Boron neutron capture therapy (BNCT) for newly-diagnosed glioblastoma: Comparison of clinical results obtained with BNCT and conventional treatment

Journal of Medical Investigation

Volumn 61, Issue 3-4, 2014, Pages 254-263

  Kageji, Teruyoshi ^a   Nagahiro, Shinji ^a   Mizobuchi, Yoshifumi ^a   Matsuzaki, Kazuhito ^b   Nakagawa, Yoshinobu ^c   Kumada, Hiroaki ^d  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b TOKUSHIMA PREFECTURAL CENTRAL HOSPITAL   (Japan)

^c SHIKOKU MEDICAL CENTER FOR CHILDREN AND ADULTS   (Japan)

^d UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

BNCT; Glioma; Radiation

Indexed keywords

BOROCAPTATE; TEMOZOLOMIDE;

ACUTE HEART INFARCTION; ADULT; AGED; CENTRAL NERVOUS SYSTEM METASTASIS; CONTROLLED STUDY; CYTOREDUCTIVE SURGERY; DISTANT METASTASIS; EXTERNAL BEAM RADIOTHERAPY; FOLLOW UP; GLIOBLASTOMA; HUMAN; INTERMETHOD COMPARISON; KARNOFSKY PERFORMANCE STATUS; MAJOR CLINICAL STUDY; NEUTRON CAPTURE THERAPY; OUTCOME ASSESSMENT; PEROPERATIVE CARE; RADIATION NECROSIS; RADIATION RESPONSE; REVIEW; SURVIVAL RATE; SURVIVAL TIME; TUMOR INVASION; WOUND INFECTION; ADOLESCENT; BRAIN NEOPLASMS; CHILD; COMPARATIVE STUDY; MIDDLE AGED; MORTALITY;

ADOLESCENT; ADULT; AGED; BORON NEUTRON CAPTURE THERAPY; BRAIN NEOPLASMS; CHILD; GLIOBLASTOMA; HUMANS; MIDDLE AGED; SURVIVAL RATE;

EID: 84907567821     PISSN: 13431420     EISSN: 13496867     Source Type: Journal    
DOI: 10.2152/jmi.61.254     Document Type: Review

References (31)

