Resistance of LPS-activated bone marrow derived macrophages to apoptosis mediated by dexamethasone

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Haim, Yasmin Ohana ^a   Unger, Naamit Deshet ^a   Souroujon, Miriam C ^c   Mittelman, Moshe ^a,b   Neumann, Drorit ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^c OPEN UNIVERSITY OF ISRAEL   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; DEXAMETHASONE; DIFFERENTIATION ANTIGEN; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR ALPHA; GLUCOCORTICOID RECEPTOR BETA; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; MONOCYTE-MACROPHAGE DIFFERENTIATION ANTIGEN;

ANIMAL; APOPTOSIS; BAGG ALBINO MOUSE; BONE MARROW CELL; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; FEMALE; GENETICS; IMMUNOLOGY; MACROPHAGE; METABOLISM; MOUSE; UPREGULATION;

ANIMALS; ANTIGENS, CD11B; ANTIGENS, DIFFERENTIATION; APOPTOSIS; BONE MARROW CELLS; CHEMOKINE CCL3; DEXAMETHASONE; FEMALE; GLUCOCORTICOIDS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; UP-REGULATION;

EID: 84907746150     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep04323     Document Type: Article

References (47)

1. Chrousos, G. P. Stress and sex versus immunity and inflammation. Sci Signal 3, pe36 (2010).
2. Henley, D. E. & Lightman, S. L. New insights into corticosteroid-binding globulin and glucocorticoid delivery. Neuroscience 180, 1-8 (2011).
3. Whitehouse, M. W. Anti-inflammatory glucocorticoid drugs: reflections after 60 years. Inflammopharmacology 19, 1-19 (2011).
4. Stary, G. et al.Glucocorticosteroids modify Langerhans cells to produce TGF-beta and expand regulatory T cells. J Immunol 186, 103-112 (2011).
5. Castro, R., Zou, J., Secombes, C. J. & Martin, S. A. Cortisol modulates the induction of inflammatory gene expression in a rainbow trout macrophage cell line. Fish Shellfish Immunol 30, 215-223 (2011).
6. Kassi, E. &Moutsatsou, P. Glucocorticoid receptor signaling and prostate cancer. Cancer Lett 302, 1-10 (2011).
7. Burton, J. M., O'Connor, P. W., Hohol, M. & Beyene, J. Oral versus intravenous steroids for treatment of relapses in multiple sclerosis. Cochrane Database Syst Rev 12, CD006921 (2012).
8. Kalish, L., Snidvongs, K., Sivasubramaniam, R., Cope, D. & Harvey, R. J. Topical steroids for nasal polyps. Cochrane Database Syst Rev 12, CD006549 (2012).
9. Moreau, P. et al. Bortezomib plus dexamethasone versus reduced-dose bortezomib, thalidomide plus dexamethasone as induction treatment before autologous stem cell transplantation in newly diagnosed multiple myeloma. Blood 118, 5752-5758; quiz 5982 (2011).
10. Barczyk, K. et al. Glucocorticoids promote survival of anti-inflammatory macrophages via stimulation of adenosine receptor A3. Blood 116, 446-455 (2010).
11. Classen, A., Lloberas, J. & Celada, A. Macrophage activation: classical versus alternative. Methods Mol Biol 531, 29-43 (2009).
12. Hume, D. A. The mononuclear phagocyte system. Curr Opin Immunol 18, 49-53 (2006).
13. Kleinnijenhuis, J., Oosting, M., Joosten, L.A., Netea, M. G.&Van Crevel, R. Innate immune recognition of Mycobacterium tuberculosis. Clin Dev Immunol 2011, 405310 (2011).
14. Palusinska-Szysz, M. & Janczarek,M. Innate immunity to Legionella and toll-like receptors - review. Folia Microbiol (Praha) 55, 508-514 (2010).
15. Opal, S. M. Endotoxins and other sepsis triggers. Contrib Nephrol 167, 14-24 (2010).
16. Moreno, R., Afonso, S. & Fevereiro, T. Incidence of sepsis in hospitalized patients. Curr Infect Dis Rep 8, 346-350 (2006).
17. Prigent, H., Maxime, V. & Annane, D. Science review: mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids. Crit Care 8, 243-252 (2004).
18. Annane, D. et al. A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA 283, 1038-1045 (2000).
19. Bhattacharyya, S., Brown, D. E., Brewer, J. A., Vogt, S. K. & Muglia, L. J. Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase. Blood 109, 4313-4319 (2007).
20. Goodwin, J. E., Feng, Y., Velazquez, H. & Sessa, W. C. Endothelial glucocorticoid receptor is required for protection against sepsis. Proc Natl Acad Sci U S A 110, 306-311 (2013).
21. Rearte, B., Landoni, V., Laborde, E., Fernandez, G.&Isturiz, M. Differential effects of glucocorticoids in the establishment and maintenance of endotoxin tolerance. Clin Exp Immunol 159, 208-216 (2010).
