메뉴 건너뛰기




Volumn 54, Issue 1, 2013, Pages 28-35

Extended-release antiepileptic drugs: A comparison of pharmacokinetic parameters relative to original immediate-release formulations

Author keywords

Anticonvulsants; Epilepsy; Extended release preparations; Medication adherence; Pharmacokinetics

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; DEPAKOTE DR; ETIRACETAM; LAMOTRIGINE; OXCARBAZEPINE; PARACETAMOL; PHENYTOIN; UNCLASSIFIED DRUG; VALPROATE SEMISODIUM;

EID: 84872061537     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/epi.12043     Document Type: Review
Times cited : (52)

References (46)
  • 1
    • 67349192949 scopus 로고    scopus 로고
    • The descriptive epidemiology of epilepsy-A review
    • Banerjee PN, Filippi D, Allen HW,. (2009) The descriptive epidemiology of epilepsy-a review. Epilepsy Res 85: 31-45.
    • (2009) Epilepsy Res , vol.85 , pp. 31-45
    • Banerjee, P.N.1    Filippi, D.2    Allen, H.W.3
  • 2
    • 34548080314 scopus 로고    scopus 로고
    • Extended-release formulations for the treatment of epilepsy
    • Bialer M,. (2007) Extended-release formulations for the treatment of epilepsy. CNS Drugs 21: 765-774.
    • (2007) CNS Drugs , vol.21 , pp. 765-774
    • Bialer, M.1
  • 4
    • 77958508858 scopus 로고    scopus 로고
    • Efficacy, safety, and potential of extended-release lamotrigine in the treatment of epileptic patients
    • Blaszczyk B, Czuczwar SJ,. (2010) Efficacy, safety, and potential of extended-release lamotrigine in the treatment of epileptic patients. Neuropsychiatr Dis Treat 6: 145-150.
    • (2010) Neuropsychiatr Dis Treat , vol.6 , pp. 145-150
    • Blaszczyk, B.1    Czuczwar, S.J.2
  • 6
    • 84872081409 scopus 로고    scopus 로고
    • Center for Drug Evaluation and ResearchGuidance for industry - bioavailability and bioequivalence studies for orally administered drug products - general considerations. Available at
    • Center for Drug Evaluation and Research (2003) Guidance for industry-bioavailability and bioequivalence studies for orally administered drug products-general considerations. Available at: http://www.fda.gov/downloads/ Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm070124.pdf (Accessed November 13, 2012).
    • (2003)
  • 7
    • 0024343414 scopus 로고
    • How often is medication taken as prescribed? A novel assessment technique
    • Cramer JA, Mattson RH, Prevey ML, Scheyer RD, Ouellette VL,. (1989) How often is medication taken as prescribed? A novel assessment technique. JAMA 261: 3273-3277.
    • (1989) JAMA , vol.261 , pp. 3273-3277
    • Cramer, J.A.1    Mattson, R.H.2    Prevey, M.L.3    Scheyer, R.D.4    Ouellette, V.L.5
  • 8
    • 39749112624 scopus 로고    scopus 로고
    • Prevalence and cost of nonadherence with antiepileptic drugs in an adult managed care population
    • Davis KL, Candrilli SD, Edin HM,. (2005) Prevalence and cost of nonadherence with antiepileptic drugs in an adult managed care population. Epilepsia 49: 446-454.
    • (2005) Epilepsia , vol.49 , pp. 446-454
    • Davis, K.L.1    Candrilli, S.D.2    Edin, H.M.3
  • 9
    • 84872065861 scopus 로고    scopus 로고
    • [package insert]Abbott Laboratories, North Chicago, IL
    • Depakote ER [package insert] (2010) Abbott Laboratories, North Chicago, IL.
    • (2010) Depakote ER
  • 10
    • 0036227094 scopus 로고    scopus 로고
    • Comparison of the bioavailability of unequal doses of divalproex sodium extended-release formulation relative to the delayed-release formulation in healthy volunteers
    • Dutta S, Zhang Y, Selness DS, Lee LL, Williams LA, Sommerville KW,. (2002) Comparison of the bioavailability of unequal doses of divalproex sodium extended-release formulation relative to the delayed-release formulation in healthy volunteers. Epilepsy Res 49: 1-10.
