Structure and function of the UV-B photoreceptor UVR8

Current Opinion in Structural Biology

Volumn 29, Issue , 2014, Pages 52-57

  Jenkins, Gareth I ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; RECEPTOR; UBIQUITIN PROTEIN LIGASE COP1; UNCLASSIFIED DRUG; UV RESISTANCE LOCUS 8 PROTEIN; ARABIDOPSIS PROTEIN; COP1 PROTEIN, ARABIDOPSIS; NONHISTONE PROTEIN; UBIQUITIN PROTEIN LIGASE; UVR8 PROTEIN, ARABIDOPSIS; VISUAL PROTEINS AND PIGMENTS;

AMINO TERMINAL SEQUENCE; ARABIDOPSIS; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CHEMICAL BOND; DIMERIZATION; ENERGY TRANSFER; NONHUMAN; PHOTOMORPHOGENESIS; PHOTORECEPTOR; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SURFACE PROPERTY; ULTRAVIOLET B RADIATION; CHEMICAL STRUCTURE; CHEMISTRY; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION;

ARABIDOPSIS; ARABIDOPSIS PROTEINS; CHROMOSOMAL PROTEINS, NON-HISTONE; MODELS, MOLECULAR; PHOTORECEPTORS, PLANT; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES;

EID: 84907817560     PISSN: 0959440X     EISSN: 1879033X     Source Type: Journal    
DOI: 10.1016/j.sbi.2014.09.004     Document Type: Review

References (44)

