Early netrin-1 expression impairs central nervous system remyelination

Annals of Neurology

Volumn 76, Issue 2, 2014, Pages 252-268

  Tepavčevic̈, Vanja ^a,b,c   Kerninon, Christophe ^a,b,c   Aigrot, Marie Stéphane ^a,b,c   Meppiel, Elodie ^a,b,c   Mozafari, Sabah ^a,b,c   Arnould Laurent, Raphaelle ^a,b,c   Ravassard, Philippe ^a,b,c   Kennedy, Timothy E ^d   Nait Oumesmar, Brahim ^a,b,c   Lubetzki, Catherine ^a,b,c,e  

^a SORBONNE UNIVERSITÉ   (France)

^b INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE   (France)

^c CNRS   (France)

^d MCGILL UNIVERSITY   (Canada)

^e ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

LYSOPHOSPHATIDYLCHOLINE; NETRIN 1; NETRIN 1 RECEPTOR; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; NERVE GROWTH FACTOR; NETRIN RECEPTORS; NETRIN-1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL DIFFERENTIATION; CELL MIGRATION ASSAY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DEMYELINATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REMYELINIZATION; STEM CELL; UPREGULATION; ANIMAL; C57BL MOUSE; DEMYELINATING DISEASE; DISEASE MODEL; METABOLISM; NERVE REGENERATION; NEURAL STEM CELL; PHYSIOLOGY;

ANIMALS; CENTRAL NERVOUS SYSTEM; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; MICE; MICE, INBRED C57BL; NERVE GROWTH FACTORS; NERVE REGENERATION; NEURAL STEM CELLS; OLIGODENDROGLIA; RECEPTORS, CELL SURFACE; TUMOR SUPPRESSOR PROTEINS;

EID: 84907597996     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.24201     Document Type: Article

References (38)