    • (2002) Epilepsy Res , vol.49 , pp. 1-10
    • Dutta, S.1    Zhang, Y.2    Selness, D.S.3    Lee, L.L.4    Williams, L.A.5    Sommerville, K.W.6
  • 11
    • 77955474116 scopus 로고    scopus 로고
    • Do regulatory bioequivalence requirements adequately reflect the therapeutic equivalence of modified-release drug products?
    • Endrenyi L, Tothfalusi L,. (2010) Do regulatory bioequivalence requirements adequately reflect the therapeutic equivalence of modified-release drug products? J Pharm Pharm Sci 13: 107-113.
    • (2010) J Pharm Pharm Sci , vol.13 , pp. 107-113
    • Endrenyi, L.1    Tothfalusi, L.2
  • 12
    • 57249099772 scopus 로고    scopus 로고
    • Nonadherence to antiepileptic drugs and increased mortality: Findings from the RANSOM Study
    • Faught E, Duh MS, Weiner JR, Guerin A, Cunnington MC,. (2008) Nonadherence to antiepileptic drugs and increased mortality: findings from the RANSOM Study. Neurology 71: 1572-1578.
    • (2008) Neurology , vol.71 , pp. 1572-1578
    • Faught, E.1    Duh, M.S.2    Weiner, J.R.3    Guerin, A.4    Cunnington, M.C.5
  • 13
    • 61849088332 scopus 로고    scopus 로고
    • Impact of nonadherence to antiepileptic drugs on health care utilization and costs: Findings from the RANSOM study
    • Faught RE, Weiner JR, Guerin A, Cunnington MC, Duh MS,. (2009) Impact of nonadherence to antiepileptic drugs on health care utilization and costs: findings from the RANSOM study. Epilepsia 50: 501-509.
    • (2009) Epilepsia , vol.50 , pp. 501-509
    • Faught, R.E.1    Weiner, J.R.2    Guerin, A.3    Cunnington, M.C.4    Duh, M.S.5
  • 14
    • 0031936095 scopus 로고    scopus 로고
    • Pharmacokinetic evaluation of twice-daily extended-release carbamazepine (CBZ) and four-times-daily immediate-release CBZ in patients with epilepsy
    • Garnett WR, Levy B, McLean AM, Zhang Y, Couch RA, Rudnic EM, Pellock JM, Belendiuk GW,. (1998) Pharmacokinetic evaluation of twice-daily extended-release carbamazepine (CBZ) and four-times-daily immediate-release CBZ in patients with epilepsy. Epilepsia 39: 274-279.
    • (1998) Epilepsia , vol.39 , pp. 274-279
    • Garnett, W.R.1    Levy, B.2    McLean, A.M.3    Zhang, Y.4    Couch, R.A.5    Rudnic, E.M.6    Pellock, J.M.7    Belendiuk, G.W.8
  • 15
    • 0016756438 scopus 로고
    • The epidemiology of epilepsy in Rochester, Minnesota, 1935 through 1967
    • Hauser WA, Kurland LT,. (1975) The epidemiology of epilepsy in Rochester, Minnesota, 1935 through 1967. Epilepsia 16: 1-66.
    • (1975) Epilepsia , vol.16 , pp. 1-66
    • Hauser, W.A.1    Kurland, L.T.2
  • 16
    • 0027152087 scopus 로고
    • Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984
    • Hauser WA, Annegers JF, Kurland LT,. (1993) Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia 34: 453-468.
    • (1993) Epilepsia , vol.34 , pp. 453-468
    • Hauser, W.A.1    Annegers, J.F.2    Kurland, L.T.3
  • 17
    • 0023574269 scopus 로고
    • Lamotrigine: Single-dose pharmacokinetics and initial 1 week experience in refractory epilepsy
    • Jawad S, Yuen WC, Peck AW, Hamilton MJ, Oxley JR, Richens A,. (1987) Lamotrigine: single-dose pharmacokinetics and initial 1 week experience in refractory epilepsy. Epilepsy Res 1: 194-201.
    • (1987) Epilepsy Res , vol.1 , pp. 194-201
    • Jawad, S.1    Yuen, W.C.2    Peck, A.W.3    Hamilton, M.J.4    Oxley, J.R.5    Richens, A.6
  • 18
    • 0025125545 scopus 로고
    • Pharmacokinetic comparison of two carbamazepine slow-release formulations
    • Jensen PK, Moller A, Gram L, Jensen NO, Dam M,. (1990) Pharmacokinetic comparison of two carbamazepine slow-release formulations. Acta Neurol Scand 82: 135-137.
