Urotensin II increases foam cell formation by repressing ABCA1 expression through the ERK/NF-κB pathway in THP-1 macrophages

Biochemical and Biophysical Research Communications

Volumn 452, Issue 4, 2014, Pages 998-1003

  Wang, Yan ^a   Wu, Jian Feng ^a   Tang, Yan Yan ^b   Zhang, Min ^b   Li, Yuan ^b   Chen, Kong ^a   Zeng, Meng Ya ^a   Yao, Feng ^b   Xie, Wei ^b   Zheng, Xi Long ^c   Zeng, Gao Feng ^a   Tang, Chao Ke ^b  

^a THE SECOND AFFILIATED HOSPITAL OF UNIVERSITY OF SOUTH CHINA   (China)

^b UNIVERSITY OF SOUTH CHINA   (China)

^c UNIVERSITY OF CALGARY   (Canada)

Author keywords

ABCA1; Cholesterol efflux; ERK; NF B; Urotensin II

Indexed keywords

ABC TRANSPORTER A1; CHOLESTEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; RNA; UROTENSIN II; ABCA1 PROTEIN, HUMAN; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN; UROTENSIN;

ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FOAM CELL; GENE CONTROL; GENE REPRESSION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MACROPHAGE; CELL LINE; CELL PROLIFERATION; CYTOLOGY; DOWN REGULATION; DRUG EFFECTS; LIPID METABOLISM; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ATP BINDING CASSETTE TRANSPORTER 1; CELL LINE; CELL PROLIFERATION; CHOLESTEROL; DOWN-REGULATION; FOAM CELLS; HUMANS; LIPID METABOLISM; MAP KINASE SIGNALING SYSTEM; NF-KAPPA B; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; UROTENSINS;

EID: 84907891096     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.09.030     Document Type: Article

References (35)