1. Athanassiou H, Synodinou M, Maragoudakis E, Paraskevaidis M, Verigos C, Misailidou D, Antonnadou D, Saris G, Beroukas K, Karageorgis P: Randomized phase II study of temozolomide and radiotherapy compared with radiotherapy alone in newly diagnosed glioblastoma multiforme. J Clin Oncol 23: 2372-2377, 2005
2. Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO for the European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups and the National Cancer Institute of Canada Clinical Trial Group: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Eng J Med 352: 987-996, 2005
3. Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJB, Janzer RC, Ludwin SK, Allgeier A, Fisher B, Belanger K, Hau P, Brandes AA, Gijtenbeek J, Marosi C, Vecht CJ, Mokhtari K, Wesseling P, Villa S, Eisenhauer E, Gorlia T, Weller M, Lacombe D, Cairncross JG, Mirimanoff RO: Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial: Lancet Oncol 10: 459-466, 2009
4. Locher GL: Biological effects and therapeutic possibilities of neutron. Am J Roentgenol 36: 1-13, 1936
5. Hatanaka, H: Introduction. In: Hatanaka H, editor. Boron Neutron Capture Therapy for Tumors. Niigata: Nishimura: p. 1-28, 1986
6. Barth RF, Coderre JA, Vicente MG, Blue TE: Boron neutron capture therapy of cancer: Current status and future prospects. Clin Cancer Res 11: 3987-4002, 2005
7. Hatanaka H, Kamano S, Amano K, Hojo S, Sano K, Egawa S, Yasukochi H: Clinical experience of boron-neutron capture therapy for gliomas. A comparison with conventional chemo-immuno-radiotherapy. In: Hatanaka H, editor. Boron Neutron Capture Therapy for Tumors. Niigata: Nishimura: p. 349-379, 1986
8. Nakagawa Y, Hatanaka H: Boron neutron capture therapy -Clinical brain tumor study. J Neurooncol 33: 105-115, 1997
9. Hatanaka H, Nakagawa Y: Clinical results of long-surviving brain tumor patients who underwent boron neutron capture therapy. Int J Radiat Oncol Biol Phys 28: 1061-1066, 1994
10. Nakagawa Y: Boron neutron capture therapy: The past to the present. Int J Radiat Oncol Biol Phys 28: 1217, 1994
11. Nakagawa Y, Pooh K, Kobayshi T, Kageji T, Uyama S, Matsumura A, Kumada H: Clinical review of Japanese experience with boron neutron capture therapy and a proposed strategy using epithermal neutron beams. J. Neurooncol 62: 87-99, 2003
12. Kageji T, Nagahiro S, Matsuzaki K, Mizobuchi Y, Toi H, Nakagawa Y, Kumada H: Boron neutron capture therapy using mixed epithermal and thermal neutron beams in patients with malignant glioma -Correlation between radiation dose and radiation injury and clinical outcome. Int J Radiat Oncol Biol Phys 65: 1446-1455, 2006
13. Kumada H, Yamamoto K, Matsumura A, Yamamoto T, Nakagawa Y, Nakai K, Kageji T: Verification of the computational dosimetry system in JAERI (JCDS) for boron neutron capture therapy. Physics Med Biol 49: 3353-3365, 2004
14. Kumada H, Yamamoto K, Yamamoto T, Nakai K, Nakagawa Y, Kageji T, Matsumura A: Improvement of dose calculation accuracy for BNCT dosimetry by the multi-voxel method in JCDS. Appl Radiat Isotope 61: 1045-1050, 2004
15. Miyatake S, Kuwabara H, Kajimoto Y, Aoki A, Yokoyama K, Yamada M, Kuroiwa K, Tsuji M, Imahori Y, Kirihata M, Sakurai Y, Masunaga S, Nagata K, Maruhashi A, Ono K: Modified boron neutron capture therapy for malignant gliomas performed using epithermal neutron and two boron compounds with different accumulation mechanisms: An efficacy study based on findings on neuroimages. J Neurosurg 103: 1000-1009, 2005
16. Mirimanoff RO, Gorlia T, Mason W, Van den Bent MJ, Kortmann RD, Fisher B, Reni M, Brandes AA, Curschmann J, Villa S, Cairncross G, Allgeier A, Lacombe D, Stupp R: Radiotherapy and temozolomide for newly diagnosed glioblastoma: Recursive partitioning analysis of the EORTC26981/22981-NCIC CE3 phase III randomized trial. J Clin Oncol 24: 2563-2569, 2006
17. Kageji T, Otersen B, Gabel D, Huiskamp R, Nakagawa Y, Matsumoto K: Interaction of mercaptoundecahydrododecaborate (BSH) with phosphatidylcholine: relevance to neutron capture therapy. Biochimica et Biophysica Acta 1391: 377-383, 1998
18. Ono K, Masunaga S, Suzuki M, Kinashi Y, Takagaki M, Akaboshi M: The combined effect of boronophenylalanine and borocaptate in boron neutron capture therapy for SCCVII tumors in mice. Int J Radiat Oncol Biol Phys 43: 431-436, 1999
19. Laramore GE, Spence AM: Boron neutron capture therapy (BNCT) for high-grade gliomas of the brain: A cautionary note. Int J Radiat Oncol Biol Phys 36: 241-246, 1996
20. Kankaanranta L, Seppälä T, Koivunoro H, Välimäki P, Beule A, Collan J, Kortesniemi M, Uusi-Simola J, Kotiluoto P, Auterinen I, Serèn T, Paetau A, Saarilahti K, Savolainen S, Joensuu H: L-Boronophenylalanine-mediated boron neutron capture therapy for malignant glioma progressing after external beam radiation therapy: A phase I study. Int J Radiat Oncol Biol Phys 80: 369-376, 2011
21. Vos MJ, Turowski B, Zanella FE, Paquis P, Siefert A, Hideghety K, Haselberger K, Grochulla F, Postma TJ, Wittig A, Heimans JJ, Slotman BJ, Vandertop WP, Sauerwein W: Radiologic findings in patients treated with boron neutron capture for glioblastoma multiforme within EORTC trial 11961. Int J Radiat Oncol Biol Phys 61: 392-399, 2005
22. Henriksson R, Capala J, Michanek A, Lindahl S, Salford LG, Franze L, Blomquist E, Westlin J, Bergenheim AT: Boron neutron capture therapy (BNCT) for glioblastoma multiforme: A phase II study evaluating a prolonged highdose of boronophenylalanine (BPA). Radiother Oncol 88: 183-191, 2008
23. Sköld K, Stenstam BH, Diaz AZ, Giusti V, Pellettieri L, Hopewell JW: Boron neutron capture therapy for glioblastoma multiforme: Advantage of prolonged infusion of BPA-f. Acta Neurol Scand 122: 58-62, 2010
24. Sköld K, Gorlia T, Pellettieri L, Giusti V, HS B, Hopewell JW: Boron neutron capture therapy for newly diagnosed glioblastoma multiforme: An assessment of clinical potential. Br J Radiol 83: 596-603, 2010
25. Pellettieri L, HS B, Rezaei A, Giusti V, Skold K: An investigation of boron neutron capture therapy for recurrent glioblastoma multiforme. Acta Neurol Scand 117: 191-197, 2008
26. Kawabata S, Miyataka S, Kajimoto Y, Kuroda Y, Kuroiwa T, Imahori Y, Kirihata M, Sakurai Y, Kobayashi T, Ono K: The early successful treatment of glioblastoma patients with modified boron neutron capture therapy: Report of two cases. J Neurooncol 65: 159-165, 2003
27. Kawabata S, Miyatake S, Kuroiwa T, Yokoyama K, Doi A, Iida K, Miyata S, Nonoguchi N, Michiue H, Takahashi M, Inomata T, Imahori Y, Kirihata M, Sakurai Y, Maruhashi A, Kumada H, Ono K: Boron neutron capture therapy for newly diagnosed glioblastoma. J Radiat Res 50: 51-60, 2009
28. Yamamoto T, Naka K, Kageji T, Kumada H, Endo K, Matsuda M, Matsumura A: Boron neutron capture therapy for newly diagnosed glioblastoma. Radiother Oncol 91: 80-84, 2009
29. Yamamoto T, Matsumura A, Nakai K, Shibata Y, Endo K, Sakurai F, Kishi T, Kumada H, Yamamoto K, Torii Y: Current clinical results of the Tsukuba BNCT trial. Appl Radiat Isotope 61: 1089-1093, 2004
30. Kageji T, Mizobuchi Y, Nagahiro S, Nakagawa Y, Kumada H: Clinical results of boron neutron capture therapy (BNCT) for glioblastoma. Appl Radiat Isotope 69: 1823-1825, 2011
31. Tanaka H, Sakurai Y, Suzuki M, Masunaga S, Mitsumoto T, Fujita K, Kashino G, Kinashi Y, Liu Y, Takada M, Ono K, Maruhashi A: Experimental verification of beam characteristics for cyclotron-based epithermal neutron source (C-BENS). Appl Radiat Isotope 69: 1642-1645, 2011