Refractory epilepsy: Clinical overview

Epilepsia

Volumn 48, Issue SUPPL. 1, 2007, Pages 3-7

  French, Jacqueline A ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Epilepsy; Intractable; Nonresponders; Pharmacogenomics; Pharmacoresistance; Prognostic factors; Refractory; Responder; Treatment resistant

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; LAMOTRIGINE; TOPIRAMATE; VALPROIC ACID;

ANAMNESIS; CONFERENCE PAPER; DATA ANALYSIS; DRUG EXPOSURE; ENVIRONMENT; EPILEPSY; HUMAN; INCIDENCE; PRIORITY JOURNAL; UNSPECIFIED SIDE EFFECT;

ANTICONVULSANTS; DRUG DESIGN; DRUG RESISTANCE; EPILEPSY; HUMANS; INCIDENCE; PHARMACOGENETICS; TREATMENT OUTCOME;

EID: 33847117296     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2007.00992.x     Document Type: Conference Paper

References (26)

1. Brodie MJ. Diagnosing and predicting refractory epilepsy. Acta Neurol Scand Suppl 2005;181:36-9.
2. Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med 2000;342:314-9.
3. Berg AT, Langfitt J, Shinnar S, et al. Howlong does it take for partial epilepsy to become intractable? Neurology 2003;60:186-90.
4. Semah F, Picot MC, Adam C, et al. Is the underlying cause of epilepsy a major prognostic factor for recurrence? Neurology 1998;51:1256-62.
5. Callaghan BC, French JA, Anand K, et al. Treatment changes associated with remission in a refractory adult epilepsy population. Epilepsia 2005;5(6C):S594.
6. BergAT, Shinnar S, Levy SR, et al. Early development of intractable epilepsy in children: a prospective study. Neurology 2001;56:1430-1.
7. Gardiner M. Genetics of idiopathic generalized epilepsies. Epilepsia 2005;46(suppl 9):15-20.
8. Stephen LJ, Kwan P, Shapiro D, et al. Hormone profiles in young adults with epilepsy treated with sodium valproate or lamotrigine monotherapy. Epilepsia 2001;42:1002-6.
9. Hauser WA. GH Sergievsky Center, College of Physicians and Surgeons. Columbia University, New York, NY. Personal communication, 2005.
10. Collaborative Group for the Study of Epilepsy. Prognosis of epilepsy in newly referred patients: a multicenter prospective study of the effects of monotherapy on the long-term course of epilepsy. Epilepsia 1992;33:45-51.
11. Marson A, Jacoby A, Johnson A, et al. Medical Research Council MESS Study Group. Immediate versus deferred antiepileptic drug treatment for early epilepsy and single seizures: a randomised controlled trial. Lancet 2005;365:2007-13.
12. Placencia M, Sander JW, Shorvon SD, et al. Antiepileptic drug treatment in a community health care setting in northern Ecuador: a prospective 12-month assessment. Epilepsy Res 1993;14:237-44.
13. Shinnar S, Berg AT, O'Dell C, et al. Predictors of multiple seizures in a cohort of children prospectively followed from the time of their first unprovoked seizure. Ann Neurol 2000;48:137-9.
14. Hauser WA, Rich SS, Lee JR, et al. Risk of recurrent seizures after two unprovoked seizures. N Engl J Med 1998;338:429-34.
15. Dlugos DJ, Sammel MD, Strom BL, et al. Response to first drug trial predicts outcome in childhood temporal lobe epilepsy. Neurology 2001;57:2259-64.
16. Cockerell OC, Johnson AL, Sander JW, et al. Prognosis of epilepsy: a review and further analysis of the first nine years of the British National General Practice Study of Epilepsy, a prospective populationbased study. Epilepsia 1997;38:31-46.
17. Berg AT, Shinnar S. Complex febrile seizures. Epilepsia 1996;37:126-33.
18. Shafer SQ, Jauser WA, Annegers JF, et al. EEG and other early predictors of epilepsy remission: a community study. Epilepsia 1998;29:590-600.
19. Zhang ZJ, Xing GQ, Russell S, et al. Unidirectional cross-tolerance from levetiracetam to carbamazepine in amygdala-kindled seizures. Epilepsia 2003;44:1487-93.
20. Krupp E, Heynen T, Li XL, et al. Tolerance to the anticonvulsant effects of lamotrigine on amygdala kindled seizures: cross-tolerance to carbamazepine but not valproate or diazepam.
21. French JA, Kanner AM, Bautista J, et al. Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy. Neurology 2004;62:1261-73.
22. Cramer JA, Fisher R, Ben-Menachem E, et al. New antiepileptic drugs: comparison of key clinical trials. Epilepsia 1999;40:590-600.
23. Barcs G, Walker EB, Elger CE, et al. Oxcarbazepine placebo-controlled, dose-ranging trial in refractory partial epilepsy. Epilepsia 2000;41:1597-607.
24. Cereghino JJ, Biton V, Abou-Kahalil B, et al. Levetiracetam for partial seizures: results of a double-blind, randomized clinical trial. Neurology 2000;55:236-42.
25. Faught E,Ayala R, Montouris GG, et al. Randomized controlled trial of zonisamide for the treatment of refractory partial-onset seizures. Neurology 2001;57:1774-9.
26. French JA, Kugler AR, Robbins JL, et al. Dose-response trial of pregabalin adjunctive therapy in patients with partial seizures. Neurology 2003;60:1631-7.