Pharmacodynamic and pharmacokinetic interactions of perampanel and other antiepileptic drugs in a rat amygdala kindling model

Seizure

Volumn 23, Issue 9, 2014, Pages 732-739

  Wu, Ting ^a   Nagaya, Yoko ^a   Hanada, Takahisa ^a,b  

^a EISAI CO LTD   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Antiepileptic drugs; EEG; Kindling; Localization related epilepsy

Indexed keywords

CARBAMAZEPINE; ETIRACETAM; LAMOTRIGINE; PERAMPANEL; VALPROIC ACID; ANTICONVULSIVE AGENT; PYRIDONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASOLATERAL AMYGDALA; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG MEGADOSE; ELECTROENCEPHALOGRAPHY; KINDLING; LATENT PERIOD; LOW DRUG DOSE; MALE; MOTOR DYSFUNCTION; NEUROTOXICITY; NONHUMAN; PHASE 3 CLINICAL TRIAL (TOPIC); RAT; ROTAROD TEST; SEIZURE; STATISTICAL SIGNIFICANCE; ANALYSIS OF VARIANCE; ANIMAL; BLOOD; DISEASE MODEL; DRUG EFFECTS; DRUG INTERACTION; ELECTROENCEPHALOGRAM; MOTOR ACTIVITY; WISTAR RAT;

ANALYSIS OF VARIANCE; ANIMALS; ANTICONVULSANTS; BRAIN WAVES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTROENCEPHALOGRAPHY; KINDLING, NEUROLOGIC; MALE; MOTOR ACTIVITY; PYRIDONES; RATS; RATS, WISTAR; ROTAROD PERFORMANCE TEST;

EID: 84907688208     PISSN: 10591311     EISSN: 15322688     Source Type: Journal    
DOI: 10.1016/j.seizure.2014.06.001     Document Type: Article

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