    • (1990) Acta Neurol Scand , vol.82 , pp. 135-137
    • Jensen, P.K.1    Moller, A.2    Gram, L.3    Jensen, N.O.4    Dam, M.5
  • 19
    • 34248154262 scopus 로고    scopus 로고
    • Comparison of patient compliance with once-daily and twice-daily antibiotic regimens in respiratory tract infections: Results of a randomized trial
    • Kardas P,. (2007) Comparison of patient compliance with once-daily and twice-daily antibiotic regimens in respiratory tract infections: results of a randomized trial. J Antimicrob Chemother 59: 531-536.
    • (2007) J Antimicrob Chemother , vol.59 , pp. 531-536
    • Kardas, P.1
  • 20
    • 0036853592 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of incidence studies of epilepsy and unprovoked seizures
    • Kotsopoulos IA, van MT, Kessels FG, de Krom MC, Knottnerus JA,. (2002) Systematic review and meta-analysis of incidence studies of epilepsy and unprovoked seizures. Epilepsia 43: 1402-1409.
    • (2002) Epilepsia , vol.43 , pp. 1402-1409
    • Kotsopoulos, I.A.1    Van, M.T.2    Kessels, F.G.3    De Krom, M.C.4    Knottnerus, J.A.5
  • 21
    • 84872078010 scopus 로고    scopus 로고
    • [package insert]GlaxoSmithKline, Research Triangle Park, NC
    • Lamictal XR [package insert] (2011) GlaxoSmithKline, Research Triangle Park, NC.
    • (2011) Lamictal XR
  • 22
    • 0023724557 scopus 로고
    • Compliance during treatment of epilepsy
    • Leppik IE,. (1988) Compliance during treatment of epilepsy. Epilepsia 29 (Suppl. 2): S79-S84.
    • (1988) Epilepsia , vol.29 , Issue.SUPPL. 2
    • Leppik, I.E.1
  • 23
    • 0035098028 scopus 로고    scopus 로고
    • Mortality in epilepsy in the first 11 to 14 years after diagnosis: Multivariate analysis of a long-term, prospective, population-based cohort
    • Lhatoo SD, Johnson AL, Goodridge DM, MacDonald BK, Sander JW, Shorvon SD,. (2001) Mortality in epilepsy in the first 11 to 14 years after diagnosis: multivariate analysis of a long-term, prospective, population-based cohort. Ann Neurol 49: 336-344.
    • (2001) Ann Neurol , vol.49 , pp. 336-344
    • Lhatoo, S.D.1    Johnson, A.L.2    Goodridge, D.M.3    MacDonald, B.K.4    Sander, J.W.5    Shorvon, S.D.6
  • 24
    • 59949091286 scopus 로고    scopus 로고
    • Association of antiepileptic drug nonadherence with risk of seizures in adults with epilepsy
    • Manjunath R, Davis KL, Candrilli SD, Ettinger AB,. (2009) Association of antiepileptic drug nonadherence with risk of seizures in adults with epilepsy. Epilepsy Behav 14: 372-378.
    • (2009) Epilepsy Behav , vol.14 , pp. 372-378
    • Manjunath, R.1    Davis, K.L.2    Candrilli, S.D.3    Ettinger, A.B.4
  • 25
    • 2542523065 scopus 로고    scopus 로고
    • Improved CNS tolerability following conversion from immediate- to extended-release carbamazepine
    • Miller AD, Krauss GL, Hamzeh FM,. (2004) Improved CNS tolerability following conversion from immediate- to extended-release carbamazepine. Acta Neurol Scand 109: 374-377.
    • (2004) Acta Neurol Scand , vol.109 , pp. 374-377
    • Miller, A.D.1    Krauss, G.L.2    Hamzeh, F.M.3
  • 26
    • 58749091078 scopus 로고    scopus 로고
    • Better adherence with once-daily antiretroviral regimens: A meta-analysis
    • Parienti JJ, Bangsberg DR, Verdon R, Gardner EM,. (2009) Better adherence with once-daily antiretroviral regimens: a meta-analysis. Clin Infect Dis 48: 484-488.
