Synthesis and evaluation of 9-deoxy analogues of (-)-thysanone, an inhibitor of HRV 3C protease

European Journal of Medicinal Chemistry

Volumn 87, Issue , 2014, Pages 220-227

  Young Jeong, Joo ^a,b   Sperry, Jonathan ^a   Taylor, John A ^b   Brimble, Margaret A ^a,c  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c MAURICE WILKINS CENTRE FOR MOLECULAR BIODISCOVERY   (New Zealand)

Author keywords

CeH activation; HRV 3C protease; Inhibitor; Pyranonaphthoquinone; Thysanone

Indexed keywords

2 BROMO 3 (2 HYDROXYPROPYL) 6 ISOPROXYNAPHTHALENE 1,4 DIONE; 2 BROMO 6 HYDROXY 1,4, DIMETHOXYNAPHTHALENE; 2 BROMO 6 ISOPROPOXY 1,4 DIMETHOXYNAPHTHALENE; 2 BROMO 6 ISOPROPOXYNAPHTHALENE 1,4 DIONE; 2 BROMO 7 HYDROXY 1,4 DIMETHOXYNAPHTHALENE 8; 5,10 DIHYDROXY 7 ISOPROPOXY 3 METHYL 3,4,5,10 TETRAHYDRO 1H BENZO[G]ISOCHROMEN 1 ONE; 6 HYDROXY 1,4 DIMETHOXYNAPHTHALENE; 6 ISOPROPOXY 1,4 DIOXO 1,4 DIHYDRONAPHTHALENE 2 CARBOXYLATE; 7 HYDROXY 3 METHYL 3,4 DIHYDRO 1H BENZO[G] ISOCHROMENE 5,10 DIONE; 7 ISOPROPOXY 3 METHYL 3,4 DIHYDRO 1H BENZO[G]ISOCHROMENE 1,5,10 TRIONE; 7 ISOPROPOXY 3 METHYL 3,4 DIHYDRO 1H BENZO[G]ISOCHROMENE 5,10 DIONE; 9 DEOXYTHYSANONE DERIVATIVE; ANTIVIRUS AGENT; ETHYL 6 ISOPROPOXY 1,4 DIMETHOXY 2 NAPHTHOATE; NAPHTHALENE DERIVATIVE; PHENOL DERIVATIVE; PROTEINASE; PROTEINASE INHIBITOR; QUINONE DERIVATIVE; UNCLASSIFIED DRUG; 3C PROTEASES; BENZOPYRAN DERIVATIVE; CYSTEINE PROTEINASE; NAPHTHOQUINONE; THYSANONE; VIRUS PROTEIN;

ALKYLATION; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CHEMICAL INTERACTION; CHEMICAL REACTION; CLINICAL EVALUATION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; HUMAN; HUMAN RHINOVIRUS; HYDROGEN BOND; HYDROLYSIS; SOLID; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DESIGN; ENZYMOLOGY; METABOLISM; RHINOVIRUS; SYNTHESIS;

BENZOPYRANS; CHEMISTRY TECHNIQUES, SYNTHETIC; CYSTEINE ENDOPEPTIDASES; DRUG DESIGN; NAPHTHOQUINONES; PROTEASE INHIBITORS; RHINOVIRUS; VIRAL PROTEINS;

EID: 84907575362     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.09.063     Document Type: Article

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