Efficacy of ellagic acid and sildenafil in diabetes-induced sexual dysfunction

Pharmacognosy Magazine

Volumn 10, Issue 39, 2014, Pages S581-S587

  Goswami, Sumanta Kumar ^a   Vishwanath, Manikanta ^a   Gangadarappa, Suma ^a   Razdan, Rema ^a   Inamdar, Mohammed Naseeruddin ^a  

^a AL AMEEN COLLEGE OF PHARMACY   (India)

Author keywords

AGE; corpus cavernosum smooth muscle; Diabetes; ellagic acid; sexual dysfunction; sildenafil

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ELLAGIC ACID; SILDENAFIL;

ADJUVANT THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DRUG EFFICACY; ERECTILE DYSFUNCTION; FEMALE; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; SEXUAL BEHAVIOR; SEXUAL FUNCTION; SMOOTH MUSCLE RELAXATION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TREATMENT DURATION;

EID: 84907907917     PISSN: 09731296     EISSN: 09764062     Source Type: Journal    
DOI: 10.4103/0973-1296.139790     Document Type: Article

References (23)

1. Creager MA, Luscher TF, Cosentino F, Beckman JA. Diabetes and vascular disease: Pathophysiology, clinical consequences, and medical therapy: Part I. Circulation 2003;108:1527-32.
2. Hakim LS, Goldstein I. Diabetic sexual dysfunction. Endocrinol Metab Clin North Am 1996;25:379-400.
3. Musicki B, Burnett AL. Endothelial dysfunction in diabetic erectile dysfunction. Int J Impot Res 2007;19:129-38.
4. De Young L, Yu D, Bateman RM, Brock GB. Oxidative stress and antioxidant therapy: Their impact in diabetes-associated erectile dysfunction. J Androl 2004;25:830-6.
5. Daniel EM, Krupnick AS, Heur YH, Blinzler JA, Nims RW, Stoner GD. Extraction, stability, and quantitation of ellagic acid in various fruits and nuts. J Food Compost Anal 1989;2:338-49.
6. Goswami SK, Pandre MK, Jamwal R, Dethe S, Agarwal A, Inamdar MN. Screening for Rho-kinase 2 inhibitory potential of Indian medicinal plants used in management of erectile dysfunction. J Ethnopharmacol 2012;144:483-9.
7. Vattem DA, Shetty K. Biological functionality of ellagic acid: A review. J Food Biochem 2005;29:234-66.
8. Malini P, Kanchan G, Rajadurai M. Antidiabetic efficacy of ellagic acid in streptozotocin induced Diabetes mellitus in albino Wistar rats. Asian J Pharm Clin Res 2011;4:124-8.
9. Suresh S, Prakash S. Effect of Mucuna pruriens (Linn.) on sexual behavior and sperm parameters in streptozotocin-induced diabetic male rat. J Sex Med 2012;9:3066-78.
10. Pennock CA, Murphy D, Sellers J, Longdon KJ. A comparison of autoanalyser methods for the estimation of glucose in blood. Clin Chim Acta 1973;48:193-201.
11. Kaplan LA. Carbohydrates and metabolites. In: Kaplan LA, Pesce AJ, editors. Clinical Chemistry: Theory, analysis and co-relation. Toronto: C. V. Mosby; 1984. p. 1032-40.
12. Khajuria DK, Razdan R, Mahapatra DR. Description of a new method of ovariectomy in female rats. Rev Bras Reumatol 2012;52:462-70.
13. Agmo A. Male rat sexual behavior. Brain Res Protoc 1997;1:203-9.
14. Goswami SK, Inamdar MN, Pandre MK, Jamwal R, Dethe S. Erectogenic and aphrodisiac effects of Butea frondosa Koenig ex Roxb. in rats: Involvement of enzyme inhibition. Evid Based Complement Alternat Med 2013;2013:874894.
15. Perez Gutierrez RM, Flores Cotera LB, Gonzalez AM. Evaluation of the antioxidant and anti-glication effects of the hexane extract from Piper auritum leaves in vitro and beneficial activity on oxidative stress and advanced glycation end-product-mediated renal injury in streptozotocin-treated diabetic rats. Molecules 2012;17:11897-919.
16. Italiano G, Calabrò A, Pagano F. A simplified in vitro preparation of the corpus cavernosum as a tool for investigating erectile pharmacology in the rat. Pharmacol Res 1994;30:325-34.
17. Bivalacqua TJ, Champion HC, Usta MF, Cellek S, Chitaley K, Webb RC, et al. RhoA/Rho kinase suppresses endothelial nitric oxide synthase in the penis: A mechanism for diabetes-associated erectile dysfunction. Proc Natl Acad Sci USA 2004;101:9121-6.
18. Jin L, Ying Z, Webb RC. Activation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aorta. Am J Physiol Heart Circ Physiol 2004;287:H1495-500.
19. Kajimoto H, Hashimoto K, Bonnet SN, Haromy A, Harry G, Moudgil R, et al. Oxygen activates the Rho/Rho-Kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: A newly recognized mechanism for sustaining ductal constriction. Circulation 2007;115:1777-88.
20. Tsai MH, Jiang MJ. Reactive oxygen species are involved in regulating α1-adrenoceptor-activated vascular smooth muscle contraction. J Biomed Sci 2010;17:67.
21. Jernigan NL, Walker BR, Resta TC. Reactive oxygen species mediate RhoA/Rho kinase-induced Ca2+sensitization in pulmonary vascular smooth muscle following chronic hypoxia. Am J Physiol Lung Cell Mol Physiol 2008;295:L515-29.
22. Stuckey BG, Jadzinsky MN, Murphy LJ, Montorsi F, Kadioglu A, Fraige F, et al. Sildenafil citrate for treatment of erectile dysfunction in men with type 1 diabetes: Results of a randomized controlled trial. Diabetes Care 2003;26:279-84.
23. Milani E, Nikfar S, Khorasani R, Zamani MJ, Abdollahi M. Reduction of diabetes-induced oxidative stress by phosphodiesterase inhibitors in rats. Comp Biochem Physiol C Toxicol Pharmacol 2005;140:251-5.