Visceral Leishmaniasis and HIV Coinfection in Latin America

PLoS Neglected Tropical Diseases

Volumn 8, Issue 9, 2014, Pages

  Lindoso, José Angelo ^a,b   Cota, Gláucia Fernandes ^c,d   da Cruz, Alda Maria ^d,e   Goto, Hiro ^b   Maia Elkhoury, Ana Nilce Silveira ^f   Romero, Gustavo Adolfo Sierra ^g,h,i   de Sousa Gomes, Márcia Leite ^j   Santos Oliveira, Joanna Reis ^d   Rabello, Ana ^d  

^a INSTITUTO DE INFECTOLOGIA EMÍLIO RIBAS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c FUNDAÇÃO HOSPITALAR DO ESTADO DE MINAS GERAIS   (Brazil)

^d INSTITUTO OSWALDO CRUZ   (Brazil)

^e STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^f WORLD HEALTH ORGANIZATION   (Switzerland)

^g UNIVERSITY OF BRASILIA   (Brazil)

^h Instituto Nacional de Ciência e Tecnologia de Avaliação de Tecnologia em Saúde   (Brazil)

ⁱ Fundação de Amparo à Pesquisa do Estado do Amazonas FAPEAM   (Brazil)

^j MINISTÉRIO DA SAÚDE   (Brazil)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; AMPHOTERICIN B LIPID COMPLEX; CD38 ANTIGEN; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MACROPHAGE MIGRATION INHIBITION FACTOR; TUMOR NECROSIS FACTOR;

ARTICLE; BONE MARROW BIOPSY; DIARRHEA; DISEASE CONTROL; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEVER; FLUORESCENT ANTIBODY TECHNIQUE; HEPATOMEGALY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; LEISHMANIA INFANTUM; LETHALITY; MIXED INFECTION; POLYMERASE CHAIN REACTION; RELAPSE; SENSITIVITY ANALYSIS; SOUTH AND CENTRAL AMERICA; SPLENOMEGALY; VISCERAL LEISHMANIASIS; BRAZIL; COINFECTION; HIV INFECTIONS; LEISHMANIASIS, VISCERAL; PARASITOLOGY; VIROLOGY;

BRAZIL; COINFECTION; HIV INFECTIONS; HUMANS; LATIN AMERICA; LEISHMANIASIS, VISCERAL;

EID: 84907571964     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0003136     Document Type: Article

References (81)

