Introduction of gluten, HLA status, and the risk of celiac disease in children

New England Journal of Medicine

Volumn 371, Issue 14, 2014, Pages 1295-1303

  Lionetti, Elena ^a,b   Castellaneta, Stefania ^a,e   Francavilla, Ruggiero ^a,f   Pulvirenti, Alfredo ^a,c,d   Tonutti, Elio ^a,g   Arnarri, Sergio ^a,h   Barbato, Maria ^a,i   Barbera, Cristiana ^a,j   Barera, Graziano ^a,k   Bellantoni, Antonelia ^a,m   Castellano, Emanuela ^a,n   Guariso, Graziella ^a,o   Limongelli, Maria Giovanna ^a,p   Pellegrino, Salvatore ^a,q   Polloni, Carlo ^a,r   Ughi, Claudio ^a,s   Zuin, Giovanna ^a,l   Fasano, Alessio ^a,t,u   Catassi, Carlo ^a,b,u  

^a SIGENP (Italian Society of Pediatric Gastroenterology Hepatology and Nutrition)   (Italy)

^b UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^c Departmentof Pediatrics   (Italy)

^d Clinical and Molecular Biomedicine   (Italy)

^e UNIVERSITY OF CATANIA   (Italy)

^f UNIVERSITY OF BARI   (Italy)

^g UNIVERSITY HOSPITAL OF UDINE   (Italy)

^h S MARIA NUOVA HOSPITAL   (Italy)

ⁱ SAPIENZA UNIVERSITY OF ROME   (Italy)

^j UNIVERSITY OF TURIN   (Italy)

^k SAN RAFFAELE HOSPITAL   (Italy)

^l V BUZZI CHILDREN S HOSPITAL   (Italy)

^m BIANCHI MELACRINO MORELLI HOSPITAL   (Italy)

ⁿ G GASLINI INSTITUTE   (Italy)

^o UNIVERSITY OF PADOVA   (Italy)

^p UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^q UNIVERSITY OF MESSINA   (Italy)

^r Rovereto Hospital   (Italy)

^s UNIVERSITY OF PISA   (Italy)

^t Division of Pediatric Gastroenterology and Nutrition and Center for Celiac Research MassGeneral Hospital for Children   (Italy)

^u HARVARD MEDICAL SCHOOL   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ENDOMYSIUM ANTIBODY; GLIADIN ANTIBODY; GLUTEN; HLA ANTIGEN; HLA DQ2 ANTIGEN; HLA DQ8 ANTIGEN; AUTOANTIBODY; GLIADIN; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2;

AGE; ALLELE; ANTIBODY BLOOD LEVEL; AUTOIMMUNITY; BREAST FEEDING; CELIAC DISEASE; CHILD; CHILD NUTRITION; CLINICAL EFFECTIVENESS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIETARY INTAKE; FEMALE; FOLLOW UP; GENETIC PREDISPOSITION; GENETIC RISK; GENOTYPE; GLUTEN FREE DIET; HIGH RISK POPULATION; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN A DEFICIENCY; INTESTINE BIOPSY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OUTCOME ASSESSMENT; PREVALENCE; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; REVIEW; RISK ASSESSMENT; RISK FACTOR; SEROLOGY; ARTICLE; BLOOD; COMPARATIVE STUDY; DIET; GENETICS; IMMUNOLOGY; INFANT; KAPLAN MEIER METHOD; NEWBORN; ONSET AGE; PATHOLOGY; PRESCHOOL CHILD; PROTEIN INTAKE; RISK; SMALL INTESTINE;

AGE FACTORS; AGE OF ONSET; AUTOANTIBODIES; BREAST FEEDING; CELIAC DISEASE; CHILD; CHILD, PRESCHOOL; DIET; DIETARY PROTEINS; FEMALE; GENOTYPE; GLIADIN; GLUTENS; GTP-BINDING PROTEINS; HLA ANTIGENS; HUMANS; INFANT; INFANT, NEWBORN; INTESTINE, SMALL; KAPLAN-MEIER ESTIMATE; MALE; PROSPECTIVE STUDIES; RISK; TRANSGLUTAMINASES;

EID: 84907863258     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1400697     Document Type: Article

References (36)

