Crystal structures and structure-activity relationships of imidazothiazole derivatives as IDO1 inhibitors

ACS Medicinal Chemistry Letters

Volumn 5, Issue 10, 2014, Pages 1119-1123

  Tojo, Shingo ^a   Kohno, Tetsuya ^a   Tanaka, Tomoyuki ^a   Kamioka, Seiji ^a   Ota, Yosuke ^a   Ishii, Takayuki ^a   Kamimoto, Keiko ^a   Asano, Shigehiro ^a   Isobe, Yoshiaki ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

crystal structure; imidazothiazole; Indoleamine 2,3 dioxygenagse 1; induced fit; structure based drug discovery

Indexed keywords

AMIDE; AMINO ACID; CARBOXYLIC ACID; ESTER DERIVATIVE; HEME; INDOLEAMINE 2,3 DIOXYGENASE; INDOLEAMINE 2,3 DIOXYGENASE 1; INDOLEAMINE 2,3 DIOXYGENASE 1 INHIBITOR; INDOLEAMINE 2,3 DIOXYGENASE INHIBITOR; ISOCYANATE; METAL COMPLEX; NITROGEN; THIAZOLE DERIVATIVE; TRIS(2 CARBOXYETHYL)PHOSPHINE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVATION; ENZYME INHIBITION; HYDROLYSIS; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION;

EID: 84907902924     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml500247w     Document Type: Article

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