Physical activity correlates with glutamate receptor gene expression in spinally-projecting RVLM neurons: A laser capture microdissection study

Brain Research

Volumn 1585, Issue , 2014, Pages 51-62

  Subramanian, Madhan ^a   Holt, Avril G ^a   Mueller, Patrick J ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Laser capture; Microdissection; Physical activity; qRT PCR; Retrograde tracer; RVLM; Sedentary; Spinally projecting

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA2; 4 AMINOBUTYRIC ACID RECEPTOR; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR 1; GLUTAMATE RECEPTOR 2; GLUTAMATE RECEPTOR 3; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2C; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2D;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL LABELING; CONTROLLED STUDY; CORRELATIONAL STUDY; FLUORESCENCE ANALYSIS; GENE EXPRESSION; GENE EXPRESSION PROFILING; LASER CAPTURE MICRODISSECTION; MALE; NERVE CELL; NONHUMAN; PHYSICAL ACTIVITY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ROSTRAL VENTROLATERAL PORTION OF THE MEDULLA NEURON; SEDENTARY LIFESTYLE; ANIMAL; CYTOLOGY; GENETICS; MEDULLA OBLONGATA; METABOLISM; MOTOR ACTIVITY; NEUROANATOMICAL TRACT TRACING; PHYSIOLOGY; SPINAL CORD; SPRAGUE DAWLEY RAT;

ANIMALS; GENE EXPRESSION; LASER CAPTURE MICRODISSECTION; MALE; MEDULLA OBLONGATA; MOTOR ACTIVITY; NEUROANATOMICAL TRACT-TRACING TECHNIQUES; NEURONS; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA; RECEPTORS, GLUTAMATE; SPINAL CORD;

EID: 84907671057     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2014.06.021     Document Type: Article

References (48)