1. Fasano A, Catassi C. Celiac disease. N Engl J Med 2012;367:2419-26.
2. Green PH, Cellier C. Celiac disease. N Engl J Med 2007;357:1731-43.
3. Rubio-Tapia A, Van Dyke CT, Lahr BD, et al. Predictors of family risk for celiac disease: a population-based study. Clin Gastroenterol Hepatol 2008;6:983-7.
4. Högberg L, Fälth-Magnusson K, Grodzinsky E, Stenhammar L. Familial prevalence of coeliac disease: a twenty-year follow-up study. Scand J Gastroenterol 2003;38:61-5.
5. Catassi C, Kryszak D, Bhatti B, et al. Natural history of celiac disease autoimmunity in a USA cohort followed since 1974. Ann Med 2010;42:530-8.
6. Abadie V, Sollid LM, Barreiro LB, Jabri B. Integration of genetic and immunological insights into a model of celiac disease pathogenesis. Annu Rev Immunol 2011;29:493-525.
7. Liu E, Lee HS, Aronsson CA, et al. Risk of pediatric celiac disease according to HLA haplotype and country. N Engl J Med 2014;371:42-9.
8. Latronico N. History of pediatrics. Torino, Italy: Minerva Medica, 1977.
9. Prescott SL, Smith P, Tang M, et al. The importance of early complementary feeding in the development of oral tolerance: concerns and controversies. Pediatr Allergy Immunol 2008;19:375-80.
10. Zeiger RS, Heller S. The development and prediction of atopy in high-risk children: follow-up at age seven years in a prospective randomized study of combined maternal and infant food allergen avoidance. J Allergy Clin Immunol 1995; 95:1179-90.
11. Ivarsson A, Persson LA, Nyström L, et al. Epidemic of coeliac disease in Swedish children. Acta Paediatr 2000;89:165-71.
12. Ivarsson A, Myléus A, Norström F, et al. Prevalence of childhood celiac disease and changes in infant feeding. Pediatrics 2013;131(3):e687-e694.
13. Norris JM, Barriga K, Klingensmith G, et al. Timing of initial cereal exposure in infancy and risk of islet autoimmunity. JAMA 2003;290:1713-20.
14. Norris JM, Barriga K, Hoffenberg EJ, et al. Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease. JAMA 2005;293:2343-51.
15. Agostoni C, Decsi T, Fewtrell M, et al. Complementary feeding: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 2008; 46:99-110.
16. van Overbeek FM, Uil-Dieterman IG, Mol IW, Köhler-Brands L, Heymans HS, Mulder CJ. The daily gluten intake in relatives of patients with coeliac disease compared with that of the general Dutch population. Eur J Gastroenterol Hepatol 1997;9:1097-9.
17. Lionetti E, Castellaneta S, Pulvirenti A, et al. Prevalence and natural history of potential celiac disease in at-family-risk infants prospectively investigated from birth. J Pediatr 2012;161:908-14.
18. Romanos J, van Diemen CC, Nolte IM, et al. Analysis of HLA and non-HLA alleles can identify individuals at high risk for celiac disease. Gastroenterology 2009; 137:834-40.
19. Romanos J, Rosén A, Kumar V, et al. PreventCD Group. Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants. Gut 2014;63:415-22.
20. Oberhuber G, Granditsch G, Vogelsang H. The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol 1999;11:1185-94.
21. Hothorn T, Hornik K, Zeileis A. Unbiased recursive partitioning: A conditional inference framework. J Comput Graph Stat 2006;15:651-74.
22. Hummel S, Pflüger M, Hummel M, Bonifacio E, Ziegler AG. Primary dietary intervention study to reduce the risk of islet autoimmunity in children at increased risk for type 1 diabetes: the BABYDIET study. Diabetes Care 2011;34:1301-5.
23. Vader W, Stepniak D, Kooy Y, et al. The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses. Proc Natl Acad Sci U S A 2003; 100:12390-5.
24. Ziegler AG, Schmid S, Huber D, Hummel M, Bonifacio E. Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies. JAMA 2003; 290:1721-8.
25. Størdal K, White RA, Eggesbø M. Early feeding and risk of celiac disease in a prospective birth cohort. Pediatrics 2013;132 (5):e1202-e1209. Published online 2013Oct7.
26. Ivarsson A, Hernell O, Stenlund H, Persson LA. Breast-feeding protects against celiac disease. Am J Clin Nutr 2002;75:914-21.
27. Peters U, Schneeweiss S, Trautwein EA, Erbersdobler HF. A case-control study of the effect of infant feeding on celiac disease. Ann Nutr Metab 2001;45:135-42.
28. Greco L, Auricchio S, Mayer M, Grimaldi M. Case control study on nutritional risk factors in celiac disease. J Pediatr Gastroenterol Nutr 1988;7:395-9.
29. Auricchio S, Folio D, de Ritis G, et al. Does breast feeding protect against the development of clinical symptoms of celiac disease in children? J Pediatr Gastroenterol Nutr 1983;2:428-33.
30. Akobeng AK, Ramanan AV, Buchan I, Heller RF. Effect of breast feeding on risk of coeliac disease: a systematic review and meta-analysis of observational studies. Arch Dis Child 2006;91:39-43.
31. Szajewska H, Chmielewska A, Pies̈cik-Lech M, et al. Systematic review: early infant feeding and the prevention of coeliac disease. Aliment Pharmacol Ther 2012; 36:607-18.
32. Vriezinga SL, Auricchio R, Bravi E, et al. Randomized feeding intervention in infants at high risk for celiac disease. N Engl J Med 2014;371:1304-15.
33. Hill ID, Dirks MH, Liptak GS, et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 2005;40:1-19.
34. Hus by S, Koletzko S, Korponay-Szabó IR, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr 2012;54:136-60.
35. Tosco A, Salvati VM, Auricchio R, et al. Natural history of potential celiac disease in children. Clin Gastroenterol Hepatol 2011;9:320-5.
36. Anderson RP, Henry MJ, Taylor R, et al. A novel serogenetic approach determines the community prevalence of celiac disease and informs improved diagnostic pathways. BMC Med 2013;11:188.