22. Kinne, R. W., Brauer, R., Stuhlmuller, B., Palombo-Kinne, E. & Burmester, G. R. Macrophages in rheumatoid arthritis. Arthritis Res 2, 189-202 (2000).
23. Nguyen, K. B., McCombe, P. A. & Pender, M. P. Increased apoptosis of T lymphocytes and macrophages in the central and peripheral nervous systems of Lewis rats with experimental autoimmune encephalomyelitis treated with dexamethasone. J Neuropathol Exp Neurol 56, 58-69 (1997).
24. Fong, C. C. et al. Dexamethasone protects RAW264.7 macrophages from growth arrest and apoptosis induced by H2O2 through alteration of gene expression patterns and inhibition of nuclear factor-kappa B (NF-kappaB) activity. Toxicology 236, 16-28 (2007).
25. Ayroldi, E. & Riccardi, C. Glucocorticoid-induced leucine zipper (GILZ): a new important mediator of glucocorticoid action. FASEB J 23, 3649-3658 (2009).
26. Li, G., Gleinich, A., Lau, H. & Zimmermann, M. Staurosporine-induced apoptosis presents with unexpected cholinergic effects in a differentiated neuroblastoma cell line. Neurochem Int 61, 1011-1020 (2012).
27. Im, S. A. et al. Synergistic activation of monocytes by polysaccharides isolated from Salicornia herbacea and interferon-gamma. J Ethnopharmacol 111, 365-370 (2007).
28. Engler, H., Engler, A., Bailey, M. T. & Sheridan, J. F. Tissue-specific alterations in the glucocorticoid sensitivity of immune cells following repeated social defeat in mice. J Neuroimmunol 163, 110-119 (2005).
29. Chihara, T. et al. HIV-1 proteins preferentially activate anti-inflammatory M2- type macrophages. J Immunol 188, 3620-3627 (2012).
30. Hinds, T. D., Jr. et al.Discovery of glucocorticoid receptor-beta in mice with a role in metabolism. Mol Endocrinol 24, 1715-1727 (2010).
31. Romano, A. et al. Intravenous injection of bortezomib, melphalan and dexamethasone in refractory and relapsed multiple myeloma. Ann Oncol (2012).
32. Lu, Y. S. et al. Effects of glucocorticoids on the growth and chemosensitivity of carcinoma cells are heterogeneous and require high concentration of functional glucocorticoid receptors. World J Gastroenterol 11, 6373-6380 (2005).
33. Kim, J. et al. Macrophages and mesenchymal stromal cells support survival and proliferation of multiple myeloma cells. Br J Haematol 158, 336-346 (2012).
34. Weiss, J. M. et al.Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy. J Exp Med 207, 2455-2467 (2010).
35. Hashimoto, D. et al. Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity 38, 792-804 (2013).
36. Oakley, R. H. & Cidlowski, J. A. The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease. J Allergy Clin Immunol 132, 1033-1044 (2013).
37. Bonin, C. P. et al. Lipopolysaccharide-induced inhibition of transcription of tlr4 in vitro is reversed by dexamethasone and correlates with presence of conserved NFkappaB binding sites. Biochem Biophys Res Commun 432, 256-261 (2013).
38. Abraham, S. M. et al. Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatise 1. J Exp Med 203, 1883-1889 (2006).
39. Brown, J., Wang, H., Hajishengallis, G. N. &Martin,M. TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. J Dent Res 90, 417-427 (2011).
40. Rogatsky, I., Logan, S. K. & Garabedian, M. J. Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase. Proc Natl Acad Sci U S A 95, 2050-2055 (1998).
41. Vazquez-Tello, A., Halwani, R., Hamid, Q. & Al-Muhsen, S. Glucocorticoid Receptor-Beta Up-Regulation and Steroid Resistance Induction by IL-17 and IL- 23 Cytokine Stimulation in Peripheral Mononuclear Cells. J Clin Immunol (2012).
42. Chen, H. L. & Li, L. R. Glucocorticoid receptor gene polymorphisms and glucocorticoid resistance in inflammatory bowel disease: a meta-analysis. Dig Dis Sci 57, 3065-3075 (2012).
43. Ledderose, C. et al. Corticosteroid resistance in sepsis is influenced by microRNA- 124 - induced downregulation of glucocorticoid receptor-alpha. Crit Care Med 40, 2745-2753 (2012).
44. Barnes, P. J. Glucocorticosteroids: current and future directions. Br J Pharmacol 163, 29-43 (2011).
45. Boltz-Nitulescu, G. et al. Differentiation of rat bone marrow cells into macrophages under the influence of mouse L929 cell supernatant. J Leukoc Biol 41, 83-91 (1987).
46. Lee, S., Yun, H. S. & Kim, S. H. The comparative effects of mesoporous silica nanoparticles and colloidal silica on inflammation and apoptosis. Biomaterials 32, 9434-9443 (2011).
47. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65, 55-63 (1983).