메뉴 건너뛰기




Volumn 124, Issue 15, 2014, Pages 2400-2407

NUP98/NSD1 and FLT3/ITD coexpression is more prevalent in younger AML patients and leads to induction failure: A COG and SWOG report

(13)  Ostronoff, Fabiana a,b   Othus, Megan a,c   Gerbing, Robert B d   Loken, Michael R e   Raimondi, Susana C f   Hirsch, Betsy A g   Lange, Beverly J h   Petersdorf, Stephen i   Radich, Jerald a,b   Appelbaum, Frederick R a,b   Gamis, Alan S d,j   Alonzo, Todd A d,k   Meshinchi, Soheil a,d  


Author keywords

[No Author keywords available]

Indexed keywords

FLT3 LIGAND; NUCLEAR RECEPTOR BINDING SET DOMAIN PROTEIN 1; TUMOR MARKER; UNCLASSIFIED DRUG; CD135 ANTIGEN; FLT3 PROTEIN, HUMAN; NUP98-NSD1 PROTEIN, HUMAN; ONCOPROTEIN;

EID: 84907653350     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-04-570929     Document Type: Article
Times cited : (104)

References (42)
  • 1
    • 33846635060 scopus 로고    scopus 로고
    • Influence of new molecular prognostic markers in patients with karyotypically normal acute myeloid leukemia: Recent advances
    • Mrózek K, Döhner H, Bloomfield CD. Influence of new molecular prognostic markers in patients with karyotypically normal acute myeloid leukemia: recent advances. Curr Opin Hematol. 2007;14(2):106-114.
    • (2007) Curr Opin Hematol , vol.14 , Issue.2 , pp. 106-114
    • Mrózek, K.1    Döhner, H.2    Bloomfield, C.D.3
  • 2
    • 42949142189 scopus 로고    scopus 로고
    • Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
    • German-Austrian Acute Myeloid Leukemia Study Group
    • Schlenk RF, Döhner K, Krauter J, et al; German-Austrian Acute Myeloid Leukemia Study Group. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med. 2008;358(18):1909-1918.
    • (2008) N Engl J Med , vol.358 , Issue.18 , pp. 1909-1918
    • Schlenk, R.F.1    Döhner, K.2    Krauter, J.3
  • 3
    • 0034672269 scopus 로고    scopus 로고
    • Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: A Southwest Oncology Group/Eastern Cooperative Oncology Group Study
    • Slovak ML, Kopecky KJ, Cassileth PA, et al. Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group Study. Blood. 2000;96(13):4075-4083.
    • (2000) Blood , vol.96 , Issue.13 , pp. 4075-4083
    • Slovak, M.L.1    Kopecky, K.J.2    Cassileth, P.A.3
  • 4
    • 0037114753 scopus 로고    scopus 로고
    • Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: Results from Cancer and Leukemia Group B (CALGB 8461)
    • Cancer and Leukemia Group B (CALGB 8461)
    • Byrd JC, Mrózek K, Dodge RK, et al; Cancer and Leukemia Group B (CALGB 8461). Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). Blood. 2002;100(13):4325-4336.
    • (2002) Blood , vol.100 , Issue.13 , pp. 4325-4336
    • Byrd, J.C.1    Mrózek, K.2    Dodge, R.K.3
  • 5
    • 77955914238 scopus 로고    scopus 로고
    • Refinement of cytogenetic classification in acute myeloid leukemia: Determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials
    • National Cancer Research Institute Adult Leukaemia Working Group
    • Grimwade D, Hills RK, Moorman AV, et al; National Cancer Research Institute Adult Leukaemia Working Group. Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials. Blood. 2010;116(3):354-365.
    • (2010) Blood , vol.116 , Issue.3 , pp. 354-365
    • Grimwade, D.1    Hills, R.K.2    Moorman, A.V.3
  • 6
    • 77954933160 scopus 로고    scopus 로고
    • Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council Treatment trials AML 10 and 12
    • Harrison CJ, Hills RK, Moorman AV, et al. Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council Treatment trials AML 10 and 12. J Clin Oncol. 2010;28(16):2674-2681.
    • (2010) J Clin Oncol , vol.28 , Issue.16 , pp. 2674-2681
    • Harrison, C.J.1    Hills, R.K.2    Moorman, A.V.3
  • 7
    • 77954089584 scopus 로고    scopus 로고
    • Array-based genomic resequencing of human leukemia
    • Yamashita Y, Yuan J, Suetake I, et al. Array-based genomic resequencing of human leukemia. Oncogene. 2010;29(25):3723-3731.