1. Lainson R, Shaw JJ (1987) Evolution, classification and geographical distribution. In: Peters W, Killick-Kendrick R, editors. The Leishmaniasis in Biology and Medicine. London: Academic Press. pp. 1–20.
2. Pan American Health Organization, WHO (2013) Leishmaniases: Epidemiological Report of the Americas. Washington, D.C.: Pan American Health Organization, World Health Organization.
3. Alvar J, Velez ID, Bern C, Herrero M, Desjeux P, et al. (2012) Leishmaniasis worldwide and global estimates of its incidence. PLoS ONE 7: e35671.
4. UNAIDS (2012) Global report: UNAIDS report on the global AIDS epidemic. Geneva: World Health Organization.
5. UNAIDS (2012) World AIDS Day Report. Available: http://www.unaids.org/en/media/unaids/contentassets/documents/epidemiology/2012/gr2012/jc2434_worldaidsday_results_en.pdf. Accessed 15 August 2014.
6. Alvar J, Aparicio P, Aseffa A, Den Boer M, Canavate C, et al. (2008) The relationship between leishmaniasis and AIDS: the second 10 years. Clin Microbiol Rev 21: 334–359 table of contents.
7. Alvar J, Canavate C, Gutierrez-Solar B, Jimenez M, Laguna F, et al. (1997) Leishmania and human immunodeficiency virus coinfection: the first 10 years. Clin Microbiol Rev 10: 298–319.
8. Nicodemo EL, Duarte MI, Corbett CE, Nicodemo AC, Matta VL, et al. (1990) Visceral leishmaniasis in AIDS patient. Rev Inst Med Trop Sao Paulo 32: 310–311.
9. de la Loma A, Alvar J, Martinez Galiano E, Blazquez J, Alcala Munoz A, et al. (1985) Leishmaniasis or AIDS? Trans R Soc Trop Med Hyg 79: 421–422.
10. Rabello A, Orsini M, Disch J, (2003) Leishmania/HIV co-infection in Brazil: an appraisal. Ann Trop Med Parasitol 97 Suppl 1: 17–28.
11. Ministério da Saúde (2013) Leishmaniose visceral. Brasília (Distrito Federal): Ministério da Saúde.
12. Maia-Elkhoury AN, Alves WA, Sousa-Gomes ML, Sena JM, Luna EA, (2008) Visceral leishmaniasis in Brazil: trends and challenges. Cad Saude Publica 24: 2941–2947.
13. Lima IP, Muller MC, Holanda TA, Harhay M, Costa CH, et al. (2013) Human immunodeficiency virus/Leishmania infantum in the first foci of urban American visceral leishmaniasis: clinical presentation from 1994 to 2010. Rev Soc Bras Med Trop 46: 156–160.
14. Nascimento ET, Moura ML, Queiroz JW, Barroso AW, Araujo AF, et al. (2011) The emergence of concurrent HIV-1/AIDS and visceral leishmaniasis in Northeast Brazil. Trans R Soc Trop Med Hyg 105: 298–300.
15. Sousa-Gomes ML, Maia-Elkhoury ANS, Pelissari DM, Lima FEF Jr, Sena JM, et al. (2011) Co-infection Leishmania/HIV in Brazil: Epidemiological, Clinical and Laboratorial Aspects. Brasília: Epidemiololgia Serviços Saúde. pp. 519/526.
16. Epidemiológica BMdSSdVeSDdV (2011) Manual de recomendações para diagnóstico, tratamento e acompanhamento de pacientes com a coinfecção Leishmania-HIV. In: Ministério da Saúde SdVeS, editor. Brasilia: Ministério da Saúde. 106 p.
17. Maia-Elkhoury AN, Carmo EH, Sousa-Gomes ML, Mota E, (2007) [Analysis of visceral leishmaniasis reports by the capture-recapture method]. Rev Saude Publica 41: 931–937.
18. Carranza-Tamayo CO, de Assis TS, Neri AT, Cupolillo E, Rabello A, et al. (2009) Prevalence of Leishmania infection in adult HIV/AIDS patients treated in a tertiary-level care center in Brasilia, Federal District, Brazil. Trans R Soc Trop Med Hyg 103: 743–748.
19. Orsini M, Canela JR, Disch J, Maciel F, Greco D, et al. (2012) High frequency of asymptomatic Leishmania spp. infection among HIV-infected patients living in endemic areas for visceral leishmaniasis in Brazil. Trans R Soc Trop Med Hyg 106: 283–288.
20. Bernier R, Barbeau B, Olivier M, Tremblay MJ, (1998) Mycobacterium tuberculosis mannose-capped lipoarabinomannan can induce NF-kappaB-dependent activation of human immunodeficiency virus type 1 long terminal repeat in T cells. J Gen Virol 79 (Pt 6) 1353–1361.
21. Bernier R, Turco SJ, Olivier M, Tremblay M, (1995) Activation of human immunodeficiency virus type 1 in monocytoid cells by the protozoan parasite Leishmania donovani. J Virol 69: 7282–7285.
22. Garg R, Barat C, Ouellet M, Lodge R, Tremblay MJ, (2009) Leishmania infantum amastigotes enhance HIV-1 production in cocultures of human dendritic cells and CD4 T cells by inducing secretion of IL-6 and TNF-alpha. PLoS Negl Trop Dis 3: e441.