1. Frohnmeyer H., Staiger D. Ultraviolet-B radiation-mediated responses in plants. Balancing damage and protection. Plant Physiol 2003, 133:1420-1428.
2. Ulm R., Nagy F. Signalling and gene regulation in response to ultraviolet light. Curr Opin Plant Biol 2005, 8:1-6.
3. Jenkins G.I. Signal transduction in responses to UV-B radiation. Ann Rev Plant Biol 2009, 60:407-431.
4. Kliebenstein D.J., Lim J.E., Landry L.G., Last R.L. Arabidopsis UVR8 regulates ultraviolet-B signal transduction and tolerance and contains sequence similarity to human Regulator of Chromatin Condensation 1. Plant Physiol 2002, 130:234-243.
5. Brown B.A., Cloix C., Jiang G.H., Kaiserli E., Herzyk P., Kliebenstein D.J., Jenkins G.I. A UV-B-specific signaling component orchestrates plant UV protection. Proc Natl Acad Sci U S A 2005, 102:18225-18230.
6. Favory J.J., Stec A., Gruber H., Rizzini L., Oravecz A., Funk M., Albert A., Cloix C., Jenkins G.I., Oakeley E.J., Seidlitz H.K., Nagy F., Ulm R. Interaction of COP1 and UVR8 regulates UV-B-induced photomorphogenesis and stress acclimation in Arabidopsis. EMBO J 2009, 28:591-601.
7. Rizzini L., Favory J.-J., Cloix C., Faggionato D., O'Hara A., Kaiserli E., Baumeister R., Schäfer E., Nagy F., Jenkins G.I., Ulm R. Perception of UV-B by the Arabidopsis UVR8 protein. Science 2011, 332:103-106.
8. Tilbrook K., Arongaus A.B., Binkert M., Heijde M., Yin R., Ulm R. The UVR8 UV-B photoreceptor: perception, signaling and response. Arabidopsis Book 2013, 11:e0164. 10.1199/tab.0164.
9. Jenkins G.I. The UV-B photoreceptor UVR8: from structure to physiology. Plant Cell 2014, 26:21-37.
10. Christie J.M., Arvai A.S., Baxter K.J., Heilmann M., Pratt A.J., O'Hara A., Kelly S.M., Hothorn M., Smith B.O., Hitomi K., Jenkins G.I., Getzoff E.D. Plant UVR8 photoreceptor senses UV-B by tryptophan-mediated disruption of cross-dimer salt bridges. Science 2012, 335:1492-1496.
11. Wu D., Hu Q., Yan Z., Chen W., Yan C., Huang X., Zhang J., Yang P., Deng H., Wang J., Deng X., Shi Y. Structural basis of ultraviolet-B perception by UVR8. Nature 2012, 484:214-219.
12. Jiang L., Wang Y., Björn L.O., He J.-X., Li S.-S. Sensing of UV-B radiation by plants. Plant Signal Behav 2012, 7:1-5.
13. Heijde M., Ulm R. UV-B photoreceptor-mediated signaling in plants. Trends Plant Sci 2012, 17:230-237.
14. Li J., Yang L., Jin D., Nezames C.D., Terzaghi W., Deng X.-W. UV-B-induced photomorphogenesis in Arabidopsis. Protein Cell 2013, 4:485-492.
15. Xu C., Min J. Structure and function of WD40 domain proteins. Protein Cell 2011, 2:202-214.
16. Renault L., Nassar N., Vetter I., Becker J., Klebe C., Roth M., Wittinghofer A. The 1.7A crystal structure of the regulator of chromatin condensation (RCC1) reveals a seven-bladed propeller. Nature 1998, 392:97-101.
17. Hadjebi O., Casas-Terradellas E., Garcia-Gonzalo F.R., Rosa J.L. The RCC1 superfamily: from genes, to function, to disease. Biochim Biophys Acta 2008, 1783:1467-1479.
18. Huang X., Yang P., Ouyang X., Chen L., Deng X.W. Photoactivated UVR8-COP1 module determines photomorphogenic UV-B signaling output in Arabidopsis. PLOS Genet 2014, 10:e1004218.
19. Wu M., Strid A., Eriksson L.A. Interactions and stabilities of the UV RESISTANCE LOCUS8 (UVR8) protein dimer and its key mutants. J Chem Inf Model 2013, 53:1736-1746.
20. O'Hara A., Jenkins G.I. In vivo function of tryptophans in the Arabidopsis UV-B photoreceptor UVR8. Plant Cell 2012, 24:3755-3766.
21. Heijde M., Binkert M., Yin R., Ares-Orpel F., Rizzini L., Van De Slijke E., Persiau G., Nolf J., Gevaert K., De Jaeger G., Ulm R. Constitutively active UVR8 photoreceptor variant in Arabidopsis. Proc Natl Acad Sci U S A 2013, 110:20326-20331.
22. Wu M., Strid A., Eriksson L.A. Photochemical reaction mechanism of UV-B-induced monomerization of UVR8 dimers as the first signaling event in UV-B-regulated gene expression in plants. J Phys Chem B 2014, 118:951-965.
23. Li X., Chung L.W., Morokuma K., Li G. A theoretical study on the UVR8 photoreceptor: sensing ultraviolet-B by tryptophan and dissociation of homodimer. J Chem Theory Comput 2014, 10:3319-3330.