    • (2010) Oncogene , vol.29 , Issue.25 , pp. 3723-3731
    • Yamashita, Y.1    Yuan, J.2    Suetake, I.3
  • 8
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • Mardis ER, Ding L, Dooling DJ, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med. 2009;361(11):1058-1066.
    • (2009) N Engl J Med , vol.361 , Issue.11 , pp. 1058-1066
    • Mardis, E.R.1    Ding, L.2    Dooling, D.J.3
  • 9
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • Ley TJ, Ding L, Walter MJ, et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med. 2010;363(25):2424-2433.
    • (2010) N Engl J Med , vol.363 , Issue.25 , pp. 2424-2433
    • Ley, T.J.1    Ding, L.2    Walter, M.J.3
  • 10
    • 84885586438 scopus 로고    scopus 로고
    • Genomic landscapes and clonality of de novo AML
    • Miller CA, Wilson RK, Ley TJ. Genomic landscapes and clonality of de novo AML. N Engl J Med. 2013;369(15):1473.
    • (2013) N Engl J Med , vol.369 , Issue.15 , pp. 1473
    • Miller, C.A.1    Wilson, R.K.2    Ley, T.J.3
  • 11
    • 80053354797 scopus 로고    scopus 로고
    • NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern
    • Hollink IH, van den Heuvel-Eibrink MM, Arentsen-Peters ST, et al. NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern. Blood. 2011;118(13):3645-3656.
    • (2011) Blood , vol.118 , Issue.13 , pp. 3645-3656
    • Hollink, I.H.1    Van Den Heuvel-Eibrink, M.M.2    Arentsen-Peters, S.T.3
  • 12
    • 0035883090 scopus 로고    scopus 로고
    • A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia
    • Jaju RJ, Fidler C, Haas OA, et al. A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia. Blood. 2001;98(4):1264-1267.
    • (2001) Blood , vol.98 , Issue.4 , pp. 1264-1267
    • Jaju, R.J.1    Fidler, C.2    Haas, O.A.3
  • 13
    • 0036530203 scopus 로고    scopus 로고
    • A cryptic t(5;11)(q35;p15.5) in 2 children with acute myeloid leukemia with apparently normal karyotypes, identified by a multiplex fluorescence in situ hybridization telomere assay
    • Brown J, Jawad M, Twigg SR, et al. A cryptic t(5;11)(q35;p15.5) in 2 children with acute myeloid leukemia with apparently normal karyotypes, identified by a multiplex fluorescence in situ hybridization telomere assay. Blood. 2002;99(7):2526-2531.
    • (2002) Blood , vol.99 , Issue.7 , pp. 2526-2531
    • Brown, J.1    Jawad, M.2    Twigg, S.R.3
  • 14
    • 0036836507 scopus 로고    scopus 로고
    • Cryptic translocation t(5;11)(q35;p15.5) with involvement of the NSD1 and NUP98 genes without 5q deletion in childhood acute myeloid leukemia
    • Panarello C, Rosanda C, Morerio C. Cryptic translocation t(5;11)(q35;p15.5) with involvement of the NSD1 and NUP98 genes without 5q deletion in childhood acute myeloid leukemia. Genes Chromosomes Cancer. 2002;35(3):277-281.
    • (2002) Genes Chromosomes Cancer , vol.35 , Issue.3 , pp. 277-281
    • Panarello, C.1    Rosanda, C.2    Morerio, C.3
  • 15
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis PD, Gale RE, Frew ME, et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood. 2001;98(6):1752-1759.
    • (2001) Blood , vol.98 , Issue.6 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3
  • 16
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede C, Steudel C, Mohr B, et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood. 2002;99(12):4326-4335.
    • (2002) Blood , vol.99 , Issue.12 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3
  • 17
    • 33845254595 scopus 로고    scopus 로고
    • Clinical implications of FLT3 mutations in pediatric AML
    • Meshinchi S, Alonzo TA, Stirewalt DL, et al. Clinical implications of FLT3 mutations in pediatric AML. Blood. 2006;108(12):3654-3661.
    • (2006) Blood , vol.108 , Issue.12 , pp. 3654-3661
    • Meshinchi, S.1    Alonzo, T.A.2    Stirewalt, D.L.3
  • 18
    • 41949090673 scopus 로고    scopus 로고
    • The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
    • Medical Research Council Adult Leukaemia Working Party
