High levels of T lymphocyte activation in Leishmania-HIV-1 co-infected individuals despite low HIV viral load

BMC Infectious Diseases

Volumn 10, Issue , 2010, Pages

  Santos Oliveira, Joanna R ^a   Giacoia Gripp, Carmem B W ^a   Alexandrino de Oliveira, Priscilla ^b   Amato, Valdir S ^c   Lindoso, Jose T L ^c   Goto, Hiro ^c   Oliveira Neto, Manoel P ^d   Mattos, Marise S ^d   Grinsztejn, Beatriz ^d   Morgado, Mariza G ^a   Da Cruz, Alda M ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL UNIVERSITY OF MATO GROSSO DO SUL   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d Funda??o Oswaldo Cruz   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANTILEISHMANIAL AGENT; ANTIRETROVIRUS AGENT; CD38 ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LEISHMANIASIS; MALE; MIXED INFECTION; REMISSION; T LYMPHOCYTE ACTIVATION; TEGUMENTARY LEISHMANIASIS; VIREMIA; VIRUS LOAD; VISCERAL LEISHMANIASIS; CD4 CD8 RATIO; CHEMISTRY; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; MIDDLE AGED; T LYMPHOCYTE; VIROLOGY; WESTERN HEMISPHERE;

ADULT; AMERICAS; ANTIGENS, CD38; CD4 LYMPHOCYTE COUNT; CD4-CD8 RATIO; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; LEISHMANIASIS; MALE; MIDDLE AGED; T-LYMPHOCYTES; VIRAL LOAD;

EID: 78650278299     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-10-358     Document Type: Article

References (35)