23. Mock DJ, Hollenbaugh JA, Daddacha W, Overstreet MG, Lazarski CA, et al. (2012) Leishmania induces survival, proliferation and elevated cellular dNTP levels in human monocytes promoting acceleration of HIV co-infection. PLoS Pathog 8: e1002635.
24. Barreto-de-Souza V, Pacheco GJ, Silva AR, Castro-Faria-Neto HC, Bozza PT, et al. (2006) Increased Leishmania replication in HIV-1-infected macrophages is mediated by tat protein through cyclooxygenase-2 expression and prostaglandin E2 synthesis. J Infect Dis 194: 846–854.
25. Zhao C, Thibault S, Messier N, Ouellette M, Papadopoulou B, et al. (2006) In primary human monocyte-derived macrophages exposed to Human immunodeficiency virus type 1, does the increased intracellular growth of Leishmania infantum rely on its enhanced uptake? J Gen Virol 87: 1295–1302.
26. Lodge R, Ouellet M, Barat C, Andreani G, Kumar P, et al. (2012) HIV-1 promotes intake of Leishmania parasites by enhancing phosphatidylserine-mediated, CD91/LRP-1-dependent phagocytosis in human macrophages. PLoS ONE 7: e32761.
27. Antinori S, Calattini S, Longhi E, Bestetti G, Piolini R, et al. (2007) Clinical use of polymerase chain reaction performed on peripheral blood and bone marrow samples for the diagnosis and monitoring of visceral leishmaniasis in HIV-infected and HIV-uninfected patients: a single-center, 8-year experience in Italy and review of the literature. Clin Infect Dis 44: 1602–1610.
28. Cruz I, Canavate C, Rubio JM, Morales MA, Chicharro C, et al. (2002) A nested polymerase chain reaction (Ln-PCR) for diagnosing and monitoring Leishmania infantum infection in patients co-infected with human immunodeficiency virus. Trans R Soc Trop Med Hyg 96 Suppl 1: S185–189.
29. Santos-Oliveira JR, Regis EG, Giacoia-Gripp CB, Valverde JG, Alexandrino-de-Oliveira P, et al. (2013) Microbial translocation induces an intense proinflammatory response in patients with visceral leishmaniasis and HIV type 1 coinfection. J Infect Dis 208: 57–66.
30. Da-Cruz AM, Machado ES, Menezes JA, Rutowitsch MS, Coutinho SG, (1992) Cellular and humoral immune responses of a patient with American cutaneous leishmaniasis and AIDS. Trans R Soc Trop Med Hyg 86: 511–512.
31. Da-Cruz AM, Rodrigues AC, Mattos M, Oliveira-Neto MP, Sabbaga-Amato V, et al. (2006) [Immunopathologic changes in HIV-Leishmania co-infection]. Rev Soc Bras Med Trop 39 Suppl 3: 75–79.
32. Rosenthal E, Marty P, del Giudice P, Pradier C, Ceppi C, et al. (2000) HIV and Leishmania coinfection: a review of 91 cases with focus on atypical locations of Leishmania. Clin Infect Dis 31: 1093–1095.
33. Balkhair A, Ben Abid F, (2008) Gastric and cutaneous dissemination of visceral leishmaniasis in a patient with advanced HIV. Int J Infect Dis 12: 111–113.
34. Gomez Senent S, Adan Merino L, Mora Sanz P, (2009) [Kala azar with gastric involvement]. Gastroenterol Hepatol 32: 176–177.
35. Benito JM, Lopez M, Soriano V, (2004) The role of CD8+ T-cell response in HIV infection. AIDS Rev 6: 79–88.
36. Lawn SD, Butera ST, Folks TM, (2001) Contribution of immune activation to the pathogenesis and transmission of human immunodeficiency virus type 1 infection. Clin Microbiol Rev 14: 753–777 table of contents.
37. Costa CH, Werneck GL, Costa DL, Holanda TA, Aguiar GB, et al. (2010) Is severe visceral leishmaniasis a systemic inflammatory response syndrome? A case control study. Rev Soc Bras Med Trop 43: 386–392.
38. Goto H, Prianti M, (2009) Immunoactivation and immunopathogeny during active visceral leishmaniasis. Rev Inst Med Trop Sao Paulo 51: 241–246.
39. Santos-Oliveira JR, Da-Cruz AM, (2012) Lipopolysaccharide-Induced Cellular Activation May Participate in the Immunopathogenesis of Visceral Leishmaniasis Alone or in HIV Coinfection. Int J Microbiol 2012: 364534.
40. Sinha PK, Bimal S, Singh SK, Pandey K, Gangopadhyay DN, et al. (2006) Pre- & post-treatment evaluation of immunological features in Indian visceral leishmaniasis (VL) patients with HIV co-infection. Indian J Med Res 123: 197–202.