1. K. Amendt, J. Czachurski, K. Dembowsky, and H. Seller Bulbospinal projections to the intermediolateral cell column: a neuroanatomical study J. Auton. Nerv. Syst. 1 1979 103 107
2. R.A. Dampney Blood pressure regulation by C1 neurons in the rostral ventrolateral medulla: new light on the subject J. Physiol. 587 2009 5513
3. R.A.L. Dampney Functional organization of central pathways regulating the cardiovascular system Physiol. Rev. 74 1994 323 364
4. R.A.L. Dampney, W.W. Blessing, and E. Tan Origin of tonic GABAergic inputs to vasopressor neurons in the subretrofacial nucleus of the rabbit J. Auton. Nerv. Syst. 24 1988 227 239
5. R. Dingledine, K. Borges, D. Bowie, and S.F. Traynelis The glutamate receptor ion channels Pharmacol. Rev. 51 1999 7 61
6. S.M. Dravid, A. Prakash, and S.F. Traynelis Activation of recombinant NR1/NR2C NMDA receptors J. Physiol. 586 2008 4425 4439
7. M.A. Edwards, R.A. Loxley, K. Powers-Martin, J. Lipski, D.J. McKitrick, L.F. Arnolda, and J.K. Phillips Unique levels of expression of N-methyl-d-aspartate receptor subunits and neuronal nitric oxide synthase in the rostral ventrolateral medulla of the spontaneously hypertensive rat Brain Res. Mol. Brain Res. 129 2004 33 43
8. M.R. Emmert-Buck, R.F. Bonner, P.D. Smith, R.F. Chuaqui, Z. Zhuang, S.R. Goldstein, R.A. Weiss, and L.A. Liotta Laser capture microdissection Science 274 1996 998 1001
9. J. Farmer, X. Zhao, H. Van Praag, K. Wodtke, F.H. Gage, and B.R. Christie Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo Neuroscience 124 2004 71 79
10. J.P. Fisher, C.N. Young, and P.J. Fadel Central sympathetic overactivity: maladies and mechanisms Auton. Neurosci. 148 2009 5 15
11. C.M. Foley, J.J. Stanton, E.M. Price, J.T. Cunningham, E.M. Hasser, and C.M. Heesch GABA(A) alpha1 and alpha2 receptor subunit expression in rostral ventrolateral medulla in nonpregnant and pregnant rats Brain Res. 975 2003 196 206
12. P.G. Guyenet The sympathetic control of blood pressure Nat. Rev. Neurosci. 7 2006 335 346
13. P.G. Guyenet, and R.L. Stornetta The presympathetic cells of the rostral ventrolateral medulla (RVLM): anatomy, physiology and role in the control of circulation N.J. Dun, B.H. Machado, P.M. Pilowsky, Neural Mechanisms of Cardiovascular Regulation 2004 Kluwer Academic Publishers Norwell, MA 187 218
14. S.M. Hermes, J.L. Mitchell, M.B. Silverman, P.J. Lynch, B.L. McKee, T.W. Bailey, M.C. Andresen, and S.A. Aicher Sustained hypertension increases the density of AMPA receptor subunit, GluR1, in baroreceptive regions of the nucleus tractus solitarii of the rat Brain Res. 1187 2008 125 136
15. D.A. Huber, and A.M. Schreihofer Altered regulation of the rostral ventrolateral medulla in hypertensive obese Zucker rats Am. J. Physiol. Heart Circ. Physiol. 301 2011 H230 H240
16. I.A. Kerman, B.J. Buck, S.J. Evans, H. Akil, and S.J. Watson Combining laser capture microdissection with quantitative real-time PCR: effects of tissue manipulation on RNA quality and gene expression J. Neurosci. Methods 153 2006 71 85
17. J.M. Kiely, and F.J. Gordon Non-NMDA receptors in the rostral ventrolateral medulla mediate somatosympathetic pressor responses J. Auton. Nerv. Syst. 43 1993 231 240
18. A.C. Kleiber, H. Zheng, H.D. Schultz, J.D. Peuler, and K.P. Patel Exercise training normalizes enhanced glutamate-mediated sympathetic activation from the PVN in heart failure Am. J. Physiol. Regul. Integr. Comp. Physiol. 294 2008 R1863 R1872
19. D.-P. Li, and H.-L. Pan Plasticity of GABAergic control of hypothalamic presympathetic neurons in hypertension Am. J. Physiol. Heart Circ. Physiol. 290 2005 H1110 H1119
20. 1 receptors within the paraventricular nucleus of hypothalamus in rats with heart failure Cir. Res. 93 2003 990 997
21. J.C. Lin, W.L. Tsao, and Y. Wang Cardiovascular effects of NMDA in the RVLM of spontaneously hypertensive rats Brain Res. Bull. 37 1995 289 294
22. J. Lipski, R. Kanjhan, B. Kruszewska, and M. Smith Barosensitive neurons in the rostral ventrolateral medulla of the in vivo: morphological properties and relationship to C1 adrenergic neurons Neuroscience 69 1995 601 618
23. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 2001 402 408
24. I.J. Llewellyn-Smith, and P.J. Mueller Immunoreactivity for the NMDA NR1 subunit in bulbospinal catecholamine and serotonin neurons of rat ventral medulla Auton. Neurosci 2013
25. R. Malinow, and R.C. Malenka AMPA receptor trafficking and synaptic plasticity Annu. Rev. Neurosci. 25 2002 103 126
