (2009) RelB enhances prostate cancer growth: Implications for the role of the nuclear factor-kappaB alternative pathway in tumorigenicity. Cancer Res 69(8):3267-3271.
    • (2009) Cancer Res , vol.69 , Issue.8 , pp. 3267-3271
    • Xu, Y.1
  • 39
    • 84874362151 scopus 로고    scopus 로고
    • The nf-κb relb protein is an oncogenic driver of mesenchymal glioma
    • Lee DW, et al. (2013) The NF-κB RelB protein is an oncogenic driver of mesenchymal glioma. PLoS ONE 8(2):e57489.
    • (2013) PLoS ONE , vol.8 , Issue.2 , pp. e57489
    • Lee, D.W.1
  • 40
    • 77950931419 scopus 로고    scopus 로고
    • Matrix metal oproteinases: Regulators of the tumor microenvironment
    • Kessenbrock K, Plaks V, Werb Z (2010) Matrix metal oproteinases: Regulators of the tumor microenvironment. Cell 141(1):52-67.
    • (2010) Cell , vol.141 , Issue.1 , pp. 52-67
    • Kessenbrock, K.1    Plaks, V.2    Werb, Z.3


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