In vitro and in vivo evaluation of self-nanoemulsifying drug delivery systems of cilostazol for oral and parenteral administration

International Journal of Pharmaceutics

Volumn 476, Issue 1, 2014, Pages 60-69

  Mahmoud, Dina B ^a   Shukr, Marwa H ^a   Bendas, Ehab R ^b  

^a NATIONAL ORGANIZATION FOR DRUG CONTROL AND RESEARCH NODCAR   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

Cilostazol; Intravenous administration; Oral administration; Pharmacokinetics; Self nanoemulsyfying systems

Indexed keywords

ALCOHOL; CILOSTAZOL; COSURFACTANT; CREMOPHOR; DIETHYLENE GLYCOL MONOETHYL ETHER; DODECYL SULFATE SODIUM; LABRASOL; MACROGOL 400; MYRISTIC ACID ISOPROPYL ESTER; PHOSPHATE BUFFERED SALINE; POLOXAMER; POLYSORBATE 20; POLYSORBATE 80; PROPANOL; PROPYLENE GLYCOL; SORBITAN OLEATE; TRIACETIN; ANTITHROMBOCYTIC AGENT; EMULSION; SURFACTANT; TABLET; TETRAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; AUTOCLAVE; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG SAFETY; DRUG SOLUBILITY; HEMOLYSIS; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NANOEMULSION; NONHUMAN; PARTICLE SIZE; PHASE SEPARATION; SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM; SUSPENSION; TABLET FORMULATION; THERMODYNAMICS; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; BIOAVAILABILITY; CHEMISTRY; COMPARATIVE STUDY; EMULSION; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MEDICINAL CHEMISTRY; ORAL DRUG ADMINISTRATION; PROCEDURES; RABBIT; SOLUBILITY; TABLET; VISCOSITY;

ADMINISTRATION, INTRAVENOUS; ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; EMULSIONS; HUMANS; PARTICLE SIZE; PLATELET AGGREGATION INHIBITORS; RABBITS; SOLUBILITY; SURFACE-ACTIVE AGENTS; TABLETS; TETRAZOLES; THERMODYNAMICS; VISCOSITY;

EID: 84907811551     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.09.045     Document Type: Article

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