26. S.C. Malpas Sympathetic nervous system overactivity and its role in the development of cardiovascular disease Physiol. Rev. 90 2010 513 557
27. M.C. Martins-Pinge, L.K. Becker, M.R. Garcia, D.B. Zoccal, R.V. Neto, L.S. Basso, H.C. de Souza, and O.U. Lopes Attenuated pressor responses to amino acids in the rostral ventrolateral medulla after swimming training in conscious rats Auton. Neurosci. 122 2005 21 28
28. Y. Meng, Y. Zhang, and Z. Jia Synaptic transmission and plasticity in the absence of AMPA glutamate receptor GluR2 and GluR3 Neuron 39 2003 163 176
29. N.A. Mischel, and P.J. Mueller In)activity-dependent alterations in resting and reflex control of splanchnic sympathetic nerve activity J. Appl. Physiol. 111 2011 1854 1862
30. N.A. Mischel, I.J. Llewellyn-Smith, and P.J. Mueller Physical (in)activity dependent structural plasticity in bulbospinal catecholaminergic neurons of rat rostral ventrolateral medulla J. Comp. Neurol. 522 2014 499 513
31. T. Miyawaki, J. Minson, L. Arnolda, I. Llewellyn-Smith, J. Chalmers, and P. Pilowsky AMPA/kainate receptors mediate sympathetic chemoreceptor reflex in the rostral ventrolateral medulla Brain Res. 726 1996 64 68
32. T. Miyawaki, A.K. Goodchild, and P.M. Pilowsky Evidence for a tonic GABA-ergic inhibition of excitatory respiratory-related afferents to presympathetic neurons in the rostral ventrolateral medulla Brain Res. 924 2002 56 62
33. A inhibition of the RVLM following hindlimb unloading in rats Am. J. Physiol. 283 2002 R604 R614
34. P.J. Mueller Exercise training and sympathetic nervous system activity: evidence for physical activity dependent neural plasticity Clin. Exp. Pharmacol. Physiol. 34 2007 377 384
35. P.J. Mueller Physical (in)activity-dependent alterations at the rostral ventrolateral medulla: influence on sympathetic nervous system regulation Am. J. Physiol. Regul. Integr. Comp. Physiol. 298 2010 R1468 R1474
36. P.J. Mueller, and N.A. Mischel Selective enhancement of glutamate-mediated pressor responses after GABA(A) receptor blockade in the RVLM of sedentary versus spontaneous wheel running rats Front. Physiol. 3 2012 447
37. T. Nakamura, K. Kawabe, and H.N. Sapru Cold pressor test in the rat: medullary and spinal pathways and neurotransmitters Am. J. Physiol. Heart Circ. Physiol. 295 2008 H1780 H1787
38. G. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates 2007 Elsevier Inc. Burlington, MA
39. C.Y. Pietersen, M.P. Lim, L. Macey, T.U. Woo, and K.C. Sonntag Neuronal type-specific gene expression profiling and laser-capture microdissection Methods Mol. Biol. 755 2011 327 343
40. P.M. Pilowsky, S.B. Abbott, P.G. Burke, M.M. Farnham, C.M. Hildreth, N.N. Kumar, Q. Li, T. Lonergan, S. McMullan, D. Spirovski, and A.K. Goodchild Metabotropic neurotransmission and integration of sympathetic nerve activity by the rostral ventrolateral medulla in the rat Clin. Exp. Pharmacol. Physiol. 35 2008 508 511
41. A.M. Schreihofer, and A.F. Sved The ventrolateral medulla and sympathetic regulation of arterial pressure I.J. Llewellyn-Smith, A.J.M. Verberne, Autonomic control of cardiovascular function 2011 Oxford University Press New York 78 97
42. J.K. Smith, and K.W. Barron Cardiovascular effects of l-glutamate and tetrodotoxin microinjected into the rostral and caudal ventrolateral medulla in normotensive and spontaneously hypertensive rats Brain Res. 506 1 1990 1 8
43. R.L. Stornetta, C.P. Sevigny, A.M. Schreihofer, D.L. Rosin, and P.G. Guyenet Vesicular glutamate transporter DNPI/VGLUT2 is expressed by both C1 adrenergic and nonaminergic presympathetic vasomotor neurons of the rat medulla J. Comp. Neurol. 444 2002 207 220
44. A.F. Sved Tonic glutamatergic drive of RVLM vasomotor neurons? Am. J. Physiol. Regul. Integr. Comp. Physiol. 287 2004 R1301 R1303
45. W.Z. Wang, L.G. Wang, L. Gao, and W. Wang Contribution of AMPA/kainate receptors in the rostral ventrolateral medulla to the hypotensive and sympathoinhibitory effects of clonidine Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 2007 R1232 R1238
46. W.Z. Wang, L. Gao, H.J. Wang, I.H. Zucker, and W. Wang Tonic glutamatergic input in the rostral ventrolateral medulla is increased in rats with chronic heart failure Hypertension 53 2009 370 374
47. F. Yao, F. Yu, L. Gong, D. Taube, D.D. Rao, and R.G. MacKenzie Microarray analysis of fluoro-gold labeled rat dopamine neurons harvested by laser capture microdissection J. Neurosci. Methods 143 2005 95 106
48. I.H. Zucker, W. Wang, M. Brandle, H.D. Schultz, and K.P. Patel Neural regulation of sympathetic nerve activity in heart failure Prog. Cardiovasc. Dis. 37 1995 397 414