41. Alexandrino-de-Oliveira P, Santos-Oliveira JR, Dorval ME, Da-Costa F, Pereira GR, et al. (2010) HIV/AIDS-associated visceral leishmaniasis in patients from an endemic area in Central-west Brazil. Mem Inst Oswaldo Cruz 105: 692–697.
42. Cota GF, de Sousa MR, Rabello A, (2011) Predictors of visceral leishmaniasis relapse in HIV-infected patients: a systematic review. PLoS Negl Trop Dis 5: e1153.
43. Barral-Netto M, Barral A, Santos SB, Carvalho EM, Badaro R, et al. (1991) Soluble IL-2 receptor as an agent of serum-mediated suppression in human visceral leishmaniasis. J Immunol 147: 281–284.
44. Nylen S, Maurya R, Eidsmo L, Manandhar KD, Sundar S, et al. (2007) Splenic accumulation of IL-10 mRNA in T cells distinct from CD4+CD25+ (Foxp3) regulatory T cells in human visceral leishmaniasis. J Exp Med 204: 805–817.
45. Peruhype-Magalhaes V, Martins-Filho OA, Prata A, Silva Lde A, Rabello A, et al. (2006) Mixed inflammatory/regulatory cytokine profile marked by simultaneous raise of interferon-gamma and interleukin-10 and low frequency of tumour necrosis factor-alpha(+) monocytes are hallmarks of active human visceral Leishmaniasis due to Leishmania chagasi infection. Clin Exp Immunol 146: 124–132.
46. Santos-Oliveira JR, Giacoia-Gripp CB, Alexandrino de Oliveira P, Amato VS, Lindoso JA, et al. (2010) High levels of T lymphocyte activation in Leishmania-HIV-1 co-infected individuals despite low HIV viral load. BMC Infect Dis 10: 358.
47. Santos-Oliveira JR, Da-Cruz AM, Pires LH, Cupolillo E, Kuhls K, et al. (2011) Atypical lesions as a sign of cutaneous dissemination of visceral leishmaniasis in a human immunodeficiency virus-positive patient simultaneously infected by two viscerotropic Leishmania species. Am J Trop Med Hyg 85: 55–59.
48. Guadalupe M, Reay E, Sankaran S, Prindiville T, Flamm J, et al. (2003) Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy. J Virol 77: 11708–11717.
49. Alvarez-Nebreda ML, Alvarez-Fernandez E, Rada S, Branas F, Maranon E, et al. (2005) Unusual duodenal presentation of leishmaniasis. J Clin Pathol 58: 1321–1322.
50. Hicks L, Kant P, Tay PH, Vincini V, Schuster H, et al. (2009) Visceral Leishmaniasis presenting with intestinal failure: a case report and literature review. Eur J Gastroenterol Hepatol 21: 117–122.
51. Molaei M, Minakari M, Pejhan S, Mashayekhi R, Modaress Fatthi AR, et al. (2011) Intestinal leishmaniasis in acquired immunodeficiency syndrome. Iran Red Crescent Med J 13: 348–351.
52. Roselino AM, Chociay MF, Costa RS, Machado AA, Figueiredo JF, (2008) L. (L.) chagasi in AIDS and visceral leishmaniasis (kala-azar) co-infection. Rev Inst Med Trop Sao Paulo 50: 251–254.
53. Mehandru S, Poles MA, Tenner-Racz K, Horowitz A, Hurley A, et al. (2004) Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. J Exp Med 200: 761–770.
54. Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, et al. (2006) Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 12: 1365–1371.
55. Douek DC, Roederer M, Koup RA, (2009) Emerging concepts in the immunopathogenesis of AIDS. Annu Rev Med 60: 471–484.
56. Cota GF, de Sousa MR, Fereguetti TO, Rabello A, (2013) Efficacy of anti-leishmania therapy in visceral leishmaniasis among HIV infected patients: a systematic review with indirect comparison. PLoS Negl Trop Dis 7: e2195.
57. Savino W, (2006) The thymus is a common target organ in infectious diseases. PLoS Pathog 2: e62.
58. Chehter EZ, Longo MA, Laudanna AA, Duarte MI, (2001) Pancreatic involvement in co-infection visceral leishmaniasis and HIV: histological and ultrastructural aspects. Rev Inst Med Trop Sao Paulo 43: 75–78.
59. Hernandez DE, Oliver M, Martinez C, Planas G, (1995) Visceral leishmaniasis with cutaneous and rectal dissemination due to Leishmania braziliensis in acquired immunodeficiency syndrome (AIDS). Int J Dermatol 34: 114–115.
60. Balagopal A, Ray SC, De Oca RM, Sutcliffe CG, Vivekanandan P, et al. (2009) Kupffer cells are depleted with HIV immunodeficiency and partially recovered with antiretroviral immune reconstitution. AIDS 23: 2397–2404.
61. Duarte MI, de Andrade HF, JrTakamura CF, Sesso A, Tuon FF, (2009) TGF-beta and mesenchymal hepatic involvement after visceral leishmaniasis. Parasitol Res 104: 1129–1136.
