Interaction of immune complexes with Fc receptors in mesangial cells: A potential target for the treatment of IgA nephropathy

Nephrology

Volumn 3, Issue 1, 1997, Pages 95-101

  Gomez Guerrero C ^a   Duque, N ^a   Lopez Armada M J ^a   Casado, M T ^a   Vivanco, F ^a   Egido, J ^a,b  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b Hospital UniversitarioFundación Jiménez Díaz   (Spain)

Author keywords

cytokines; Fc receptors; glomerulonephritis; mesangial cells

Indexed keywords

FC RECEPTOR; FIBRONECTIN; IMMUNOGLOBULIN A; MONOCYTE CHEMOTACTIC PROTEIN 1;

ANIMAL CELL; ANTIGEN ANTIBODY COMPLEX; CATABOLISM; CELL PROLIFERATION; CONFERENCE PAPER; GLOMERULONEPHRITIS; HUMAN; HUMAN CELL; IMMUNE COMPLEX DEPOSITION; IMMUNOGLOBULIN A NEPHROPATHY; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION;

EID: 0030941065     PISSN: 13205358     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1797.1997.tb00197.x     Document Type: Conference Paper

References (29)

1. Sedor JR, Carey WS, Emancipator SN. Immune complex bind to cultured rat glomerular mesangial cells to stimulate superoxide release. Evidence for an Fc receptor. J. Immunol. 1987; 138: 3751
2. Singhal PC, Santiago A, Satriano J, Hays RM, Schlondorff D. Effects of vasoactive agents on uptake of immunoglobulin G complexes by mesangial cells. Am. J. Physiol. 1990; 258: F589.
3. Neuwirth R, Singhal P, Diamond B et al. Evidence for immunoglobulin Fc receptor-mediated prostaglandin 2 and platelet-activating factor formation by cultured rat mesangial cells. J. Clin. Invest. 1988; 82: 936.
4. Hora K, Satriano JA, Santiago A et al. Receptors for IgG complexes activate synthesis of monocyte chemoattractant peptide 1 and colony-stimulating factor 1 Proc. Natl Acad. Sci. 1992; 89: 1745.
5. Gómez-Guerrero C, González E, Egido J. Evidence for a specific IgA receptor in rat and human messangial cells. J. Immunol. 1993; 151: 7172.
6. Gómez-Guerrero C, González E, Hernando P, Ruiz-Ortega M, Egido J. Interaction of mesangial cells with IgA and IgG immune complexes: a possible mechanism of glomerular injury in IgA nephropathy. Contrib. Nephrol. 1993; 104: 127.
7. Gómez-Guerrero C, López-Armada MJ, González E, Egido J. Soluble IgA and IgG aggregates are carabolized by cultured rat mesangial cells and induce production of TNF-α and IL-6, and proliferation. J. Immunol. 1994; 153: 5247.
8. Marx M, Sterzel B, Sorokin L. Renal matrix and adhesion in injury and inflammation. Curr. Opin. Nephrol. Hypert. 1993; 2: 257.
9. Klahr S, Schreiner G, Ichikawas I. The progression of renal disease. N. Engl. J. Med. 1988; 318: 1657.
10. Ortiz A, Gómez-Chiarri M, Alonso J et al. The potential role of inflammatory and fibrogenic cytokines in the glomerular diseases. J. Lipid Mediat. 1994; 9: 55.
11. Horii Y, Muraguchi A, Iwako M et al. Involvement of IL-6 in mesangial proliferative glomerulonephritis. J. Immunol. 1989; 143: 3949.
12. Suzuki S, Ebihara I, Tomino Y, Koide H. Transcriptional activation of matrix genes by transforming growth factor β1 in mesangial cells. Exp. Nephrol. 1993; 1: 229.
13. Border WA, Rouslahti E. Transforming growth factor β in disease: The dark side of tissue repair. J. Clin. Invest. 1992; 90: 1-7.
14. Nikolic-Patterson DJ, Lan HY, Hill PA, Atkins RC. Macrophages in renal injury. Kidney Int. 1994; 45: S79.
15. Schlöndorff, D. The role of chemokines in the initiation and progression of renal disease. Kidney Int. 1995; 47: S44.
16. Stahl RA, Thaiss F, Disser M, Helmchen U, Hora K, Schlöndorff D. Increased expression of monocyte chemoattractant protein-1 in anti-thymocyte-induced glomerulonephritis. Kidney Int. 1993; 44: 1036-47.
17. Johnstone A, Thorpe R (eds). In: Immunochemistry in Practice. Blackwell Science, Oxford, 1982; 53.
18. 2+ mobilization in rat and human mesangial cells. J. Immunol. 1996; 156: 4369.
19. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 1985; 260: 3440.
20. Rovin BH, Dickerson JA, Tan LC, Hebert CA. Activation of nuclear factor-κB correlates with MCP-1 expression by human mesangial cells. Kidney Int. 1995; 48: 1263.
21. Löpez-Armada MJ, Gómez-Guerrero C, Egido J. Receptors for immune complexes activate gene expression and synthesis of matrix proteins in cultured rat and human mesangial cells. Role of transforming growth factor β. J. Immunol. 1996; 156 (in press).
22. Sánchez-Crespo M, Alonso F, Barat A, Egido J. Rat serum sickness: Possible role of inflammatory mediators allowing deposition of immune complexes in the glomerular basement membrane. Clin. Exp. Immunol. 1982; 49: 631.
23. Floege J, Eng E, Young BA, Johnson RJ. Factor involved in the regulation of mesangial cell proliferation in vitro and in vivo. Kidney Int. 1993; 43: S47.
24. Schreck R, Meier B, Männal DN, Dröge W, Baeuerle PA. Dithiocarbamates as potent inhibitors of nuclear factor κB activation in intact cells. J. Exp. Med. 1992; 175: 1181.
25. Hynes RO. Fibronectins. Springer Verlag, New York, 1990.
26. Alonso J, Gómez-Chiarri M, Serón D, Condom E, Ortiz A, Egido J. Glomerular upregulation of EIIIA and V120 fibronectin isoforms in proliferative immune complex nephritis. Kidney Int. 1996 (in press).
27. Satriano J, Schlondorff D. Activation and attenuation of transcription factor NF-κB in mouse glomerular mesangial cells in response to tumor necrosis factor-α, immunoglobulin G, and adenosine 3′:5′-cyclic monophosphate. J. Clin. Invest. 1994; 94: 1629.
28. Knauss TC, Mene P, Ricatani A et al. Immune complex activation of rat glomerular mesangial cells: dependence on the Fc region of antibody. Am. J. Physiol. 1989; 257: F478.
29. Rostoker G, Desvaux-Belghiti D, Pilatte Y et al. High-dose immunoglobulin therapy for severe IgA nephropathy and Henoch-Schönlein purpura. Ann. Intern. Med. 1994; 120: 476.