1. Alvar J, Aparicio P, Aseffa A, Den Boer M, Cañavate C, Dedet JP, Gradoni L, Ter Horst R, López-Vélez R, Moreno J. The relationship between leishmaniasis and AIDS: the second 10 years. Clin Microbiol Rev 2008, 21:334-359. 10.1128/CMR.00061-07, 2292576, 18400800.
2. Coura JR, Galvão-Castro B, Grimaldi G. Disseminated American cutaneous leishmaniasis in a patient with AIDS. Mem Inst Oswaldo Cruz 1987, 82:581-582.
3. Da-Cruz AM, Mattos M, Oliveira-Neto MP, Coutinho Z, Machado ES, Coutinho SG. Cellular immune responses to Leishmania braziliensis in patients with AIDS-associated American cutaneous leishmaniasis. Trans R Soc Trop Med Hyg 2000, 94:569-571. 10.1016/S0035-9203(00)90090-7, 11132391.
4. Couppié P, Clyti E, Sobesky M, Bissuel F, Del Giudice P, Saint-Marie D, Debret JP, Carme B, Pradinaud D. Comparative study of cutaneous leishmaniasis in human immunodeficiency virus (HIV)-infected patients and non-HIV-infected patients in French Guiana. Br J Dermatol 2004, 151:1165-1171. 10.1111/j.1365-2133.2004.06226.x, 15606511.
5. Lindoso JA, Barbosa RN, Posada-Vergara MP, Duarte MI, Oyafuso LK, Amato VS, Goto H. Unusual manifestations of tegumentary leishmaniasis in AIDS patients from the New World. Br J Dermatol 2009, 160:311-318. 10.1111/j.1365-2133.2008.08908.x, 19187345.
6. Padovese V, Terranova M, Toma L, Barnabas GA, Morrone A. Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns. Trans R Soc Trop Med Hyg 2009, 103:707-711. 10.1016/j.trstmh.2009.02.023, 19356780.
7. Rabello A, Orsini M, Disch J. Leishmania/HIV co-infection in Brazil: an appraisal. Ann Trop Med Parasitol 2003, 97:S17-S28.
8. Carvalho EM, Bacellar O, Barral A, Badaró R, Johnson WD. Antigen-specific immunosupression in visceral leishmaniasis is cell mediated. J Clin Invest 1989, 83:860-864. 10.1172/JCI113969, 303759, 2522103.
9. Saha S, Mondal S, Banerjee A, Ghose J, Bhowmick S, Ali N. Immune responses in kala-azar. Indian J Med Re 2006, 123:245-266.
10. Schriefer A, Wilson ME, Carvalho EM. Recent developments leading toward a paradigm switch in the diagnostic and therapeutic approach to human leishmaniasis. Curr Opin Infect Dis 2008, 21:483-488. 10.1097/QCO.0b013e32830d0ee8, 2593452, 18725797.
11. Goto H, Prianti MG. Immunoactivation and immunopathogeny during active visceral leishmaniasis. Rev Inst Med Trop São Paulo 2009, 51:241-246.
12. Da-Cruz AM, Bittar R, Mattos M, Oliveira-Neto MP, Nogueira R, Pinho-Ribeiro V, Azeredo-Coutinho RB, Coutinho SG. T-cell-mediated immune responses in patients with cutaneous or mucosal leishmaniasis: long-term evaluation after therapy. Clin Diagn Lab Immunol 2002, 9:251-256. 119941, 11874860.
13. Zhao C, Papadopoulou B, Tremblay MJ. Leishmania infantum enhances human immunodeficiency virus type-1 replication in primary human macrophages through a complex cytokine network. Clin Immunol 2004, 113:81-88. 10.1016/j.clim.2004.06.003, 15380533.
14. Cacopardo B, Nigro L, Preiser W, Fama A, Satariano MI, Braner J, Celesia BM, Weber B, Russo R, Doerr HW. Prolonged Th2 cell activation and increased viral replication in HIV-Leishmania co-infected patients despite treatment. Trans R Soc Trop Med Hyg 1996, 90:434-435. 10.1016/S0035-9203(96)90538-6, 8882199.
15. Wolday D, Akuffo H, Fessahaye G, Valentine A, Britton S. Live and killed human immunodeficiency virus type-1 increases the intracellular growth of Leishmania donovani in monocyte-derived cells. Scand J Infect Dis 1998, 30:29-34. 10.1080/003655498750002268, 9670355.
16. Barreto de Souza V, Pacheco GJ, Silva AR, Castro-Faria-Neto HC, Bozza PT, Saraiva EM, Bou-Habbib DC. Increased Leishmania replication in HIV-1-infected macrophages is mediated by tat protein through cyclooxygenase-2 expression and prostaglandin E2 synthesis. J Infect Dis 2006, 194:846-854. 10.1086/506618, 16941353.
17. Lopez-Velez R, Casado J, Pintado V. Decline of a visceral leishmaniasis epidemic in HIV-infected patients after the introduction of highly active antiretroviral therapy (HAART). Clin Microbiol Infect 2001, 7:394-395. 10.1046/j.1198-743x.2001.00270.x, 11531992.
18. Del Giudice P, Mary-Krause M, Pradier C, Grabar S, Dellamonica P, Marty P, Gastaut JA, Costagliola D, Rosenthal E, . the clinical Group of the French Hospital Database on HIV Impact of highly active antiretroviral therapy on the incidence of visceral leishmaniasis in aFrench Cohort of patients infected with human immunodeficiency virus. J Infect Dis 2002, 186:1366-1370. 10.1086/344325, 12402211, the clinical Group of the French Hospital Database on HIV.