    • (2009) Clin Infect Dis , vol.48 , pp. 484-488
    • Parienti, J.J.1    Bangsberg, D.R.2    Verdon, R.3    Gardner, E.M.4
  • 27
    • 3042677985 scopus 로고    scopus 로고
    • Extended-release formulations: Simplifying strategies in the management of antiepileptic drug therapy
    • Pellock JM, Smith MC, Cloyd JC, Uthman B, Wilder BJ,. (2004) Extended-release formulations: simplifying strategies in the management of antiepileptic drug therapy. Epilepsy Behav 5: 301-307.
    • (2004) Epilepsy Behav , vol.5 , pp. 301-307
    • Pellock, J.M.1    Smith, M.C.2    Cloyd, J.C.3    Uthman, B.4    Wilder, B.J.5
  • 28
    • 77950893876 scopus 로고    scopus 로고
    • Immediate-release versus controlled-release carbamazepine in the treatment of epilepsy
    • Powell G, Saunders M, Marson AG,. (2010) Immediate-release versus controlled-release carbamazepine in the treatment of epilepsy. Cochrane Database Syst Rev CD007124.
    • (2010) Cochrane Database Syst Rev
    • Powell, G.1    Saunders, M.2    Marson, A.G.3
  • 29
    • 0025280953 scopus 로고
    • Pharmacokinetic profile of a 300-mg extended phenytoin sodium capsule (Dilantin) formulation
    • Randinitis EJ, Buchanan RA, Kinkel AW,. (1990) Pharmacokinetic profile of a 300-mg extended phenytoin sodium capsule (Dilantin) formulation. Epilepsia 31: 458-464.
    • (1990) Epilepsia , vol.31 , pp. 458-464
    • Randinitis, E.J.1    Buchanan, R.A.2    Kinkel, A.W.3
  • 30
    • 32544453192 scopus 로고    scopus 로고
    • Every-12-hour administration of extended-release divalproex in patients with epilepsy: Impact on plasma valproic acid concentrations
    • Reed RC, Dutta S, Cavanaugh JH, Locke C, Granneman GR,. (2006) Every-12-hour administration of extended-release divalproex in patients with epilepsy: impact on plasma valproic acid concentrations. Epilepsy Behav 8: 391-396.
    • (2006) Epilepsy Behav , vol.8 , pp. 391-396
    • Reed, R.C.1    Dutta, S.2    Cavanaugh, J.H.3    Locke, C.4    Granneman, G.R.5
  • 31
    • 77954519842 scopus 로고    scopus 로고
    • What do the suffixes - XR, ER, Chrono, Chronosphere - Really mean as it pertains to modified-release antiepileptic drugs?
    • Reed RC, Meinhold J, Dutta S, Liu W, Qiu Y,. (2010) What do the suffixes-XR, ER, Chrono, Chronosphere-really mean as it pertains to modified-release antiepileptic drugs? J Clin Pharm Ther 35: 373-383.
    • (2010) J Clin Pharm Ther , vol.35 , pp. 373-383
    • Reed, R.C.1    Meinhold, J.2    Dutta, S.3    Liu, W.4    Qiu, Y.5
  • 35
    • 15344348832 scopus 로고    scopus 로고
    • Clinical comparison of extended-release divalproex versus delayed-release divalproex: Pooled data analyses from nine trials
    • Smith MC, Centorrino F, Welge JA, Collins MA,. (2004) Clinical comparison of extended-release divalproex versus delayed-release divalproex: pooled data analyses from nine trials. Epilepsy Behav 5: 746-751.
    • (2004) Epilepsy Behav , vol.5 , pp. 746-751
    • Smith, M.C.1    Centorrino, F.2    Welge, J.A.3    Collins, M.A.4
  • 36
    • 70149095970 scopus 로고    scopus 로고
    • Oxcarbazepine extended-release formulation in epilepsy
    • Steinhoff BJ,. (2009) Oxcarbazepine extended-release formulation in epilepsy. Expert Rev Clin Pharmacol 2: 155-162.
    • (2009) Expert Rev Clin Pharmacol , vol.2 , pp. 155-162
    • Steinhoff, B.J.1
  • 37
    • 70449624785 scopus 로고    scopus 로고
    • Short-term impact of the switch from immediate-release to extended-release oxcarbazepine in epilepsy patients on high dosages
    • Steinhoff BJ, Wendling AS,. (2009) Short-term impact of the switch from immediate-release to extended-release oxcarbazepine in epilepsy patients on high dosages. Epilepsy Res 87: 256-259.
