Prelamin A accumulation in endothelial cells induces premature senescence and functional impairment

Atherosclerosis

Volumn 237, Issue 1, 2014, Pages 45-52

  Bonello Palot, Nathalie ^a,b   Simoncini, Stéphanie ^b   Robert, Stéphane ^b   Bourgeois, Patrice ^a   Sabatier, Florence ^b,c   Levy, Nicolas ^a,b   Dignat George, Françoise ^b,c   Badens, Catherine ^a,b  

^a TIMONE HOSPITAL   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c HÔPITAL DE LA CONCEPTION   (France)

Author keywords

Aging; Atherosclerosis; Lamin A; Senescence; Vascular endothelium

Indexed keywords

ATAZANAVIR; INTERCELLULAR ADHESION MOLECULE 1; LAMIN A; PRAVASTATIN; PRELAMIN A; UNCLASSIFIED DRUG; ZOLEDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; ICAM1 PROTEIN, HUMAN; IMIDAZOLE DERIVATIVE; NUCLEAR PROTEIN; OLIGOPEPTIDE; PROTEIN PRECURSOR; PYRIDINE DERIVATIVE;

ARTICLE; ATHEROSCLEROSIS; BIOACCUMULATION; CELL ADHESION; CELL AGING; CONTROLLED STUDY; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM CELL; FARNESYLATION; FUNCTIONAL DISEASE; HUMAN; HUMAN CELL; MONOCYTE; NUCLEAR SHAPE; PREMATURE AGING; UMBILICAL CORD BLOOD; UMBILICAL VEIN; CELL CULTURE; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; INFLAMMATION; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PROGERIA; UMBILICAL CORD; UMBILICAL VEIN ENDOTHELIAL CELL;

CELL ADHESION; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; DIPHOSPHONATES; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; IMIDAZOLES; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; MICROSCOPY, FLUORESCENCE; MONOCYTES; NEOVASCULARIZATION, PATHOLOGIC; NUCLEAR PROTEINS; OLIGOPEPTIDES; PRAVASTATIN; PROGERIA; PROTEIN PRECURSORS; PYRIDINES; UMBILICAL CORD; UMBILICAL VEINS;

EID: 84907801436     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2014.08.036     Document Type: Article

References (32)