    • Gale RE, Green C, Allen C, et al; Medical Research Council Adult Leukaemia Working Party. The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood. 2008;111(5):2776-2784.
    • (2008) Blood , vol.111 , Issue.5 , pp. 2776-2784
    • Gale, R.E.1    Green, C.2    Allen, C.3
  • 19
    • 84875225956 scopus 로고    scopus 로고
    • Analysis of NUP98/NSD1 translocations in adult AML and MDS patients
    • Thol F, Kölking B, Hollink IH, et al. Analysis of NUP98/NSD1 translocations in adult AML and MDS patients. Leukemia. 2013;27(3):750-754.
    • (2013) Leukemia , vol.27 , Issue.3 , pp. 750-754
    • Thol, F.1    Kölking, B.2    Hollink, I.H.3
  • 20
    • 84873570235 scopus 로고    scopus 로고
    • A rare but specific subset of adult AML patients can be defined by the cytogenetically cryptic NUP98-NSD1 fusion gene
    • Fasan A, Haferlach C, Alpermann T, Kern W, Haferlach T, Schnittger S. A rare but specific subset of adult AML patients can be defined by the cytogenetically cryptic NUP98-NSD1 fusion gene. Leukemia. 2013;27(1):245-248.
    • (2013) Leukemia , vol.27 , Issue.1 , pp. 245-248
    • Fasan, A.1    Haferlach, C.2    Alpermann, T.3    Kern, W.4    Haferlach, T.5    Schnittger, S.6
  • 21
    • 84877923461 scopus 로고    scopus 로고
    • NUP98-NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia
    • Shiba N, Ichikawa H, Taki T, et al. NUP98-NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia. Genes Chromosomes Cancer. 2013;52(7):683-693.
    • (2013) Genes Chromosomes Cancer , vol.52 , Issue.7 , pp. 683-693
    • Shiba, N.1    Ichikawa, H.2    Taki, T.3
  • 22
    • 84884699891 scopus 로고    scopus 로고
    • NUP98-NSD1 fusion in association with FLT3-ITD mutation identifies a prognostically relevant subgroup of pediatric acute myeloid leukemia patients suitable for monitoring by real time quantitative PCR
    • Akiki S, Dyer SA, Grimwade D, et al. NUP98-NSD1 fusion in association with FLT3-ITD mutation identifies a prognostically relevant subgroup of pediatric acute myeloid leukemia patients suitable for monitoring by real time quantitative PCR. Genes Chromosomes Cancer. 2013;52(11):1053-1064.
    • (2013) Genes Chromosomes Cancer , vol.52 , Issue.11 , pp. 1053-1064
    • Akiki, S.1    Dyer, S.A.2    Grimwade, D.3
  • 23
    • 38949185746 scopus 로고    scopus 로고
    • Outcomes in CCG-2961, a children's oncology group phase 3 trial for untreated pediatric acute myeloid leukemia: A report from the children's oncology group
    • Lange BJ, Smith FO, Feusner J, et al. Outcomes in CCG-2961, a children's oncology group phase 3 trial for untreated pediatric acute myeloid leukemia: a report from the children's oncology group. Blood. 2008;111(3):1044-1053.
    • (2008) Blood , vol.111 , Issue.3 , pp. 1044-1053
    • Lange, B.J.1    Smith, F.O.2    Feusner, J.3
  • 24
    • 80055064760 scopus 로고    scopus 로고
    • AAML03P1, a pilot study of the safety of gemtuzumab ozogamicin in combination with chemotherapy for newly diagnosed childhood acute myeloid leukemia: A report from the Children's Oncology Group
    • Cooper TM, Franklin J, Gerbing RB, et al. AAML03P1, a pilot study of the safety of gemtuzumab ozogamicin in combination with chemotherapy for newly diagnosed childhood acute myeloid leukemia: a report from the Children's Oncology Group. Cancer. 2012;118(3):761-769.
    • (2012) Cancer , vol.118 , Issue.3 , pp. 761-769
    • Cooper, T.M.1    Franklin, J.2    Gerbing, R.B.3
  • 25
    • 84907192040 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin in children and adolescents with de novo acute myeloid leukemia improves event-free survival by reducing relapse risk: Results from the randomized phase III Children's Oncology Group Trial AAML0531
    • [published online ahead of print August 4, 2014]
    • Gamis AS, Alonzo TA, Meshinichi S, et al. Gemtuzumab ozogamicin in children and adolescents with de novo acute myeloid leukemia improves event-free survival by reducing relapse risk: results from the randomized phase III Children's Oncology Group Trial AAML0531 [published online ahead of print August 4, 2014]. J Clin Oncol. doi:10.1200/JCO.2014.55.3628.
