Azurocidin‑induced inhibition of oxygen metabolism in mitochondria is antagonized by heparin

Experimental and Therapeutic Medicine

Volumn 8, Issue 5, 2014, Pages 1473-1478

  Wang, Liang ^a   Liu, Zhiyong ^a   Dong, Zhe ^a   Pan, Jieyi ^a   Ma, Xiaochun ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Azurocidin; Heparin; Mitochondrial oxygen metabolism function; Sepsis

Indexed keywords

AZUROCIDIN; GREEN FLUORESCENT PROTEIN; HEPARIN;

ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG ANTAGONISM; ELECTRON MICROSCOPY; ENDOCYTOSIS; FLOW CYTOMETRY; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MITOCHONDRIAL OXYGEN METABOLISM; POLYMERASE CHAIN REACTION; PROGNOSIS; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; SEPSIS; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING;

EID: 84907813382     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2014.1939     Document Type: Article

References (22)

1. Mu E, Ding R, An X, et al: Heparin attenuates lipopolysaccharide-induced acute lung injury by inhibiting nitric oxide synthase and TGF-β/Smad signaling pathway. Thromb Res 129: 479-485, 2012.
2. Zhao D, Ding R, Mao Y, et al: Heparin rescues sepsis-associated acute lung injury and lethality through the suppression of inflammatory responses. Inflammation 35: 1825-1832, 2012.
3. Ding R, Zhao D, Guo R, Zhang Z and Ma X: Treatment with unfractionated heparin attenuates coagulation and inflammation in endotoxemic mice. Thromb Res 128: e160-e165, 2011.
4. Han J, Ding R, Zhao D, Zhang Z and Ma X: Unfractionated heparin attenuates lung vascular leak in a mouse model of sepsis: role of RhoA/Rho kinase pathway. Thromb Res 132: e42-e47, 2013.
5. Levy MM, Fink MP, Marshall JC, et al; International Sepsis Definitions Conference: 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 29: 530-538, 2003.
6. Garrabou G, Morén C, López S, et al: The effects of sepsis on mitochondria. J Infect Dis 205: 392-400, 2012.
7. Spronk PE, Kanoore-Edul VS and Ince C: Microcirculatory and mitochondrial distress syndrome (MMDS): A new look at sepsis. In: Functional Hemodynamic Monitoring. Pinsky MR and Payden D (eds). Vol 42. Springer, Berlin, pp47-67, 2005.
8. Totsukawa G, Yamakita Y, Yamashiro S, et al: Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts. J Cell Biol 150: 797-806, 2000.
9. Rasmussen PB, Bjørn S, Hastrup S, et al: Characterization of recombinant human HBP/CAP37/azurocidin, a pleiotropic mediator of inflammation-enhancing LPS-induced cytokine release from monocytes. FEBS Lett 390: 109-112, 1996.
10. Olofsson AM, Vestberg M, Herwald H, et al: Heparin-binding protein targeted to mitochondrial compartments protects endothelial cells from apoptosis. J Clin Invest 104: 885-894, 1999.
11. Mai S, Klinkenberg M, Auburger G, Bereiter-Hahn J and Jendrach M: Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1. J Cell Sci 123: 917-926, 2010.
12. Chew MS, Linder A, Santen S, et al: Increased plasma levels of heparin-binding protein in patients with shock: a prospective, cohort study. Inflamm Res 61: 375-379, 2012.
13. Holub M and Beran O: Should heparin-binding protein levels be routinely monitored in patients with severe sepsis and septic shock? Crit Care 16: 133, 2012.
14. Linder A, Akesson P, Inghammar M, et al: Elevated plasma levels of heparin-binding protein in intensive care unit patients with severe sepsis and septic shock. Critical Care 16: R90, 2012.
15. Tapper H, Karlsson A, Morgelin M, Flodgaard H and Herwald H: Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles. Blood 99: 1785-1793, 2002.
16. Flodgaard H, Ostergaard E, Bayne S, et al: Covalent structure of two novel neutrophile leucocyte-derived proteins of porcine and human origin. Neutrophile elastase homologues with strong monocyte and fibroblast chemotactic activities. Eur J Biochem 197: 535-547, 1991.
17. Nieuwdorp M, Meuwese MC, Vink H, et al: The endothelial glycocalyx: a potential barrier between health and vascular disease. Curr Opin Lipidol 16: 507-511, 2005.
18. Arfors KE, Lundberg C, Lindbom L, et al: A monoclonal antibody to the membrane glycoprotein complex CD18 inhibits polymorphonuclear leukocyte accumulation and plasma leakage in vivo. Blood 69: 338-340, 1987.
19. Chertov O, Ueda H, Xu LL, et al: Identification of human neutrophil-derived cathepsin G and azurocidin/CAP37 as chemoattractants for mononuclear cells and neutrophils. J Exp Med 186: 739-747, 1997.
20. Soehnlein O, Xie X, Ulbrich H, et al: Neutrophil-derived heparin-binding protein (HBP/CAP37) deposited on endothelium enhances monocyte arrest under flow conditions. J Immunol 174: 6399-6405, 2005.
21. Lunemann JD, Buttgereit F, Tripmacher R, et al: Norepinephrine inhibits energy metabolism of human peripheral blood mononuclear cells via adrenergic receptors. Biosci Rep 21: 627-635, 2001.
22. Perry AJ, Rimmer KA, Mertens HD, et al: Structure, topology and function of the translocase of the outer membrane of mitochondria. Plant Physiol Biochem 46: 265-274, 2008.