Glucocorticoid receptor gene polymorphisms and glucocorticoid resistance in inflammatory bowel disease: A meta-analysis

Digestive Diseases and Sciences

Volumn 57, Issue 12, 2012, Pages 3065-3075

  Chen, Hong Lin ^a   Li, Li Ren ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

Gene polymorphism; Glucocorticoid receptor; Glucocorticoid resistance; Inflammatory bowel disease; Meta analysis

Indexed keywords

GLUCOCORTICOID RECEPTOR;

CROHN DISEASE; DISEASE RESISTANCE; DNA POLYMORPHISM; EFFECT SIZE; ENTERITIS; GENETIC ASSOCIATION; HETEROZYGOTE; HUMAN; META ANALYSIS; PRIORITY JOURNAL; PUBLISHING; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; ULCERATIVE COLITIS;

GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; HUMANS; INFLAMMATORY BOWEL DISEASES; POLYMORPHISM, GENETIC; RECEPTORS, GLUCOCORTICOID;

EID: 84871628040     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-012-2293-2     Document Type: Review

References (33)

1. Thia KT, Loftus EV Jr, Sandborn WJ, et al. An update on the epidemiology of inflammatory bowel disease in Asia. Am J Gastroenterol. 2008;103:3167-3182.
2. Benchimol EI, Guttmann A, Griffiths AM, et al. Increasing incidence of paediatric inflammatory bowel disease in Ontario, Canada: evidence from health administrative data. Gut. 2009;58:1490-1497.
3. Herrinton LJ, Liu L, Lewis JD, et al. Incidence and prevalence of inflammatory bowel disease in a Northern California managed care organization. Am J Gastroenterol. 2008;103:1996-2002.
4. Castro M, Papadatou B, Baldassare M, et al. Inflammatory bowel disease in children and adolescents in Italy: data from the pediatric national IBD register (1996-2003). Inflamm Bowel Dis. 2008;14:1246-1252.
5. Katz JA. Treatment of inflammatory bowel disease with corticosteroids. Gastroenterol Clin North Am. 2004;33:171-189.
6. Tung J, Loftus EV Jr, Freese DK, et al. A population-based study of the frequency of corticosteroid resistance and dependence in pediatric patients with Crohn's disease and ulcerative colitis. Inflamm Bowel Dis. 2006;12:1093-1100.
7. De Iudicibus S, Franca R, Martelossi S, et al. Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease. World J Gastroenterol. 2011;17:1095-1108.
8. Raddatz D, Middel P, Bockemühl M, et al. Glucocorticoid receptor expression in inflammatory bowel disease: evidence for a mucosal down-regulation in steroid-unresponsive ulcerative colitis. Aliment Pharmacol Ther. 2004;19:47-61.
9. Fujishima S, Takeda H, Kawata S, Yamakawa M. The relationship between the expression of the glucocorticoid receptor in biopsied colonic mucosa and the glucocorticoid responsiveness of ulcerative colitis patients. Clin Immunol. 2009;133:208-217.
10. Encio IJ, Detera-Wadleigh SD. The genomic structure of the human glucocorticoid receptor. J Biol Chem. 1991;266:7182-7188.
11. Laura M, Erica LT, van den Akker, Steven WJ, et al. Clinical features associated with glucocorticoid receptor polymorphisms. An overview. Ann N Y Acad Sci. 2009; 1179:179-198.
12. van Rossum EF, Lamberts SW. Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition. Recent Prog Horm Res. 2004;59:333-357.
13. Lau J, Ioannidis JP, Schmid CH. Quantitative synthesis in systematic reviews. Ann Intern Med. 1997;127:820-826.
14. Higgins JPT, Thompson SG, Deek JJ, et al. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557-560.
15. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177-188.
16. Egger M, Davey SG, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629-634.
17. Dupont WD, Plummer WD. Power and sample size calculations: a review and computer program. Control Clin Trials. 1990;11:116-128.
18. Krupovesa A, Macke D, Deslandresa C, et al. Variation in the glucocorticoid receptor gene (NR3C1) maybe associated with corticosteroid dependency and resistance in children with Crohn's disease. Pharmacogen Genomics. 2011;21:454-461.
19. Jessica M, Christa W, Jyrki JE, Gerd AK-U. Glucocorticoid receptor gene haplotype structure and steroid therapy outcome in IBD patients. World J Gastroenterol. 2010;16:3888-3896.
20. De Iudicibus S, Stocco G, Martelossi S, et al. Genetic predictors of glucocorticoid response in pediatric patients with inflammatory bowel diseases. J Clin Gastroenterol. 2011;45:e1-e7.
21. Maltese P, Palma L, Sfara C, et al. Glucocorticoid resistance in Crohn's disease and ulcerative colitis: an association study investigating GR and FKBP5 gene polymorphisms. Pharmacogenomics J. 2011. doi: 10.1038/tpj.2011.26.
22. De Iudicibus S, Stocco G, Martelossi S, et al. Association of BclI polymorphism of the glucocorticoid receptor gene locus with response to glucocorticoids in inflammatory bowel disease. Gut. 2007;56:1319-1320.
23. Barnes PJ, Adcock IM. Glucocorticoid resistance in inflammatory diseases. Lancet. 2009;373:1905-1917.
24. Farrell RJ, Kelleher D. Glucocorticoid resistance in inflammatory bowel disease. J Endocrinol. 2003;178:339-346.
25. Russcher H, Smit P, van den Akker EL, et al. Two polymorphisms in the glucocorticoid receptor gene directly affect glucocorticoid-regulated gene expression. J Clin Endocrinol Metab. 2005;90:5804-5810.
26. van Rossum EF, Koper JW, Huizenga NA, et al. A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels. Diabetes. 2002;51:3128-3134.
27. Marti A, Ochoa MC, Sánchez-Villegas A, et al. Meta-analysis on the effect of the N363S polymorphism of the glucocorticoid receptor gene (GRL) on human obesity. BMC Med Genet. 2006;25:50.
28. van Rossum EF, Koper JW, van den Beld AW, et al. Identification of the BclI polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo and body mass index. Clin Endocrinol (Oxf). 2003;59:585-592.
29. Annese V, Valvano MR, Palmieri O, et al. Multidrug resistance 1 gene in inflammatory bowel disease: a meta-analysis. World J Gastroenterol. 2006;12:3636-3644.
30. McManus R. Mechanisms of steroid action and resistance in inflammation and disease. J Endocrinol. 2003;178:1-4.
31. Szczepankiewicz A, Breborowicz A, Sobkowiak P, et al. No association of glucocorticoid receptor polymorphisms with asthma and response to glucocorticoids. Adv Med Sci. 2008;53:245-250.
32. Pietras T, Panek M, Tworek D, et al. The BclI single nucleotide polymorphism of the human glucocorticoid receptor gene h-GR/NR3C1 promoter in patients with bronchial asthma: pilot study. Mol Biol Rep. 2011;38:3953-3958.
33. van Oosten MJ, Dolhain RJ, Koper JW, et al. Polymorphisms in the glucocorticoid receptor gene that modulate glucocorticoid sensitivity are associated with rheumatoid arthritis. Arthritis Res Ther. 2010;12:R159.