    • J Clin Oncol
    • Gamis, A.S.1    Alonzo, T.A.2    Meshinichi, S.3
  • 26
    • 84881305790 scopus 로고    scopus 로고
    • A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia
    • Petersdorf SH, Kopecky KJ, Slovak M, et al. A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia. Blood. 2013;121(24):4854-4860.
    • (2013) Blood , vol.121 , Issue.24 , pp. 4854-4860
    • Petersdorf, S.H.1    Kopecky, K.J.2    Slovak, M.3
  • 27
    • 28444449081 scopus 로고    scopus 로고
    • Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype
    • Schnittger S, Schoch C, Kern W, et al. Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype. Blood. 2005;106(12):3733-3739.
    • (2005) Blood , vol.106 , Issue.12 , pp. 3733-3739
    • Schnittger, S.1    Schoch, C.2    Kern, W.3
  • 28
    • 69249229646 scopus 로고    scopus 로고
    • Prevalence and prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia (AML): A report from the Children's Oncology Group
    • Ho PA, Alonzo TA, Gerbing RB, et al. Prevalence and prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group. Blood. 2009;113(26):6558-6566.
    • (2009) Blood , vol.113 , Issue.26 , pp. 6558-6566
    • Ho, P.A.1    Alonzo, T.A.2    Gerbing, R.B.3
  • 29
    • 77956275074 scopus 로고    scopus 로고
    • Prevalence and prognostic implications of WT1 mutations in pediatric acute myeloid leukemia (AML): A report from the Children's Oncology Group
    • Ho PA, Zeng R, Alonzo TA, et al. Prevalence and prognostic implications of WT1 mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group. Blood. 2010;116(5):702-710.
    • (2010) Blood , vol.116 , Issue.5 , pp. 702-710
    • Ho, P.A.1    Zeng, R.2    Alonzo, T.A.3
  • 30
    • 84865406961 scopus 로고    scopus 로고
    • Residual disease detected by multidimensional flow cytometry signifies high relapse risk in patients with de novo acute myeloid leukemia: A report from Children's Oncology Group
    • Loken MR, Alonzo TA, Pardo L, et al. Residual disease detected by multidimensional flow cytometry signifies high relapse risk in patients with de novo acute myeloid leukemia: a report from Children's Oncology Group. Blood. 2012;120(8):1581-1588.
    • (2012) Blood , vol.120 , Issue.8 , pp. 1581-1588
    • Loken, M.R.1    Alonzo, T.A.2    Pardo, L.3
  • 31
    • 84864945751 scopus 로고    scopus 로고
    • FLT3 mutation status is a predictor of early death in pediatric acute promyelocytic leukemia: A report from the Children's Oncology Group
    • Kutny MA, Moser BK, Laumann K, et al. FLT3 mutation status is a predictor of early death in pediatric acute promyelocytic leukemia: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2012;59(4):662-667.
    • (2012) Pediatr Blood Cancer , vol.59 , Issue.4 , pp. 662-667
    • Kutny, M.A.1    Moser, B.K.2    Laumann, K.3
  • 32
    • 21744440587 scopus 로고    scopus 로고
    • Prognostic implication of FLT3 and Ras gene mutations in patients with acute promyelocytic leukemia (APL): A retrospective study from the European APL Group
    • European APL Group
    • Callens C, Chevret S, Cayuela JM, et al; European APL Group. Prognostic implication of FLT3 and Ras gene mutations in patients with acute promyelocytic leukemia (APL): a retrospective study from the European APL Group. Leukemia. 2005;19(7):1153-1160.
    • (2005) Leukemia , vol.19 , Issue.7 , pp. 1153-1160
    • Callens, C.1    Chevret, S.2    Cayuela, J.M.3
  • 33
    • 33745184051 scopus 로고    scopus 로고
    • A retrospective study of 69 patients with t(6;9)(p23;q34) AML emphasizes the need for a prospective, multicenter initiative for rare 'poor prognosis' myeloid malignancies
    • Slovak ML, Gundacker H, Bloomfield CD, et al. A retrospective study of 69 patients with t(6;9)(p23;q34) AML emphasizes the need for a prospective, multicenter initiative for rare 'poor prognosis' myeloid malignancies. Leukemia. 2006;20(7):1295-1297.
    • (2006) Leukemia , vol.20 , Issue.7 , pp. 1295-1297