19. Casado JL, Lopez-Velez R, Pintado V, Quereda C, Antela A, Moreno S. Relapsing visceral leishmaniasis in HIV-infected patients undergoing successful protease inhibitor therapy. Eur J Clin Microbiol Infect Dis 2001, 20:202-205. 10.1007/s100960100457, 11347673.
20. Nigro L, Rizzo ML, Vancheri C, La rosa R, Mastruzzo C, Tomaselli V, Ragusa A, Manuele R, Cacopardo B. CCR5 and CCR3 expression on T CD3+ lymphocytes from HIV/Leishmania co-infected subjects. Med Microbiol Immunol 2007, 196:253-255. 10.1007/s00430-007-0046-1, 17457607.
21. Preiser W, Cacopardo B, Nigro L, Braner J, Nunnari A, Doerr HW, Weber B. Immunological findings in HIV-Leishmania coinfection. Intervirology 1996, 39:285-288.
22. Grossman Z, Meier-Schellersheim M, Paul WE, Picker LJ. Pathogenesis of HIV infection: what the virus spare is as important as what it destroys. Nat Med 2006, 12:289-295. 10.1038/nm1380, 16520776.
23. Bofill M, Mocroft A, Lipman M, Medina E, Borthwick NJ, Sabin CA, Timms A, Winter M, Baptista L, Johnson MA, Lee CA, Phillips AN, Janossy G. Increased numbers of primed activated CD8+CD38+CD45RO+ T cells predict the decline of CD4+ T cells in HIV-infected patients. AIDS 1996, 10:827-834. 10.1097/00002030-199607000-00005, 8828739.
24. Benito JM, Lopez M, Lozano S, Martinez P, Gonzalez-Lahoz J, Soriano V. CD38 expression on CD8+ T lymphocytes as a marker of residual virus replication in chronically HIV-infected patients receiving antiretroviral therapy. AIDS Res Hum Retroviruses 2004, 20:227-233. 10.1089/088922204773004950, 15018711.
25. Douek D, Roederer M, Koup R. Emerging concepts in the immunopathogenesis of AIDS. Annu Rev Med 2009, 60:471-484. 10.1146/annurev.med.60.041807.123549, 2716400, 18947296.
26. Bentwich Z, Kalinkovich A, Weisman Z. Immune activation is a dominant factor in the pathogenesis of African AIDS. Immunol Today 1995, 16:187-191. 10.1016/0167-5699(95)80119-7, 7734046.
27. Rodrigues DS, Cunha RM, Kallas EG, Salomão R. Distribution of naive/effector CD4+ T lymphocytes and expression of CD38 on CD8+ T lymphocytes in AIDS patients with tuberculosis. Braz J Infect Dis 2003, 7:161-165. 10.1590/S1413-86702003000200010, 12959688.
28. Gonzalez VD, Falconer K, Blom KG, Reichard O, Mørn B, Laursen AL, Weis N, Alaeus A, Sandberg JK. High levels of chronic immune activation in the T-cell compartments of patients coinfected with hepatitis C virus and human immunodeficiency virus type 1 and on highly active antiretroviral therapy are reverted by alpha interferon and ribavirin treatment. J Virol 2009, 83:11407-11411. 10.1128/JVI.01211-09, 2772767, 19710147.
29. Maidana-Giret MT, Silva TM, Sauer MM, Tomiyama H, Levi JE, Bassichetto KC, Nishiya A, Diaz RS, Sabino EC, Palacios R, Kallas EG. GB virus type C infection modulates T-cell activation independently of HIV-1 viral load. AIDS 2009, 23:2277-2287. 10.1097/QAD.0b013e32832d7a11, 19773635.
30. Jacobson MA, Ditmer DP, Sinclair E, Martin JN, Deeks SG, Hunt P, Mocarski ES, Shiboski C. Human herpesvirus replication and abnormal CD8+ T cell activation and low CD4+ T cell counts in antiretroviral-suppressed HIV-infected patients. Plos One 2009, 4:e5277. 10.1371/journal.pone.0005277, 2667217, 19381272.
31. Mattos M, Caiza A, Fernandes O, Gonçalves AJS, Pirmez C, Souza CSF, Oliveira-Neto MP. American cutaneous leishmaniasis associated with HIV infection: report of four cases. J Eur Acad Dermatol Venerol 1998, 10:218-225.
32. Daher ED, Fonseca PP, Gerhard ES, Silva Leitão TD, Silva GB. Clinical and epidemiological features of visceral leishmaniasis and HIV co-infection in 15 patients from Brazil. J Parasitol 2008, 2:1.
33. McCune JM. The dynamics of CD4+ T-cell depletion in HIV disease. Nature 2001, 410:974-979. 10.1038/35073648, 11309627.
34. Benito JM, López M, Lozano S, González-Lahoz J, Soriano V. Down-regulation of interleukin-7 receptor (CD127) in HIV infection is associated with T cell activation and is a main factor influencing restoration of CD4(+) cells after antiretroviral therapy. J Infect Dis 2008, 198:1466-73. 10.1086/592716, 18847371.
35. Liu Z, Cumberland WG, Hultin LE, Prince HE, Detels R, Giorgi JV. Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression. J Acquir Immune Defic Syndr Hum Retrovirol 1997, 16:83-92.