1. Scaffidi P., Misteli T. Lamin A-dependent nuclear defects in human aging. Science 2006, 312(5776):1059-1063.
2. Cao K., Capell B.C., Erdos M.R., Djabali K., Collins F.S. Alamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells. ProcNatlAcadSci U S A 2007, 104(12):4949-4954.
3. Scaffidi P., Misteli T. Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. Nat Cell Biol 2008, 10(4):452-459.
4. Rodriguez S., Coppedè F., Sagelius H., Eriksson M. Increased expression of the Hutchinson-Gilford progeria syndrome truncated lamin A transcript during cell aging. Eur J Hum Genet 2009, 17(7):928-937.
5. De Sandre-Giovannoli A., Bernard R., Cau P., Navarro C., Amiel J., Boccaccio I., et al. Lamin A truncation in Hutchinson-Gilford progeria. Science 2003, 300(5628):2055.
6. Eriksson M., Brown W.T., Gordon L.B., Glynn M.W., Singer J., Scott L., et al. Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature 2003, 423(6937):293-298.
7. Rusiñol A.E., Sinensky M.S. Farnesylated lamins, progeroid syndromes and farnesyl transferase inhibitors. JCell Sci 2006, 119(Pt 16):3265-3272.
8. Navarro C.L., Cau P., Lévy N. Molecular bases of progeroid syndromes. Hum Mol Genet 2006, 15(2):R151-R161.
9. Csoka A.B., English S.B., Simkevich C.P., Ginzinger D.G., Butte A.J., Schatten G.P., et al. Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional dysregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis. Aging Cell 2004, 3:235-243.
10. Varela I., Cadinanos J., Pendas A.M., Gutierrez-Fernandez A., Folgueras A.R., Sanchez L.M., et al. Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature 2005, 437:564-568.
11. Liu B., Wang J., Chan K.M., Tjia W.M., Deng W., Guan X., et al. Genomic instability in laminopathy-based premature aging. Nat Med 2005, 11(7):780-785.
12. Capell B.C., Collins F.S., Nabel E.G. Mechanisms of cardiovascular disease in accelerated aging syndromes. Circ Res 2007, 101(1):13-26.
13. Columbaro M., Capanni C., Mattioli E., Novelli G., Parnaik V.K., Squarzoni S., et al. Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment. Cell Mol Life Sci 2005, 62(22):2669-2678.
14. Varela I., Pereira S., Ugalde A.P., Navarro C.L., Suárez M.F., Cau P., et al. Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging. Nat Med 2008, 14(7):767-772.
15. Caron M., Auclair M., Donadille B., Béréziat V., Guerci B., Laville M., et al. Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence. Cell Death Differ 2007, 14:1759-1767.
16. Coffinier C., Hudon S.E., Farber E.A., Chang S.Y., Hrycyna C.A., Young S.G., et al. HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells. Proc Natl Acad Sci U S A 2007, 104(33):13432-13437.
17. Maraldi N.M., Capanni C., Cenni V., Fini M., Lattanzi G. Laminopathies and lamin-associated signaling pathways. JCell Biochem 2011, 112(4):979-992.
18. Candelario J., Borrego S., Reddy S., Comai L. Accumulation of distinct prelamin A variants in human diploid fibroblasts differentially affects cell homeostasis. Exp Cell Res 2011, 317(3):319-329.
19. Ragnauth C.D., Warren D.T., Liu Y., McNair R., Tajsic T., Figg N., et al. Prelamin A acts to accelerate smooth muscle cell senescence and is a novel biomarker of human vascular aging. Circulation 2010, 121(20):2200-2210.
20. Lefèvre C., Auclair M., Boccara F., Bastard J.P., Capeau J., Vigouroux C., et al. Premature senescence of vascular cells is induced by HIV protease inhibitors: implication of prelamin A and reversion by statin. Arterioscler Thromb Vasc Biol 2010, 30(12):2611-2620.
21. Dou L., Bertrand E., Cerini C., Faure V., Sampol J., Vanholder R., et al. The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair. Kidney Int 2004, 65(2):442-451.
22. Britten C.D., Rowinsky E.K., Soignet S., Patnaik A., Yao S.L., Deutsch P., et al. Aphase I and pharmacological study of the farnesyl protein transferase inhibitor L-778,123 in patients with solid malignancies. Clin Cancer Res 2001, 7(12):3894-3903.
23. Osorio F.G., Navarro C.L., Cadiñanos J., López-Mejía I.C., Quirós P.M., Bartoli C., et al. Splicing-directed therapy in a new mouse model of human accelerated aging. Sci Transl Med 2011, 3(106):106ra107.
24. Minamino T., Komuro I. Vascular cell senescence: contribution to atherosclerosis. Circ Res 2007, 100(1):15-26.
25. Sabatier F., Camoin-Jau L., Anfosso F., Sampol J., Dignat-George F. Circulating endothelial cells, microparticles and progenitors: key players towards the definition of vascular competence. JCell Mol Med 2009, 13(3):454-471.
26. Libby P., Ridker P.M., Hansson G.K. Progress and challenges in translating the biology of atherosclerosis. Nature 2011, 473(7347):317-325.
27. Wang Y., Ostlund C., Worman H.J. Blocking protein farnesylation improves nuclear shape abnormalities in keratinocytes of mice expressing the prelamin A variant in Hutchinson-Gilford progeria syndrome. Nucleus 2010, 1(5):432-439.
28. Klein-Soyer C., Stierle A., Bouderbala B., Cazenave J.P. Effects of an extract of human brain containing growth factor activity on the proliferation of human vascular endothelial cells in primary culture. Biol Cell 1984, 2:9-20.
29. Ingram D.A., Mead L.E., Tanaka H., Meade V., Fenoglio A., Mortell K., et al. Identificationof a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cordblood. Blood 2004, 104(9):2752-2760.
30. Dutour A., Roll P., Gaborit B., Courrier S., Alessi M.C., Tregouet D.A., et al. High preval laminopathies among patients metabolic syndrome. Hum Mol Genet. 2011, 20(19):3779-3786.
31. Robert S., Poncelet P., Lacroix R., Raoult D., Dignat-George F. More on: calibration for the measurement of microparticles: value of calibrated polystyrene beads for flow cytometry-based sizing of biological microparticles. JThromb Haemost 2011, 9(8):1676-1678.
32. Vaporcyian A.A., Jones Ml, Ward P.A. Rapid analysis of leukocyte-endothelial cell adhesion. JImmunol Methods 1993, 159:93-100.