1. G.J. Randolph Mechanisms that regulate macrophage burden in atherosclerosis Circ. Res. 114 11 2014 1757 1771
2. Y. Yamauchi, C.C. Chang, M. Hayashi, S. Abe-Dohmae, P.C. Reid, and T.Y. Chang Intracellular cholesterol mobilization involved in the ABCA1/apolipoprotein-mediated assembly of high density lipoprotein in fibroblasts J. Lipid Res. 45 10 2004 1943 1951
3. G.J. Zhao, K. Yin, Y.C. Fu, and C.K. Tang The interaction of ApoA-I and ABCA1 triggers signal transduction pathways to mediate efflux of cellular lipids Mol. Med. 18 2012 149 158
4. R.J. Aiello, D. Brees, P.A. Bourassa, L. Royer, S. Lindsey, and T. Coskran Increased atherosclerosis in hyperlipidemic mice with inactivation of ABCA1 in macrophages Arterioscler. Thromb. Vasc. Biol. 22 4 2002 630 637
5. R.R. Singaraja, H. Visscher, E.R. James, A. Chroni, J.M. Coutinho, and L.R. Brunham Specific mutations in ABCA1 have discrete effects on ABCA1 function and lipid phenotypes both in vivo and in vitro Circ. Res. 99 4 2006 389 397
6. J.F. Oram, and A.M. Vaughan ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins Curr. Opin. Lipidol. 11 3 2000 253 260
7. R.S. Ames, H.M. Sarau, J.K. Chambers, R.N. Willette, N.V. Aiyar, and A.M. Romanic Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14 Nature 401 6750 1999 282 286
8. S.A. Douglas, and E.H. Ohlstein Human urotensin-II, the most potent mammalian vasoconstrictor identified to date, as a therapeutic target for the management of cardiovascular disease Trends Cardiovasc. Med. 10 6 2000 229 237
9. N. Bousette, L. Patel, S.A. Douglas, E.H. Ohlstein, and A. Giaid Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta Atherosclerosis 176 1 2004 117 123
10. T. Watanabe, S. Arita, Y. Shiraishi, T. Suguro, T. Sakai, and S. Hongo Human urotensin II promotes hypertension and atherosclerotic cardiovascular diseases Curr. Med. Chem. 16 5 2009 550 563
11. S.A. Douglas, A.C. Sulpizio, V. Piercy, H.M. Sarau, R.S. Ames, and N.V. Aiyar Differential vasoconstrictor activity of human urotensin-II in vascular tissue isolated from the rat, mouse, dog, pig, marmoset and cynomolgus monkey Br. J. Pharmacol. 131 7 2000 1262 1274
12. L. Shi, W. Ding, D. Li, Z. Wang, H. Jiang, and J. Zhang Proliferation and anti-apoptotic effects of human urotensin II on human endothelial cells Atherosclerosis 188 2 2006 260 264
13. T. Watanabe, T. Suguro, T. Kanome, Y. Sakamoto, S. Kodate, and T. Hagiwara Human urotensin II accelerates foam cell formation in human monocyte-derived macrophages Hypertension 46 4 2005 738 744
14. D. Yan, M.I. Mayranpaa, J. Wong, J. Perttila, M. Lehto, and M. Jauhiainen OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages J. Biol. Chem. 283 1 2008 332 340
15. G.J. Zhao, S.L. Tang, Y.C. Lv, X.P. Ouyang, P.P. He, and F. Yao NF-kappaB suppresses the expression of ATP-binding cassette transporter A1/G1 by regulating SREBP-2 and miR-33a in mice Int. J. Cardiol. 171 3 2014 e93 e95
16. Y.C. Lv, K. Yin, Y.C. Fu, D.W. Zhang, W.J. Chen, and C.K. Tang Posttranscriptional regulation of ATP-binding cassette transporter A1 in lipid metabolism DNA Cell Biol. 32 7 2013 348 358
17. C.Y. Lee, Y.T. Tsai, S.H. Loh, J.C. Liu, T.H. Chen, and H.H. Chao Urotensin II induces interleukin 8 expression in human umbilical vein endothelial cells PLoS ONE 9 2 2014 e90278
18. X. Zhou, Z. Yin, X. Guo, D.P. Hajjar, and J. Han Inhibition of ERK1/2 and activation of liver X receptor synergistically induce macrophage ABCA1 expression and cholesterol efflux J. Biol. Chem. 285 9 2010 6316 6326
19. P. Ziltener, C. Mueller, B. Haenig, M.W. Scherz, and O. Nayler Urotensin II mediates ERK1/2 phosphorylation and proliferation in GPR14-transfected cell lines J. Recept. Signal Transduction Res. 22 1-4 2002 155 168
20. Y.W. Hu, Q. Wang, X. Ma, X.X. Li, X.H. Liu, and J. Xiao TGF-beta1 up-regulates expression of ABCA1, ABCG1 and SR-BI through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells J. Atherosclerosis Thrombosis 17 5 2010 493 502
21. X.R. Hao, D.L. Cao, Y.W. Hu, X.X. Li, X.H. Liu, and J. Xiao IFN-gamma down-regulates ABCA1 expression by inhibiting LXR alpha in a JAK/STAT signaling pathway-dependent manner Atherosclerosis 203 2 2009 417 428
22. C.K. Tang, G.H. Yi, J.H. Yang, L.S. Liu, Z. Wang, and C.G. Ruan Oxidized LDL upregulated ATP binding cassette transporter-1 in THP-1 macrophages Acta Pharmacol. Sin. 25 5 2004 581 586
23. C.K. Tang, G.H. Tang, G.H. Yi, Z. Wang, L.S. Liu, and S. Wan Effect of apolipoprotein A-I on ATP binding cassette transporter A1 degradation and cholesterol efflux in THP-1 macrophage-derived foam cells Acta Biochim. Biophys. Sin. 36 3 2004 218 226
24. C.K. Tang, J.H. Yang, G.H. Yi, Z. Wang, L.S. Liu, and Z.Y. Wan Effects of oleate on ATP binding cassette transporter A1 expression and cholesterol efflux in THP-1 macrophage-derived foam cells Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35 12 2003 1077 1082
25. P. Costet, F. Lalanne, M.C. Gerbod-Giannone, J.R. Molina, X. Fu, and E.G. Lund Retinoic acid receptor-mediated induction of ABCA1 in macrophages Mol. Cell. Biol. 23 21 2003 7756 7766
26. S. Arora, and S.J. Nicholls Atherosclerotic plaque reduction: blood pressure, dyslipidemia, atherothrombosis Drugs Today 44 9 2008 711 718
27. K. Yin, D.F. Liao, and C.K. Tang ATP-binding membrane cassette transporter A1 (ABCA1): a possible link between inflammation and reverse cholesterol transport Mol. Med. 16 9-10 2010 438 449
28. G. Li, H.M. Gu, and D.W. Zhang ATP-binding cassette transporters and cholesterol translocation IUBMB Life 65 6 2013 505 512
29. L. Yvan-Charvet, N. Wang, and A.R. Tall Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses Arterioscler. Thromb. Vasc. Biol. 30 2 2010 139 143
30. H. Al Kindi, A. Hafiane, Z. You, I. Albanese, L. Pilote, and J. Genest Circulating levels of the vasoactive peptide urotensin II in patients with acute coronary syndrome and stable coronary artery disease Peptides 55 2014 151 157
31. J.J. Maguire, R.E. Kuc, K.E. Wiley, M.J. Kleinz, and A.P. Davenport Cellular distribution of immunoreactive urotensin-II in human tissues with evidence of increased expression in atherosclerosis and a greater constrictor response of small compared to large coronary arteries Peptides 25 10 2004 1767 1774
32. J.P. Segain, M. Rolli-Derkinderen, N. Gervois, D. Raingeard de la Bletiere, G. Loirand, and P. Pacaud Urotensin II is a new chemotactic factor for UT receptor-expressing monocytes J. Immunol. 179 2 2007 901 909
33. D. Duffy, and D.J. Rader Update on strategies to increase HDL quantity and function Nat. Rev. Cardiol. 6 7 2009 455 463
34. J.F. Wu, Y. Wang, M. Zhang, Y.Y. Tang, B. Wang, and P.P. He Growth differentiation factor-15 induces expression of ATP-binding cassette transporter A1 through PI3-K/PKCzeta/SP1 pathway in THP-1 macrophages Biochem. Biophys. Res. Commun. 444 3 2014 325 331
35. D.J. Rader, E.T. Alexander, G.L. Weibel, J. Billheimer, and G.H. Rothblat The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis J. Lipid Res. 50 Suppl. 2009 S189 S194