Downregulated interleukin 37 expression associated with aggravation of intervertebral disc degeneration

International Journal of Clinical and Experimental Pathology

Volumn 7, Issue 2, 2014, Pages 656-662

  Wan, Zhong Yuan ^a   Sun, Zhen ^a   Song, Fang ^b   Chen, Yu Fei ^a   Zhang, Wei Lin ^a   Wang, Hai Qiang ^a   Luo, Zhuo Jing ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Anti inflammatory cytokine; Interleukin 16; Interleukin 37; Interleukin 1 beta; Intervertebral disc degeneration

Indexed keywords

AUTACOID; IL37 PROTEIN, HUMAN; INTERLEUKIN 1; INTERLEUKIN 16; INTERLEUKIN 37; MESSENGER RNA;

ADULT; ANTI-INFLAMMATORY CYTOKINE; ARTICLE; COMPARATIVE STUDY; DISEASE COURSE; DOWN REGULATION; FEMALE; GENETICS; HUMAN; IMMUNOLOGY; INJURY; INTERLEUKIN-1 BETA; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; INTERVERTEBRAL DISKECTOMY; MALE; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SEVERITY OF ILLNESS INDEX; SPINE FRACTURE; SPINE FUSION; WESTERN BLOTTING; YOUNG ADULT;

ANTI-INFLAMMATORY CYTOKINE; INTERLEUKIN 16; INTERLEUKIN 37; INTERLEUKIN-1 BETA; INTERVERTEBRAL DISC DEGENERATION;

ADULT; BLOTTING, WESTERN; DISEASE PROGRESSION; DISKECTOMY; DOWN-REGULATION; FEMALE; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-1; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; SPINAL FRACTURES; SPINAL FUSION; YOUNG ADULT;

EID: 84907756047     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Brisby H, Tao H, Ma DD, Diwan AD. Cell therapy for disc degeneration-potentials and pitfalls. Orthop Clin North Am 2004; 35: 85-93
2. Adams MA, Roughley PJ. What is intervertebral disc degeneration, and what causes it? Spine 2006; 31: 2151-2161
3. Johnson WE, Roberts S. 'Rumours of my death may have been greatly exaggerated': a brief review of cell death in human intervertebral disc disease and implications for cell transplantation therapy. Biochem Soc Trans 2007; 35: 680-682
4. Le Maitre CL, Pockert A, Buttle DJ, Freemont AJ, Hoyland JA. Matrix synthesis and degradation in human intervertebral disc degeneration. Biochem Soc Trans 2007; 35: 652-655
5. Le Maitre CL, Freemont AJ, Hoyland JA. The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis Res Ther 2005; 7: 732-745
6. Millward-Sadler SJ, Costello PW, Freemont AJ, Hoyland JA. Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration. Arthritis Res Ther 2009; 11: 65
7. Bulau AM, Fink M, Maucksch C, Kappler R, Mayr D, Wagner K, Bufler P. In vivo expression of interleukin-37 reduces local and systemic inflammation in concanavalin A-induced hepatitis. ScientificWorldJournal 2011; 11: 2480-2490
8. Sakai N, Van Sweringen HL, Belizaire RM, Quillin RC, Schuster R, Blanchard J, Burns JM, Tevar AD, Edwards MJ, Lentsch AB. IL-37 reduces liver inflammatory injury via effects on hepatocytes and non-parenchymal cells. J Gastroenterol Hepatol 2012; 27: 1609-1616
9. Nold MF, Nold-Petry CA, Zepp JA, Palmer BE, Bufler P, Dinarello CA. IL-37 is a fundamental inhibitor of innate immunity. Nat Immunol 2010; 11: 1014-1022
10. Imaeda H, Takahashi K, Fujimoto T, Kasumi E, Ban H, Bamba S, Sonoda H, Shimizu T, Fujiyama Y, Andoh A. Epithelial expression of interleukin-37b in inflammatory bowel disease. Clin Exp Immunol 2013; 172: 410-416
11. Griffith JF, Wang YX, Antonio GE, Choi KC, Yu A, Ahuja AT, Leung PC. Modified Pfirrmann grading system for lumbar intervertebral disc degeneration. Spine 2007; 32: 708-712
12. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-685
13. Kang JD, Georgescu HI, McIntyre-Larkin L, Stefanovic-Racic M, Donaldson WF 3rd, Evans CH. Herniated lumbar intervertebral discs sponta neously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2. Spine 1996; 21: 271-277
14. Weiler C, Nerlich AG, Bachmeier BE, Boos N. Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: a study in surgical specimen and autopsy controls. Spine 2005; 30: 44-53; discussion 54
15. Freemont AJ. The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain. Rheumatology (Oxford) 2009; 48: 5-10
16. Conti P, Kempuraj D, Kandere K, Di Gioacchino M, Reale M, Barbacane RC, Castellani ML, Mortari U, Boucher W, Letourneau R, Theoharides TC. Interleukin-16 network in inflammation and allergy. Allergy Asthma Proc 2002; 23: 103-108
17. Glass WG, Sarisky RT, Vecchio AM. Not-so-sweet sixteen: the role of IL-16 in infectious and immune-mediated inflammatory diseases. J Interferon Cytokine Res 2006; 26: 511-520
18. Cruikshank WW, Kornfeld H, Center DM. Interleukin-16. J Leukoc Biol 2000; 67: 757-766
19. Richmond J, Tuzova M, Cruikshank W, Center D. Regulation of cellular processes by interleukin-16 in homeostasis and cancer. J Cell Physiol 2014; 229: 139-147
20. Risbud MV, Shapiro IM. Role of cytokines in intervertebral disc degeneration: pain and disc content. Nat Rev Rheumatol 2014 Jan; 10: 44-56
21. Solovieva S, Kouhia S, Leino-Arjas P, Ala-Kokko L, Luoma K, Raininko R, Saarela J, Riihimäki H. Interleukin 1 polymorphisms and intervertebral disc degeneration. Epidemiology 2004; 15: 626-633
22. Kumar S, McDonnell PC, Lehr R, Tierney L, Tzimas MN, Griswold DE, Capper EA, Tal-Singer R, Wells GI, Doyle ML, Young PR. Identification and initial characterization of four novel members of the interleukin-1 family. J Biol Chem 2000; 275: 10308-10314
23. Kumar S, Hanning CR, Brigham-Burke MR, Rieman DJ, Lehr R, Khandekar S, Kirkpatrick RB, Scott GF, Lee JC, Lynch FJ, Gao W, Gambotto A, Lotze MT. Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-γ production. Cytokine 2002; 18: 61-71
24. Fujita H, Inoue Y, Seto K, Komitsu N, Aihara M. Interleukin-37 is elevated in subjects with atopic dermatitis. J Dermatol Sci 2013; 69: 173-175