62. Tuyama AC, Hong F, Saiman Y, Wang C, Ozkok D, et al. (2010) Human immunodeficiency virus (HIV)-1 infects human hepatic stellate cells and promotes collagen I and monocyte chemoattractant protein-1 expression: implications for the pathogenesis of HIV/hepatitis C virus-induced liver fibrosis. Hepatology 52: 612–622.
63. Cota GF, de Sousa MR, de Mendonca AL, Patrocinio A, Assuncao LS, et al. (2014) Leishmania-HIV Co-infection: Clinical Presentation and Outcomes in an Urban Area in Brazil. PLoS Negl Trop Dis 8: e2816.
64. Bittencourt A, Silva N, Straatmann A, Nunes VL, Follador I, et al. (2003) Post-kala-azar dermal leishmaniasis associated with AIDS. Braz J Infect Dis 7: 229–233.
65. Carnauba D, JrKonishi CT, Petri V, Martinez IC, Shimizu L, et al. (2009) Atypical disseminated leishmaniasis similar to post-kala-azar dermal leishmaniasis in a Brazilian AIDS patient infected with Leishmania (Leishmania) infantum chagasi: a case report. Int J Infect Dis 13: e504–507.
66. Orsini M, Silva M, Luz ZM, Disch J, Fernandes O, et al. (2002) Identification of Leishmania chagasi from skin in Leishmania/HIV co-infection: a case report. Rev Soc Bras Med Trop 35: 259–262.
67. Ramos-Santos C, Hernandez-Montes O, Sanchez-Tejeda G, Monroy-Ostria A, (2000) Visceral leishmaniosis caused by Leishmania (L.) mexicana in a Mexican patient with human immunodeficiency virus infection. Mem Inst Oswaldo Cruz 95: 733–737.
68. Posada-Vergara MP, Lindoso JA, Tolezano JE, Pereira-Chioccola VL, Silva MV, et al. (2005) Tegumentary leishmaniasis as a manifestation of immune reconstitution inflammatory syndrome in 2 patients with AIDS. J Infect Dis 192: 1819–1822.
69. Cota GF, de Sousa MR, Demarqui FN, Rabello A, (2012) The diagnostic accuracy of serologic and molecular methods for detecting visceral leishmaniasis in HIV infected patients: meta-analysis. PLoS Negl Trop Dis 6: e1665.
70. Cota GF, de Sousa MR, de Freitas Nogueira BM, Gomes LI, Oliveira E, et al. (2013) Comparison of parasitological, serological, and molecular tests for visceral leishmaniasis in HIV-infected patients: a cross-sectional delayed-type study. Am J Trop Med Hyg 89: 570–577.
71. Boelaert M, El-Safi S, Hailu A, Mukhtar M, Rijal S, et al. (2008) Diagnostic tests for kala-azar: a multi-centre study of the freeze-dried DAT, rK39 strip test and KAtex in East Africa and the Indian subcontinent. Trans R Soc Trop Med Hyg 102: 32–40.
72. Chappuis F, Rijal S, Jha UK, Desjeux P, Karki BM, et al. (2006) Field validity, reproducibility and feasibility of diagnostic tests for visceral leishmaniasis in rural Nepal. Trop Med Int Health 11: 31–40.
73. Souza GF, Biscione F, Greco DB, Rabello A, (2012) Slow clinical improvement after treatment initiation in Leishmania/HIV coinfected patients. Rev Soc Bras Med Trop 45: 147–150.
74. Daher EF, Fonseca PP, Gerhard ES, Leitao TM, Silva Junior GB, (2009) Clinical and epidemiological features of visceral leishmaniasis and HIV co-infection in fifteen patients from Brazil. J Parasitol 95: 652–655.
75. van Griensven J, Diro E, Lopez-Velez R, Boelaert M, Lynen L, et al. (2013) HIV-1 protease inhibitors for treatment of visceral leishmaniasis in HIV-co-infected individuals. Lancet Infect Dis 13: 251–259.
76. Inocencio da Luz R, Romero GA, Dorval ME, Cruz I, Canavate C, et al. (2011) Drug susceptibility of Leishmania infantum (syn. Leishmania chagasi) isolates from Brazilian HIV-positive and HIV-negative patients. J Antimicrob Chemother 66: 677–679.
77. Romero GA, Boelaert M, (2010) Control of visceral leishmaniasis in latin america-a systematic review. PLoS Negl Trop Dis 4: e584.
78. Dye C, (1996) The logic of visceral leishmaniasis control. Am J Trop Med Hyg 55: 125–130.
79. Costa DN, Codeco CT, Silva MA, Werneck GL, (2013) Culling dogs in scenarios of imperfect control: realistic impact on the prevalence of canine visceral leishmaniasis. PLoS Negl Trop Dis 7: e2355.
80. Croft SL, Olliaro P, (2011) Leishmaniasis chemotherapy–challenges and opportunities. Clin Microbiol Infect 17: 1478–1483.
81. Nissapatorn V, Sawangjaroen N, (2011) Parasitic infections in HIV infected individuals: diagnostic & therapeutic challenges. Indian J Med Res 134: 878–897.