24. Voityuk A.A., Marcus R.A., Michel-Beyerle M. On the mechanism of photoinduced dimer dissociation in the plant UVR8 photoreceptor. Proc Natl Acad Sci U S A 2014, 111:5219-5224.
25. Liu Z., Li X., Zhong F.W., Li J., Wang L., Shi Y., Zhong D. Quenching dynamics of ultraviolet-light perception by UVR8 photoreceptor. J Phys Chem Lett 2014, 5:69-72.
26. Brown B.A., Jenkins G.I. UV-B signaling pathways with different fluence-rate response profiles are distinguished in mature Arabidopsis leaf tissue by requirement for UVR8, HY5, and HYH. Plant Physiol 2008, 146:576-588.
27. Safrany J., Haasz V., Mate Z., Ciolfi A., Feher B., Oravecz A., Stec A., Dalllmann G., Morelli G., Ulm R., Nagy F. Identification of a novel cis-regulatory element for UV-B-induced transcription in Arabidopsis. Plant J 2008, 54:402-414.
28. Brown B.A., Headland L.R., Jenkins G.I. UV-B action spectrum for UVR8-mediated HY5 transcript accumulation in Arabidopsis. Photochem Photobiol 2009, 85:1147-1155.
29. Huang X., Ouyang X., Yang P., Lau O.S., Chen L., Wei N., Deng X.W. Conversion from CUL4-based COP1-SPA E3 apparatus to UVR8-COP1-SPA complexes underlies a distinct biochemical function of COP1 under UV-B. Proc Natl Acad Sci U S A 2013, 110:16669-16674.
30. Oravecz A., Baumann A., Máté Z., Brzezinska A., Molinier J., Oakeley E.J., Ádám É., Schäfer E., Nagy F., Ulm R. CONSTITUTIVELY PHOTOMORPHOGENIC1 is required for the UV-B response in Arabidopsis. Plant Cell 2006, 18:1975-1990.
31. Huang X., Ouyang X., Yang P., Lau O.S., Li G., Li J., Chen H., Deng X.W. Arabidopsis FHY3 and HY5 positively mediate induction of COP1 transcription in response to photomorphogenic UV-B light. Plant Cell 2012, 24:4590-4606.
32. Lau O.S., Deng X.W. The photomorphogenic repressors COP1 and DET1: 20 years later. Trends Plant Sci 2012, 17:584-593.
33. Zhu D., Maier A., Lee J.-H., Laubinger S., Saijo Y., Wang H., Qu L.-J., Hoecker U., Deng X.W. Biochemical characterization of Arabidopsis complexes containing CONSTITUTIVELY PHOTOMORPHOGENIC1 and SUPPRESSOR OF PHYA proteins in light control of plant development. Plant Cell 2008, 20:2307-2323.
34. Osterlund M.T., Hardtke C.S., Wei N., Deng X.W. Targeted destabilization of HY5 during light-regulated development of Arabidopsis. Nature 2000, 405:462-466.
35. Huang X., Deng X.W. Organization of protein complexes under photomorphogenic UV-B in Arabidopsis. Plant Signal Behav 2013, 8:e27206.
36. Cloix C., Kaiserli K., Heilmann M., Baxter K.J., Brown B.A., O'Hara A., Smith B.O., Christie J.M., Jenkins G.I. The C-terminal region of the UV-B photoreceptor UVR8 initiates signaling through interaction with COP1. Proc Natl Acad Sci U S A 2012, 109:16366-16370.
37. Wu M., Eriksson L.A., Strid A. Theoretical prediction of the protein-protein interaction between Arabidopsis thaliana COP1 and UVR8. Theor Chem Acc 2013, 132:1371.
38. Heilmann M., Jenkins G.I. Rapid reversion from monomer to dimer regenerates the ultraviolet-B photoreceptor UV RESISTANCE LOCUS8 in intact Arabidopsis plants. Plant Physiol 2013, 161:547-555.
39. Heijde M., Ulm R. Reversion of the Arabidopsis UV-B photoreceptor UVR8 to the homodimeric ground state. Proc Natl Acad Sci U S A 2013, 110:1113-1118.
40. Grüber H., Heijde M., Heller W., Albert A., Seidlitz H.K., Ulm R. Negative feedback regulation of UV-B-induced photomorphogenesis and stress acclimation in Arabidopsis. Proc Natl Acad Sci U S A 2010, 107:20132-20137.
41. Kaiserli E., Jenkins G.I. UV-B promotes rapid nuclear translocation of the UV-B-specific signaling component UVR8 and activates its function in the nucleus. Plant Cell 2007, 19:2662-2673.
42. Indorf M., Cordero J., Neuhaus G., Rodriguez-Franco M. Salt tolerance (STO), a stress-related protein, has a major role in light signalling. Plant J 2007, 51:563-574.
43. Jiang L., Wang Y., Li Q.F., Bjorn L.O., He J.X., Li S.S. Arabidopsis STO/BBX24 negatively regulates UV-B signaling by interacting with COP1 and repressing HY5 transcriptional activity. Cell Res 2012, 22:1046-1057.
44. Jiang L., Wang Y., Bjorn L.O., Li S. Arabidopsis RADICAL-INDUCED CELL DEATH1 is involved in UV-B signaling. Photochem Photobiol Sci 2009, 8:838-846.