    • Slovak, M.L.1    Gundacker, H.2    Bloomfield, C.D.3
  • 34
    • 78149467263 scopus 로고    scopus 로고
    • High frequencies of simultaneous FLT3-ITD, WT1 and KIT mutations in hematological malignancies with NUP98-fusion genes
    • Taketani T, Taki T, Nakamura T, et al. High frequencies of simultaneous FLT3-ITD, WT1 and KIT mutations in hematological malignancies with NUP98-fusion genes. Leukemia. 2010;24(11):1975-1977.
    • (2010) Leukemia , vol.24 , Issue.11 , pp. 1975-1977
    • Taketani, T.1    Taki, T.2    Nakamura, T.3
  • 35
    • 67650886013 scopus 로고    scopus 로고
    • Acute myeloid leukemia bearing t(7;11)(p15;p15) is a distinct cytogenetic entity with poor outcome and a distinct mutation profile: Comparative analysis of 493 adult patients
    • Chou WC, Chen CY, Hou HA, et al. Acute myeloid leukemia bearing t(7;11)(p15;p15) is a distinct cytogenetic entity with poor outcome and a distinct mutation profile: comparative analysis of 493 adult patients. Leukemia. 2009;23(7):1303-1310.
    • (2009) Leukemia , vol.23 , Issue.7 , pp. 1303-1310
    • Chou, W.C.1    Chen, C.Y.2    Hou, H.A.3
  • 36
    • 33746620006 scopus 로고    scopus 로고
    • The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia
    • Palmqvist L, Argiropoulos B, Pineault N, et al. The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia. Blood. 2006;108(3):1030-1036.
    • (2006) Blood , vol.108 , Issue.3 , pp. 1030-1036
    • Palmqvist, L.1    Argiropoulos, B.2    Pineault, N.3
  • 37
    • 68049142925 scopus 로고    scopus 로고
    • Acute myeloid leukemia with NUP98-HOXC13 fusion and FLT3 internal tandem duplication mutation: Case report and literature review
    • Tosić N, Stojiljković M, Colović N, Colović M, Pavlović S. Acute myeloid leukemia with NUP98-HOXC13 fusion and FLT3 internal tandem duplication mutation: case report and literature review. Cancer Genet Cytogenet. 2009;193(2):98-103.
    • (2009) Cancer Genet Cytogenet , vol.193 , Issue.2 , pp. 98-103
    • Tosić, N.1    Stojiljković, M.2    Colović, N.3    Colović, M.4    Pavlović, S.5
  • 38
    • 84903739416 scopus 로고    scopus 로고
    • Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: A report from the Children's Oncology Group
    • Tarlock K, Alonzo TA, Moraleda PP, et al. Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: a report from the Children's Oncology Group. Br J Haematol. 2014;166(2):254-259.
    • (2014) Br J Haematol , vol.166 , Issue.2 , pp. 254-259
    • Tarlock, K.1    Alonzo, T.A.2    Moraleda, P.P.3
  • 39
    • 43549123118 scopus 로고    scopus 로고
    • Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model
    • Li L, Piloto O, Nguyen HB, et al. Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model. Blood. 2008;111(7):3849-3858.
    • (2008) Blood , vol.111 , Issue.7 , pp. 3849-3858
    • Li, L.1    Piloto, O.2    Nguyen, H.B.3
  • 40
    • 84863376366 scopus 로고    scopus 로고
    • Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model
    • Greenblatt S, Li L, Slape C, et al. Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model. Blood. 2012;119(12):2883-2894.
    • (2012) Blood , vol.119 , Issue.12 , pp. 2883-2894
    • Greenblatt, S.1    Li, L.2    Slape, C.3
  • 41
    • 34347392874 scopus 로고    scopus 로고
    • NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis
    • Wang GG, Cai L, Pasillas MP, Kamps MP. NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis. Nat Cell Biol. 2007;9(7):804-812.
    • (2007) Nat Cell Biol , vol.9 , Issue.7 , pp. 804-812
    • Wang, G.G.1    Cai, L.2    Pasillas, M.P.3    Kamps, M.P.4
  • 42
    • 79960058024 scopus 로고    scopus 로고
    • Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor
    • Daigle SR, Olhava EJ, Therkelsen CA, et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell. 2011;20(1):53-65.
    • (2011) Cancer Cell , vol.20 , Issue.1 , pp. 53-65
    • Daigle, S.R.1    Olhava, E.J.2    Therkelsen, C.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.