    • (2009) Epilepsy Res , vol.87 , pp. 256-259
    • Steinhoff, B.J.1    Wendling, A.S.2
  • 38
    • 0031742446 scopus 로고    scopus 로고
    • Controlled, multidose, pharmacokinetic evaluation of two extended-release carbamazepine formulations (Carbatrol and Tegretol-XR)
    • Stevens RE, Limsakun T, Evans G, Mason DH Jr,. (1998) Controlled, multidose, pharmacokinetic evaluation of two extended-release carbamazepine formulations (Carbatrol and Tegretol-XR). J Pharm Sci 87: 1531-1534.
    • (1998) J Pharm Sci , vol.87 , pp. 1531-1534
    • Stevens, R.E.1    Limsakun, T.2    Evans, G.3    Mason, Jr.D.H.4
  • 39
    • 0028858553 scopus 로고
    • Double-blind crossover comparison of Tegretol-XR and Tegretol in patients with epilepsy
    • Tegretol OROS Osmotic Release Delivery System Study Group
    • Tegretol OROS Osmotic Release Delivery System Study Group. (1995) Double-blind crossover comparison of Tegretol-XR and Tegretol in patients with epilepsy. Neurology 45: 1703-1707.
    • (1995) Neurology , vol.45 , pp. 1703-1707
  • 40
    • 39749110172 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics of lamotrigine when converting from a twice-daily immediate-release to a once-daily extended-release formulation in subjects with epilepsy (The COMPASS Study)
    • Tompson DJ, Ali I, Oliver-Willwong R, Job S, Zhu L, Lemme F, Hammer AE, Vuong A, Messenheimer JA,. (2008) Steady-state pharmacokinetics of lamotrigine when converting from a twice-daily immediate-release to a once-daily extended-release formulation in subjects with epilepsy (The COMPASS Study). Epilepsia 49: 410-417.
    • (2008) Epilepsia , vol.49 , pp. 410-417
    • Tompson, D.J.1    Ali, I.2    Oliver-Willwong, R.3    Job, S.4    Zhu, L.5    Lemme, F.6    Hammer, A.E.7    Vuong, A.8    Messenheimer, J.A.9
  • 41
    • 37249091680 scopus 로고    scopus 로고
    • Exposure-response analysis reveals that clinically important toxicity difference can exist between bioequivalent carbamazepine tablets
    • Tothfalusi L, Speidl S, Endrenyi L,. (2008) Exposure-response analysis reveals that clinically important toxicity difference can exist between bioequivalent carbamazepine tablets. Br J Clin Pharmacol 65: 110-122.
    • (2008) Br J Clin Pharmacol , vol.65 , pp. 110-122
    • Tothfalusi, L.1    Speidl, S.2    Endrenyi, L.3
  • 42
    • 84872056691 scopus 로고    scopus 로고
    • [package insert]Novartis Pharmaceuticals Corporation, East Hanover, NJ
    • Trileptal [package insert] (2011) Novartis Pharmaceuticals Corporation, East Hanover, NJ.
    • (2011) Trileptal
  • 43
    • 56749112207 scopus 로고    scopus 로고
    • Pharmacotherapeutics of epilepsy: Use of lamotrigine and expectations for lamotrigine extended release
    • Werz MA,. (2008) Pharmacotherapeutics of epilepsy: use of lamotrigine and expectations for lamotrigine extended release. Ther Clin Risk Manag 4: 1035-1046.
    • (2008) Ther Clin Risk Manag , vol.4 , pp. 1035-1046
    • Werz, M.A.1
  • 44
    • 84872072085 scopus 로고    scopus 로고
    • 2006 World Health OrganizationNeurological disorders: public health challenges. Available at:(accessed August 14, 2012)
    • World Health Organization (2006) Neurological disorders: public health challenges. Available at: http://www.who.int/mental-health/neurology/neurodiso/ en/index.html (accessed August 14, 2012).
  • 45
    • 84872086075 scopus 로고    scopus 로고
    • World Health Organization (2009) Epilepsy fact sheet no. 999. Available at:(Accessed August 14, 2012)
    • World Health Organization (2009) Epilepsy fact sheet no. 999. Available at: http://www.who.int/mediacentre/factsheets/fs999/en/index.html (Accessed August 14, 2012).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.