1. Kuhlmann T, Miron V, Cui Q, et al. Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. Brain 2008; 131 (pt 7): 1749-1758.
2. Piaton G, Williams A, Seilhean D, Lubetzki C,. Remyelination in multiple sclerosis. Prog Brain Res 2009; 175: 453-464.
3. Wolswijk G,. Oligodendrocyte precursor cells in the demyelinated multiple sclerosis spinal cord. Brain 2002; 125 (pt 2): 338-349.
4. Boyd A, Zhang H, Williams A,. Insufficient OPC migration into demyelinated lesions is a cause of poor remyelination in MS and mouse models. Acta Neuropathol 2013; 125: 841-859.
5. Kotter MR, Setzu A, Sim FJ, et al. Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination. Glia 2001; 35: 204-212.
6. Foote AK, Blakemore WF,. Inflammation stimulates remyelination in areas of chronic demyelination. Brain 2005; 128 (pt 3): 528-539.
7. Setzu A, Lathia JD, Zhao C, et al. Inflammation stimulates myelination by transplanted oligodendrocyte precursor cells. Glia 2006; 54: 297-303.
8. Blakemore WF,. Regeneration and repair in multiple sclerosis: the view of experimental pathology. J Neurol Sci 2008; 265: 1-4.
9. Bin JM, Rajasekharan S, Kuhlmann T, et al. Full-length and fragmented netrin-1 in multiple sclerosis plaques are inhibitors of oligodendrocyte precursor cell migration. Am J Pathol 2013; 183: 673-680.
10. Serafini T, Colamarino SA, Leonardo ED, et al. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell 1996; 87: 1001-1014.
11. Lu X, Le Noble F, Yuan L, et al. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 2004; 432: 179-186.
12. Klinghoffer RA, Hamilton TG, Hoch R, Soriano P,. An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during development. Dev Cell 2002; 2: 103-113.
13. Piaton G, Aigrot MS, Williams A, et al. Class 3 semaphorins influence oligodendrocyte precursor recruitment and remyelination in adult central nervous system. Brain 2011; 134 (pt 4): 1156-1167.
14. Watkins TA, Emery B, Mulinyawe S, Barres BA,. Distinct stages of myelination regulated by gamma-secretase and astrocytes in a rapidly myelinating CNS coculture system. Neuron 2008; 60: 555-569.
15. Manitt C, Colicos MA, Thompson KM, et al. Widespread expression of netrin-1 by neurons and oligodendrocytes in the adult mammalian spinal cord. J Neurosci 2001; 21: 3911-3922.
16. Lu QR, Yuk D, Alberta JA, et al. Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron 2000; 25: 317-329.
17. Zhou Q, Wang S, Anderson DJ,. Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron 2000; 25: 331-343.
18. Arnett HA, Fancy SP, Alberta JA, et al. bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science 2004; 306: 2111-2115.
19. Manitt C, Kennedy TE,. Where the rubber meets the road: netrin expression and function in developing and adult nervous systems. Prog Brain Res 2002; 137: 425-442.
20. Jarjour AA, Kennedy TE,. Oligodendrocyte precursors on the move: mechanisms directing migration. Neuroscientist 2004; 10: 99-105.
21. Spassky N, de Castro F, Le Bras B, et al. Directional guidance of oligodendroglial migration by class 3 semaphorins and netrin-1. J Neurosci 2002; 22: 5992-6004.
22. Jarjour AA, Manitt C, Moore SW, et al. Netrin-1 is a chemorepellent for oligodendrocyte precursor cells in the embryonic spinal cord. J Neurosci 2003; 23: 3735-3744.
23. Tsai HH, Tessier-Lavigne M, Miller RH,. Netrin 1 mediates spinal cord oligodendrocyte precursor dispersal. Development 2003; 130: 2095-2105.
24. Hong K, Hinck L, Nishiyama M, et al. A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell 1999; 97: 927-941.
25. Lai Wing Sun K, Correia JP, Kennedy TE,. Netrins: versatile extracellular cues with diverse functions. Development 2011; 138: 2153-2169.
26. Manitt C, Wang D, Kennedy TE, Howland DR,. Positioned to inhibit: netrin-1 and netrin receptor expression after spinal cord injury. J Neurosci Res 2006; 84: 1808-1820.
27. Löw K, Culbertson M, Bradke F, et al. Netrin-1 is a novel myelin-associated inhibitor to axon growth. J Neurosci 2008; 28: 1099-1108.
28. Lu H, Wang Y, Yuan F, et al. Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral artery occlusion. Front Med 2011; 5: 86-93.
29. Sun H, Le T, Chang TT, et al. AAV-mediated netrin-1 overexpression increases peri-infarct blood vessel density and improves motor function recovery after experimental stroke. Neurobiol Dis 2011; 44: 73-83.
30. Cayre M, Courtès S, Martineau F, et al. Netrin 1 contributes to vascular remodeling in the subventricular zone and promotes progenitor emigration after demyelination. Development 2013; 140: 3107-3117.
31. Blakemore WF,. Invasion of Schwann cells into the spinal cord of the rat following local injections of lysolecithin. J Neuropath Appl Neurobiol 1976; 2: 21-39.
32. Rajasekharan S, Baker KA, Horn KE, et al. Netrin 1 and Dcc regulate oligodendrocyte process branching and membrane extension via Fyn and RhoA. Development 2009; 136: 415-426.
33. Kornek B, Lassmann H,. Neuropathology of multiple sclerosis-new concepts. Brain Res Bull 2003; 61: 321-326.
34. Irvine KA, Blakemore WF,. Remyelination protects axons from demyelination-associated axon degeneration. Brain 2008; 131 (pt 6): 1464-1477.
35. Moll NM, Hong E, Fauveau M, et al. SOX17 is expressed in regenerating oligodendrocytes in experimental models of demyelination and in multiple sclerosis. Glia 2013; 61: 1659-1672.
36. Back SA, Tuohy TM, Chen H, et al. Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation. Nat Med 2005; 11: 966-972.
37. Stoffels JM, de Jonge JC, Stancic M, et al. Fibronectin aggregation in multiple sclerosis lesions impairs remyelination. Brain 2013; 136 (pt 1): 116-131.
38. Charles P, Reynolds R, Seilhean D, et al. Re-expression of PSA-NCAM by demyelinated axons: an inhibitor of remyelination in multiple sclerosis? Brain 2002; 125 (pt 9): 1972-1979.