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Volumn 12, Issue 40, 2014, Pages 7927-7931

Anion effects to deliver enhanced iridium catalysts for hydrogen isotope exchange processes

Author keywords

[No Author keywords available]

Indexed keywords

ANION EFFECTS; HYDROGEN ISOTOPE EXCHANGE; IRIDIUM CATALYST;

EID: 84907550552     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/c4ob01570c     Document Type: Article
Times cited : (40)

References (38)
  • 34
    • 0041417706 scopus 로고    scopus 로고
    • For information on the fundamentals of green chemistry and the impact of solvents on pharmaceutical organic synthesis, see
    • E. Martìnez-Viviente P. S. Pregosin Inorg. Chem. 2003 42 2209
    • (2003) Inorg. Chem. , vol.42 , pp. 2209
    • Martìnez-Viviente, E.1    Pregosin, P.S.2
  • 37
    • 84856711960 scopus 로고    scopus 로고
    • The increased selectivity for position d when using 1a in 2-MeTHF may be based on the increased polarity of the solvent relative to DCM and the resultant increase in competition between substrate and solvent for coordination to iridium. Coordination of the amide carbonyl and labelling via a 5-membered metallacycle (position d) is more facile than via the 6-membered metallacycle (position c; see ref. 9 for details). Additionally, coordination through the nitro group (for labelling at a and b) is presumed to be weaker than for the amide. For a recent discussion on the use of coordinating additives to increase reaction chemoselectivity, see
    • R. A. Sheldon Chem. Soc. Rev. 2012 41 1437
    • (2012) Chem. Soc. Rev. , vol.41 , pp. 1437
    • Sheldon, R.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.