Studies on the anticonvulsant activity of 4-alkyl-1,2,4-triazole-3-thiones and their effect on GABAergic system

European Journal of Medicinal Chemistry

Volumn 86, Issue , 2014, Pages 690-699

  Plech, Tomasz ^a   Kaproń, Barbara ^a   Łuszczki, Jarogniew J ^a,b   Paneth, Agata ^a   Siwek, Agata ^c   Kołaczkowski, Marcin ^c   Zołnierek, Maria ^c   Nowak, Gabriel ^c  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

^c JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

(MES) test; 124 Triazole 3 thiones; Chimney test; GABAergic system; Maximal electroshock induced seizure; Radioligand binding assay

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 BUTYL 5 (2,3 DICHLOROPHENYL) 4 ETHYL 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 4 BUTYL 5 (3 CHLOROBENZYL) 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 5 (2,3 DICHLOROPHENYL) 4 ETHYL 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 5 (2,3 DICHLOROPHENYL) 4 HEPTYL 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 5 (2,3 DICHLOROPHENYL) 4 HEXYL 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 5 (2,3 DICHLOROPHENYL) 4 PENTYL 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 5 (3 CHLOROBENZYL) 4 DECYL 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 5 (3 CHLOROBENZYL) 4 DODECYL 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 5 (3 CHLOROBENZYL) 4 ETHYL 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 5 (3 CHLOROBENZYL) 4 HEPTYL 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 5 (3 CHLOROBENZYL) 4 HEXYL 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 5 (3 CHLOROBENZYL) 4 NONYL 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 5 (3 CHLOROBENZYL) 4 OCTYL 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; 5 (3 CHLOROBENZYL) 4 PENTYL 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; BENZODIAZEPINE; RADIOLIGAND; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; ANTICONVULSIVE AGENT; MERCAPTOTRIAZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; BINDING ASSAY; BINDING SITE; CHIMNEY TEST; CONTROLLED STUDY; GABAERGIC SYSTEM; MALE; MOTOR PERFORMANCE; MOUSE; NONHUMAN; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; ELECTRIC SHOCK; METABOLISM; SEIZURES; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTICONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROSHOCK; MALE; MICE; MOLECULAR STRUCTURE; RECEPTORS, GABA-A; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84907855614     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.09.034     Document Type: Article

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